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Items: 1 to 50 of 73

1.

CAMK2-dependent signaling in neurons is essential for survival.

Kool MJ, Onori MP, Borgesius NZ, van de Bree JE, Elgersma-Hooisma M, Nio E, Bezstarosti K, Buitendijk GHS, Aghadavoud Jolfaei M, Demmers JAA, Elgersma Y, van Woerden GM.

J Neurosci. 2019 May 7. pii: 1341-18. doi: 10.1523/JNEUROSCI.1341-18.2019. [Epub ahead of print]

PMID:
31064859
2.

The expanded clinical spectrum of anti-GABABR encephalitis and added value of KCTD16 autoantibodies.

van Coevorden-Hameete MH, de Bruijn MAAM, de Graaff E, Bastiaansen DAEM, Schreurs MWJ, Demmers JAA, Ramberger M, Hulsenboom ESP, Nagtzaam MMP, Boukhrissi S, Veldink JH, Verschuuren JJGM, Hoogenraad CC, Sillevis Smitt PAE, Titulaer MJ.

Brain. 2019 Jun 1;142(6):1631-1643. doi: 10.1093/brain/awz094.

3.

Heterogeneous clinical phenotypes and cerebral malformations reflected by rotatin cellular dynamics.

Vandervore LV, Schot R, Kasteleijn E, Oegema R, Stouffs K, Gheldof A, Grochowska MM, van der Sterre MLT, van Unen LMA, Wilke M, Elfferich P, van der Spek PJ, Heijsman D, Grandone A, Demmers JAA, Dekkers DHW, Slotman JA, Kremers GJ, Schaaf GJ, Masius RG, van Essen AJ, Rump P, van Haeringen A, Peeters E, Altunoglu U, Kalayci T, Poot RA, Dobyns WB, Bahi-Buisson N, Verheijen FW, Jansen AC, Mancini GMS.

Brain. 2019 Apr 1;142(4):867-884. doi: 10.1093/brain/awz045. Erratum in: Brain. 2019 Jun 1;142(6):e29.

4.

FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER.

Wienholz F, Zhou D, Turkyilmaz Y, Schwertman P, Tresini M, Pines A, van Toorn M, Bezstarosti K, Demmers JAA, Marteijn JA.

Nucleic Acids Res. 2019 May 7;47(8):4011-4025. doi: 10.1093/nar/gkz055.

5.

Identifying cystogenic paracrine signaling molecules in cyst fluid of patients with polycystic kidney disease.

Kenter AT, van Rossum-Fikkert SE, Salih M, Verhagen PCMS, van Leenders GJLH, Demmers JAA, Jansen G, Gribnau J, Zietse R, Hoorn EJ.

Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F204-F213. doi: 10.1152/ajprenal.00470.2018. Epub 2018 Nov 7.

PMID:
30403162
6.

DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones.

Mandemaker IK, Geijer ME, Kik I, Bezstarosti K, Rijkers E, Raams A, Janssens RC, Lans H, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA.

EMBO Rep. 2018 Oct;19(10). pii: e45566. doi: 10.15252/embr.201745566. Epub 2018 Aug 13.

7.

Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.

van der Pluijm I, Burger J, van Heijningen PM, IJpma A, van Vliet N, Milanese C, Schoonderwoerd K, Sluiter W, Ringuette LJ, Dekkers DHW, Que I, Kaijzel EL, Te Riet L, MacFarlane EG, Das D, van der Linden R, Vermeij M, Demmers JA, Mastroberardino PG, Davis EC, Yanagisawa H, Dietz HC, Kanaar R, Essers J.

Cardiovasc Res. 2018 Nov 1;114(13):1776-1793. doi: 10.1093/cvr/cvy150.

8.

Human Osteoblast-Derived Extracellular Matrix with High Homology to Bone Proteome Is Osteopromotive.

Baroncelli M, van der Eerden BCJ, Chatterji S, Rull Trinidad E, Kan YY, Koedam M, van Hengel IAJ, Alves RDAM, Fratila-Apachitei LE, Demmers JAA, van de Peppel J, van Leeuwen JPTM.

Tissue Eng Part A. 2018 Sep;24(17-18):1377-1389. doi: 10.1089/ten.TEA.2017.0448. Epub 2018 May 21.

PMID:
29667532
9.

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.

Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA.

Sci Rep. 2017 Nov 10;7(1):15353. doi: 10.1038/s41598-017-15194-y.

10.

Improvement of ubiquitylation site detection by Orbitrap mass spectrometry.

van der Wal L, Bezstarosti K, Sap KA, Dekkers DHW, Rijkers E, Mientjes E, Elgersma Y, Demmers JAA.

J Proteomics. 2018 Feb 10;172:49-56. doi: 10.1016/j.jprot.2017.10.014. Epub 2017 Nov 6.

11.

DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells.

Mohd-Sarip A, Teeuwssen M, Bot AG, De Herdt MJ, Willems SM, Baatenburg de Jong RJ, Looijenga LHJ, Zatreanu D, Bezstarosti K, van Riet J, Oole E, van Ijcken WFJ, van de Werken HJG, Demmers JA, Fodde R, Verrijzer CP.

Cell Rep. 2017 Jul 5;20(1):61-75. doi: 10.1016/j.celrep.2017.06.020.

12.

Quantitative Proteomics Reveals Extensive Changes in the Ubiquitinome after Perturbation of the Proteasome by Targeted dsRNA-Mediated Subunit Knockdown in Drosophila.

Sap KA, Bezstarosti K, Dekkers DHW, Voets O, Demmers JAA.

J Proteome Res. 2017 Aug 4;16(8):2848-2862. doi: 10.1021/acs.jproteome.7b00156. Epub 2017 Jul 11.

PMID:
28665616
13.

Identification of Chloride Intracellular Channel Protein 3 as a Novel Gene Affecting Human Bone Formation.

Brum AM, van der Leije CS, Schreuders-Koedam M, Verhoeven J, Janssen M, Dekkers DH, Demmers JA, Eijken M, van de Peppel J, van Leeuwen JP, van der Eerden BC.

JBMR Plus. 2017 Apr 28;1(1):16-26. doi: 10.1002/jbm4.10003. eCollection 2017 Aug.

14.

Comparative proteomic profiling of human osteoblast-derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation and mineralization.

Baroncelli M, van der Eerden BC, Kan YY, Alves RD, Demmers JA, van de Peppel J, van Leeuwen JP.

J Cell Physiol. 2018 Jan;233(1):387-395. doi: 10.1002/jcp.25898. Epub 2017 May 19.

PMID:
28272740
15.

Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration.

van den Berg DLC, Azzarelli R, Oishi K, Martynoga B, Urbán N, Dekkers DHW, Demmers JA, Guillemot F.

Neuron. 2017 Jan 18;93(2):348-361. doi: 10.1016/j.neuron.2016.11.047. Epub 2016 Dec 29.

16.

Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis.

Engelen-Lee J, Blokhuis AM, Spliet WGM, Pasterkamp RJ, Aronica E, Demmers JAA, Broekhuizen R, Nardo G, Bovenschen N, Van Den Berg LH.

Amyotroph Lateral Scler Frontotemporal Degener. 2017 May;18(3-4):210-220. doi: 10.1080/21678421.2016.1245757. Epub 2016 Nov 29.

PMID:
27899032
17.

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.

Drost R, Dhillon KK, van der Gulden H, van der Heijden I, Brandsma I, Cruz C, Chondronasiou D, Castroviejo-Bermejo M, Boon U, Schut E, van der Burg E, Wientjens E, Pieterse M, Klijn C, Klarenbeek S, Loayza-Puch F, Elkon R, van Deemter L, Rottenberg S, van de Ven M, Dekkers DH, Demmers JA, van Gent DC, Agami R, Balmaña J, Serra V, Taniguchi T, Bouwman P, Jonkers J.

J Clin Invest. 2016 Aug 1;126(8):2903-18. doi: 10.1172/JCI70196. Epub 2016 Jul 25.

18.

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein.

Urbán N, van den Berg DL, Forget A, Andersen J, Demmers JA, Hunt C, Ayrault O, Guillemot F.

Science. 2016 Jul 15;353(6296):292-5. doi: 10.1126/science.aaf4802.

19.

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways.

Blokhuis AM, Koppers M, Groen EJ, van den Heuvel DM, Dini Modigliani S, Anink JJ, Fumoto K, van Diggelen F, Snelting A, Sodaar P, Verheijen BM, Demmers JA, Veldink JH, Aronica E, Bozzoni I, den Hertog J, van den Berg LH, Pasterkamp RJ.

Acta Neuropathol. 2016 Aug;132(2):175-96. doi: 10.1007/s00401-016-1575-8. Epub 2016 May 10.

20.

Correction: Detection of Alpha-Toxin and Other Virulence Factors in Biofilms of Staphylococcus aureus on Polystyrene and a Human Epidermal Model.

den Reijer PM, Haisma EM, Lemmens-den Toom NA, Willemse J, Koning RI, Demmers JA, Dekkers DH, Rijkers E, El Ghalbzouri A, Nibbering PH, van Wamel W.

PLoS One. 2016 Mar 24;11(3):e0152544. doi: 10.1371/journal.pone.0152544. eCollection 2016. No abstract available.

21.

Combgap contributes to recruitment of Polycomb group proteins in Drosophila.

Ray P, De S, Mitra A, Bezstarosti K, Demmers JA, Pfeifer K, Kassis JA.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3826-31. doi: 10.1073/pnas.1520926113. Epub 2016 Mar 21.

22.

Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease.

Salih M, Demmers JA, Bezstarosti K, Leonhard WN, Losekoot M, van Kooten C, Gansevoort RT, Peters DJ, Zietse R, Hoorn EJ; DIPAK Consortium.

J Am Soc Nephrol. 2016 Oct;27(10):3079-3092. Epub 2016 Mar 3.

23.

Elevated Plasma Cardiac Troponin T Levels Caused by Skeletal Muscle Damage in Pompe Disease.

Wens SC, Schaaf GJ, Michels M, Kruijshaar ME, van Gestel TJ, In 't Groen S, Pijnenburg J, Dekkers DH, Demmers JA, Verdijk LB, Brusse E, van Schaik RH, van der Ploeg AT, van Doorn PA, Pijnappel WW.

Circ Cardiovasc Genet. 2016 Feb;9(1):6-13. doi: 10.1161/CIRCGENETICS.115.001322. Epub 2016 Jan 19.

PMID:
26787432
24.

Detection of Alpha-Toxin and Other Virulence Factors in Biofilms of Staphylococcus aureus on Polystyrene and a Human Epidermal Model.

den Reijer PM, Haisma EM, Lemmens-den Toom NA, Willemse J, Koning RI, Demmers JA, Dekkers DH, Rijkers E, El Ghalbzouri A, Nibbering PH, van Wamel W.

PLoS One. 2016 Jan 7;11(1):e0145722. doi: 10.1371/journal.pone.0145722. eCollection 2016. Erratum in: PLoS One. 2016;11(3):e0152544. Koning, R A [corrected to Koning, R I].

25.

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.

van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ.

Dev Cell. 2015 Dec 7;35(5):537-552. doi: 10.1016/j.devcel.2015.11.008.

26.

Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism.

Lu X, Meima ME, Nelson JK, Sorrentino V, Loregger A, Scheij S, Dekkers DH, Mulder MT, Demmers JA, M-Dallinga-Thie G, Zelcer N, Danser AH.

Circ Res. 2016 Jan 22;118(2):222-9. doi: 10.1161/CIRCRESAHA.115.306799. Epub 2015 Nov 18.

PMID:
26582775
27.

A Testis-Specific Chaperone and the Chromatin Remodeler ISWI Mediate Repackaging of the Paternal Genome.

Doyen CM, Chalkley GE, Voets O, Bezstarosti K, Demmers JA, Moshkin YM, Verrijzer CP.

Cell Rep. 2015 Nov 17;13(7):1310-1318. doi: 10.1016/j.celrep.2015.10.010. Epub 2015 Nov 5.

28.

The core spliceosome as target and effector of non-canonical ATM signalling.

Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA.

Nature. 2015 Jul 2;523(7558):53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24.

29.

Identification of protein receptors for coronaviruses by mass spectrometry.

Raj VS, Lamers MM, Smits SL, Demmers JA, Mou H, Bosch BJ, Haagmans BL.

Methods Mol Biol. 2015;1282:165-82. doi: 10.1007/978-1-4939-2438-7_15.

PMID:
25720480
30.

Integrative analysis of genomics and proteomics data on clinical breast cancer tissue specimens extracted with acid guanidinium thiocyanate-phenol-chloroform.

Braakman RB, Bezstarosti K, Sieuwerts AM, de Weerd V, van Galen AM, Stingl C, Luider TM, Timmermans MA, Smid M, Martens JW, Foekens JA, Demmers JA, Umar A.

J Proteome Res. 2015 Mar 6;14(3):1627-36. doi: 10.1021/acs.jproteome.5b00046. Epub 2015 Feb 2.

PMID:
25611981
31.

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.

Meinders M, Kulu DI, van de Werken HJ, Hoogenboezem M, Janssen H, Brouwer RW, van Ijcken WF, Rijkers EJ, Demmers JA, Krüger I, van den Berg TK, Suske G, Gutiérrez L, Philipsen S.

Blood. 2015 Mar 19;125(12):1957-67. doi: 10.1182/blood-2014-08-593343. Epub 2014 Dec 23.

32.

Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster.

Sap KA, Bezstarosti K, Dekkers DH, van den Hout M, van Ijcken W, Rijkers E, Demmers JA.

Proteomics. 2015 Feb;15(4):725-38. doi: 10.1002/pmic.201400308. Epub 2015 Jan 14.

PMID:
25403936
33.

Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth.

Morhayim J, van de Peppel J, Demmers JA, Kocer G, Nigg AL, van Driel M, Chiba H, van Leeuwen JP.

FASEB J. 2015 Jan;29(1):274-85. doi: 10.1096/fj.14-261404. Epub 2014 Oct 30.

PMID:
25359493
34.

NLS-tagging: an alternative strategy to tag nuclear proteins.

Giraud G, Stadhouders R, Conidi A, Dekkers DH, Huylebroeck D, Demmers JA, Soler E, Grosveld FG.

Nucleic Acids Res. 2014 Dec 1;42(21). doi: 10.1093/nar/gku869. Epub 2014 Sep 26.

35.

Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization.

Reddy BA, van der Knaap JA, Bot AG, Mohd-Sarip A, Dekkers DH, Timmermans MA, Martens JW, Demmers JA, Verrijzer CP.

Mol Cell. 2014 Feb 6;53(3):458-70. doi: 10.1016/j.molcel.2013.12.017. Epub 2014 Jan 23.

36.

Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.

Moshkin YM, Doyen CM, Kan TW, Chalkley GE, Sap K, Bezstarosti K, Demmers JA, Ozgur Z, van Ijcken WF, Verrijzer CP.

PLoS Genet. 2013;9(9):e1003719. doi: 10.1371/journal.pgen.1003719. Epub 2013 Sep 26.

37.

Erythropoietic defect associated with reduced cell proliferation in mice lacking the 26S proteasome shuttling factor Rad23b.

Bergink S, Theil AF, Toussaint W, De Cuyper IM, Kulu DI, Clapes T, van der Linden R, Demmers JA, Mul EP, van Alphen FP, Marteijn JA, van Gent T, Maas A, Robin C, Philipsen S, Vermeulen W, Mitchell JR, Gutiérrez L.

Mol Cell Biol. 2013 Oct;33(19):3879-92. doi: 10.1128/MCB.05772-11. Epub 2013 Jul 29.

38.

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells.

Ramakrishnaiah V, Thumann C, Fofana I, Habersetzer F, Pan Q, de Ruiter PE, Willemsen R, Demmers JA, Stalin Raj V, Jenster G, Kwekkeboom J, Tilanus HW, Haagmans BL, Baumert TF, van der Laan LJ.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13109-13. doi: 10.1073/pnas.1221899110. Epub 2013 Jul 22.

39.

Subunits of the histone chaperone CAF1 also mediate assembly of protamine-based chromatin.

Doyen CM, Moshkin YM, Chalkley GE, Bezstarosti K, Demmers JA, Rathke C, Renkawitz-Pohl R, Verrijzer CP.

Cell Rep. 2013 Jul 11;4(1):59-65. doi: 10.1016/j.celrep.2013.06.002. Epub 2013 Jun 27.

40.

Activin A suppresses osteoblast mineralization capacity by altering extracellular matrix (ECM) composition and impairing matrix vesicle (MV) production.

Alves RD, Eijken M, Bezstarosti K, Demmers JA, van Leeuwen JP.

Mol Cell Proteomics. 2013 Oct;12(10):2890-900. doi: 10.1074/mcp.M112.024927. Epub 2013 Jun 17.

41.

An immunoaffinity purification method for the proteomic analysis of ubiquitinated protein complexes.

Schwertman P, Bezstarosti K, Laffeber C, Vermeulen W, Demmers JA, Marteijn JA.

Anal Biochem. 2013 Sep 15;440(2):227-36. doi: 10.1016/j.ab.2013.05.020. Epub 2013 Jun 3.

42.

ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN.

Groen EJ, Fumoto K, Blokhuis AM, Engelen-Lee J, Zhou Y, van den Heuvel DM, Koppers M, van Diggelen F, van Heest J, Demmers JA, Kirby J, Shaw PJ, Aronica E, Spliet WG, Veldink JH, van den Berg LH, Pasterkamp RJ.

Hum Mol Genet. 2013 Sep 15;22(18):3690-704. doi: 10.1093/hmg/ddt222. Epub 2013 May 15.

PMID:
23681068
43.

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

Raj VS, Mou H, Smits SL, Dekkers DH, Müller MA, Dijkman R, Muth D, Demmers JA, Zaki A, Fouchier RA, Thiel V, Drosten C, Rottier PJ, Osterhaus AD, Bosch BJ, Haagmans BL.

Nature. 2013 Mar 14;495(7440):251-4. doi: 10.1038/nature12005.

PMID:
23486063
44.

GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication.

Kuster DW, Sequeira V, Najafi A, Boontje NM, Wijnker PJ, Witjas-Paalberends ER, Marston SB, Dos Remedios CG, Carrier L, Demmers JA, Redwood C, Sadayappan S, van der Velden J.

Circ Res. 2013 Feb 15;112(4):633-9. doi: 10.1161/CIRCRESAHA.112.275602. Epub 2012 Dec 31.

45.

Binding of carboxypeptidase N to fibrinogen and fibrin.

Talens S, Lebbink JH, Malfliet JJ, Demmers JA, Uitte de Willige S, Leebeek FW, Rijken DC.

Biochem Biophys Res Commun. 2012 Oct 19;427(2):421-5. doi: 10.1016/j.bbrc.2012.09.081. Epub 2012 Sep 21.

PMID:
23000409
46.

Identification of fibrin clot-bound plasma proteins.

Talens S, Leebeek FW, Demmers JA, Rijken DC.

PLoS One. 2012;7(8):e41966. doi: 10.1371/journal.pone.0041966. Epub 2012 Aug 3.

47.

Proteomic analysis of the microenvironment of developing oocytes.

Twigt J, Steegers-Theunissen RP, Bezstarosti K, Demmers JA.

Proteomics. 2012 May;12(9):1463-71. doi: 10.1002/pmic.201100240.

PMID:
22589193
48.

Transcription-independent function of Polycomb group protein PSC in cell cycle control.

Mohd-Sarip A, Lagarou A, Doyen CM, van der Knaap JA, Aslan Ü, Bezstarosti K, Yassin Y, Brock HW, Demmers JA, Verrijzer CP.

Science. 2012 May 11;336(6082):744-7. doi: 10.1126/science.1215927. Epub 2012 Apr 5.

49.

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.

Schwertman P, Lagarou A, Dekkers DH, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA, Fousteri M, Vermeulen W, Marteijn JA.

Nat Genet. 2012 May;44(5):598-602. doi: 10.1038/ng.2230.

PMID:
22466611
50.

Remodelers organize cellular chromatin by counteracting intrinsic histone-DNA sequence preferences in a class-specific manner.

Moshkin YM, Chalkley GE, Kan TW, Reddy BA, Ozgur Z, van Ijcken WF, Dekkers DH, Demmers JA, Travers AA, Verrijzer CP.

Mol Cell Biol. 2012 Feb;32(3):675-88. doi: 10.1128/MCB.06365-11. Epub 2011 Nov 28.

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