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Effect of stress on human biology: Epigenetics, adaptation, inheritance, and social significance.

Denhardt DT.

J Cell Physiol. 2018 Mar;233(3):1975-1984. doi: 10.1002/jcp.25837. Epub 2017 Apr 27. Review.


Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.

Martín-Alonso M, García-Redondo AB, Guo D, Camafeita E, Martínez F, Alfranca A, Méndez-Barbero N, Pollán Á, Sánchez-Camacho C, Denhardt DT, Seiki M, Vázquez J, Salaices M, Redondo JM, Milewicz D, Arroyo AG.

Circ Res. 2015 Jul 3;117(2):e13-26. doi: 10.1161/CIRCRESAHA.117.305108. Epub 2015 May 11.


Hindlimb-unloading suppresses B cell population in the bone marrow and peripheral circulation associated with OPN expression in circulating blood cells.

Ezura Y, Nagata J, Nagao M, Hemmi H, Hayata T, Rittling S, Denhardt DT, Noda M.

J Bone Miner Metab. 2015 Jan;33(1):48-54. doi: 10.1007/s00774-014-0568-8. Epub 2014 May 16.


An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells.

Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts AI, Rabson AB, Ren G, Zhang Y, Wang Y, Denhardt DT, Shi Y.

Stem Cells. 2014 Feb;32(2):327-37. doi: 10.1002/stem.1567.


Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels.

Schunke KJ, Coyle L, Merrill GF, Denhardt DT.

J Cell Physiol. 2013 Oct;228(10):2006-14. doi: 10.1002/jcp.24367.


Osteopontin regulates interleukin-17 production in hepatitis.

Diao H, Liu X, Wu Z, Kang L, Cui G, Morimoto J, Denhardt DT, Rittling S, Iwakura Y, Uede T, Li L.

Cytokine. 2012 Oct;60(1):129-37. doi: 10.1016/j.cyto.2012.06.287. Epub 2012 Jul 19.


Osteopontin Deficiency Suppresses Tumor Necrosis Factor-α-Induced Apoptosis in Chondrocytes.

Yumoto K, Nifuji A, Rittling SR, Tsuchiya Y, Kon S, Uede T, Denhardt DT, Hemmi H, Notomi T, Hayata T, Ezura Y, Nakamoto T, Noda M.

Cartilage. 2012 Jan;3(1):79-85. doi: 10.1177/1947603511421502.


Sympathetic control of bone mass regulated by osteopontin.

Nagao M, Feinstein TN, Ezura Y, Hayata T, Notomi T, Saita Y, Hanyu R, Hemmi H, Izu Y, Takeda S, Wang K, Rittling S, Nakamoto T, Kaneko K, Kurosawa H, Karsenty G, Denhardt DT, Vilardaga JP, Noda M.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17767-72. doi: 10.1073/pnas.1109402108. Epub 2011 Oct 11.


Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress, and interstitial fibrosis in the kidney.

Irita J, Okura T, Jotoku M, Nagao T, Enomoto D, Kurata M, Desilva VR, Miyoshi K, Matsui Y, Uede T, Denhardt DT, Rittiling SR, Higaki J.

Am J Physiol Renal Physiol. 2011 Oct;301(4):F833-44. doi: 10.1152/ajprenal.00557.2010. Epub 2011 Jul 6.


Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology.

Morishita M, Ono N, Miyai K, Nakagawa T, Hanyu R, Nagao M, Kamolratanakul P, Notomi T, Rittling SR, Denhardt DT, Kronenberg HM, Ezura Y, Hayata T, Nakamoto T, Noda M.

Tissue Cell. 2011 Jun;43(3):196-200. doi: 10.1016/j.tice.2011.02.003. Epub 2011 Apr 21.


Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen.

Baliga SS, Merrill GF, Shinohara ML, Denhardt DT.

PLoS One. 2011 Jan 21;6(1):e14568. doi: 10.1371/journal.pone.0014568.


Involvement of osteopontin in the matrix-degrading and proangiogenic changes mediated by nicotine in pancreatic cancer cells.

Lazar M, Sullivan J, Chipitsyna G, Gong Q, Ng CY, Salem AF, Aziz T, Witkiewicz A, Denhardt DT, Yeo CJ, Arafat HA.

J Gastrointest Surg. 2010 Oct;14(10):1566-77. doi: 10.1007/s11605-010-1338-0. Epub 2010 Sep 8.


Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: role of osteopontin.

Lazar M, Sullivan J, Chipitsyna G, Aziz T, Salem AF, Gong Q, Witkiewicz A, Denhardt DT, Yeo CJ, Arafat HA.

Surgery. 2010 Aug;148(2):298-309. doi: 10.1016/j.surg.2010.05.002. Epub 2010 Jun 25.


Crystallographically engineered, hydrothermally crystallized hydroxyapatite films: an in vitro study of bioactivity.

Haders DJ, Kazanecki CC, Denhardt DT, Riman RE.

J Mater Sci Mater Med. 2010 May;21(5):1531-42. doi: 10.1007/s10856-010-4031-7. Epub 2010 Mar 16.


Osteopontin deficiency impairs wear debris-induced osteolysis via regulation of cytokine secretion from murine macrophages.

Shimizu S, Okuda N, Kato N, Rittling SR, Okawa A, Shinomiya K, Muneta T, Denhardt DT, Noda M, Tsuji K, Asou Y.

Arthritis Rheum. 2010 May;62(5):1329-37. doi: 10.1002/art.27400.


Impaired angiogenic response in the corneas of mice lacking osteopontin.

Fujita N, Fujita S, Okada Y, Fujita K, Kitano A, Yamanaka O, Miyamoto T, Kon S, Uede T, Rittling SR, Denhardt DT, Saika S.

Invest Ophthalmol Vis Sci. 2010 Feb;51(2):790-4. doi: 10.1167/iovs.09-3420. Epub 2009 Sep 9.


Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice.

Matsui Y, Iwasaki N, Kon S, Takahashi D, Morimoto J, Matsui Y, Denhardt DT, Rittling S, Minami A, Uede T.

Arthritis Rheum. 2009 Aug;60(8):2362-71. doi: 10.1002/art.24705.


Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma.

Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA.

Surgery. 2009 Aug;146(2):232-40. doi: 10.1016/j.surg.2009.03.036.


Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.

Grassinger J, Haylock DN, Storan MJ, Haines GO, Williams B, Whitty GA, Vinson AR, Be CL, Li S, Sørensen ES, Tam PP, Denhardt DT, Sheppard D, Choong PF, Nilsson SK.

Blood. 2009 Jul 2;114(1):49-59. doi: 10.1182/blood-2009-01-197988. Epub 2009 May 5.


Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells.

Chipitsyna G, Gong Q, Anandanadesan R, Alnajar A, Batra SK, Wittel UA, Cullen DM, Akhter MP, Denhardt DT, Yeo CJ, Arafat HA.

Int J Cancer. 2009 Jul 15;125(2):276-85. doi: 10.1002/ijc.24388.


Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus.

Maeno Y, Shinzato M, Nagashima S, Rittling SR, Denhardt DT, Uede T, Taniguchi K.

Viral Immunol. 2009 Apr;22(2):139-44. doi: 10.1089/vim.2008.0054.


Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin monoclonal antibody.

Wang KX, Shi YF, Ron Y, Kazanecki CC, Denhardt DT.

J Immunol. 2009 Feb 15;182(4):2485-91. doi: 10.4049/jimmunol.0803023.


Osteopontin: role in immune regulation and stress responses.

Wang KX, Denhardt DT.

Cytokine Growth Factor Rev. 2008 Oct-Dec;19(5-6):333-45. doi: 10.1016/j.cytogfr.2008.08.001. Epub 2008 Oct 25. Review.


Osteopontin regulates development and function of invariant natural killer T cells.

Diao H, Iwabuchi K, Li L, Onoe K, Van Kaer L, Kon S, Saito Y, Morimoto J, Denhardt DT, Rittling S, Uede T.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15884-9. doi: 10.1073/pnas.0806089105. Epub 2008 Oct 3.


Osteopontin is dispensable for protection against high load systemic fungal infection.

Sato I, Yamamoto N, Rittling SR, Denhardt DT, Hino M, Morimoro J, Sakai F, Fujie A, Uede T.

Int Immunopharmacol. 2008 Oct;8(10):1441-8. doi: 10.1016/j.intimp.2008.06.001. Epub 2008 Jun 30.


Characterization of osteopontin expression and function after status epilepticus.

Borges K, Gearing M, Rittling S, Sorensen ES, Kotloski R, Denhardt DT, Dingledine R.

Epilepsia. 2008 Oct;49(10):1675-85. doi: 10.1111/j.1528-1167.2008.01613.x. Epub 2008 Jun 3.


Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts.

Ono N, Nakashima K, Rittling SR, Schipani E, Hayata T, Soma K, Denhardt DT, Kronenberg HM, Ezura Y, Noda M.

J Biol Chem. 2008 Jul 11;283(28):19400-9. doi: 10.1074/jbc.M800005200. Epub 2008 Apr 16.


Corneal wound healing in an osteopontin-deficient mouse.

Miyazaki K, Okada Y, Yamanaka O, Kitano A, Ikeda K, Kon S, Uede T, Rittling SR, Denhardt DT, Kao WW, Saika S.

Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1367-75. doi: 10.1167/iovs.07-1007.


Control of osteopontin signaling and function by post-translational phosphorylation and protein folding.

Kazanecki CC, Uzwiak DJ, Denhardt DT.

J Cell Biochem. 2007 Nov 1;102(4):912-24. Review.


OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application.

Chung CJ, Soma K, Rittling SR, Denhardt DT, Hayata T, Nakashima K, Ezura Y, Noda M.

J Cell Physiol. 2008 Mar;214(3):614-20.


Characterization of anti-osteopontin monoclonal antibodies: Binding sensitivity to post-translational modifications.

Kazanecki CC, Kowalski AJ, Ding T, Rittling SR, Denhardt DT.

J Cell Biochem. 2007 Nov 1;102(4):925-35.


Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production.

Wang KX, Shi Y, Denhardt DT.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14777-82. Epub 2007 Sep 4.


Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties.

Christensen B, Kazanecki CC, Petersen TE, Rittling SR, Denhardt DT, Sørensen ES.

J Biol Chem. 2007 Jul 6;282(27):19463-72. Epub 2007 May 11.


Osteopontin aggravates experimental autoimmune uveoretinitis in mice.

Kitamura M, Iwabuchi K, Kitaichi N, Kon S, Kitamei H, Namba K, Yoshida K, Denhardt DT, Rittling SR, Ohno S, Uede T, Onoé K.

J Immunol. 2007 May 15;178(10):6567-72.


Osteopontin is required for mechanical stress-dependent signals to bone marrow cells.

Ishijima M, Tsuji K, Rittling SR, Yamashita T, Kurosawa H, Denhardt DT, Nifuji A, Ezura Y, Noda M.

J Endocrinol. 2007 May;193(2):235-43.


Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in bone.

Kato N, Kitahara K, Rittling SR, Nakashima K, Denhardt DT, Kurosawa H, Ezura Y, Noda M.

J Endocrinol. 2007 Apr;193(1):171-82.


Osteopontin deficiency and aging on nanomechanics of mouse bone.

Kavukcuoglu NB, Denhardt DT, Guzelsu N, Mann AB.

J Biomed Mater Res A. 2007 Oct;83(1):136-44.


Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain.

Wung JK, Perry G, Kowalski A, Harris PL, Bishop GM, Trivedi MA, Johnson SC, Smith MA, Denhardt DT, Atwood CS.

Curr Alzheimer Res. 2007 Feb;4(1):67-72.


Osteopontin expression and function within the dorsal root ganglion.

Marsh BC, Kerr NC, Isles N, Denhardt DT, Wynick D.

Neuroreport. 2007 Jan 22;18(2):153-7.


Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium.

Saika S, Shirai K, Yamanaka O, Miyazaki K, Okada Y, Kitano A, Flanders KC, Kon S, Uede T, Kao WW, Rittling SR, Denhardt DT, Ohnishi Y.

Lab Invest. 2007 Feb;87(2):130-8. Epub 2007 Jan 8.


The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation.

Mori N, Majima T, Iwasaki N, Kon S, Miyakawa K, Kimura C, Tanaka K, Denhardt DT, Rittling S, Minami A, Uede T.

Matrix Biol. 2007 Jan;26(1):42-53. Epub 2006 Sep 15.


Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss.

Ishijima M, Ezura Y, Tsuji K, Rittling SR, Kurosawa H, Denhardt DT, Emi M, Nifuji A, Noda M.

Exp Cell Res. 2006 Oct 1;312(16):3075-83. Epub 2006 Jun 7.


Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha expression and non-programmed cell death.

Da Silva AP, Pollett A, Rittling SR, Denhardt DT, Sodek J, Zohar R.

J Cell Physiol. 2006 Sep;208(3):629-39.


An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells.

Lai CF, Seshadri V, Huang K, Shao JS, Cai J, Vattikuti R, Schumacher A, Loewy AP, Denhardt DT, Rittling SR, Towler DA.

Circ Res. 2006 Jun 23;98(12):1479-89. Epub 2006 May 18.


Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel post-transcriptional, post-translational regulation.

Khan SA, Cook AC, Kappil M, Günthert U, Chambers AF, Tuck AB, Denhardt DT.

Clin Exp Metastasis. 2005;22(8):663-73. Epub 2006 May 12.


Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice.

Schroeter M, Zickler P, Denhardt DT, Hartung HP, Jander S.

Brain. 2006 Jun;129(Pt 6):1426-37. Epub 2006 Apr 24.


Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice.

Maeno Y, Nakazawa S, Yamamoto N, Shinzato M, Nagashima S, Tanaka K, Sasaki J, Rittling SR, Denhardt DT, Uede T, Taniguchi K.

Infect Immun. 2006 Apr;74(4):2423-7.


Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts.

Koyama Y, Rittling SR, Tsuji K, Hino K, Salincarnboriboon R, Yano T, Taketani Y, Nifuji A, Denhardt DT, Noda M.

Endocrinology. 2006 Jun;147(6):3040-9. Epub 2006 Mar 2.


Tissue inhibitor of metalloproteinases-1 stimulates gene expression in MDA-MB-435 human breast cancer cells by means of its ability to inhibit metalloproteinases.

Porter JF, Sharma S, Wilson DL, Kappil MA, Hart RP, Denhardt DT.

Breast Cancer Res Treat. 2005 Nov;94(2):185-93.


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