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Deployment of DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair.

Thapar U, Demple B.

DNA Repair (Amst). 2019 Apr;76:11-19. doi: 10.1016/j.dnarep.2019.02.001. Epub 2019 Feb 4.


Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence.

Burra S, Marasco D, Malfatti MC, Antoniali G, Virgilio A, Esposito V, Demple B, Galeone A, Tell G.

DNA Repair (Amst). 2019 Jan;73:129-143. doi: 10.1016/j.dnarep.2018.11.010. Epub 2018 Nov 22.


Expression of Genes Involved in Stress, Toxicity, Inflammation, and Autoimmunity in Relation to Cadmium, Mercury, and Lead in Human Blood: A Pilot Study.

Monastero RN, Vacchi-Suzzi C, Marsit C, Demple B, Meliker JR.

Toxics. 2018 Jul 6;6(3). pii: E35. doi: 10.3390/toxics6030035.


Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma.

Ströbel T, Madlener S, Tuna S, Vose S, Lagerweij T, Wurdinger T, Vierlinger K, Wöhrer A, Price BD, Demple B, Saydam O, Saydam N.

Sci Rep. 2017 Aug 29;7(1):9674. doi: 10.1038/s41598-017-10013-w.


How are base excision DNA repair pathways deployed in vivo?

Thapar U, Demple B.

F1000Res. 2017 Mar 16;6:279. doi: 10.12688/f1000research.10538.1. eCollection 2017. Review.


Risky repair: DNA-protein crosslinks formed by mitochondrial base excision DNA repair enzymes acting on free radical lesions.

Caston RA, Demple B.

Free Radic Biol Med. 2017 Jun;107:146-150. doi: 10.1016/j.freeradbiomed.2016.11.025. Epub 2016 Nov 17. Review.


When DNA repair goes wrong: BER-generated DNA-protein crosslinks to oxidative lesions.

Quiñones JL, Demple B.

DNA Repair (Amst). 2016 Aug;44:103-109. doi: 10.1016/j.dnarep.2016.05.014. Epub 2016 May 20. Review.


Temporal variability of urinary cadmium in spot urine samples and first morning voids.

Vacchi-Suzzi C, Porucznik CA, Cox KJ, Zhao Y, Ahn H, Harrington JM, Levine KE, Demple B, Marsit CJ, Gonzalez A, Luft B, Meliker JR.

J Expo Sci Environ Epidemiol. 2017 May;27(3):306-312. doi: 10.1038/jes.2016.28. Epub 2016 May 11.


Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1.

Suresh Kumar MA, Peluso M, Chaudhary P, Dhawan J, Beheshti A, Manickam K, Thapar U, Pena L, Natarajan M, Hlatky L, Demple B, Naidu M.

PLoS One. 2015 Jul 24;10(7):e0133016. doi: 10.1371/journal.pone.0133016. eCollection 2015.


Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo.

Quiñones JL, Thapar U, Yu K, Fang Q, Sobol RW, Demple B.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8602-7. doi: 10.1073/pnas.1501101112. Epub 2015 Jun 29.


Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.

Vascotto C, Lirussi L, Poletto M, Tiribelli M, Damiani D, Fabbro D, Damante G, Demple B, Colombo E, Tell G.

Oncogene. 2015 Jun;34(26):3482. doi: 10.1038/onc.2015.191. No abstract available.


Base excision DNA repair and cancer.

Tell G, Demple B.

Oncotarget. 2015 Jan 20;6(2):584-5. No abstract available.


Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance.

Madlener S, Ströbel T, Vose S, Saydam O, Price BD, Demple B, Saydam N.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17844-9. doi: 10.1073/pnas.1304784110. Epub 2013 Oct 14.


Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.

Vascotto C, Lirussi L, Poletto M, Tiribelli M, Damiani D, Fabbro D, Damante G, Demple B, Colombo E, Tell G.

Oncogene. 2014 May 29;33(22):2876-87. doi: 10.1038/onc.2013.251. Epub 2013 Jul 8. Erratum in: Oncogene. 2015 Jun;34(26):3482.


Indo-US workshop on base excision DNA repair, brain function and aging.

Demple B, Rao KS, Bohr VA.

Mech Ageing Dev. 2012 Apr;133(4):v-vi. doi: 10.1016/S0047-6374(12)00063-2. No abstract available.


A DNA-based nanomechanical device used to characterize the distortion of DNA by Apo-SoxR protein.

Liu C, Kim E, Demple B, Seeman NC.

Biochemistry. 2012 Feb 7;51(5):937-43. doi: 10.1021/bi201196s. Epub 2012 Jan 26.


Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin.

Fung H, Demple B.

J Biol Chem. 2011 Feb 18;286(7):4968-77. doi: 10.1074/jbc.M110.146498. Epub 2010 Nov 15.


DNA repair in mammalian mitochondria: Much more than we thought?

Liu P, Demple B.

Environ Mol Mutagen. 2010 Jun;51(5):417-26. doi: 10.1002/em.20576. Review.


Biochemical evaluation of genotoxic biomarkers for 2-deoxyribonolactone-mediated cross-link formation with histones.

Son MY, Jun HI, Lee KG, Demple B, Sung JS.

J Toxicol Environ Health A. 2009;72(21-22):1311-7. doi: 10.1080/15287390903212402.


Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae.

Auerbach PA, Demple B.

Mutagenesis. 2010 Jan;25(1):63-9. doi: 10.1093/mutage/gep045. Epub 2009 Nov 9.


DNA-mediated redox signaling for transcriptional activation of SoxR.

Lee PE, Demple B, Barton JK.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13164-8. doi: 10.1073/pnas.0906429106. Epub 2009 Jul 27.


Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation.

Kuwano Y, Rabinovic A, Srikantan S, Gorospe M, Demple B.

Mol Cell Biol. 2009 May;29(10):2622-35. doi: 10.1128/MCB.01495-08. Epub 2009 Mar 16.


Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates.

Zheng L, Zhou M, Guo Z, Lu H, Qian L, Dai H, Qiu J, Yakubovskaya E, Bogenhagen DF, Demple B, Shen B.

Mol Cell. 2008 Nov 7;32(3):325-36. doi: 10.1016/j.molcel.2008.09.024.


Community organizers and (bio)filmmaking.

Demple B.

Nat Chem Biol. 2008 Nov;4(11):653-4. doi: 10.1038/nchembio1108-653. No abstract available.


Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.

Liu P, Qian L, Sung JS, de Souza-Pinto NC, Zheng L, Bogenhagen DF, Bohr VA, Wilson DM 3rd, Shen B, Demple B.

Mol Cell Biol. 2008 Aug;28(16):4975-87. doi: 10.1128/MCB.00457-08. Epub 2008 Jun 9.


DNA binding shifts the redox potential of the transcription factor SoxR.

Gorodetsky AA, Dietrich LE, Lee PE, Demple B, Newman DK, Barton JK.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3684-9. doi: 10.1073/pnas.0800093105. Epub 2008 Mar 3.


Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair.

Gellon L, Carson DR, Carson JP, Demple B.

DNA Repair (Amst). 2008 Feb 1;7(2):187-98. Epub 2007 Nov 5.


Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury.

Narciso L, Fortini P, Pajalunga D, Franchitto A, Liu P, Degan P, Frechet M, Demple B, Crescenzi M, Dogliotti E.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17010-5. Epub 2007 Oct 16.


The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.

Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B, Perrino FW, Lieberman J.

Mol Cell. 2006 Jul 7;23(1):133-42.


Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW.

Cell. 2006 Jan 27;124(2):315-29.


Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coli.

Park W, Peña-Llopis S, Lee Y, Demple B.

Biochem Biophys Res Commun. 2006 Mar 3;341(1):51-6. Epub 2006 Jan 6.


Expression analysis of the fpr (ferredoxin-NADP+ reductase) gene in Pseudomonas putida KT2440.

Lee Y, Peña-Llopis S, Kang YS, Shin HD, Demple B, Madsen EL, Jeon CO, Park W.

Biochem Biophys Res Commun. 2006 Jan 27;339(4):1246-54.


Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA.

Auerbach P, Bennett RA, Bailey EA, Krokan HE, Demple B.

Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17711-6. Epub 2005 Nov 28. Erratum in: Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4328.


Molecular and biological roles of Ape1 protein in mammalian base excision repair.

Demple B, Sung JS.

DNA Repair (Amst). 2005 Dec 8;4(12):1442-9. Epub 2005 Sep 30. Review.


Carbon monoxide mediates protection against nitric oxide toxicity in HeLa cells.

Reiter TA, Demple B.

Free Radic Biol Med. 2005 Oct 15;39(8):1075-88.


Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates.

Koutsolioutsou A, Peña-Llopis S, Demple B.

Antimicrob Agents Chemother. 2005 Jul;49(7):2746-52.


A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia.

Bishop A, Yet SF, Lee ME, Perrella MA, Demple B.

Biochem Biophys Res Commun. 2004 Dec 3;325(1):3-9.


Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression.

Chander M, Demple B.

J Biol Chem. 2004 Oct 1;279(40):41603-10. Epub 2004 Jul 29.


SoxRS-regulated expression and genetic analysis of the yggX gene of Escherichia coli.

Pomposiello PJ, Koutsolioutsou A, Carrasco D, Demple B.

J Bacteriol. 2003 Nov;185(22):6624-32.

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