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Items: 28


Clec10a regulates mite-induced dermatitis.

Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A.

Sci Immunol. 2019 Dec 6;4(42). pii: eaax6908. doi: 10.1126/sciimmunol.aax6908.


Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies.

Yoshimura Y, Denda-Nagai K, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, Noji M, Shichino S, Chiba Y, Irimura T.

Sci Rep. 2019 Nov 12;9(1):16641. doi: 10.1038/s41598-019-53052-1.


Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma.

Yoshimoto T, Matsubara D, Soda M, Ueno T, Amano Y, Kihara A, Sakatani T, Nakano T, Shibano T, Endo S, Hagiwara K, Fukayama M, Denda-Nagai K, Irimura T, Mano H, Niki T.

Cancer Sci. 2019 Sep;110(9):3006-3011. doi: 10.1111/cas.14129. Epub 2019 Aug 16.


Specific expression of MUC21 in micropapillary elements of lung adenocarcinomas - Implications for the progression of EGFR-mutated lung adenocarcinomas.

Matsumura M, Okudela K, Nakashima Y, Mitsui H, Denda-Nagai K, Suzuki T, Arai H, Umeda S, Tateishi Y, Koike C, Kataoka T, Irimura T, Ohashi K.

PLoS One. 2019 Apr 11;14(4):e0215237. doi: 10.1371/journal.pone.0215237. eCollection 2019.


A Critical Domain of Ebolavirus Envelope Glycoprotein Determines Glycoform and Infectivity.

Fujihira H, Usami K, Matsuno K, Takeuchi H, Denda-Nagai K, Furukawa JI, Shinohara Y, Takada A, Kawaoka Y, Irimura T.

Sci Rep. 2018 Apr 3;8(1):5495. doi: 10.1038/s41598-018-23357-8.


The macrophage galactose-type lectin can function as an attachment and entry receptor for influenza virus.

Ng WC, Liong S, Tate MD, Irimura T, Denda-Nagai K, Brooks AG, Londrigan SL, Reading PC.

J Virol. 2014 Feb;88(3):1659-72. doi: 10.1128/JVI.02014-13. Epub 2013 Nov 20.


A unique dermal dendritic cell subset that skews the immune response toward Th2.

Murakami R, Denda-Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T.

PLoS One. 2013 Sep 9;8(9):e73270. doi: 10.1371/journal.pone.0073270. eCollection 2013. Erratum in: PLoS One. 2014;9(3):e93236.


Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo.

Sugiura D, Denda-Nagai K, Takashima M, Murakami R, Nagai S, Takeda K, Irimura T.

PLoS One. 2012;7(9):e44770. doi: 10.1371/journal.pone.0044770. Epub 2012 Sep 17.


Mucin 21 in esophageal squamous epithelia and carcinomas: analysis with glycoform-specific monoclonal antibodies.

Tian Y, Denda-Nagai K, Kamata-Sakurai M, Nakamori S, Tsukui T, Itoh Y, Okada K, Yi Y, Irimura T.

Glycobiology. 2012 Sep;22(9):1218-26. doi: 10.1093/glycob/cws082. Epub 2012 May 19.


Involvement of viral envelope GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin.

Usami K, Matsuno K, Igarashi M, Denda-Nagai K, Takada A, Irimura T.

Biochem Biophys Res Commun. 2011 Apr 1;407(1):74-8. doi: 10.1016/j.bbrc.2011.02.110. Epub 2011 Mar 6.


Organ microenvironment plays significant roles through Fas ligand in vaccine-induced CD4(+) T cell dependent suppression of tumor growth at the orthotopic site.

Sugiura D, Denda-Nagai K, Takeda K, Irimura T.

Cancer Sci. 2010 Sep;101(9):1965-9. doi: 10.1111/j.1349-7006.2010.01634.x.


Mucin 21/epiglycanin modulates cell adhesion.

Yi Y, Kamata-Sakurai M, Denda-Nagai K, Itoh T, Okada K, Ishii-Schrade K, Iguchi A, Sugiura D, Irimura T.

J Biol Chem. 2010 Jul 9;285(28):21233-40. doi: 10.1074/jbc.M109.082875. Epub 2010 Apr 13.


Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells.

Denda-Nagai K, Aida S, Saba K, Suzuki K, Moriyama S, Oo-Puthinan S, Tsuiji M, Morikawa A, Kumamoto Y, Sugiura D, Kudo A, Akimoto Y, Kawakami H, Bovin NV, Irimura T.

J Biol Chem. 2010 Jun 18;285(25):19193-204. doi: 10.1074/jbc.M110.113613. Epub 2010 Mar 19.


MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo.

Kumamoto Y, Denda-Nagai K, Aida S, Higashi N, Irimura T.

PLoS One. 2009;4(5):e5619. doi: 10.1371/journal.pone.0005619. Epub 2009 May 19.


A C-type lectin MGL1/CD301a plays an anti-inflammatory role in murine experimental colitis.

Saba K, Denda-Nagai K, Irimura T.

Am J Pathol. 2009 Jan;174(1):144-52. doi: 10.2353/ajpath.2009.080235. Epub 2008 Dec 18.


Differential effector mechanisms induced by vaccination with MUC1 DNA in the rejection of colon carcinoma growth at orthotopic sites and metastases.

Sugiura D, Aida S, Denda-Nagai K, Takeda K, Kamata-Sakurai M, Yagita H, Irimura T.

Cancer Sci. 2008 Dec;99(12):2477-84. doi: 10.1111/j.1349-7006.2008.00967.x. Epub 2008 Nov 17.


The amino acids involved in the distinct carbohydrate specificities between macrophage galactose-type C-type lectins 1 and 2 (CD301a and b) of mice.

Oo-Puthinan S, Maenuma K, Sakakura M, Denda-Nagai K, Tsuiji M, Shimada I, Nakamura-Tsuruta S, Hirabayashi J, Bovin NV, Irimura T.

Biochim Biophys Acta. 2008 Feb;1780(2):89-100. Epub 2007 Nov 4.


Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin.

Itoh Y, Kamata-Sakurai M, Denda-Nagai K, Nagai S, Tsuiji M, Ishii-Schrade K, Okada K, Goto A, Fukayama M, Irimura T.

Glycobiology. 2008 Jan;18(1):74-83. Epub 2007 Oct 31.


Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells.

Napoletano C, Rughetti A, Agervig Tarp MP, Coleman J, Bennett EP, Picco G, Sale P, Denda-Nagai K, Irimura T, Mandel U, Clausen H, Frati L, Taylor-Papadimitriou J, Burchell J, Nuti M.

Cancer Res. 2007 Sep 1;67(17):8358-67.


Properties of blocking and non-blocking monoclonal antibodies specific for human macrophage galactose-type C-type lectin (MGL/ClecSF10A/CD301).

Sano Y, Usami K, Izawa R, Denda-Nagai K, Higashi N, Kimura T, Suzuki N, Irimura T.

J Biochem. 2007 Jan;141(1):127-36. Epub 2006 Dec 13.


The dermal microenvironment induces the expression of the alternative activation marker CD301/mMGL in mononuclear phagocytes, independent of IL-4/IL-13 signaling.

Dupasquier M, Stoitzner P, Wan H, Cerqueira D, van Oudenaren A, Voerman JS, Denda-Nagai K, Irimura T, Raes G, Romani N, Leenen PJ.

J Leukoc Biol. 2006 Oct;80(4):838-49. Epub 2006 Jul 18.


Identification of sialoadhesin as a dominant lymph node counter-receptor for mouse macrophage galactose-type C-type lectin 1.

Kumamoto Y, Higashi N, Denda-Nagai K, Tsuiji M, Sato K, Crocker PR, Irimura T.

J Biol Chem. 2004 Nov 19;279(47):49274-80. Epub 2004 Sep 13.


Vaccination of mice with MUC1 cDNA suppresses the development of lung metastases.

Kamata M, Denda-Nagai K, Kubota N, Aida S, Takeda K, Irimura T.

Clin Exp Metastasis. 2002;19(8):689-96.


Macrophage C-type lectin on bone marrow-derived immature dendritic cells is involved in the internalization of glycosylated antigens.

Denda-Nagai K, Kubota N, Tsuiji M, Kamata M, Irimura T.

Glycobiology. 2002 Jul;12(7):443-50.


The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells.

Higashi N, Fujioka K, Denda-Nagai K, Hashimoto S, Nagai S, Sato T, Fujita Y, Morikawa A, Tsuiji M, Miyata-Takeuchi M, Sano Y, Suzuki N, Yamamoto K, Matsushima K, Irimura T.

J Biol Chem. 2002 Jun 7;277(23):20686-93. Epub 2002 Mar 27.


MUC1 in carcinoma-host interactions.

Denda-Nagai K, Irimura T.

Glycoconj J. 2000 Jul-Sep;17(7-9):649-58. Review.


Absence of correlation of MUC1 expression to malignant behavior of renal cell carcinoma in experimental systems.

Denda-Nagai K, Fujita K, Fujime M, Nakatsugawa S, Ishigaki T, Irimura T.

Clin Exp Metastasis. 2000;18(1):77-81.


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