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Items: 1 to 50 of 93

1.

Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.

Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M Jr, Denison MR, Perlman S.

MBio. 2018 May 1;9(3). pii: e00272-18. doi: 10.1128/mBio.00272-18.

2.

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape.

Wang L, Shi W, Chappell JD, Joyce MG, Zhang Y, Kanekiyo M, Becker MM, van Doremalen N, Fischer R, Wang N, Corbett KS, Choe M, Mason RD, Van Galen JG, Zhou T, Saunders KO, Tatti KM, Haynes LM, Kwong PD, Modjarrad K, Kong WP, McLellan JS, Denison MR, Munster VJ, Mascola JR, Graham BS.

J Virol. 2018 Mar 7. pii: JVI.02002-17. doi: 10.1128/JVI.02002-17. [Epub ahead of print]

3.

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR.

MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18.

4.

Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations.

Graepel KW, Lu X, Case JB, Sexton NR, Smith EC, Denison MR.

MBio. 2017 Nov 7;8(6). pii: e01503-17. doi: 10.1128/mBio.01503-17.

5.

Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity.

Case JB, Li Y, Elliott R, Lu X, Graepel KW, Sexton NR, Smith EC, Weiss SR, Denison MR.

J Virol. 2017 Dec 14;92(1). pii: e01531-17. doi: 10.1128/JVI.01531-17. Print 2018 Jan 1.

6.

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7348-E7357. doi: 10.1073/pnas.1707304114. Epub 2017 Aug 14.

7.

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653.

8.

Middle East Respiratory Syndrome.

Arabi YM, Balkhy HH, Hayden FG, Bouchama A, Luke T, Baillie JK, Al-Omari A, Hajeer AH, Senga M, Denison MR, Nguyen-Van-Tam JS, Shindo N, Bermingham A, Chappell JD, Van Kerkhove MD, Fowler RA.

N Engl J Med. 2017 Feb 9;376(6):584-594. doi: 10.1056/NEJMsr1408795. No abstract available.

9.

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins.

Athmer J, Fehr AR, Grunewald M, Smith EC, Denison MR, Perlman S.

MBio. 2017 Jan 31;8(1). pii: e02320-16. doi: 10.1128/mBio.02320-16.

10.

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses.

Mounce BC, Cesaro T, Moratorio G, Hooikaas PJ, Yakovleva A, Werneke SW, Smith EC, Poirier EZ, Simon-Loriere E, Prot M, Tamietti C, Vitry S, Volle R, Khou C, Frenkiel MP, Sakuntabhai A, Delpeyroux F, Pardigon N, Flamand M, Barba-Spaeth G, Lafon M, Denison MR, Albert ML, Vignuzzi M.

J Virol. 2016 Oct 14;90(21):9683-9692. Print 2016 Nov 1.

11.

Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens.

Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen OB, Denison MR.

J Virol. 2016 Jul 27;90(16):7415-7428. doi: 10.1128/JVI.00080-16. Print 2016 Aug 15.

12.
13.

Evaluation of candidate vaccine approaches for MERS-CoV.

Wang L, Shi W, Joyce MG, Modjarrad K, Zhang Y, Leung K, Lees CR, Zhou T, Yassine HM, Kanekiyo M, Yang ZY, Chen X, Becker MM, Freeman M, Vogel L, Johnson JC, Olinger G, Todd JP, Bagci U, Solomon J, Mollura DJ, Hensley L, Jahrling P, Denison MR, Rao SS, Subbarao K, Kwong PD, Mascola JR, Kong WP, Graham BS.

Nat Commun. 2015 Jul 28;6:7712. doi: 10.1038/ncomms8712.

14.

Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry.

Mainou BA, Ashbrook AW, Smith EC, Dorset DC, Denison MR, Dermody TS.

J Virol. 2015 Sep;89(17):8701-12. doi: 10.1128/JVI.00739-15. Epub 2015 Jun 24.

15.

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.

Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD.

J Biol Chem. 2015 Aug 7;290(32):19403-22. doi: 10.1074/jbc.M115.651463. Epub 2015 Jun 8.

16.

Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity.

Smith EC, Case JB, Blanc H, Isakov O, Shomron N, Vignuzzi M, Denison MR.

J Virol. 2015 Jun;89(12):6418-26. doi: 10.1128/JVI.00110-15. Epub 2015 Apr 8.

17.

Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications.

Beachboard DC, Anderson-Daniels JM, Denison MR.

J Virol. 2015 Feb;89(4):2080-9. doi: 10.1128/JVI.02776-14. Epub 2014 Dec 3.

18.

Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses.

Smith EC, Sexton NR, Denison MR.

Annu Rev Virol. 2014 Nov;1(1):111-32. doi: 10.1146/annurev-virology-031413-085507. Epub 2014 Jun 2.

PMID:
26958717
19.

Novel poxvirus infection in 2 patients from the United States.

Osadebe LU, Manthiram K, McCollum AM, Li Y, Emerson GL, Gallardo-Romero NF, Doty JB, Wilkins K, Zhao H, Drew CP, Metcalfe MG, Goldsmith CS, Muehlenbachs A, Googe PB, Dunn J, Duenckel T, Henderson H, Carroll DS, Zaki SR, Denison MR, Reynolds MG, Damon IK.

Clin Infect Dis. 2015 Jan 15;60(2):195-202. doi: 10.1093/cid/ciu790. Epub 2014 Oct 9.

20.

Coronaviruses induce entry-independent, continuous macropinocytosis.

Freeman MC, Peek CT, Becker MM, Smith EC, Denison MR.

MBio. 2014 Aug 5;5(4):e01340-14. doi: 10.1128/mBio.01340-14.

21.

A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant.

Agnihothram S, Yount BL Jr, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS.

MBio. 2014 Mar 25;5(2):e00047-14. doi: 10.1128/mBio.00047-14.

22.

Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation.

Freeman MC, Graham RL, Lu X, Peek CT, Denison MR.

J Virol. 2014 May;88(10):5319-27. doi: 10.1128/JVI.00021-14. Epub 2014 Mar 12.

23.

Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity.

Smith EC, Denison MR.

PLoS Pathog. 2013;9(12):e1003760. doi: 10.1371/journal.ppat.1003760. Epub 2013 Dec 5. Review. No abstract available.

24.

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012.

Khuri-Bulos N, Payne DC, Lu X, Erdman D, Wang L, Faouri S, Shehabi A, Johnson M, Becker MM, Denison MR, Williams JV, Halasa NB.

Clin Microbiol Infect. 2014 Jul;20(7):678-82. doi: 10.1111/1469-0691.12438. Epub 2013 Dec 9.

25.

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses.

Agnihothram S, Gopal R, Yount BL Jr, Donaldson EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS.

J Infect Dis. 2014 Apr 1;209(7):995-1006. doi: 10.1093/infdis/jit609. Epub 2013 Nov 18.

26.

Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity.

Stobart CC, Sexton NR, Munjal H, Lu X, Molland KL, Tomar S, Mesecar AD, Denison MR.

J Virol. 2013 Dec;87(23):12611-8. doi: 10.1128/JVI.02050-13. Epub 2013 Sep 11.

27.

Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.

Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR.

PLoS Pathog. 2013 Aug;9(8):e1003565. doi: 10.1371/journal.ppat.1003565. Epub 2013 Aug 15. Erratum in: PLoS Pathog. 2014 Jul;10(7):e1004342. Surdel, Matthew C [added].

28.

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.

Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS.

Nat Med. 2012 Dec;18(12):1820-6. doi: 10.1038/nm.2972. Epub 2012 Nov 11.

29.

Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive.

Beachboard DC, Lu X, Baker SC, Denison MR.

Virology. 2013 Jan 20;435(2):210-3. doi: 10.1016/j.virol.2012.10.001. Epub 2012 Oct 23.

30.

Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses.

Smith EC, Denison MR.

Curr Opin Virol. 2012 Oct;2(5):519-24. doi: 10.1016/j.coviro.2012.07.005. Epub 2012 Aug 1. Review.

PMID:
22857992
32.

Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity.

Denison MR, Graham RL, Donaldson EF, Eckerle LD, Baric RS.

RNA Biol. 2011 Mar-Apr;8(2):270-9. Epub 2011 Mar 1. Review.

33.

Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.

Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M.

PLoS Pathog. 2011 Jan 6;7(1):e1001258. doi: 10.1371/journal.ppat.1001258.

34.

ANDES: Statistical tools for the ANalyses of DEep Sequencing.

Li K, Venter E, Yooseph S, Stockwell TB, Eckerle LD, Denison MR, Spiro DJ, Methé BA.

BMC Res Notes. 2010 Jul 15;3:199. doi: 10.1186/1756-0500-3-199.

35.

Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.

Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR.

PLoS Pathog. 2010 May 6;6(5):e1000896. doi: 10.1371/journal.ppat.1000896.

36.

Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing.

Gadlage MJ, Denison MR.

J Virol. 2010 Jul;84(13):6894-8. doi: 10.1128/JVI.00752-10. Epub 2010 Apr 28.

37.

Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus.

Dulek DE, Williams JV, Creech CB, Schulert AK, Frangoul HA, Domm J, Denison MR, Chappell JD.

Clin Infect Dis. 2010 Jun 1;50(11):1493-6. doi: 10.1086/652655.

PMID:
20415572
38.

H1N1 infection mimicking the clinical presentation of gastrointestinal GVHD in a patient following allo-SCT.

Frangoul H, Domm J, Denison MR, Calder C, Black J.

Bone Marrow Transplant. 2011 Jan;46(1):152-3. doi: 10.1038/bmt.2010.66. Epub 2010 Apr 12. No abstract available.

PMID:
20383217
39.

Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function.

Gadlage MJ, Sparks JS, Beachboard DC, Cox RG, Doyle JD, Stobart CC, Denison MR.

J Virol. 2010 Jan;84(1):280-90. doi: 10.1128/JVI.01772-09.

40.

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.

Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19944-9. doi: 10.1073/pnas.0808116105. Epub 2008 Nov 26.

41.

Seeking membranes: positive-strand RNA virus replication complexes.

Denison MR.

PLoS Biol. 2008 Oct 28;6(10):e270. doi: 10.1371/journal.pbio.0060270. Review. No abstract available.

42.

Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization.

Gadlage MJ, Graham RL, Denison MR.

J Virol. 2008 Dec;82(23):11964-9. doi: 10.1128/JVI.01126-07. Epub 2008 Sep 24.

43.

A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing.

Sparks JS, Donaldson EF, Lu X, Baric RS, Denison MR.

J Virol. 2008 Jun;82(12):5999-6008. doi: 10.1128/JVI.00203-08. Epub 2008 Apr 2.

44.

Genetic analysis of Murine hepatitis virus nsp4 in virus replication.

Sparks JS, Lu X, Denison MR.

J Virol. 2007 Nov;81(22):12554-63. Epub 2007 Sep 12.

45.

High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.

Eckerle LD, Lu X, Sperry SM, Choi L, Denison MR.

J Virol. 2007 Nov;81(22):12135-44. Epub 2007 Sep 5.

46.

Coronavirus replication does not require the autophagy gene ATG5.

Zhao Z, Thackray LB, Miller BC, Lynn TM, Becker MM, Ward E, Mizushima NN, Denison MR, Virgin HW 4th.

Autophagy. 2007 Nov-Dec;3(6):581-5. Epub 2007 Jul 24.

PMID:
17700057
47.

Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication.

Deming DJ, Graham RL, Denison MR, Baric RS.

J Virol. 2007 Oct;81(19):10280-91. Epub 2007 Jul 18.

48.

Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing.

Donaldson EF, Graham RL, Sims AC, Denison MR, Baric RS.

J Virol. 2007 Jul;81(13):7086-98. Epub 2007 Apr 11.

49.

SARS coronavirus replicase proteins in pathogenesis.

Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR.

Virus Res. 2008 Apr;133(1):88-100. Epub 2007 Mar 29.

50.

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis.

Donaldson EF, Sims AC, Graham RL, Denison MR, Baric RS.

J Virol. 2007 Jun;81(12):6356-68. Epub 2007 Mar 28.

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