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Items: 39


Development of a novel fluorescent activity assay for lecithin:cholesterol acyltransferase.

Sakurai T, Sakurai A, Vaisman BL, Nishida T, Neufeld EB, Demosky SJ Jr, Sampson ML, Shamburek RD, Freeman LA, Remaley AT.

Ann Clin Biochem. 2018 Jul;55(4):414-421. doi: 10.1177/0004563217733285. Epub 2017 Nov 2.


Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31.

Freeman LA, Demosky SJ Jr, Konaklieva M, Kuskovsky R, Aponte A, Ossoli AF, Gordon SM, Koby RF, Manthei KA, Shen M, Vaisman BL, Shamburek RD, Jadhav A, Calabresi L, Gucek M, Tesmer JJG, Levine RL, Remaley AT.

J Pharmacol Exp Ther. 2017 Aug;362(2):306-318. doi: 10.1124/jpet.117.240457. Epub 2017 Jun 2.


High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation.

Thacker SG, Zarzour A, Chen Y, Alcicek MS, Freeman LA, Sviridov DO, Demosky SJ Jr, Remaley AT.

Immunology. 2016 Nov;149(3):306-319. doi: 10.1111/imm.12638. Epub 2016 Aug 28.


Lipoprotein X Causes Renal Disease in LCAT Deficiency.

Ossoli A, Neufeld EB, Thacker SG, Vaisman B, Pryor M, Freeman LA, Brantner CA, Baranova I, Francone NO, Demosky SJ Jr, Vitali C, Locatelli M, Abbate M, Zoja C, Franceschini G, Calabresi L, Remaley AT.

PLoS One. 2016 Feb 26;11(2):e0150083. doi: 10.1371/journal.pone.0150083. eCollection 2016.


Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice.

Vaisman BL, Vishnyakova TG, Freeman LA, Amar MJ, Demosky SJ, Liu C, Stonik JA, Sampson ML, Pryor M, Bocharov AV, Eggerman TL, Patterson AP, Remaley AT.

Biomed Res Int. 2015;2015:607120. doi: 10.1155/2015/607120. Epub 2015 Oct 4.


Cellular Localization and Trafficking of the Human ABCG1 Transporter.

Neufeld EB, O'Brien K, Walts AD, Stonik JA, Demosky SJ, Malide D, Combs CA, Remaley AT.

Biology (Basel). 2014 Nov 14;3(4):781-800. doi: 10.3390/biology3040781.


Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis.

Vaisman BL, Demosky SJ, Stonik JA, Ghias M, Knapper CL, Sampson ML, Dai C, Levine SJ, Remaley AT.

J Lipid Res. 2012 Jan;53(1):158-67. doi: 10.1194/jlr.M018713. Epub 2011 Oct 27.


High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent mechanism.

Sekine Y, Demosky SJ, Stonik JA, Furuya Y, Koike H, Suzuki K, Remaley AT.

Mol Cancer Res. 2010 Sep;8(9):1284-94. doi: 10.1158/1541-7786.MCR-10-0008. Epub 2010 Jul 29.


Structure/function relationships of apolipoprotein a-I mimetic peptides: implications for antiatherogenic activities of high-density lipoprotein.

D'Souza W, Stonik JA, Murphy A, Demosky SJ, Sethi AA, Moore XL, Chin-Dusting J, Remaley AT, Sviridov D.

Circ Res. 2010 Jul 23;107(2):217-27. doi: 10.1161/CIRCRESAHA.110.216507. Epub 2010 May 27.


Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides.

Sethi AA, Stonik JA, Thomas F, Demosky SJ, Amar M, Neufeld E, Brewer HB, Davidson WS, D'Souza W, Sviridov D, Remaley AT.

J Biol Chem. 2008 Nov 21;283(47):32273-82. doi: 10.1074/jbc.M804461200. Epub 2008 Sep 19.


Immunoassay interference by a commonly used blood collection tube additive, the organosilicone surfactant silwet L-720.

Bowen RA, Chan Y, Ruddel ME, Hortin GL, Csako G, Demosky SJ Jr, Remaley AT.

Clin Chem. 2005 Oct;51(10):1874-82. Epub 2005 Aug 11.


Serum amyloid A promotes ABCA1-dependent and ABCA1-independent lipid efflux from cells.

Stonik JA, Remaley AT, Demosky SJ, Neufeld EB, Bocharov A, Brewer HB.

Biochem Biophys Res Commun. 2004 Sep 3;321(4):936-41.


The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease.

Neufeld EB, Stonik JA, Demosky SJ Jr, Knapper CL, Combs CA, Cooney A, Comly M, Dwyer N, Blanchette-Mackie J, Remaley AT, Santamarina-Fojo S, Brewer HB Jr.

J Biol Chem. 2004 Apr 9;279(15):15571-8. Epub 2004 Jan 27.


Low-density lipoprotein receptor and apolipoprotein A-I and B expression in human enterocytes.

Sviridov D, Hoeg JM, Eggerman T, Demosky SJ, Safonova IG, Brewer HB.

Digestion. 2003;67(1-2):67-70.


Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway.

Remaley AT, Thomas F, Stonik JA, Demosky SJ, Bark SE, Neufeld EB, Bocharov AV, Vishnyakova TG, Patterson AP, Eggerman TL, Santamarina-Fojo S, Brewer HB.

J Lipid Res. 2003 Apr;44(4):828-36. Epub 2003 Jan 16.


The ABCA1 transporter functions on the basolateral surface of hepatocytes.

Neufeld EB, Demosky SJ Jr, Stonik JA, Combs C, Remaley AT, Duverger N, Santamarina-Fojo S, Brewer HB Jr.

Biochem Biophys Res Commun. 2002 Oct 4;297(4):974-9.


Cellular localization and trafficking of the human ABCA1 transporter.

Neufeld EB, Remaley AT, Demosky SJ, Stonik JA, Cooney AM, Comly M, Dwyer NK, Zhang M, Blanchette-Mackie J, Santamarina-Fojo S, Brewer HB Jr.

J Biol Chem. 2001 Jul 20;276(29):27584-90. Epub 2001 May 10.


Apolipoprotein specificity for lipid efflux by the human ABCAI transporter.

Remaley AT, Stonik JA, Demosky SJ, Neufeld EB, Bocharov AV, Vishnyakova TG, Eggerman TL, Patterson AP, Duverger NJ, Santamarina-Fojo S, Brewer HB Jr.

Biochem Biophys Res Commun. 2001 Jan 26;280(3):818-23.


LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits.

Brousseau ME, Kauffman RD, Herderick EE, Demosky SJ Jr, Evans W, Marcovina S, Santamarina-Fojo S, Brewer HB Jr, Hoeg JM.

Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):450-8.


Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase.

Brousseau ME, Wang J, Demosky SJ Jr, Vaisman BL, Talley GD, Santamarina-Fojo S, Brewer HB Jr, Hoeg JM.

J Lipid Res. 1998 Aug;39(8):1558-67.


Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: receptor expression modulates high-density lipoproteins.

Brown DR, Brousseau ME, Shamburek RD, Talley GD, Meyn S, Demosky SJ Jr, Santamarina-Fojo S, Brewer HB Jr, Hoeg JM.

Metabolism. 1996 Dec;45(12):1447-57.


Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis.

Hoeg JM, Santamarina-Fojo S, Bérard AM, Cornhill JF, Herderick EE, Feldman SH, Haudenschild CC, Vaisman BL, Hoyt RF Jr, Demosky SJ Jr, Kauffman RD, Hazel CM, Marcovina SM, Brewer HB Jr.

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11448-53.


Lecithin:cholesterol acyltransferase overexpression generates hyperalpha-lipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits.

Hoeg JM, Vaisman BL, Demosky SJ Jr, Meyn SM, Talley GD, Hoyt RF Jr, Feldman S, Bérard AM, Sakai N, Wood D, Brousseau ME, Marcovina S, Brewer HB Jr, Santamarina-Fojo S.

J Biol Chem. 1996 Feb 23;271(8):4396-402.


Regulation of LDL receptor, apoB, and apoE protein and mRNA in Hep G2 cells.

Kraft HG, Demosky SJ Jr, Schumacher K, Brewer HB Jr, Hoeg JM.

DNA Cell Biol. 1992 May;11(4):291-300.


Apolipoprotein B upstream suppressor site: identification of an element which can decrease apolipoprotein B transcription.

Ross RS, Li AC, Hoeg JM, Schumacher UK, Demosky SJ Jr, Brewer HB Jr.

Biochem Biophys Res Commun. 1991 May 15;176(3):1116-22.


Both apolipoproteins B-48 and B-100 are synthesized and secreted by the human intestine.

Hoeg JM, Sviridov DD, Tennyson GE, Demosky SJ Jr, Meng MS, Bojanovski D, Safonova IG, Repin VS, Kuberger MB, Smirnov VN, et al.

J Lipid Res. 1990 Oct;31(10):1761-9.


Human apolipoprotein A-I. Post-translational modification by covalent phosphorylation.

Beg ZH, Stonik JA, Hoeg JM, Demosky SJ Jr, Fairwell T, Brewer HB Jr.

J Biol Chem. 1989 Apr 25;264(12):6913-21.


Apolipoprotein B synthesized by Hep G2 cells undergoes fatty acid acylation.

Hoeg JM, Meng MS, Ronan R, Demosky SJ Jr, Fairwell T, Brewer HB Jr.

J Lipid Res. 1988 Sep;29(9):1215-20.


Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects.

Hoeg JM, Edge SB, Demosky SJ Jr, Starzl TE, Triche T, Gregg RE, Brewer HB Jr.

Biochim Biophys Acta. 1986 May 21;876(3):646-57.


The expressed human hepatic receptor for low-density lipoproteins differs from the fibroblast low-density lipoprotein receptor.

Hoeg JM, Demosky SJ Jr, Lackner KJ, Osborne JC Jr, Oliver C, Brewer HB Jr.

Biochim Biophys Acta. 1986 Mar 21;876(1):13-21.


The effect of portacaval shunt on hepatic lipoprotein metabolism in familial hypercholesterolemia.

Hoeg JM, Demosky SJ Jr, Schaefer EJ, Starzl TE, Porter KA, Brewer HB Jr.

J Surg Res. 1985 Nov;39(5):369-77.


Characterization of a human hepatic receptor for high density lipoproteins.

Hoeg JM, Demosky SJ Jr, Edge SB, Gregg RE, Osborne JC Jr, Brewer HB Jr.

Arteriosclerosis. 1985 May-Jun;5(3):228-37.


Distinct hepatic receptors for low density lipoprotein and apolipoprotein E in humans.

Hoeg JM, Demosky SJ Jr, Gregg RE, Schaefer EJ, Brewer HB Jr.

Science. 1985 Feb 15;227(4688):759-61.


Characterization of plasma lipids and lipoproteins in cholesteryl ester storage disease.

Kelly DR, Hoeg JM, Demosky SJ Jr, Brewer HB Jr.

Biochem Med. 1985 Feb;33(1):29-37.


Filipin as a flow microfluorometry probe for cellular cholesterol.

Muller CP, Stephany DA, Winkler DF, Hoeg JM, Demosky SJ Jr, Wunderlich JR.

Cytometry. 1984 Jan;5(1):42-54.


Characterization of neutral and acid ester hydrolase in Wolman's disease.

Hoeg JM, Demosky SJ Jr, Brewer HB Jr.

Biochim Biophys Acta. 1982 Apr 15;711(1):59-65.


Cholesteryl ester storage disease: a most unusual manifestation of deficiency of two lysosomal enzyme activities.

Fredrickson DS, Sloan HR, Ferrans VJ, Demosky SJ Jr.

Trans Assoc Am Physicians. 1972;85:109-19. No abstract available.


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