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Items: 1 to 50 of 59

1.

The evolutionary history of 2,658 cancers.

Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD; PCAWG Evolution & Heterogeneity Working Group, Spellman PT, Wedge DC, Van Loo P; PCAWG Consortium.

Nature. 2020 Feb;578(7793):122-128. doi: 10.1038/s41586-019-1907-7. Epub 2020 Feb 6.

PMID:
32025013
2.

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.

Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, Santamarina M, Ju YS, Temes J, Garcia-Souto D, Detering H, Li Y, Rodriguez-Castro J, Dueso-Barroso A, Bruzos AL, Dentro SC, Blanco MG, Contino G, Ardeljan D, Tojo M, Roberts ND, Zumalave S, Edwards PAW, Weischenfeldt J, Puiggròs M, Chong Z, Chen K, Lee EA, Wala JA, Raine K, Butler A, Waszak SM, Navarro FCP, Schumacher SE, Monlong J, Maura F, Bolli N, Bourque G, Gerstein M, Park PJ, Wedge DC, Beroukhim R, Torrents D, Korbel JO, Martincorena I, Fitzgerald RC, Van Loo P, Kazazian HH, Burns KH; PCAWG Structural Variation Working Group, Campbell PJ, Tubio JMC; PCAWG Consortium.

Nat Genet. 2020 Feb 5. doi: 10.1038/s41588-019-0562-0. [Epub ahead of print]

PMID:
32024998
3.

Neoantigen-directed immune escape in lung cancer evolution.

Rosenthal R, Cadieux EL, Salgado R, Bakir MA, Moore DA, Hiley CT, Lund T, Tanić M, Reading JL, Joshi K, Henry JY, Ghorani E, Wilson GA, Birkbak NJ, Jamal-Hanjani M, Veeriah S, Szallasi Z, Loi S, Hellmann MD, Feber A, Chain B, Herrero J, Quezada SA, Demeulemeester J, Van Loo P, Beck S, McGranahan N, Swanton C; TRACERx consortium.

Nature. 2019 Mar;567(7749):479-485. doi: 10.1038/s41586-019-1032-7. Epub 2019 Mar 20.

4.

Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.

Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P.

Nat Commun. 2019 Jan 28;10(1):525. doi: 10.1038/s41467-019-08512-7.

5.

Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.

Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P.

Nat Commun. 2018 Dec 17;9(1):5397. doi: 10.1038/s41467-018-07842-2.

6.

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.

Sharma S, Čermáková K, De Rijck J, Demeulemeester J, Fábry M, El Ashkar S, Van Belle S, Lepšík M, Tesina P, Duchoslav V, Novák P, Hubálek M, Srb P, Christ F, Řezáčová P, Hodges HC, Debyser Z, Veverka V.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7053-E7062. doi: 10.1073/pnas.1803909115. Epub 2018 Jul 11.

7.

Recurrent rearrangements of FOS and FOSB define osteoblastoma.

Fittall MW, Mifsud W, Pillay N, Ye H, Strobl AC, Verfaillie A, Demeulemeester J, Zhang L, Berisha F, Tarabichi M, Young MD, Miranda E, Tarpey PS, Tirabosco R, Amary F, Grigoriadis AE, Stratton MR, Van Loo P, Antonescu CR, Campbell PJ, Flanagan AM, Behjati S.

Nat Commun. 2018 Jun 1;9(1):2150. doi: 10.1038/s41467-018-04530-z.

8.

Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import.

Demeulemeester J, Blokken J, De Houwer S, Dirix L, Klaassen H, Marchand A, Chaltin P, Christ F, Debyser Z.

Retrovirology. 2018 Jan 12;15(1):5. doi: 10.1186/s12977-018-0389-2.

9.

Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.

Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P.

Nat Commun. 2017 Oct 31;8(1):1221. doi: 10.1038/s41467-017-01355-0. Erratum in: Nat Commun. 2018 Dec 17;9(1):5397. Nat Commun. 2019 Jan 28;10(1):525.

10.

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.

El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juge S, Boeckx N, Engelman A, Van Vlierberghe P, Debyser Z, De Rijck J.

Blood. 2018 Jan 4;131(1):95-107. doi: 10.1182/blood-2017-05-786962. Epub 2017 Oct 30.

11.

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy.

El Ashkar S, Van Looveren D, Schenk F, Vranckx LS, Demeulemeester J, De Rijck J, Debyser Z, Modlich U, Gijsbers R.

Mol Ther Nucleic Acids. 2017 Jun 16;7:231-245. doi: 10.1016/j.omtn.2017.04.002. Epub 2017 Apr 12.

12.

Atom probe tomography analysis of SiGe fins embedded in SiO2: Facts and artefacts.

Melkonyan D, Fleischmann C, Arnoldi L, Demeulemeester J, Kumar A, Bogdanowicz J, Vurpillot F, Vandervorst W.

Ultramicroscopy. 2017 Aug;179:100-107. doi: 10.1016/j.ultramic.2017.04.006. Epub 2017 Apr 15.

PMID:
28460266
13.

Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing.

Demeulemeester J, Kumar P, Møller EK, Nord S, Wedge DC, Peterson A, Mathiesen RR, Fjelldal R, Zamani Esteki M, Theunis K, Fernandez Gallardo E, Grundstad AJ, Borgen E, Baumbusch LO, Børresen-Dale AL, White KP, Kristensen VN, Van Loo P, Voet T, Naume B.

Genome Biol. 2016 Dec 9;17(1):250.

14.

Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras.

Vranckx LS, Demeulemeester J, Debyser Z, Gijsbers R.

PLoS One. 2016 Oct 27;11(10):e0164167. doi: 10.1371/journal.pone.0164167. eCollection 2016.

15.

LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV.

Vranckx LS, Demeulemeester J, Saleh S, Boll A, Vansant G, Schrijvers R, Weydert C, Battivelli E, Verdin E, Cereseto A, Christ F, Gijsbers R, Debyser Z.

EBioMedicine. 2016 Jun;8:248-264. doi: 10.1016/j.ebiom.2016.04.039. Epub 2016 May 13.

16.

Mapping interfacial excess in atom probe data.

Felfer P, Scherrer B, Demeulemeester J, Vandervorst W, Cairney JM.

Ultramicroscopy. 2015 Dec;159 Pt 2:438-44. doi: 10.1016/j.ultramic.2015.06.002. Epub 2015 Aug 22.

PMID:
26346774
17.

Auscultate, palpate and tap: time to re-evaluate.

Hawkes GA, Hawkes CP, Kenosi M, Demeulemeester J, Livingstone V, Ryan CA, Dempsey EM.

Acta Paediatr. 2016 Feb;105(2):178-82. doi: 10.1111/apa.13169. Epub 2015 Oct 23.

PMID:
26317177
18.

Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection.

Demeulemeester J, De Rijck J, Gijsbers R, Debyser Z.

Bioessays. 2015 Nov;37(11):1202-14. doi: 10.1002/bies.201500051. Epub 2015 Aug 21. Review.

19.

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.

Tesina P, Čermáková K, Hořejší M, Procházková K, Fábry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, Rijck J, Veverka V, Řezáčová P.

Nat Commun. 2015 Aug 6;6:7968. doi: 10.1038/ncomms8968.

PMID:
26245978
20.

Increased detection of Aedes albopictus in Belgium: no overwintering yet, but an intervention strategy is still lacking.

Deblauwe I, Demeulemeester J, De Witte J, Hendy A, Sohier C, Madder M.

Parasitol Res. 2015 Sep;114(9):3469-77. doi: 10.1007/s00436-015-4575-z. Epub 2015 Jun 26.

PMID:
26113506
21.

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.

Desimmie BA, Weydert C, Schrijvers R, Vets S, Demeulemeester J, Proost P, Paron I, De Rijck J, Mast J, Bannert N, Gijsbers R, Christ F, Debyser Z.

Retrovirology. 2015 Feb 12;12:16. doi: 10.1186/s12977-014-0134-4.

22.

HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort.

Demeulemeester J, Vets S, Schrijvers R, Madlala P, De Maeyer M, De Rijck J, Ndung'u T, Debyser Z, Gijsbers R.

Cell Host Microbe. 2014 Nov 12;16(5):651-62. doi: 10.1016/j.chom.2014.09.016. Epub 2014 Nov 12.

23.

Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia.

Cermáková K, Tesina P, Demeulemeester J, El Ashkar S, Méreau H, Schwaller J, Rezáčová P, Veverka V, De Rijck J.

Cancer Res. 2014 Sep 15;74(18):5139-51. doi: 10.1158/0008-5472.CAN-13-3602. Epub 2014 Jul 31.

24.

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.

El Ashkar S, De Rijck J, Demeulemeester J, Vets S, Madlala P, Cermakova K, Debyser Z, Gijsbers R.

Mol Ther Nucleic Acids. 2014 Jul 29;3:e179. doi: 10.1038/mtna.2014.33.

25.

The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.

De Houwer S, Demeulemeester J, Thys W, Rocha S, Dirix L, Gijsbers R, Christ F, Debyser Z.

J Biol Chem. 2014 Sep 5;289(36):25351-61. doi: 10.1074/jbc.M113.533281. Epub 2014 Jul 25.

26.

Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.

Tsirkone VG, Beutels KG, Demeulemeester J, Debyser Z, Christ F, Strelkov SV.

Acta Crystallogr F Struct Biol Commun. 2014 Jun;70(Pt 6):723-9. doi: 10.1107/S2053230X14009492. Epub 2014 May 24.

27.

4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.

Billamboz M, Suchaud V, Bailly F, Lion C, Demeulemeester J, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P.

ACS Med Chem Lett. 2013 May 17;4(7):606-11. doi: 10.1021/ml400009t. eCollection 2013 Jul 11.

28.

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).

Demeulemeester J, Chaltin P, Marchand A, De Maeyer M, Debyser Z, Christ F.

Expert Opin Ther Pat. 2014 Jun;24(6):609-32. doi: 10.1517/13543776.2014.898753. Epub 2014 Mar 25. Review.

PMID:
24666332
29.

HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.

Borrenberghs D, Thys W, Rocha S, Demeulemeester J, Weydert C, Dedecker P, Hofkens J, Debyser Z, Hendrix J.

ACS Nano. 2014 Apr 22;8(4):3531-45. doi: 10.1021/nn406615v. Epub 2014 Apr 2.

30.

Structure, mechanics, and binding mode heterogeneity of LEDGF/p75-DNA nucleoprotein complexes revealed by scanning force microscopy.

Vanderlinden W, Lipfert J, Demeulemeester J, Debyser Z, De Feyter S.

Nanoscale. 2014 May 7;6(9):4611-9. doi: 10.1039/c4nr00022f.

PMID:
24632996
31.

Schmallenberg virus circulation in culicoides in Belgium in 2012: field validation of a real time RT-PCR approach to assess virus replication and dissemination in midges.

De Regge N, Madder M, Deblauwe I, Losson B, Fassotte C, Demeulemeester J, Smeets F, Tomme M, Cay AB.

PLoS One. 2014 Jan 23;9(1):e87005. doi: 10.1371/journal.pone.0087005. eCollection 2014.

32.

Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection.

Desimmie BA, Demeulemeester J, Christ F, Debyser Z.

Drug Discov Today Technol. 2013 Dec;10(4):e517-22. doi: 10.1016/j.ddtec.2012.10.002. Review.

PMID:
24451643
33.

The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.

De Rijck J, de Kogel C, Demeulemeester J, Vets S, El Ashkar S, Malani N, Bushman FD, Landuyt B, Husson SJ, Busschots K, Gijsbers R, Debyser Z.

Cell Rep. 2013 Nov 27;5(4):886-94. doi: 10.1016/j.celrep.2013.09.040. Epub 2013 Oct 31.

34.

Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase.

Taltynov O, Demeulemeester J, Christ F, De Houwer S, Tsirkone VG, Gerard M, Weeks SD, Strelkov SV, Debyser Z.

J Biol Chem. 2013 Aug 30;288(35):25603-13. doi: 10.1074/jbc.M113.484345. Epub 2013 Jul 22.

35.

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions.

Desimmie BA, Schrijvers R, Demeulemeester J, Borrenberghs D, Weydert C, Thys W, Vets S, Van Remoortel B, Hofkens J, De Rijck J, Hendrix J, Bannert N, Gijsbers R, Christ F, Debyser Z.

Retrovirology. 2013 May 30;10:57. doi: 10.1186/1742-4690-10-57.

36.

2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance.

Desimmie BA, Demeulemeester J, Suchaud V, Taltynov O, Billamboz M, Lion C, Bailly F, Strelkov SV, Debyser Z, Cotelle P, Christ F.

ACS Chem Biol. 2013;8(6):1187-94. doi: 10.1021/cb4000426. Epub 2013 Apr 2.

PMID:
23517458
37.

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).

Méreau H, De Rijck J, Cermáková K, Kutz A, Juge S, Demeulemeester J, Gijsbers R, Christ F, Debyser Z, Schwaller J.

Leukemia. 2013 Jun;27(6):1245-53. doi: 10.1038/leu.2013.10. Epub 2013 Jan 15.

PMID:
23318960
38.

Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors.

Schrijvers R, Demeulemeester J, De Rijck J, Christ F, Gérard M, Debyser Z, Gijsbers R.

AIDS. 2013 Feb 20;27(4):539-43. doi: 10.1097/QAD.0b013e32835d0d86.

PMID:
23211777
39.

A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication.

Serrao E, Thys W, Demeulemeester J, Al-Mawsawi LQ, Christ F, Debyser Z, Neamati N.

PLoS One. 2012;7(9):e45177. doi: 10.1371/journal.pone.0045177. Epub 2012 Sep 18.

40.

Cellular cofactors of lentiviral integrase: from target validation to drug discovery.

Taltynov O, Desimmie BA, Demeulemeester J, Christ F, Debyser Z.

Mol Biol Int. 2012;2012:863405. doi: 10.1155/2012/863405. Epub 2012 Aug 7.

41.

Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein.

De Houwer S, Demeulemeester J, Thys W, Taltynov O, Zmajkovicova K, Christ F, Debyser Z.

J Biol Chem. 2012 Oct 5;287(41):34059-68. doi: 10.1074/jbc.M112.387944. Epub 2012 Aug 7.

42.

Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.

Christ F, Shaw S, Demeulemeester J, Desimmie BA, Marchand A, Butler S, Smets W, Chaltin P, Westby M, Debyser Z, Pickford C.

Antimicrob Agents Chemother. 2012 Aug;56(8):4365-74. doi: 10.1128/AAC.00717-12. Epub 2012 Jun 4.

43.

Discovery of small molecule HIV-1 integrase dimerization inhibitors.

Tintori C, Demeulemeester J, Franchi L, Massa S, Debyser Z, Christ F, Botta M.

Bioorg Med Chem Lett. 2012 May 1;22(9):3109-14. doi: 10.1016/j.bmcl.2012.03.064. Epub 2012 Mar 21.

PMID:
22483582
44.

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs.

Schrijvers R, De Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gijsbers R.

PLoS Pathog. 2012;8(3):e1002558. doi: 10.1371/journal.ppat.1002558. Epub 2012 Mar 1.

45.

Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors.

Demeulemeester J, Tintori C, Botta M, Debyser Z, Christ F.

J Biomol Screen. 2012 Jun;17(5):618-28. doi: 10.1177/1087057111436343. Epub 2012 Feb 14.

PMID:
22337657
46.

Identification of a small molecule that modulates platelet glycoprotein Ib-von Willebrand factor interaction.

Broos K, Trekels M, Jose RA, Demeulemeester J, Vandenbulcke A, Vandeputte N, Venken T, Egle B, De Borggraeve WM, Deckmyn H, De Maeyer M.

J Biol Chem. 2012 Mar 16;287(12):9461-72. doi: 10.1074/jbc.M111.311431. Epub 2012 Jan 9.

47.

Paramagnetism and antiferromagnetic interactions in Cr-doped GaN.

Pereira LM, Som T, Demeulemeester J, Van Bael MJ, Temst K, Vantomme A.

J Phys Condens Matter. 2011 Aug 31;23(34):346004. doi: 10.1088/0953-8984/23/34/346004.

PMID:
21841222
48.

Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration.

Gerard M, Deleersnijder A, Demeulemeester J, Debyser Z, Baekelandt V.

Mol Neurobiol. 2011 Aug;44(1):13-27. doi: 10.1007/s12035-011-8184-2. Epub 2011 May 7. Review.

PMID:
21553017
49.

Interplay between HIV entry and transportin-SR2 dependency.

Thys W, De Houwer S, Demeulemeester J, Taltynov O, Vancraenenbroeck R, Gérard M, De Rijck J, Gijsbers R, Christ F, Debyser Z.

Retrovirology. 2011 Jan 30;8:7. doi: 10.1186/1742-4690-8-7.

50.

Artificial neural networks applied to the analysis of synchrotron nuclear resonant scattering data.

Planckaert N, Demeulemeester J, Laenens B, Smeets D, Meersschaut J, L'abbé C, Temst K, Vantomme A.

J Synchrotron Radiat. 2010 Jan;17(1):86-92. doi: 10.1107/S0909049509042824. Epub 2009 Dec 8.

PMID:
20029116

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