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Items: 1 to 50 of 145

1.

Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.

Jones JC, Brindley CD, Elder NH, Myers MG Jr, Rajala MW, Dekaney CM, McNamee EN, Frey MR, Shroyer NF, Dempsey PJ.

Cell Mol Gastroenterol Hepatol. 2019;7(3):533-554. doi: 10.1016/j.jcmgh.2018.11.004. Epub 2018 Nov 27.

2.

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.

Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.

J Exp Med. 2018 Apr 2;215(4):1205-1225. doi: 10.1084/jem.20171696. Epub 2018 Feb 22.

3.

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.

4.

Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis.

Dempsey PJ.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2228-2239. doi: 10.1016/j.bbamcr.2017.07.011. Epub 2017 Jul 22. Review.

5.

Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition.

Feng Y, Demehri FR, Xiao W, Tsai YH, Jones JC, Brindley CD, Threadgill DW, Holst JJ, Hartmann B, Barrett TA, Teitelbaum DH, Dempsey PJ.

Cell Mol Gastroenterol Hepatol. 2017 Jan 17;3(3):447-468. doi: 10.1016/j.jcmgh.2016.12.005. eCollection 2017 May.

6.

ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.

Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR.

Cell Death Dis. 2017 Feb 23;8(2):e2622. doi: 10.1038/cddis.2017.42.

7.

Advances in Interventional Oncology: Lung Cancer.

Dempsey PJ, Ridge CA, Solomon SB.

Cancer J. 2016 Nov/Dec;22(6):393-400. Review.

PMID:
27870682
8.
9.

Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?

Dempsey PJ.

Gastroenterology. 2016 Jul;151(1):27-9. doi: 10.1053/j.gastro.2016.05.020. Epub 2016 May 27. No abstract available.

PMID:
27237596
10.

ADAM Proteases and Gastrointestinal Function.

Jones JC, Rustagi S, Dempsey PJ.

Annu Rev Physiol. 2016;78:243-76. doi: 10.1146/annurev-physiol-021014-071720. Epub 2015 Nov 19. Review.

11.

Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition.

Feng Y, Tsai YH, Xiao W, Ralls MW, Stoeck A, Wilson CL, Raines EW, Teitelbaum DH, Dempsey PJ.

Mol Cell Biol. 2015 Nov;35(21):3604-21. doi: 10.1128/MCB.00143-15. Epub 2015 Aug 17.

12.

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo.

Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR.

Stem Cell Reports. 2015 Jun 3. pii: S2213-6711(15)00122-8. doi: 10.1016/j.stemcr.2015.04.010. [Epub ahead of print]

13.

TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways.

Freeman JJ, Feng Y, Demehri FR, Dempsey PJ, Teitelbaum DH.

FASEB J. 2015 Jul;29(7):2943-58. doi: 10.1096/fj.14-269480. Epub 2015 Mar 17.

14.

ADAM10 regulates Notch function in intestinal stem cells of mice.

Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ.

Gastroenterology. 2014 Oct;147(4):822-834.e13. doi: 10.1053/j.gastro.2014.07.003. Epub 2014 Jul 16.

15.

N-cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions.

Klingener M, Chavali M, Singh J, McMillan N, Coomes A, Dempsey PJ, Chen EI, Aguirre A.

J Neurosci. 2014 Jul 16;34(29):9590-606. doi: 10.1523/JNEUROSCI.3699-13.2014.

16.

Jay J. Listinsky, MD, PhD.

Dempsey PJ.

Radiology. 2014 May;271(2):621. doi: 10.1148/radiol.14144006. No abstract available.

PMID:
24761961
17.

A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor.

Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB.

J Biol Chem. 2013 Oct 18;288(42):30742-51. doi: 10.1074/jbc.M113.492397. Epub 2013 Sep 16.

18.

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.

Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, Vignali DA.

Nat Immunol. 2013 Mar;14(3):262-70. doi: 10.1038/ni.2538. Epub 2013 Feb 3.

19.

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Colombo A, Wang H, Kuhn PH, Page R, Kremmer E, Dempsey PJ, Crawford HC, Lichtenthaler SF.

Neurobiol Dis. 2013 Jan;49:137-47. doi: 10.1016/j.nbd.2012.08.011. Epub 2012 Aug 24.

20.

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.

VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, Magness ST, Tran IT, Maillard I, Siebel C, Kolterud Å, Grosse AS, Gumucio DL, Ernst SA, Tsai YH, Dempsey PJ, Samuelson LC.

Development. 2012 Feb;139(3):488-97. doi: 10.1242/dev.070763. Epub 2011 Dec 21.

21.

TNF-α converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival.

Hilliard VC, Frey MR, Dempsey PJ, Peek RM Jr, Polk DB.

Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G338-46. doi: 10.1152/ajpgi.00057.2011. Epub 2011 May 26.

22.

The need for breast cancer screening in women undergoing elective breast surgery: an assessment of risk and risk factors for breast cancer in young women.

Sharabi SE, Bullocks JM, Dempsey PJ, Singletary SE.

Aesthet Surg J. 2010 Nov-Dec;30(6):821-31. doi: 10.1177/1090820X10386589.

PMID:
21131456
23.

Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ.

Diabetes. 2010 Dec;59(12):3090-8. doi: 10.2337/db10-0624. Epub 2010 Aug 29.

24.
25.

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.

Gibb DR, El Shikh M, Kang DJ, Rowe WJ, El Sayed R, Cichy J, Yagita H, Tew JG, Dempsey PJ, Crawford HC, Conrad DH.

J Exp Med. 2010 Mar 15;207(3):623-35. doi: 10.1084/jem.20091990. Epub 2010 Feb 15.

26.

Fluorescent substrates useful as high-throughput screening tools for ADAM9.

Moss ML, Rasmussen FH, Nudelman R, Dempsey PJ, Williams J.

Comb Chem High Throughput Screen. 2010 May;13(4):358-65.

PMID:
20015014
27.

New ultrasound-based imaging technologies are claimed to avoid unnecessary breast biopsies, but what is an "unnecessary" image-guided needle biopsy of the breast?

Dempsey PJ.

J Clin Ultrasound. 2010 Mar-Apr;38(3):111-2. doi: 10.1002/jcu.20660. No abstract available.

PMID:
20014014
28.

NCCN clinical practice guidelines in oncology: breast cancer screening and diagnosis.

Bevers TB, Anderson BO, Bonaccio E, Buys S, Daly MB, Dempsey PJ, Farrar WB, Fleming I, Garber JE, Harris RE, Heerdt AS, Helvie M, Huff JG, Khakpour N, Khan SA, Krontiras H, Lyman G, Rafferty E, Shaw S, Smith ML, Tsangaris TN, Williams C, Yankeelov T; National Comprehensive Cancer Network.

J Natl Compr Canc Netw. 2009 Nov;7(10):1060-96. Review. No abstract available. Erratum in: J Natl Compr Canc Netw. 2010 Feb;8(2):xxxvii. Buys, Sandra [corrected to Buys, Saundra]; Yaneeklov, Thomas [corrected to Yankeelov, Thomas].

PMID:
19930975
29.

ADAM10 as a therapeutic target for cancer and inflammation.

Crawford HC, Dempsey PJ, Brown G, Adam L, Moss ML.

Curr Pharm Des. 2009;15(20):2288-99. Review.

PMID:
19601831
30.

Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.

Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM Jr, Cover TL, Washington MK, Wilson KT, Polk DB.

Gastroenterology. 2009 Apr;136(4):1297-1307, e1-3. doi: 10.1053/j.gastro.2008.12.059. Epub 2009 Jan 1.

31.

Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice.

Gelling RW, Yan W, Al-Noori S, Pardini A, Morton GJ, Ogimoto K, Schwartz MW, Dempsey PJ.

Endocrinology. 2008 Dec;149(12):6053-64. doi: 10.1210/en.2008-0775. Epub 2008 Aug 7.

32.

Results of a survey on digital screening mammography: prevalence, efficiency, and use of ancillary diagnostic AIDS.

Haygood TM, Whitman GJ, Atkinson EN, Nikolova RG, Sandoval SY, Dempsey PJ.

J Am Coll Radiol. 2008 Apr;5(4):585-92. doi: 10.1016/j.jacr.2007.10.019.

PMID:
18359447
33.

ADAM10 as a target for anti-cancer therapy.

Moss ML, Stoeck A, Yan W, Dempsey PJ.

Curr Pharm Biotechnol. 2008 Feb;9(1):2-8. Review.

PMID:
18289051
34.

TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer.

Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC, Rothenberg ML, Washington MK, Coffey RJ.

Clin Cancer Res. 2008 Feb 15;14(4):1182-91. doi: 10.1158/1078-0432.CCR-07-1216.

35.

Novel role of protein kinase C-delta Tyr 311 phosphorylation in vascular smooth muscle cell hypertrophy by angiotensin II.

Nakashima H, Frank GD, Shirai H, Hinoki A, Higuchi S, Ohtsu H, Eguchi K, Sanjay A, Reyland ME, Dempsey PJ, Inagami T, Eguchi S.

Hypertension. 2008 Feb;51(2):232-8. doi: 10.1161/HYPERTENSIONAHA.107.101253. Epub 2008 Jan 7.

36.

Mammographic features of triple receptor-negative primary breast cancers in young premenopausal women.

Yang WT, Dryden M, Broglio K, Gilcrease M, Dawood S, Dempsey PJ, Valero V, Hortobagyi G, Atchley D, Arun B.

Breast Cancer Res Treat. 2008 Oct;111(3):405-10. Epub 2007 Nov 17.

PMID:
18026834
37.

Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion.

Sanderson MP, Keller S, Alonso A, Riedle S, Dempsey PJ, Altevogt P.

J Cell Biochem. 2008 Apr 15;103(6):1783-97.

38.

Diagnostic breast ultrasound: current status and future directions.

Yang W, Dempsey PJ.

Radiol Clin North Am. 2007 Sep;45(5):845-61, vii. Review.

PMID:
17888773
39.
40.

Metalloproteases regulate T-cell proliferation and effector function via LAG-3.

Li N, Wang Y, Forbes K, Vignali KM, Heale BS, Saftig P, Hartmann D, Black RA, Rossi JJ, Blobel CP, Dempsey PJ, Workman CJ, Vignali DA.

EMBO J. 2007 Jan 24;26(2):494-504.

41.

Comparison of full-field digital mammography and screen-film mammography for detection and characterization of simulated small masses.

Yang WT, Lai CJ, Whitman GJ, Murphy WA Jr, Dryden MJ, Kushwaha AC, Sahin AA, Johnston D, Dempsey PJ, Shaw CC.

AJR Am J Roentgenol. 2006 Dec;187(6):W576-81.

42.

Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer.

Hess KR, Anderson K, Symmans WF, Valero V, Ibrahim N, Mejia JA, Booser D, Theriault RL, Buzdar AU, Dempsey PJ, Rouzier R, Sneige N, Ross JS, Vidaurre T, Gómez HL, Hortobagyi GN, Pusztai L.

J Clin Oncol. 2006 Sep 10;24(26):4236-44. Epub 2006 Aug 8.

PMID:
16896004
43.

Receiver operating characteristic analysis for the detection of simulated microcalcifications on mammograms using hardcopy images.

Lai CJ, Shaw CC, Whitman GJ, Yang WT, Dempsey PJ, Nguyen V, Ice MF.

Phys Med Biol. 2006 Aug 21;51(16):3901-19. Epub 2006 Jul 26.

44.

BI-RADS-MRI: a primer.

Erguvan-Dogan B, Whitman GJ, Kushwaha AC, Phelps MJ, Dempsey PJ.

AJR Am J Roentgenol. 2006 Aug;187(2):W152-60.

PMID:
16861504
45.

ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II.

Ohtsu H, Dempsey PJ, Frank GD, Brailoiu E, Higuchi S, Suzuki H, Nakashima H, Eguchi K, Eguchi S.

Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):e133-7. Epub 2006 Jul 13.

PMID:
16840716
46.

Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors.

Sanderson MP, Dempsey PJ, Dunbar AJ.

Growth Factors. 2006 Jun;24(2):121-36. Review.

PMID:
16801132
47.

ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors.

Ohtsu H, Dempsey PJ, Eguchi S.

Am J Physiol Cell Physiol. 2006 Jul;291(1):C1-10. Review.

48.

Breast cancer screening and diagnosis.

Bevers TB, Anderson BO, Bonaccio E, Borgen PI, Buys S, Daly MB, Dempsey PJ, Farrar WB, Fleming I, Garber JE, Harris RE, Helvie M, Hoover S, Krontiras H, Shaw S, Singletary E, Sugg Skinner C, Smith ML, Tsangaris TN, Wiley EL, Williams C; National Comprehensive Cancer Network.

J Natl Compr Canc Netw. 2006 May;4(5):480-508. No abstract available.

PMID:
16687096
49.

Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding.

Sanderson MP, Abbott CA, Tada H, Seno M, Dempsey PJ, Dunbar AJ.

J Cell Biochem. 2006 Oct 1;99(2):609-23.

PMID:
16676357
50.

Primary desmoid tumor (extraabdominal fibromatosis) of the breast.

Erguvan-Dogan B, Dempsey PJ, Ayyar G, Gilcrease MZ.

AJR Am J Roentgenol. 2005 Aug;185(2):488-9. No abstract available.

PMID:
16037525

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