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Items: 1 to 50 of 56

1.

Role of Inflammatory Cell Subtypes in Heart Failure.

Strassheim D, Dempsey EC, Gerasimovskaya E, Stenmark K, Karoor V.

J Immunol Res. 2019 Sep 2;2019:2164017. doi: 10.1155/2019/2164017. eCollection 2019. Review.

2.

RhoGTPase in Vascular Disease.

Strassheim D, Gerasimovskaya E, Irwin D, Dempsey EC, Stenmark K, Karoor V.

Cells. 2019 Jun 6;8(6). pii: E551. doi: 10.3390/cells8060551. Review.

3.

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse.

Wick MJ, Harral JW, Loomis ZL, Dempsey EC.

J Vis Exp. 2018 Sep 12;(139). doi: 10.3791/57037.

4.

Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice.

Karoor V, Fini MA, Loomis Z, Sullivan T, Hersh LB, Gerasimovskaya E, Irwin D, Dempsey EC.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):154-163. doi: 10.1161/ATVBAHA.117.310207. Epub 2017 Nov 30.

5.

Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern.

Wick MJ, Loomis ZL, Harral JW, Le M, Wehling CA, Miller YE, Dempsey EC.

Transgenic Res. 2016 Dec;25(6):773-784. Epub 2016 Jul 1.

PMID:
27369050
6.

Neprilysin regulates pulmonary artery smooth muscle cell phenotype through a platelet-derived growth factor receptor-dependent mechanism.

Karoor V, Oka M, Walchak SJ, Hersh LB, Miller YE, Dempsey EC.

Hypertension. 2013 Apr;61(4):921-30. doi: 10.1161/HYPERTENSIONAHA.111.199588. Epub 2013 Feb 4.

7.

Sleep-disordered breathing, hypoxemia, and cancer mortality.

Miller YE, Karoor V, Dempsey EC, Fagan KA.

Am J Respir Crit Care Med. 2013 Feb 1;187(3):330-1. No abstract available.

PMID:
23378442
8.

Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFR-dependent mechanism.

Karoor V, Le M, Merrick D, Fagan KA, Dempsey EC, Miller YE.

Cancer Prev Res (Phila). 2012 Aug;5(8):1061-71. doi: 10.1158/1940-6207.CAPR-12-0069-T. Epub 2012 Jun 14.

9.

Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease.

Wick MJ, Buesing EJ, Wehling CA, Loomis ZL, Cool CD, Zamora MR, Miller YE, Colgan SP, Hersh LB, Voelkel NF, Dempsey EC.

Am J Respir Crit Care Med. 2011 Feb 1;183(3):330-40. doi: 10.1164/rccm.201002-0154OC. Epub 2010 Sep 2.

10.

Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors.

Karoor V, Le M, Merrick D, Dempsey EC, Miller YE.

Cancer Prev Res (Phila). 2010 Sep;3(9):1141-7. doi: 10.1158/1940-6207.CAPR-10-0005. Epub 2010 Jul 20.

11.

A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer.

Kelly K, Kittelson J, Franklin WA, Kennedy TC, Klein CE, Keith RL, Dempsey EC, Lewis M, Jackson MK, Hirsch FR, Bunn PA, Miller YE.

Cancer Prev Res (Phila). 2009 May;2(5):440-9. doi: 10.1158/1940-6207.CAPR-08-0136. Epub 2009 Apr 28.

12.

Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia.

Dempsey EC, Wick MJ, Karoor V, Barr EJ, Tallman DW, Wehling CA, Walchak SJ, Laudi S, Le M, Oka M, Majka S, Cool CD, Fagan KA, Klemm DJ, Hersh LB, Gerard NP, Gerard C, Miller YE.

Am J Pathol. 2009 Mar;174(3):782-96. doi: 10.2353/ajpath.2009.080345.

13.

Neonatal lung side population cells demonstrate endothelial potential and are altered in response to hyperoxia-induced lung simplification.

Irwin D, Helm K, Campbell N, Imamura M, Fagan K, Harral J, Carr M, Young KA, Klemm D, Gebb S, Dempsey EC, West J, Majka S.

Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L941-51. Epub 2007 Aug 10.

14.

Lung disease and PKCs.

Dempsey EC, Cool CD, Littler CM.

Pharmacol Res. 2007 Jun;55(6):545-59. Epub 2007 Apr 29. Review.

PMID:
17582782
15.

Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.

Crossno JT Jr, Garat CV, Reusch JE, Morris KG, Dempsey EC, McMurtry IF, Stenmark KR, Klemm DJ.

Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L885-97. Epub 2006 Dec 22.

16.
17.

Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension.

Case D, Irwin D, Ivester C, Harral J, Morris K, Imamura M, Roedersheimer M, Patterson A, Carr M, Hagen M, Saavedra M, Crossno J Jr, Young KA, Dempsey EC, Poirier F, West J, Majka S.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L154-64. Epub 2006 Sep 1.

18.

Impact of customized videotape education on quality of life in patients with chronic obstructive pulmonary disease.

Petty TL, Dempsey EC, Collins T, Pluss W, Lipkus I, Cutter GR, Chalmers R, Mitchell A, Weil KC.

J Cardiopulm Rehabil. 2006 Mar-Apr;26(2):112-7.

PMID:
16569981
19.

Divergent contractile and structural responses of the murine protein kinase C-epsilon null pulmonary circulation to chronic hypoxia.

Littler CM, Wehling CA, Fagan KA, Messing RO, Dempsey EC.

Chest. 2005 Dec;128(6 Suppl):620S-621S. No abstract available.

PMID:
16373877
20.

Role of rho in the increased migration of pulmonary artery smooth muscle cells observed in the neprilysin knockout mouse.

Karoor V, Walchak SJ, Miller YE, Dempsey EC.

Chest. 2005 Dec;128(6 Suppl):582S-583S. No abstract available.

PMID:
16373846
21.

Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia.

Littler CM, Wehling CA, Wick MJ, Fagan KA, Cool CD, Messing RO, Dempsey EC.

Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L1083-93. Epub 2005 Aug 5.

22.

High prevalence of occult endobronchial malignancy in high risk patients with moderate sputum atypia.

Kennedy TC, Franklin WA, Prindiville SA, Cook R, Dempsey EC, Keith RL, Hirsch FR, Merrick TA, Shroyer KR, Petty TL, Byers T, Bunn PA Jr, Miller YE.

Lung Cancer. 2005 Aug;49(2):187-91. Epub 2005 Apr 14.

PMID:
16022912
23.

High prevalence of endobronchial malignancy in high-risk patients with moderate dysplasia in sputum.

Kennedy TC, Franklin WA, Prindiville SA, Cook R, Dempsey EC, Keith RL, Hirsch FR, Merrick TA, Shroyer KR, Petty TL, Byers T, Bunn PA Jr, Miller YE.

Chest. 2004 May;125(5 Suppl):109S. No abstract available.

PMID:
15136448
24.

Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction.

Littler CM, Morris KG Jr, Fagan KA, McMurtry IF, Messing RO, Dempsey EC.

Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1321-31. Epub 2002 Dec 27.

25.

Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia.

Das M, Dempsey EC, Reeves JT, Stenmark KR.

Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L976-86.

26.

Fluorescence versus white-light bronchoscopy for detection of preneoplastic lesions: a randomized study.

Hirsch FR, Prindiville SA, Miller YE, Franklin WA, Dempsey EC, Murphy JR, Bunn PA Jr, Kennedy TC.

J Natl Cancer Inst. 2001 Sep 19;93(18):1385-91.

PMID:
11562389
27.

cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration.

Klemm DJ, Watson PA, Frid MG, Dempsey EC, Schaack J, Colton LA, Nesterova A, Stenmark KR, Reusch JE.

J Biol Chem. 2001 Dec 7;276(49):46132-41. Epub 2001 Sep 17.

28.

Hypoxia-induced pulmonary vascular remodeling: contribution of the adventitial fibroblasts.

Stenmark KR, Bouchey D, Nemenoff R, Dempsey EC, Das M.

Physiol Res. 2000;49(5):503-17. Review.

29.

Protein kinase C isozymes and the regulation of diverse cell responses.

Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO.

Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L429-38. Review.

30.

Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer.

Keith RL, Miller YE, Gemmill RM, Drabkin HA, Dempsey EC, Kennedy TC, Prindiville S, Franklin WA.

Clin Cancer Res. 2000 May;6(5):1616-25.

31.

Hypoxia induces cell-specific changes in gene expression in vascular wall cells: implications for pulmonary hypertension.

Stenmark KR, Frid M, Nemenoff R, Dempsey EC, Das M.

Adv Exp Med Biol. 1999;474:231-58. Review.

PMID:
10635005
32.

Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase c isozymes.

Das M, Dempsey EC, Bouchey D, Reyland ME, Stenmark KR.

Am J Respir Cell Mol Biol. 2000 Jan;22(1):15-25.

PMID:
10615061
34.

Hypoxic growth of bovine pulmonary artery smooth muscle cells: dependence on synergy, heterogeneity, and injury-induced phenotypic change.

Dempsey EC, Das M, Frid MG, Xu Y, Stenmark KR.

Chest. 1998 Jul;114(1 Suppl):29S-30S. No abstract available.

PMID:
9676612
35.

Hypoxia stimulates proliferation of a unique cell population isolated from the bovine vascular media.

Frid MG, Aldashev AA, Cabirac GF, Dempsey EC, Stenmark KR.

Chest. 1998 Jul;114(1 Suppl):28S-29S. No abstract available.

PMID:
9676611
36.

Selected isozymes of PKC contribute to augmented growth of fetal and neonatal bovine PA adventitial fibroblasts.

Das M, Stenmark KR, Ruff LJ, Dempsey EC.

Am J Physiol. 1997 Dec;273(6):L1276-84. doi: 10.1152/ajplung.1997.273.6.L1276.

PMID:
9435584
37.
38.

Heterogeneity in the proliferative response of bovine pulmonary artery smooth muscle cells to mitogens and hypoxia: importance of protein kinase C.

Dempsey EC, Frid MG, Aldashev AA, Das M, Stenmark KR.

Can J Physiol Pharmacol. 1997 Jul;75(7):936-44.

PMID:
9315363
39.

Smooth muscle cell heterogeneity in pulmonary and systemic vessels. Importance in vascular disease.

Frid MG, Dempsey EC, Durmowicz AG, Stenmark KR.

Arterioscler Thromb Vasc Biol. 1997 Jul;17(7):1203-9. Review.

PMID:
9261247
40.

Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties.

Xu Y, Stenmark KR, Das M, Walchak SJ, Ruff LJ, Dempsey EC.

Am J Physiol. 1997 Jul;273(1 Pt 1):L234-45.

PMID:
9252561
41.

Pregnancy stimulation of DNA synthesis and uterine blood flow in the guinea pig.

Keyes LE, Majack R, Dempsey EC, Moore LG.

Pediatr Res. 1997 May;41(5):708-15.

PMID:
9128295
42.

High frequency of K-ras codon 12 mutations in bronchoalveolar lavage fluid of patients at high risk for second primary lung cancer.

Scott FM, Modali R, Lehman TA, Seddon M, Kelly K, Dempsey EC, Wilson V, Tockman MS, Mulshine JL.

Clin Cancer Res. 1997 Mar;3(3):479-82.

43.

Expansion of bronchial epithelial cell populations by in vitro culture of explants from dysplastic and histologically normal sites.

Franklin WA, Folkvord JM, Varella-Garcia M, Kennedy T, Proudfoot S, Cook R, Dempsey EC, Helm K, Bunn PA, Miller YE.

Am J Respir Cell Mol Biol. 1996 Sep;15(3):297-304.

PMID:
8810633
44.

Detection of K-ras oncogene mutations by polymerase chain reaction-based ligase chain reaction.

Lehman TA, Scott F, Seddon M, Kelly K, Dempsey EC, Wilson VL, Mulshine JL, Modali R.

Anal Biochem. 1996 Aug 1;239(2):153-9.

PMID:
8811898
45.

Peptide amidating activity in human bronchoalveolar lavage fluid.

Scott FM, Treston AM, Shaw GL, Avis I, Sorenson J, Kelly K, Dempsey EC, Cantor AB, Tockman M, Mulshine JL.

Lung Cancer. 1996 Jun;14(2-3):239-51.

PMID:
8794407
46.

Unique growth properties of neonatal pulmonary vascular cells: importance of time- and site-specific responses, cell-cell interaction, and synergy.

Dempsey EC, Das M, Frid MG, Stenmark KR.

J Perinatol. 1996 Mar-Apr;16(2 Pt 2 Su):S2-11. Review. No abstract available.

PMID:
8732542
47.

Overexpression of endothelin-1 and enhanced growth of pulmonary artery smooth muscle cells from fawn-hooded rats.

Zamora MR, Stelzner TJ, Webb S, Panos RJ, Ruff LJ, Dempsey EC.

Am J Physiol. 1996 Jan;270(1 Pt 1):L101-9.

PMID:
8772532
49.

Enhanced growth of fetal and neonatal pulmonary artery adventitial fibroblasts is dependent on protein kinase C.

Das M, Stenmark KR, Dempsey EC.

Am J Physiol. 1995 Nov;269(5 Pt 1):L660-7.

PMID:
7491986
50.

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