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The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment.

Hou W, Chen Q, Wang H, Qiu P, Lyu X, Chen W, Chua MLK, Chinn YE, Deng CX, Wang R.

EBioMedicine. 2020 Jan 2;51:102605. doi: 10.1016/j.ebiom.2019.102605. [Epub ahead of print]


Author Correction: Drug screening of cancer cell lines and human primary tumors using droplet microfluidics.

Wong AH, Li H, Jia Y, Mak PI, da Silva Martins RP, Liu Y, Vong CM, Wong HC, Wong PK, Wang H, Sun H, Deng CX.

Sci Rep. 2019 Dec 4;9(1):18660. doi: 10.1038/s41598-019-55120-y.


Targeting immune checkpoint B7-H3 antibody-chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy.

Zhu L, Liu J, Zhou G, Ng HM, Ang IL, Ma G, Liu Y, Yang S, Zhang F, Miao K, Poon TCW, Zhang X, Yuan Z, Deng CX, Zhao Q.

Chem Commun (Camb). 2019 Nov 26;55(95):14255-14258. doi: 10.1039/c9cc06839b.


High Frequency Spectral Ultrasound Imaging to Detect Metastasis in Implanted Biomaterial Scaffolds.

Bushnell GG, Hong X, Hartfield RM, Zhang Y, Oakes RS, Rao SS, Jeruss JS, Stegemann JP, Deng CX, Shea LD.

Ann Biomed Eng. 2020 Jan;48(1):477-489. doi: 10.1007/s10439-019-02366-2. Epub 2019 Sep 23.


Synthesis and in vitro antitumor activity evaluation of copper(II) complexes with 5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline derivatives.

Zhang YL, Deng CX, Zhou WF, Zhou LY, Cao QQ, Shen WY, Liang H, Chen ZF.

J Inorg Biochem. 2019 Dec;201:110820. doi: 10.1016/j.jinorgbio.2019.110820. Epub 2019 Sep 2.


Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism.

Collin de l'Hortet A, Takeishi K, Guzman-Lepe J, Morita K, Achreja A, Popovic B, Wang Y, Handa K, Mittal A, Meurs N, Zhu Z, Weinberg F, Salomon M, Fox IJ, Deng CX, Nagrath D, Soto-Gutierrez A.

Cell Metab. 2019 Aug 6;30(2):385-401.e9. doi: 10.1016/j.cmet.2019.06.017.


[Changes of WT1 mRNA expression level in patients with myelodysplastic syndromes after hypomethylating agents and its prognostic significance].

Zhang HY, Geng SX, Li MM, Lai PL, Deng CX, Lu ZS, Huang X, Wang YL, Weng JY, Du X.

Zhonghua Xue Ye Xue Za Zhi. 2019 May 14;40(5):417-421. doi: 10.3760/cma.j.issn.0253-2727.2019.05.013. Chinese.


Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats.

Deng CX, Wu ZB, Chen Y, Yu ZM.

Chin J Integr Med. 2019 May 15. doi: 10.1007/s11655-019-2944-7. [Epub ahead of print]


SMAD signaling promotes melanoma metastasis independently of phenotype switching.

Tuncer E, Calçada RR, Zingg D, Varum S, Cheng P, Freiberger SN, Deng CX, Kleiter I, Levesque MP, Dummer R, Sommer L.

J Clin Invest. 2019 Apr 30;129(7):2702-2716. doi: 10.1172/JCI94295.


Acoustic tweezing cytometry for mechanical phenotyping of macrophages and mechanopharmaceutical cytotripsy.

Hong X, Rzeczycki PM, Keswani RK, Murashov MD, Fan Z, Deng CX, Rosania GR.

Sci Rep. 2019 Apr 5;9(1):5702. doi: 10.1038/s41598-019-42180-3.


Rapid translocation of pluripotency-related transcription factors by external uniaxial forces.

Topal T, Kim BC, Villa-Diaz LG, Deng CX, Takayama S, Krebsbach PH.

Integr Biol (Camb). 2019 Feb 26. pii: zyz003. doi: 10.1093/intbio/zyz003. [Epub ahead of print]


Dietary alanyl-glutamine improves growth performance of weaned piglets through maintaining intestinal morphology and digestion-absorption function.

Zou TD, Deng CX, Wang ZR, Ye YL, You JM.

Animal. 2019 Sep;13(9):1826-1833. doi: 10.1017/S1751731119000223. Epub 2019 Feb 21.


SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions.

Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung M, Lee SH, Kim DK, Chung C, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK.

Autophagy. 2019 Aug;15(8):1356-1375. doi: 10.1080/15548627.2019.1582743. Epub 2019 Mar 4.


PP2ACα deficiency impairs early cortical development through inducing DNA damage in neuroprojenitor cells.

Liu B, Lin L, Riazuddin S, Zubair A, Wang L, Di LJ, Li R, Dong TT, Deng CX, Tong WM.

Int J Biochem Cell Biol. 2019 Apr;109:40-58. doi: 10.1016/j.biocel.2019.01.021. Epub 2019 Jan 30.


Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers.

Huang T, Deng CX.

Int J Biol Sci. 2019 Jan 6;15(1):1-11. doi: 10.7150/ijbs.27796. eCollection 2019. Review.


Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation.

Guo S, Deng CX.

Int J Biol Sci. 2018 Nov 13;14(14):2083-2093. doi: 10.7150/ijbs.25720. eCollection 2018. Review.


Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice.

Miao K, Zhang X, Su SM, Zeng J, Huang Z, Chan UI, Xu X, Deng CX.

J Biol Chem. 2019 Jan 25;294(4):1142-1151. doi: 10.1074/jbc.RA118.006496. Epub 2018 Nov 28.


BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy.

Xu X, Chen E, Mo L, Zhang L, Shao F, Miao K, Liu J, Su SM, Valecha M, Chan UI, Zheng H, Chen M, Chen W, Chen Q, Fu H, Aladjem MI, He Y, Deng CX.

Hum Mol Genet. 2019 Mar 1;28(5):842-857. doi: 10.1093/hmg/ddy398.


Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors.

Baek HJ, Kim SE, Kim JK, Shin DH, Kim TH, Kim KG, Deng CX, Kim SS.

Int J Biol Sci. 2018 Oct 3;14(13):1769-1781. doi: 10.7150/ijbs.29242. eCollection 2018.


Acoustic Actuation of Integrin-Bound Microbubbles for Mechanical Phenotyping during Differentiation and Morphogenesis of Human Embryonic Stem Cells.

Fan Z, Xue X, Perera R, Nasr Esfahani S, Exner AA, Fu J, Deng CX.

Small. 2018 Dec;14(50):e1803137. doi: 10.1002/smll.201803137. Epub 2018 Nov 14.


Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation.

Baek HJ, Kim SE, Choi EK, Kim JK, Shin DH, Park EJ, Kim TH, Kim JY, Kim KG, Deng CX, Kim SS.

Int J Biol Sci. 2018 Oct 3;14(12):1755-1768. doi: 10.7150/ijbs.28142. eCollection 2018.


Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors.

Choi EK, Lim JA, Kim JK, Jang MS, Kim SE, Baek HJ, Park EJ, Kim TH, Deng CX, Wang RH, Kim SS.

Exp Mol Med. 2018 Oct 16;50(10):136. doi: 10.1038/s12276-018-0169-z.


Acoustic Tweezing Cytometry Induces Rapid Initiation of Human Embryonic Stem Cell Differentiation.

Topal T, Hong X, Xue X, Fan Z, Kanetkar N, Nguyen JT, Fu J, Deng CX, Krebsbach PH.

Sci Rep. 2018 Aug 28;8(1):12977. doi: 10.1038/s41598-018-30939-z.


BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition.

Zhang B, Lyu J, Liu Y, Wu C, Yang EJ, Pardeshi L, Tan K, Wong KH, Chen Q, Xu X, Deng CX, Shim JS.

Oncogene. 2018 Dec;37(49):6341-6356. doi: 10.1038/s41388-018-0408-8. Epub 2018 Jul 24.


Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol.

Yang QY, Cao QQ, Qin QP, Deng CX, Liang H, Chen ZF.

Int J Mol Sci. 2018 Jun 26;19(7). pii: E1874. doi: 10.3390/ijms19071874.


Multimode ultrasound viscoelastography for three-dimensional interrogation of microscale mechanical properties in heterogeneous biomaterials.

Hong X, Annamalai RT, Kemerer TS, Deng CX, Stegemann JP.

Biomaterials. 2018 Sep;178:11-22. doi: 10.1016/j.biomaterials.2018.05.057. Epub 2018 Jun 2.


Conditional Deletion of FOXL2 and SMAD4 in Gonadotropes of Adult Mice Causes Isolated FSH Deficiency.

Li Y, Schang G, Wang Y, Zhou X, Levasseur A, Boyer A, Deng CX, Treier M, Boehm U, Boerboom D, Bernard DJ.

Endocrinology. 2018 Jul 1;159(7):2641-2655. doi: 10.1210/en.2018-00100.


Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia.

Sun H, Miao Z, Zhang X, Chan UI, Su SM, Guo S, Wong CKH, Xu X, Deng CX.

J Biol Chem. 2018 Jun 1;293(22):8315-8329. doi: 10.1074/jbc.RA118.002297. Epub 2018 Apr 17.


The role of TGF-β/SMAD4 signaling in cancer.

Zhao M, Mishra L, Deng CX.

Int J Biol Sci. 2018 Jan 12;14(2):111-123. doi: 10.7150/ijbs.23230. eCollection 2018. Review.


BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis.

Lahusen TJ, Kim SJ, Miao K, Huang Z, Xu X, Deng CX.

Oncogene. 2018 Apr;37(17):2343-2350. doi: 10.1038/s41388-018-0127-1. Epub 2018 Feb 14.


High-frequency spectral ultrasound imaging (SUSI) visualizes early post-traumatic heterotopic ossification (HO) in a mouse model.

Ranganathan K, Hong X, Cholok D, Habbouche J, Priest C, Breuler C, Chung M, Li J, Kaura A, Hsieh HHS, Butts J, Ucer S, Schwartz E, Buchman SR, Stegemann JP, Deng CX, Levi B.

Bone. 2018 Apr;109:49-55. doi: 10.1016/j.bone.2018.01.034. Epub 2018 Feb 14.


5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions.

Wei ZZ, Qin QP, Meng T, Deng CX, Liang H, Chen ZF.

Eur J Med Chem. 2018 Feb 10;145:360-369. doi: 10.1016/j.ejmech.2017.12.092. Epub 2018 Jan 4.


A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis.

Rajendran BK, Deng CX.

Oncotarget. 2017 Aug 23;8(60):102263-102276. doi: 10.18632/oncotarget.20404. eCollection 2017 Nov 24.


Erratum: PRAJA is overexpressed in glioblastoma and contributes to neural precursor development.

Shin J, Mishra V, Glasgow E, Zaidi S, Chen J, Ohshiro K, Chitti B, Kapadia AA, Rana N, Mishra L, Deng CX, Rao S, Mishra B.

Genes Cancer. 2017 Sep;8(9-10):745. doi: 10.18632/genesandcancer.158.


Alcohol, stem cells and cancer.

Gu S, Nguyen BN, Rao S, Li S, Shetty K, Rashid A, Shukla V, Deng CX, Mishra L, Mishra B.

Genes Cancer. 2017 Sep;8(9-10):695-700. doi: 10.18632/genesandcancer.156. Review.


Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis.

Azoury SC, Reddy S, Shukla V, Deng CX.

Int J Biol Sci. 2017 Nov 2;13(12):1479-1488. doi: 10.7150/ijbs.22373. eCollection 2017. Review.


A digital microfluidic system for loop-mediated isothermal amplification and sequence specific pathogen detection.

Wan L, Chen T, Gao J, Dong C, Wong AH, Jia Y, Mak PI, Deng CX, Martins RP.

Sci Rep. 2017 Nov 6;7(1):14586. doi: 10.1038/s41598-017-14698-x.


Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer.

Lei H, Deng CX.

Int J Biol Sci. 2017 Sep 5;13(9):1163-1171. doi: 10.7150/ijbs.20792. eCollection 2017. Review.


Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype.

Shao F, Sun H, Deng CX.

Oncotarget. 2017 Aug 16;8(42):73329-73344. doi: 10.18632/oncotarget.20274. eCollection 2017 Sep 22. Review.


PRAJA is overexpressed in glioblastoma and contributes to neural precursor development.

Shin J, Mishra V, Glasgow E, Zaidi S, Chen J, Ohshiro K, Chitti B, Kapadia AA, Rana N, Mishra L, Deng CX, Rao S, Mishra B.

Genes Cancer. 2017 Jul;8(7-8):640-649. doi: 10.18632/genesandcancer.151. Erratum in: Genes Cancer. 2017 Sep;8(9-10):745.


Functional impact of Galectin-3 and TRAIL expression in breast cancer cells.

Liu XH, Deng CX, Hu PC, Wang Y, Dong YH.

Eur Rev Med Pharmacol Sci. 2017 Aug;21(16):3626-3633.


Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway.

Chen J, Zaidi S, Rao S, Chen JS, Phan L, Farci P, Su X, Shetty K, White J, Zamboni F, Wu X, Rashid A, Pattabiraman N, Mazumder R, Horvath A, Wu RC, Li S, Xiao C, Deng CX, Wheeler DA, Mishra B, Akbani R, Mishra L.

Gastroenterology. 2018 Jan;154(1):195-210. doi: 10.1053/j.gastro.2017.09.007. Epub 2017 Sep 15.


Drug screening of cancer cell lines and human primary tumors using droplet microfluidics.

Wong AH, Li H, Jia Y, Mak PI, Martins RPDS, Liu Y, Vong CM, Wong HC, Wong PK, Wang H, Sun H, Deng CX.

Sci Rep. 2017 Aug 22;7(1):9109. doi: 10.1038/s41598-017-08831-z. Erratum in: Sci Rep. 2019 Dec 4;9(1):18660.


Emerging roles of SIRT1 in fatty liver diseases.

Ding RB, Bao J, Deng CX.

Int J Biol Sci. 2017 Jul 6;13(7):852-867. doi: 10.7150/ijbs.19370. eCollection 2017. Review.


Characterization of potential driver mutations involved in human breast cancer by computational approaches.

Rajendran BK, Deng CX.

Oncotarget. 2017 Jul 25;8(30):50252-50272. doi: 10.18632/oncotarget.17225. Review.


Acoustic tweezing cytometry enhances osteogenesis of human mesenchymal stem cells through cytoskeletal contractility and YAP activation.

Xue X, Hong X, Li Z, Deng CX, Fu J.

Biomaterials. 2017 Jul;134:22-30. doi: 10.1016/j.biomaterials.2017.04.039. Epub 2017 Apr 22.


SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.

Chen Q, Hao W, Xiao C, Wang R, Xu X, Lu H, Chen W, Deng CX.

Cell Rep. 2017 Mar 28;18(13):3155-3166. doi: 10.1016/j.celrep.2017.03.006.


[Clinical analyses of 50 cases of myelodysplastic syndrome with deletion of chromosome 5q].

He Y, Du X, Weng JY, Deng CX, Geng SX, Lu ZS, Li MM, Liao PJ, Luo CW, Wu SJ, Zhong LY.

Zhonghua Xue Ye Xue Za Zhi. 2017 Feb 14;38(2):153-156. doi: 10.3760/cma.j.issn.0253-2727.2017.02.013. Chinese. No abstract available.


WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance.

Zheng H, Shao F, Martin S, Xu X, Deng CX.

Sci Rep. 2017 Mar 6;7:43517. doi: 10.1038/srep43517.


CRISPR-Cas9: from Genome Editing to Cancer Research.

Chen S, Sun H, Miao K, Deng CX.

Int J Biol Sci. 2016 Nov 4;12(12):1427-1436. eCollection 2016. Review.

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