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Impact of Toxoplasma gondii Infection on Host Non-coding RNA Responses.

Menard KL, Haskins BE, Denkers EY.

Front Cell Infect Microbiol. 2019 May 14;9:132. doi: 10.3389/fcimb.2019.00132. eCollection 2019. Review.


Toxoplasma gondii Manipulates Expression of Host Long Noncoding RNA during Intracellular Infection.

Menard KL, Haskins BE, Colombo AP, Denkers EY.

Sci Rep. 2018 Oct 9;8(1):15017. doi: 10.1038/s41598-018-33274-5.


Epithelial Sel1L is required for the maintenance of intestinal homeostasis.

Sun S, Lourie R, Cohen SB, Ji Y, Goodrich JK, Poole AC, Ley RE, Denkers EY, McGuckin MA, Long Q, Duhamel GE, Simpson KW, Qi L.

Mol Biol Cell. 2016 Feb 1;27(3):483-90. doi: 10.1091/mbc.E15-10-0724. Epub 2015 Dec 2.


Impact of Toxoplasma gondii on Dendritic Cell Subset Function in the Intestinal Mucosa.

Cohen SB, Denkers EY.

J Immunol. 2015 Sep 15;195(6):2754-62. doi: 10.4049/jimmunol.1501137. Epub 2015 Aug 17.


The gut mucosal immune response to Toxoplasma gondii.

Cohen SB, Denkers EY.

Parasite Immunol. 2015 Mar;37(3):108-17. doi: 10.1111/pim.12164. Review.


Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells.

Cohen SB, Smith NL, McDougal C, Pepper M, Shah S, Yap GS, Acha-Orbea H, Jiang A, Clausen BE, Rudd BD, Denkers EY.

J Immunol. 2015 Jan 1;194(1):210-22.


Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii.

Cohen SB, Denkers EY.

Mucosal Immunol. 2014 Jul;7(4):744-52. doi: 10.1038/mi.2014.25. Epub 2014 Apr 9. Review.


CXCR3-dependent CD4⁺ T cells are required to activate inflammatory monocytes for defense against intestinal infection.

Cohen SB, Maurer KJ, Egan CE, Oghumu S, Satoskar AR, Denkers EY.

PLoS Pathog. 2013;9(10):e1003706. doi: 10.1371/journal.ppat.1003706. Epub 2013 Oct 10.


Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca(2+) mobilization.

Smith NL, Abi Abdallah DS, Butcher BA, Denkers EY, Baird B, Holowka D.

Front Microbiol. 2013 Jul 4;4:179. doi: 10.3389/fmicb.2013.00179. eCollection 2013.


CCR2 and CD44 promote inflammatory cell recruitment during fatty liver formation in a lithogenic diet fed mouse model.

Egan CE, Daugherity EK, Rogers AB, Abi Abdallah DS, Denkers EY, Maurer KJ.

PLoS One. 2013 Jun 7;8(6):e65247. doi: 10.1371/journal.pone.0065247. Print 2013.


Toxoplasma gondii triggers phosphorylation and nuclear translocation of dendritic cell STAT1 while simultaneously blocking IFNγ-induced STAT1 transcriptional activity.

Schneider AG, Abi Abdallah DS, Butcher BA, Denkers EY.

PLoS One. 2013;8(3):e60215. doi: 10.1371/journal.pone.0060215. Epub 2013 Mar 20.


Neutrophils cast extracellular traps in response to protozoan parasites.

Abi Abdallah DS, Denkers EY.

Front Immunol. 2012 Dec 14;3:382. doi: 10.3389/fimmu.2012.00382. eCollection 2012.


CD73-generated adenosine facilitates Toxoplasma gondii differentiation to long-lived tissue cysts in the central nervous system.

Mahamed DA, Mills JH, Egan CE, Denkers EY, Bynoe MS.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16312-7. doi: 10.1073/pnas.1205589109. Epub 2012 Sep 17.


Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii.

McBerry C, Egan CE, Rani R, Yang Y, Wu D, Boespflug N, Boon L, Butcher B, Mirpuri J, Hogan SP, Denkers EY, Aliberti J, Herbert DR.

J Immunol. 2012 Sep 15;189(6):3078-84. doi: 10.4049/jimmunol.1103374. Epub 2012 Aug 15.


Phagocyte responses to protozoan infection and how Toxoplasma gondii meets the challenge.

Denkers EY, Schneider AG, Cohen SB, Butcher BA.

PLoS Pathog. 2012;8(8):e1002794. doi: 10.1371/journal.ppat.1002794. Epub 2012 Aug 2. Review. No abstract available.


Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease.

Craven M, Egan CE, Dowd SE, McDonough SP, Dogan B, Denkers EY, Bowman D, Scherl EJ, Simpson KW.

PLoS One. 2012;7(7):e41594. doi: 10.1371/journal.pone.0041594. Epub 2012 Jul 25.


Toxoplasma gondii triggers release of human and mouse neutrophil extracellular traps.

Abi Abdallah DS, Lin C, Ball CJ, King MR, Duhamel GE, Denkers EY.

Infect Immun. 2012 Feb;80(2):768-77. doi: 10.1128/IAI.05730-11. Epub 2011 Nov 21.


An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii.

Denkers EY, Bzik DJ, Fox BA, Butcher BA.

Infect Immun. 2012 Feb;80(2):476-82. doi: 10.1128/IAI.05974-11. Epub 2011 Nov 21. Review.


Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger.

Egan CE, Cohen SB, Denkers EY.

Immunol Cell Biol. 2012 Aug;90(7):668-75. doi: 10.1038/icb.2011.93. Epub 2011 Nov 8. Review.


Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.

Butcher BA, Fox BA, Rommereim LM, Kim SG, Maurer KJ, Yarovinsky F, Herbert DR, Bzik DJ, Denkers EY.

PLoS Pathog. 2011 Sep;7(9):e1002236. doi: 10.1371/journal.ppat.1002236. Epub 2011 Sep 8.


Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection.

Egan CE, Maurer KJ, Cohen SB, Mack M, Simpson KW, Denkers EY.

Mucosal Immunol. 2011 Nov;4(6):658-70. doi: 10.1038/mi.2011.31. Epub 2011 Jul 27.


Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation.

Abi Abdallah DS, Egan CE, Butcher BA, Denkers EY.

Int Immunol. 2011 May;23(5):317-26. doi: 10.1093/intimm/dxr007. Epub 2011 Mar 21.


Absence of mitogen-activated protein kinase family member c-Jun N-terminal kinase-2 enhances resistance to Toxoplasma gondii.

Sukhumavasi W, Warren AL, Del Rio L, Denkers EY.

Exp Parasitol. 2010 Nov;126(3):415-20. doi: 10.1016/j.exppara.2010.01.019. Epub 2010 Feb 1.


Toll-like receptor initiated host defense against Toxoplasma gondii.

Denkers EY.

J Biomed Biotechnol. 2010;2010:737125. doi: 10.1155/2010/737125. Epub 2009 Nov 11. Review.


Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances.

Leng J, Butcher BA, Denkers EY.

Parasite Immunol. 2009 Dec;31(12):717-28. doi: 10.1111/j.1365-3024.2009.01122.x. Review.


Toxoplasma gondii inhibits covalent modification of histone H3 at the IL-10 promoter in infected macrophages.

Leng J, Denkers EY.

PLoS One. 2009 Oct 27;4(10):e7589. doi: 10.1371/journal.pone.0007589.


CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection.

Egan CE, Craven MD, Leng J, Mack M, Simpson KW, Denkers EY.

Mucosal Immunol. 2009 Nov;2(6):527-35. doi: 10.1038/mi.2009.105. Epub 2009 Sep 9.


A gut feeling for microbes: getting it going between a parasite and its host.

Denkers EY.

Cell Host Microbe. 2009 Aug 20;6(2):104-6. doi: 10.1016/j.chom.2009.07.009. Review.


Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii.

Egan CE, Sukhumavasi W, Butcher BA, Denkers EY.

Clin Exp Immunol. 2009 Apr;156(1):17-24. doi: 10.1111/j.1365-2249.2009.03876.x. Epub 2009 Jan 21. Review.


Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation.

Leng J, Butcher BA, Egan CE, Abi Abdallah DS, Denkers EY.

J Immunol. 2009 Jan 1;182(1):489-97.


Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection.

Bierly AL, Shufesky WJ, Sukhumavasi W, Morelli AE, Denkers EY.

J Immunol. 2008 Dec 15;181(12):8485-91.


Deploying parasite profilin on a mission of invasion and danger.

Denkers EY, Striepen B.

Cell Host Microbe. 2008 Feb 14;3(2):61-3. doi: 10.1016/j.chom.2008.01.003. Review.


Understanding the multiple functions of Gr-1(+) cell subpopulations during microbial infection.

Egan CE, Sukhumavasi W, Bierly AL, Denkers EY.

Immunol Res. 2008;40(1):35-48. doi: 10.1007/s12026-007-0061-8. Review.


Mouse neutrophils require JNK2 MAPK for Toxoplasma gondii-induced IL-12p40 and CCL2/MCP-1 release.

Sukhumavasi W, Egan CE, Denkers EY.

J Immunol. 2007 Sep 15;179(6):3570-7.


Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.

Gazzinelli RT, Denkers EY.

Nat Rev Immunol. 2006 Dec;6(12):895-906. Epub 2006 Nov 17. Review.


Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages.

Kim L, Butcher BA, Lee CW, Uematsu S, Akira S, Denkers EY.

J Immunol. 2006 Aug 15;177(4):2584-91.


Toxoplasma gondii triggers Gi-dependent PI 3-kinase signaling required for inhibition of host cell apoptosis.

Kim L, Denkers EY.

J Cell Sci. 2006 May 15;119(Pt 10):2119-26. Epub 2006 Apr 25.


p47 GTPases regulate Toxoplasma gondii survival in activated macrophages.

Butcher BA, Greene RI, Henry SC, Annecharico KL, Weinberg JB, Denkers EY, Sher A, Taylor GA.

Infect Immun. 2005 Jun;73(6):3278-86.


p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection.

Kim L, Del Rio L, Butcher BA, Mogensen TH, Paludan SR, Flavell RA, Denkers EY.

J Immunol. 2005 Apr 1;174(7):4178-84.


IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages.

Butcher BA, Kim L, Panopoulos AD, Watowich SS, Murray PJ, Denkers EY.

J Immunol. 2005 Mar 15;174(6):3148-52.


Sabotage and exploitation in macrophages parasitized by intracellular protozoans.

Denkers EY, Butcher BA.

Trends Parasitol. 2005 Jan;21(1):35-41. Review.


Neutrophils, dendritic cells and Toxoplasma.

Denkers EY, Butcher BA, Del Rio L, Bennouna S.

Int J Parasitol. 2004 Mar 9;34(3):411-21. Review.


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