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Peptide and non-peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms.

Sztukowska MN, Roky M, Demuth DR.

Mol Oral Microbiol. 2019 Oct;34(5):169-182. doi: 10.1111/omi.12267. Epub 2019 Aug 15. Review.


'Second-generation' 1,2,3-triazole-based inhibitors of Porphyromonas gingivalis adherence to oral streptococci and biofilm formation.

Patil PC, Tan J, Demuth DR, Luzzio FA.

Medchemcomm. 2019 Jan 15;10(2):268-279. doi: 10.1039/c8md00405f. eCollection 2019 Feb 1.


Functional assessment of peptide-modified PLGA nanoparticles against oral biofilms in a murine model of periodontitis.

Mahmoud MY, Steinbach-Rankins JM, Demuth DR.

J Control Release. 2019 Mar 10;297:3-13. doi: 10.1016/j.jconrel.2019.01.036. Epub 2019 Jan 25.


BAR-encapsulated nanoparticles for the inhibition and disruption of Porphyromonas gingivalis-Streptococcus gordonii biofilms.

Mahmoud MY, Demuth DR, Steinbach-Rankins JM.

J Nanobiotechnology. 2018 Sep 15;16(1):69. doi: 10.1186/s12951-018-0396-4.


In Vitro and In Vivo Activity of Peptidomimetic Compounds That Target the Periodontal Pathogen Porphyromonas gingivalis.

Tan J, Patil PC, Luzzio FA, Demuth DR.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00400-18. doi: 10.1128/AAC.00400-18. Print 2018 Jul.


Identification and functional characterization of type II toxin/antitoxin systems in Aggregatibacter actinomycetemcomitans.

Schneider B, Weigel W, Sztukowska M, Demuth DR.

Mol Oral Microbiol. 2018 Jun;33(3):224-233. doi: 10.1111/omi.12215. Epub 2018 Feb 20.


Peptide-modified nanoparticles inhibit formation of Porphyromonas gingivalis biofilms with Streptococcus gordonii.

Kalia P, Jain A, Radha Krishnan R, Demuth DR, Steinbach-Rankins JM.

Int J Nanomedicine. 2017 Jun 22;12:4553-4562. doi: 10.2147/IJN.S139178. eCollection 2017.


Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.

Chen SG, Stribinskis V, Rane MJ, Demuth DR, Gozal E, Roberts AM, Jagadapillai R, Liu R, Choe K, Shivakumar B, Son F, Jin S, Kerber R, Adame A, Masliah E, Friedland RP.

Sci Rep. 2016 Oct 6;6:34477. doi: 10.1038/srep34477.


1,2,3-Triazole-based inhibitors of Porphyromonas gingivalis adherence to oral streptococci and biofilm formation.

Patil PC, Tan J, Demuth DR, Luzzio FA.

Bioorg Med Chem. 2016 Nov 1;24(21):5410-5417. doi: 10.1016/j.bmc.2016.08.059. Epub 2016 Sep 7.


QseBC, a two-component bacterial adrenergic receptor and global regulator of virulence in Enterobacteriaceae and Pasteurellaceae.

Weigel WA, Demuth DR.

Mol Oral Microbiol. 2016 Oct;31(5):379-97. doi: 10.1111/omi.12138. Epub 2015 Nov 20. Review.


Oxazoles for click chemistry II: synthesis of extended heterocyclic scaffolds.

Patil PC, Luzzio FA, Demuth DR.

Tetrahedron Lett. 2015 Jun 3;56(23):3039-3041.


Aggregatibacter actinomycetemcomitans QseBC is activated by catecholamines and iron and regulates genes encoding proteins associated with anaerobic respiration and metabolism.

Weigel WA, Demuth DR, Torres-Escobar A, Juárez-Rodríguez MD.

Mol Oral Microbiol. 2015 Oct;30(5):384-98. doi: 10.1111/omi.12101. Epub 2015 Jun 5.


Transcriptional regulation of the Aggregatibacter actinomycetemcomitans ygiW-qseBC operon by QseB and integration host factor proteins.

Juárez-Rodríguez MD, Torres-Escobar A, Demuth DR.

Microbiology. 2014 Dec;160(Pt 12):2583-94. doi: 10.1099/mic.0.083501-0. Epub 2014 Sep 15.


Integration host factor is required for replication of pYGK-derived plasmids in Aggregatibacter actinomycetemcomitans.

Torres-Escobar A, Juárez-Rodríguez MD, Demuth DR.

FEMS Microbiol Lett. 2014 Aug;357(2):184-94. doi: 10.1111/1574-6968.12510. Epub 2014 Jul 17.


Differential transcriptional regulation of Aggregatibacter actinomycetemcomitans lsrACDBFG and lsrRK operons by integration host factor protein.

Torres-Escobar A, Juárez-Rodríguez MD, Demuth DR.

J Bacteriol. 2014 Apr;196(8):1597-607. doi: 10.1128/JB.00006-14. Epub 2014 Feb 14.


Altered antigenic profiling and infectivity of Porphyromonas gingivalis in smokers and non-smokers with periodontitis.

Zeller I, Hutcherson JA, Lamont RJ, Demuth DR, Gumus P, Nizam N, Buduneli N, Scott DA.

J Periodontol. 2014 Jun;85(6):837-44. doi: 10.1902/jop.2013.130336. Epub 2013 Oct 23.


ygiW and qseBC are co-expressed in Aggregatibacter actinomycetemcomitans and regulate biofilm growth.

Juárez-Rodríguez MD, Torres-Escobar A, Demuth DR.

Microbiology. 2013 Jun;159(Pt 6):989-1001. doi: 10.1099/mic.0.066183-0. Epub 2013 Mar 21.


Construction of new cloning, lacZ reporter and scarless-markerless suicide vectors for genetic studies in Aggregatibacter actinomycetemcomitans.

Juárez-Rodríguez MD, Torres-Escobar A, Demuth DR.

Plasmid. 2013 May;69(3):211-22. doi: 10.1016/j.plasmid.2013.01.002. Epub 2013 Jan 23.


Regulon controlled by the GppX hybrid two component system in Porphyromonas gingivalis.

Hirano T, Beck DA, Wright CJ, Demuth DR, Hackett M, Lamont RJ.

Mol Oral Microbiol. 2013 Feb;28(1):70-81. doi: 10.1111/omi.12007. Epub 2012 Nov 1.


Transcriptional regulation of Aggregatibacter actinomycetemcomitans lsrACDBFG and lsrRK operons and their role in biofilm formation.

Torres-Escobar A, Juárez-Rodríguez MD, Lamont RJ, Demuth DR.

J Bacteriol. 2013 Jan;195(1):56-65. doi: 10.1128/JB.01476-12. Epub 2012 Oct 26.


Preparation of azidoaryl- and azidoalkyloxazoles for click chemistry.

Loner CM, Luzzio FA, Demuth DR.

Tetrahedron Lett. 2012 Oct 17;53(42):5641-5644.


Deep sequencing of Porphyromonas gingivalis and comparative transcriptome analysis of a LuxS mutant.

Hirano T, Beck DA, Demuth DR, Hackett M, Lamont RJ.

Front Cell Infect Microbiol. 2012 Jun 12;2:79. doi: 10.3389/fcimb.2012.00079. eCollection 2012.


Signaling transduction analysis in gingival epithelial cells after infection with Aggregatibacter actinomycetemcomitans.

Umeda JE, Demuth DR, Ando ES, Faveri M, Mayer MP.

Mol Oral Microbiol. 2012 Feb;27(1):23-33. doi: 10.1111/j.2041-1014.2011.00629.x. Epub 2011 Nov 15.


Tobacco smoke augments Porphyromonas gingivalis-Streptococcus gordonii biofilm formation.

Bagaitkar J, Daep CA, Patel CK, Renaud DE, Demuth DR, Scott DA.

PLoS One. 2011;6(11):e27386. doi: 10.1371/journal.pone.0027386. Epub 2011 Nov 14.


Community signalling between Streptococcus gordonii and Porphyromonas gingivalis is controlled by the transcriptional regulator CdhR.

Chawla A, Hirano T, Bainbridge BW, Demuth DR, Xie H, Lamont RJ.

Mol Microbiol. 2010 Dec;78(6):1510-22. doi: 10.1111/j.1365-2958.2010.07420.x. Epub 2010 Oct 26.


Structural dissection and in vivo effectiveness of a peptide inhibitor of Porphyromonas gingivalis adherence to Streptococcus gordonii.

Daep CA, Novak EA, Lamont RJ, Demuth DR.

Infect Immun. 2011 Jan;79(1):67-74. doi: 10.1128/IAI.00361-10. Epub 2010 Nov 1.


Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity.

Bagaitkar J, Demuth DR, Daep CA, Renaud DE, Pierce DL, Scott DA.

PLoS One. 2010 May 4;5(5):e9323. doi: 10.1371/journal.pone.0009323.


Autoinducer-2 and QseC control biofilm formation and in vivo virulence of Aggregatibacter actinomycetemcomitans.

Novak EA, Shao H, Daep CA, Demuth DR.

Infect Immun. 2010 Jul;78(7):2919-26. doi: 10.1128/IAI.01376-09. Epub 2010 Apr 19.


Quorum sensing regulation of biofilm growth and gene expression by oral bacteria and periodontal pathogens.

Shao H, Demuth DR.

Periodontol 2000. 2010 Feb;52(1):53-67. doi: 10.1111/j.1600-0757.2009.00318.x. Review. No abstract available.


Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis.

Pierce DL, Nishiyama S, Liang S, Wang M, Triantafilou M, Triantafilou K, Yoshimura F, Demuth DR, Hajishengallis G.

Infect Immun. 2009 Aug;77(8):3294-301. doi: 10.1128/IAI.00262-09. Epub 2009 Jun 8.


Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces apoptosis in nonproliferating macrophages by a phosphatase-independent mechanism.

Rabin SD, Flitton JG, Demuth DR.

Infect Immun. 2009 Aug;77(8):3161-9. doi: 10.1128/IAI.01227-08. Epub 2009 May 26.


Tobacco-induced alterations to Porphyromonas gingivalis-host interactions.

Bagaitkar J, Williams LR, Renaud DE, Bemakanakere MR, Martin M, Scott DA, Demuth DR.

Environ Microbiol. 2009 May;11(5):1242-53. doi: 10.1111/j.1462-2920.2008.01852.x. Epub 2009 Jan 23.


Tobacco use increases susceptibility to bacterial infection.

Bagaitkar J, Demuth DR, Scott DA.

Tob Induc Dis. 2008 Dec 18;4:12. doi: 10.1186/1617-9625-4-12.


Subversion of innate immunity by periodontopathic bacteria via exploitation of complement receptor-3.

Hajishengallis G, Wang M, Liang S, Shakhatreh MA, James D, Nishiyama S, Yoshimura F, Demuth DR.

Adv Exp Med Biol. 2008;632:203-19. Review.


Design of bacteria-agglutinating peptides derived from parotid secretory protein, a member of the bactericidal/permeability increasing-like protein family.

Gorr SU, Sotsky JB, Shelar AP, Demuth DR.

Peptides. 2008 Dec;29(12):2118-27. doi: 10.1016/j.peptides.2008.09.019. Epub 2008 Oct 5.


Molecular phylogenetic analysis of tryptophanyl-tRNA synthetase of Actinobacillus actinomycetemcomitans.

Rajendran N, Rajnarayanan RV, Demuth DR.

Z Naturforsch C J Biosci. 2008 May-Jun;63(5-6):418-28.


A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes.

Maeda K, Tribble GD, Tucker CM, Anaya C, Shizukuishi S, Lewis JP, Demuth DR, Lamont RJ.

Mol Microbiol. 2008 Sep;69(5):1153-64. doi: 10.1111/j.1365-2958.2008.06338.x. Epub 2008 Jun 28.


Induction of Aggregatibacter actinomycetemcomitans leukotoxin expression by IS1301 and orfA.

Schaeffer LM, Schmidt ML, Demuth DR.

Microbiology. 2008 Feb;154(Pt 2):528-38. doi: 10.1099/mic.0.2007/012195-0.


Role of the Clp system in stress tolerance, biofilm formation, and intracellular invasion in Porphyromonas gingivalis.

Capestany CA, Tribble GD, Maeda K, Demuth DR, Lamont RJ.

J Bacteriol. 2008 Feb;190(4):1436-46. Epub 2007 Dec 7.


Human variability in innate immunity.

Kinane DF, Demuth DR, Gorr SU, Hajishengallis GN, Martin MH.

Periodontol 2000. 2007;45:14-34. Review. No abstract available.


Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages.

Wang M, Shakhatreh MA, James D, Liang S, Nishiyama S, Yoshimura F, Demuth DR, Hajishengallis G.

J Immunol. 2007 Aug 15;179(4):2349-58.


Autoinducer 2 is required for biofilm growth of Aggregatibacter (Actinobacillus) actinomycetemcomitans.

Shao H, Lamont RJ, Demuth DR.

Infect Immun. 2007 Sep;75(9):4211-8. Epub 2007 Jun 25.


Characterization of epitopes recognized by anti-Streptococcus mutans P1 monoclonal antibodies.

McArthur WP, Rhodin NR, Seifert TB, Oli MW, Robinette RA, Demuth DR, Brady LJ.

FEMS Immunol Med Microbiol. 2007 Aug;50(3):342-53. Epub 2007 Jun 29.


Differential interaction of Aggregatibacter (Actinobacillus) actinomycetemcomitans LsrB and RbsB proteins with autoinducer 2.

Shao H, James D, Lamont RJ, Demuth DR.

J Bacteriol. 2007 Aug;189(15):5559-65. Epub 2007 May 25.


Structural characterization of peptide-mediated inhibition of Porphyromonas gingivalis biofilm formation.

Daep CA, James DM, Lamont RJ, Demuth DR.

Infect Immun. 2006 Oct;74(10):5756-62.


Porphyromonas gingivalis genes involved in community development with Streptococcus gordonii.

Simionato MR, Tucker CM, Kuboniwa M, Lamont G, Demuth DR, Tribble GD, Lamont RJ.

Infect Immun. 2006 Nov;74(11):6419-28. Epub 2006 Aug 21.


Glycoprotein 340 in normal human ocular surface tissues and tear film.

Jumblatt MM, Imbert Y, Young WW Jr, Foulks GN, Steele PS, Demuth DR.

Infect Immun. 2006 Jul;74(7):4058-63.


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