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Items: 29


Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins.

Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC.

Elife. 2019 Nov 1;8. pii: e48434. doi: 10.7554/eLife.48434.


The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn.

Demircioglu FE, Zheng W, McQuown AJ, Maier NK, Watson N, Cheeseman IM, Denic V, Egelman EH, Schwartz TU.

Nat Commun. 2019 Jul 22;10(1):3262. doi: 10.1038/s41467-019-11194-w.


TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.

An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW.

Mol Cell. 2019 Jun 6;74(5):891-908.e10. doi: 10.1016/j.molcel.2019.03.034. Epub 2019 Apr 18.


CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor.

Shoemaker CJ, Huang TQ, Weir NR, Polyakov NJ, Schultz SW, Denic V.

PLoS Biol. 2019 Apr 1;17(4):e2007044. doi: 10.1371/journal.pbio.2007044. eCollection 2019 Apr.


Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.

Solís EJ, Pandey JP, Zheng X, Jin DX, Gupta PB, Airoldi EM, Pincus D, Denic V.

Mol Cell. 2018 Feb 1;69(3):534. doi: 10.1016/j.molcel.2018.01.021. No abstract available.


Putting Your Best Egg Forward.

Patil CK, Denic V.

Dev Cell. 2018 Jan 8;44(1):5-7. doi: 10.1016/j.devcel.2017.12.016. Epub 2018 Jan 8.


The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane.

Weir NR, Kamber RA, Martenson JS, Denic V.

Elife. 2017 Sep 14;6. pii: e28507. doi: 10.7554/eLife.28507.


Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer.

Zalisko BE, Chan C, Denic V, Rock RS, Keenan RJ.

Cell Rep. 2017 Sep 5;20(10):2287-2293. doi: 10.1016/j.celrep.2017.08.035.


A pathway of targeted autophagy is induced by DNA damage in budding yeast.

Eapen VV, Waterman DP, Bernard A, Schiffmann N, Sayas E, Kamber R, Lemos B, Memisoglu G, Ang J, Mazella A, Chuartzman SG, Loewith RJ, Schuldiner M, Denic V, Klionsky DJ, Haber JE.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1158-E1167. doi: 10.1073/pnas.1614364114. Epub 2017 Feb 2.


Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.

Solís EJ, Pandey JP, Zheng X, Jin DX, Gupta PB, Airoldi EM, Pincus D, Denic V.

Mol Cell. 2016 Jul 7;63(1):60-71. doi: 10.1016/j.molcel.2016.05.014. Epub 2016 Jun 16. Erratum in: Mol Cell. 2018 Feb 1;69(3):534.


A molecular switch for selective autophagosome formation.

Kamber RA, Shoemaker CJ, Denic V.

Autophagy. 2015 Nov 2;11(11):2132-2133.


Advice to a young scientist (by someone who doesn't know how to give it).

Denic V.

Mol Biol Cell. 2015 Nov 1;26(21):3681-3. doi: 10.1091/mbc.E15-06-0341.


Receptor-Bound Targets of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase.

Kamber RA, Shoemaker CJ, Denic V.

Mol Cell. 2015 Aug 6;59(3):372-81. doi: 10.1016/j.molcel.2015.06.009. Epub 2015 Jul 9.


The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.

Wang F, Chan C, Weir NR, Denic V.

Nature. 2014 Aug 28;512(7515):441-4. doi: 10.1038/nature13471. Epub 2014 Jul 20.


Endoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathway.

Denic V, Dötsch V, Sinning I.

Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a013334. doi: 10.1101/cshperspect.a013334. Review.


A portrait of the GET pathway as a surprisingly complicated young man.

Denic V.

Trends Biochem Sci. 2012 Oct;37(10):411-7. doi: 10.1016/j.tibs.2012.07.004. Epub 2012 Aug 30. Review.


The mechanism of tail-anchored protein insertion into the ER membrane.

Wang F, Whynot A, Tung M, Denic V.

Mol Cell. 2011 Sep 2;43(5):738-50. doi: 10.1016/j.molcel.2011.07.020. Epub 2011 Aug 11.


Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.

Stefer S, Reitz S, Wang F, Wild K, Pang YY, Schwarz D, Bomke J, Hein C, Löhr F, Bernhard F, Denic V, Dötsch V, Sinning I.

Science. 2011 Aug 5;333(6043):758-62. doi: 10.1126/science.1207125. Epub 2011 Jun 30.


No country for old misfolded glycoproteins.

Denic V.

Mol Cell. 2011 Jun 24;42(6):715-7. doi: 10.1016/j.molcel.2011.06.004.


A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum.

Wang F, Brown EC, Mak G, Zhuang J, Denic V.

Mol Cell. 2010 Oct 8;40(1):159-71. doi: 10.1016/j.molcel.2010.08.038. Epub 2010 Sep 16.


The crystal structures of yeast Get3 suggest a mechanism for tail-anchored protein membrane insertion.

Hu J, Li J, Qian X, Denic V, Sha B.

PLoS One. 2009 Nov 30;4(11):e8061. doi: 10.1371/journal.pone.0008061.


Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.

Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M.

Science. 2009 Mar 27;323(5922):1693-7. doi: 10.1126/science.1167983.


Defining the glycan destruction signal for endoplasmic reticulum-associated degradation.

Quan EM, Kamiya Y, Kamiya D, Denic V, Weibezahn J, Kato K, Weissman JS.

Mol Cell. 2008 Dec 26;32(6):870-7. doi: 10.1016/j.molcel.2008.11.017.


The GET complex mediates insertion of tail-anchored proteins into the ER membrane.

Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman JS.

Cell. 2008 Aug 22;134(4):634-45. doi: 10.1016/j.cell.2008.06.025.


Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ.

Cell. 2005 Nov 4;123(3):507-19.


[Manifestations of hemorrhagic fever with renal syndrome in a military unit stationed in a combat zone].

Cirić S, Denić V, Mitrović V, Mitrović-Perisić N, Denić N, Cirić S.

Vojnosanit Pregl. 2003 Sep-Oct;60(5):605-11. Serbian.


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