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Items: 44

1.

Are tropane alkaloids present in organic foods? Detection of scopolamine and atropine in organic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.

Cirlini M, Demuth TM, Biancardi A, Rychlik M, Dall'Asta C, Bruni R.

Food Chem. 2018 Jan 15;239:141-147. doi: 10.1016/j.foodchem.2017.06.028. Epub 2017 Jun 23.

PMID:
28873551
2.

Phase I Dose-Escalation and -Expansion Study of the BRAF Inhibitor Encorafenib (LGX818) in Metastatic BRAF-Mutant Melanoma.

Delord JP, Robert C, Nyakas M, McArthur GA, Kudchakar R, Mahipal A, Yamada Y, Sullivan R, Arance A, Kefford RF, Carlino MS, Hidalgo M, Gomez-Roca C, Michel D, Seroutou A, Aslanis V, Caponigro G, Stuart DD, Moutouh-de Parseval L, Demuth T, Dummer R.

Clin Cancer Res. 2017 Sep 15;23(18):5339-5348. doi: 10.1158/1078-0432.CCR-16-2923. Epub 2017 Jun 13.

3.

A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic BRAF-Mutant Colorectal Cancer.

van Geel RMJM, Tabernero J, Elez E, Bendell JC, Spreafico A, Schuler M, Yoshino T, Delord JP, Yamada Y, Lolkema MP, Faris JE, Eskens FALM, Sharma S, Yaeger R, Lenz HJ, Wainberg ZA, Avsar E, Chatterjee A, Jaeger S, Tan E, Maharry K, Demuth T, Schellens JHM.

Cancer Discov. 2017 Jun;7(6):610-619. doi: 10.1158/2159-8290.CD-16-0795. Epub 2017 Mar 31.

4.

Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids.

Miller KN, Burhans MS, Clark JP, Howell PR, Polewski MA, DeMuth TM, Eliceiri KW, Lindstrom MJ, Ntambi JM, Anderson RM.

Aging Cell. 2017 Jun;16(3):497-507. doi: 10.1111/acel.12575. Epub 2017 Feb 3.

5.

Phase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors.

Leijen S, van Geel RM, Pavlick AC, Tibes R, Rosen L, Razak AR, Lam R, Demuth T, Rose S, Lee MA, Freshwater T, Shumway S, Liang LW, Oza AM, Schellens JH, Shapiro GI.

J Clin Oncol. 2016 Dec 20;34(36):4371-4380. doi: 10.1200/JCO.2016.67.5991. Epub 2016 Oct 31.

PMID:
27601554
6.

An accessible pharmacodynamic transcriptional biomarker for notch target engagement.

Tanis KQ, Podtelezhnikov AA, Blackman SC, Hing J, Railkar RA, Lunceford J, Klappenbach JA, Wei B, Harman A, Camargo LM, Shah S, Finney EM, Hardwick JS, Loboda A, Watters J, Bergstrom DA, Demuth T, Herman GA, Strack PR, Iannone R.

Clin Pharmacol Ther. 2016 Apr;99(4):370-80. doi: 10.1002/cpt.335. Epub 2016 Feb 17.

PMID:
26765077
7.

Regional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction.

Martin SA, DeMuth TM, Miller KN, Pugh TD, Polewski MA, Colman RJ, Eliceiri KW, Beasley TM, Johnson SC, Anderson RM.

Aging Cell. 2016 Feb;15(1):100-10. doi: 10.1111/acel.12418. Epub 2015 Nov 2.

8.

A phase II study of Givinostat in combination with hydroxycarbamide in patients with polycythaemia vera unresponsive to hydroxycarbamide monotherapy.

Finazzi G, Vannucchi AM, Martinelli V, Ruggeri M, Nobile F, Specchia G, Pogliani EM, Olimpieri OM, Fioritoni G, Musolino C, Cilloni D, Sivera P, Barosi G, Finazzi MC, Di Tollo S, Demuth T, Barbui T, Rambaldi A.

Br J Haematol. 2013 Jun;161(5):688-94. doi: 10.1111/bjh.12332. Epub 2013 Apr 10.

PMID:
23573950
9.

Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells.

Jin R, Nakada M, Teng L, Furuta T, Sabit H, Hayashi Y, Demuth T, Hirao A, Sato H, Zhao G, Hamada J.

Neurosci Lett. 2013 Feb 8;534:316-21. doi: 10.1016/j.neulet.2012.12.008. Epub 2012 Dec 20.

PMID:
23262078
10.

The degree of articular depression as a predictor of soft-tissue injuries in tibial plateau fracture.

Spiro AS, Regier M, Novo de Oliveira A, Vettorazzi E, Hoffmann M, Petersen JP, Henes FO, Demuth T, Rueger JM, Lehmann W.

Knee Surg Sports Traumatol Arthrosc. 2013 Mar;21(3):564-70. doi: 10.1007/s00167-012-2201-5. Epub 2012 Sep 11.

PMID:
22965381
11.

Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.

Krop I, Demuth T, Guthrie T, Wen PY, Mason WP, Chinnaiyan P, Butowski N, Groves MD, Kesari S, Freedman SJ, Blackman S, Watters J, Loboda A, Podtelezhnikov A, Lunceford J, Chen C, Giannotti M, Hing J, Beckman R, Lorusso P.

J Clin Oncol. 2012 Jul 1;30(19):2307-13. doi: 10.1200/JCO.2011.39.1540. Epub 2012 Apr 30.

PMID:
22547604
12.

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma.

Cook N, Frese KK, Bapiro TE, Jacobetz MA, Gopinathan A, Miller JL, Rao SS, Demuth T, Howat WJ, Jodrell DI, Tuveson DA.

J Exp Med. 2012 Mar 12;209(3):437-44. doi: 10.1084/jem.20111923. Epub 2012 Feb 20.

13.

RNAi screening of the kinome with cytarabine in leukemias.

Tibes R, Bogenberger JM, Chaudhuri L, Hagelstrom RT, Chow D, Buechel ME, Gonzales IM, Demuth T, Slack J, Mesa RA, Braggio E, Yin HH, Arora S, Azorsa DO.

Blood. 2012 Mar 22;119(12):2863-72. doi: 10.1182/blood-2011-07-367557. Epub 2012 Jan 20.

14.

Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines.

Sarcar B, Kahali S, Prabhu AH, Shumway SD, Xu Y, Demuth T, Chinnaiyan P.

Mol Cancer Ther. 2011 Dec;10(12):2405-14. doi: 10.1158/1535-7163.MCT-11-0469. Epub 2011 Oct 12.

15.

Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.

Fouladi M, Stewart CF, Olson J, Wagner LM, Onar-Thomas A, Kocak M, Packer RJ, Goldman S, Gururangan S, Gajjar A, Demuth T, Kun LE, Boyett JM, Gilbertson RJ.

J Clin Oncol. 2011 Sep 10;29(26):3529-34. doi: 10.1200/JCO.2011.35.7806. Epub 2011 Aug 8.

16.

MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.

Rajeshkumar NV, De Oliveira E, Ottenhof N, Watters J, Brooks D, Demuth T, Shumway SD, Mizuarai S, Hirai H, Maitra A, Hidalgo M.

Clin Cancer Res. 2011 May 1;17(9):2799-806. doi: 10.1158/1078-0432.CCR-10-2580. Epub 2011 Mar 9.

17.

De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model.

Watters JW, Cheng C, Majumder PK, Wang R, Yalavarthi S, Meeske C, Kong L, Sun W, Lin J, Heyer J, Ware C, Winter C, Reilly JF, Demuth T, Clark S, Chiu MI, Robinson MO, Kohl N, Kannan K.

Cancer Res. 2009 Dec 1;69(23):8949-57. doi: 10.1158/0008-5472.CAN-09-1544. Epub 2009 Nov 10.

18.

The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion.

Nakada M, Anderson EM, Demuth T, Nakada S, Reavie LB, Drake KL, Hoelzinger DB, Berens ME.

Int J Cancer. 2010 Mar 1;126(5):1155-65. doi: 10.1002/ijc.24849.

19.

Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines.

Demuth T, Rennert JL, Hoelzinger DB, Reavie LB, Nakada M, Beaudry C, Nakada S, Anderson EM, Henrichs AN, McDonough WS, Holz D, Joy A, Lin R, Pan KH, Lih CJ, Cohen SN, Berens ME.

BMC Genomics. 2008 Jan 29;9:54. doi: 10.1186/1471-2164-9-54.

20.

Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment.

Hoelzinger DB, Demuth T, Berens ME.

J Natl Cancer Inst. 2007 Nov 7;99(21):1583-93. Epub 2007 Oct 30. Review.

PMID:
17971532
21.

Autotaxin: a secreted autocrine/paracrine factor that promotes glioma invasion.

Hoelzinger DB, Nakada M, Demuth T, Rosensteel T, Reavie LB, Berens ME.

J Neurooncol. 2008 Feb;86(3):297-309. Epub 2007 Oct 11.

PMID:
17928955
22.

Estimating the cell density and invasive radius of three-dimensional glioblastoma tumor spheroids grown in vitro.

Stein AM, Nowicki MO, Demuth T, Berens ME, Lawler SE, Chiocca EA, Sander LM.

Appl Opt. 2007 Aug 1;46(22):5110-8.

PMID:
17676121
23.

MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival.

Demuth T, Reavie LB, Rennert JL, Nakada M, Nakada S, Hoelzinger DB, Beaudry CE, Henrichs AN, Anderson EM, Berens ME.

Mol Cancer Ther. 2007 Apr;6(4):1212-22. Epub 2007 Apr 3.

24.

Molecular targets of glioma invasion.

Nakada M, Nakada S, Demuth T, Tran NL, Hoelzinger DB, Berens ME.

Cell Mol Life Sci. 2007 Feb;64(4):458-78. Review.

PMID:
17260089
25.

Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.

Wang Y, O'Neil SV, Wos JA, Oppong KA, Laufersweiler MC, Soper DL, Ellis CD, Baize MW, Fancher AN, Lu W, Suchanek MK, Wang RL, Schwecke WP, Cruze CA, Buchalova M, Belkin M, De B, Demuth TP Jr.

Bioorg Med Chem. 2007 Feb 1;15(3):1311-22. Epub 2006 Nov 10.

PMID:
17127070
26.

A mathematical model of glioblastoma tumor spheroid invasion in a three-dimensional in vitro experiment.

Stein AM, Demuth T, Mobley D, Berens M, Sander LM.

Biophys J. 2007 Jan 1;92(1):356-65. Epub 2006 Oct 13.

27.

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.

Hopkins CR, O'neil SV, Laufersweiler MC, Wang Y, Pokross M, Mekel M, Evdokimov A, Walter R, Kontoyianni M, Petrey ME, Sabatakos G, Roesgen JT, Richardson E, Demuth TP Jr.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5659-63. Epub 2006 Aug 21.

PMID:
16919947
28.

Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme (ICE) inhibitors.

Soper DL, Sheville JX, O'Neil SV, Wang Y, Laufersweiler MC, Oppong KA, Wos JA, Ellis CD, Baize MW, Chen JJ, Fancher AN, Lu W, Suchanek MK, Wang RL, Schwecke WP, Cruze CA, Buchalova M, Belkin M, Wireko F, Ritter A, De B, Wang D, Demuth TP Jr.

Bioorg Med Chem. 2006 Dec 1;14(23):7880-92.

PMID:
16908171
29.

Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors.

Ellis CD, Oppong KA, Laufersweiler MC, O'Neil SV, Soper DL, Wang Y, Wos JA, Fancher AN, Lu W, Suchanek MK, Wang RL, De B, Demuth TP Jr.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4728-32. Epub 2006 Jul 25.

PMID:
16870441
30.

Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.

Soper DL, Sheville J, O'Neil SV, Wang Y, Laufersweiler MC, Oppong KA, Wos JA, Ellis CD, Fancher AN, Lu W, Suchanek MK, Wang RL, De B, Demuth TP Jr.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4233-6. Epub 2006 Jun 16.

PMID:
16782334
31.

Correlating velocity patterns with spatial dynamics in glioma cell migration.

Deisboeck TS, Demuth T, Mansury Y.

Acta Biotheor. 2005;53(3):181-90.

PMID:
16329007
32.

Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors.

O'Neil SV, Wang Y, Laufersweiler MC, Oppong KA, Soper DL, Wos JA, Ellis CD, Baize MW, Bosch GK, Fancher AN, Lu W, Suchanek MK, Wang RL, De B, Demuth TP Jr.

Bioorg Med Chem Lett. 2005 Dec 15;15(24):5434-8. Epub 2005 Oct 10.

PMID:
16216507
33.

Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme.

Laufersweiler MC, Wang Y, Soper DL, Suchanek MK, Fancher AN, Lu W, Wang RL, Oppong KA, Ellis CD, Baize MW, O'Neil SV, Wos JA, Demuth TP Jr.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4322-6.

PMID:
16046129
34.

Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis.

Oppong KA, Ellis CD, Laufersweiler MC, O'Neil SV, Wang Y, Soper DL, Baize MW, Wos JA, De B, Bosch GK, Fancher AN, Lu W, Suchanek MK, Wang RL, Demuth TP Jr.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4291-4.

PMID:
16046125
35.

Molecular mechanisms of glioma cell migration and invasion.

Demuth T, Berens ME.

J Neurooncol. 2004 Nov;70(2):217-28. Review.

PMID:
15674479
36.
37.

Development of a screening assay to measure the loss of antibacterial activity in the presence of proteins: its use in optimizing compound structure.

Roychoudhury S, Brill JL, Lu WP, White RE, Chen Z, Demuth TP Jr.

J Biomol Screen. 2003 Oct;8(5):555-8.

PMID:
14567782
38.

Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis.

Joy AM, Beaudry CE, Tran NL, Ponce FA, Holz DR, Demuth T, Berens ME.

J Cell Sci. 2003 Nov 1;116(Pt 21):4409-17. Epub 2003 Sep 16.

39.

Glioma cell motility is associated with reduced transcription of proapoptotic and proliferation genes: a cDNA microarray analysis.

Mariani L, Beaudry C, McDonough WS, Hoelzinger DB, Demuth T, Ross KR, Berens T, Coons SW, Watts G, Trent JM, Wei JS, Giese A, Berens ME.

J Neurooncol. 2001 Jun;53(2):161-76.

PMID:
11716068
40.

Migratory activity of human glioma cell lines in vitro assessed by continuous single cell observation.

Demuth T, Hopf NJ, Kempski O, Sauner D, Herr M, Giese A, Perneczky A.

Clin Exp Metastasis. 2000;18(7):589-97.

PMID:
11688964
41.

Stereoselective synthesis and antibacterial evaluation of 4-amido-isothiazolidinone oxides.

Chen Z, Demuth TP Jr, Wireko FC.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2111-5.

PMID:
11514150
42.

Concept, design, and preclinical evaluation of quinolonyl lactam antibacterials.

Hershberger PM, Demuth TP Jr.

Adv Exp Med Biol. 1998;456:239-67. Review. No abstract available.

PMID:
10549372
43.

Preparation and antimicrobial assessment of 2-thioether-linked quinolonyl-carbapenems.

Hershberger PM, Switzer AG, Yelm KE, Coleman MC, Devries CA, Rourke FJ, Davis BW, Kraft WG, Twinem TL, Koenigs PM, Paule SM, Siehnel RJ, Zoutendam PH, Imbus R, Demuth TP Jr.

J Antibiot (Tokyo). 1998 Sep;51(9):857-71.

44.

Synthesis and antibacterial activity of new C-10 quinolonyl-cephem esters.

Demuth TP Jr, White RE, Tietjen RA, Storrin RJ, Skuster JR, Andersen JA, McOsker CC, Freedman R, Rourke FJ.

J Antibiot (Tokyo). 1991 Feb;44(2):200-9.

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