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Items: 1 to 50 of 67

1.

Dual muscle-liver transduction imposes immune tolerance for muscle transgene engraftment despite preexisting immunity.

Bartolo L, Li Chung Tong S, Chappert P, Urbain D, Collaud F, Colella P, Richard I, Ronzitti G, Demengeot J, Gross DA, Mingozzi F, Davoust J.

JCI Insight. 2019 Jun 6;4(11). pii: 127008. doi: 10.1172/jci.insight.127008. eCollection 2019 Jun 6.

2.

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.

Schwartz C, Moran T, Saunders SP, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O'Neill L, Irvine AD, McKenzie ANJ, Ogg G, Walsh PT, Demengeot J, Fallon PG.

Allergy. 2019 Apr 2. doi: 10.1111/all.13801. [Epub ahead of print]

PMID:
30937919
3.

Antibodies aggravate the development of ischemic heart failure.

Keppner L, Heinrichs M, Rieckmann M, Demengeot J, Frantz S, Hofmann U, Ramos G.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1358-H1367. doi: 10.1152/ajpheart.00144.2018. Epub 2018 Aug 10.

PMID:
30095974
4.

iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity.

Bonnet M, Sarmento LM, Martins AC, Sobral D, Silva J, Demengeot J.

Front Immunol. 2017 Nov 10;8:1525. doi: 10.3389/fimmu.2017.01525. eCollection 2017.

5.

Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance.

Agua-Doce A, Caridade M, Oliveira VG, Bergman L, Lafaille MC, Lafaille JJ, Demengeot J, Graca L.

J Immunol. 2018 Jan 1;200(1):101-109. doi: 10.4049/jimmunol.1601886. Epub 2017 Nov 22.

6.

The Immunogenicity of Biologic Therapies.

Garcês S, Demengeot J.

Curr Probl Dermatol. 2018;53:37-48. doi: 10.1159/000478077. Epub 2017 Nov 7.

PMID:
29131036
7.

Tolerogenic insulin peptide therapy precipitates type 1 diabetes.

Bergman ML, Lopes-Carvalho T, Martins AC, Grieco FA, Eizirik DL, Demengeot J.

J Exp Med. 2017 Jul 3;214(7):2153-2156. doi: 10.1084/jem.20160471. Epub 2017 May 23.

8.

Myocardial aging as a T-cell-mediated phenomenon.

Ramos GC, van den Berg A, Nunes-Silva V, Weirather J, Peters L, Burkard M, Friedrich M, Pinnecker J, Abeßer M, Heinze KG, Schuh K, Beyersdorf N, Kerkau T, Demengeot J, Frantz S, Hofmann U.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2420-E2429. doi: 10.1073/pnas.1621047114. Epub 2017 Mar 2.

9.

RAG Recombinase as a Selective Pressure for Genome Evolution.

Passagem-Santos D, Bonnet M, Sobral D, Trancoso I, Silva JG, Barreto VM, Athanasiadis A, Demengeot J, Pereira-Leal JB.

Genome Biol Evol. 2016 Dec 14;8(11):3364-3376.

10.

Regulatory T cells control strain specific resistance to Experimental Autoimmune Prostatitis.

Breser ML, Lino AC, Motrich RD, Godoy GJ, Demengeot J, Rivero VE.

Sci Rep. 2016 Sep 14;6:33097. doi: 10.1038/srep33097.

11.

IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition.

Oruc Z, Oblet C, Boumediene A, Druilhe A, Pascal V, Le Rumeur E, Cuvillier A, El Hamel C, Lecardeur S, Leanderson T, Morelle W, Demengeot J, Aldigier JC, Cogné M.

J Am Soc Nephrol. 2016 Sep;27(9):2748-61. doi: 10.1681/ASN.2015080911. Epub 2016 Jan 29.

12.

Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria.

Barroso-Batista J, Demengeot J, Gordo I.

Nat Commun. 2015 Nov 30;6:8945. doi: 10.1038/ncomms9945.

13.

Host and microbiota interactions are critical for development of murine Crohn's-like ileitis.

Roulis M, Bongers G, Armaka M, Salviano T, He Z, Singh A, Seidler U, Becker C, Demengeot J, Furtado GC, Lira SA, Kollias G.

Mucosal Immunol. 2016 May;9(3):787-97. doi: 10.1038/mi.2015.102. Epub 2015 Oct 21.

14.

Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanized model.

Gibson VB, Nikolic T, Pearce VQ, Demengeot J, Roep BO, Peakman M.

Clin Exp Immunol. 2015 Dec;182(3):251-60. doi: 10.1111/cei.12687. Epub 2015 Sep 17.

15.

Escherichia coli adaptation to the gut environment: a constant fight for survival.

Gordo I, Demengeot J, Xavier K.

Future Microbiol. 2014;9(11):1235-8. doi: 10.2217/fmb.14.86. No abstract available.

16.

1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.

Ferreira GB, Gysemans CA, Demengeot J, da Cunha JP, Vanherwegen AS, Overbergh L, Van Belle TL, Pauwels F, Verstuyf A, Korf H, Mathieu C.

J Immunol. 2014 May 1;192(9):4210-20. doi: 10.4049/jimmunol.1302350. Epub 2014 Mar 24.

17.

The first steps of adaptation of Escherichia coli to the gut are dominated by soft sweeps.

Barroso-Batista J, Sousa A, Lourenço M, Bergman ML, Sobral D, Demengeot J, Xavier KB, Gordo I.

PLoS Genet. 2014 Mar 6;10(3):e1004182. doi: 10.1371/journal.pgen.1004182. eCollection 2014 Mar.

18.

Naturally secreted immunoglobulins limit B1 and MZ B-cell numbers through a microbiota-independent mechanism.

Lino AC, Mohr E, Demengeot J.

Blood. 2013 Jul 11;122(2):209-18. doi: 10.1182/blood-2012-08-447136. Epub 2013 May 30.

19.

A Novel Quantitative Fluorescent Reporter Assay for RAG Targets and RAG Activity.

Trancoso I, Bonnet M, Gardner R, Carneiro J, Barreto VM, Demengeot J, Sarmento LM.

Front Immunol. 2013 May 16;4:110. doi: 10.3389/fimmu.2013.00110. eCollection 2013.

20.

A preliminary algorithm introducing immunogenicity assessment in the management of patients with RA receiving tumour necrosis factor inhibitor therapies.

Garcês S, Antunes M, Benito-Garcia E, da Silva JC, Aarden L, Demengeot J.

Ann Rheum Dis. 2014 Jun;73(6):1138-43. doi: 10.1136/annrheumdis-2013-203296. Epub 2013 May 11.

PMID:
23666932
21.

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery.

Paiva RS, Lino AC, Bergman ML, Caramalho I, Sousa AE, Zelenay S, Demengeot J.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6494-9. doi: 10.1073/pnas.1221955110. Epub 2013 Apr 1.

22.

Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.

Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B.

Nat Immunol. 2013 Apr;14(4):372-9. doi: 10.1038/ni.2552. Epub 2013 Mar 10.

23.

The immunogenicity of anti-TNF therapy in immune-mediated inflammatory diseases: a systematic review of the literature with a meta-analysis.

Garcês S, Demengeot J, Benito-Garcia E.

Ann Rheum Dis. 2013 Dec;72(12):1947-55. doi: 10.1136/annrheumdis-2012-202220. Epub 2012 Dec 6. Review.

PMID:
23223420
24.

CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines.

Serre K, Cunningham AF, Coughlan RE, Lino AC, Rot A, Hub E, Moser K, Manz R, Ferraro A, Bird R, Toellner KM, Demengeot J, MacLennan IC, Mohr E.

Blood. 2012 Nov 29;120(23):4552-9. doi: 10.1182/blood-2012-03-417733. Epub 2012 Oct 11.

25.

Broadened T-cell repertoire diversity in ivIg-treated SLE patients is also related to the individual status of regulatory T-cells.

Costa N, Pires AE, Gabriel AM, Goulart LF, Pereira C, Leal B, Queiros AC, Chaara W, Moraes-Fontes MF, Vasconcelos C, Ferreira C, Martins J, Bastos M, Santos MJ, Pereira MA, Martins B, Lima M, João C, Six A, Demengeot J, Fesel C.

J Clin Immunol. 2013 Feb;33(2):349-60. doi: 10.1007/s10875-012-9816-7. Epub 2012 Oct 14.

PMID:
23064977
26.

Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling.

Fesel C, Barreto M, Ferreira RC, Costa N, Venda LL, Pereira C, Carvalho C, Morães-Fontes MF, Ferreira CM, Vasconcelos C, Viana JF, Santos E, Martins B, Demengeot J, Vicente AM.

PLoS One. 2012;7(3):e33992. doi: 10.1371/journal.pone.0033992. Epub 2012 Mar 29.

27.

Regulatory T cells accumulate in the lung allergic inflammation and efficiently suppress T-cell proliferation but not Th2 cytokine production.

Faustino L, Mucida D, Keller AC, Demengeot J, Bortoluci K, Sardinha LR, Carla Takenaka M, Basso AS, Faria AM, Russo M.

Clin Dev Immunol. 2012;2012:721817. doi: 10.1155/2012/721817. Epub 2011 Nov 15.

28.

Regulatory T cells contribute to diabetes protection in lipopolysaccharide-treated non-obese diabetic mice.

Caramalho I, Rodrigues-Duarte L, Perez A, Zelenay S, Penha-Gonçalves C, Demengeot J.

Scand J Immunol. 2011 Dec;74(6):585-95. doi: 10.1111/j.1365-3083.2011.02627.x.

29.

IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias.

Silva A, Laranjeira AB, Martins LR, Cardoso BA, Demengeot J, Yunes JA, Seddon B, Barata JT.

Cancer Res. 2011 Jul 15;71(14):4780-9. doi: 10.1158/0008-5472.CAN-10-3606. Epub 2011 May 18.

30.

Sub-optimal CD4+ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3+ regulatory T cells.

Oliveira VG, Caridade M, Paiva RS, Demengeot J, Graca L.

Eur J Immunol. 2011 May;41(5):1249-55. doi: 10.1002/eji.201040896.

31.

Cutting edge: Intrathymic differentiation of adaptive Foxp3+ regulatory T cells upon peripheral proinflammatory immunization.

Zelenay S, Bergman ML, Paiva RS, Lino AC, Martins AC, Duarte JH, Moraes-Fontes MF, Bilate AM, Lafaille JJ, Demengeot J.

J Immunol. 2010 Oct 1;185(7):3829-33. doi: 10.4049/jimmunol.1001281. Epub 2010 Sep 3.

32.

Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease.

Moraes-Fontes MF, Rebelo M, Caramalho I, Zelenay S, Bergman ML, Coutinho A, Demengeot J.

J Autoimmun. 2009 Sep;33(2):109-20. doi: 10.1016/j.jaut.2009.03.008. Epub 2009 Apr 11.

PMID:
19362805
33.

Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions.

Duarte JH, Zelenay S, Bergman ML, Martins AC, Demengeot J.

Eur J Immunol. 2009 Apr;39(4):948-55. doi: 10.1002/eji.200839196.

34.

Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants.

Barreto M, Ferreira RC, Lourenço L, Moraes-Fontes MF, Santos E, Alves M, Carvalho C, Martins B, Andreia R, Viana JF, Vasconcelos C, Mota-Vieira L, Ferreira C, Demengeot J, Vicente AM.

BMC Immunol. 2009 Jan 27;10:5. doi: 10.1186/1471-2172-10-5.

35.

Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse.

Côrte-Real J, Rodo J, Almeida P, Garcia J, Coutinho A, Demengeot J, Penha-Gonçalves C.

Genes Immun. 2009 Jan;10(1):93-9. doi: 10.1038/gene.2008.73. Epub 2008 Sep 25.

PMID:
18818690
36.

Physiopathology of natural auto-antibodies: the case for regulation.

Zelenay S, Moraes Fontes MF, Fesel C, Demengeot J, Coutinho A.

J Autoimmun. 2007 Dec;29(4):229-35. Review.

PMID:
17967665
37.

Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells.

Santos MA, Sarmento LM, Rebelo M, Doce AA, Maillard I, Dumortier A, Neves H, Radtke F, Pear WS, Parreira L, Demengeot J.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15454-9. Epub 2007 Sep 18.

38.

When three is not a crowd: a Crossregulation model of the dynamics and repertoire selection of regulatory CD4+ T cells.

Carneiro J, Leon K, Caramalho I, van den Dool C, Gardner R, Oliveira V, Bergman ML, Sepúlveda N, Paixão T, Faro J, Demengeot J.

Immunol Rev. 2007 Apr;216:48-68. Review.

PMID:
17367334
39.

Heme oxygenase-1 is not required for mouse regulatory T cell development and function.

Zelenay S, Chora A, Soares MP, Demengeot J.

Int Immunol. 2007 Jan;19(1):11-8. Epub 2006 Nov 2.

PMID:
17082514
40.

MHC class II molecules control murine B cell responsiveness to lipopolysaccharide stimulation.

Rodo J, Gonçalves LA, Demengeot J, Coutinho A, Penha-Gonçalves C.

J Immunol. 2006 Oct 1;177(7):4620-6.

41.
42.

Regulatory T cells in microbial infection.

Demengeot J, Zelenay S, Moraes-Fontes MF, Caramalho I, Coutinho A.

Springer Semin Immunopathol. 2006 Aug;28(1):41-50. Epub 2006 Jul 28. Review.

PMID:
16874537
43.

Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection.

Coutinho A, Caramalho I, Seixas E, Demengeot J.

Curr Top Microbiol Immunol. 2005;293:43-71. Review.

PMID:
15981475
44.

Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion.

Zelenay S, Lopes-Carvalho T, Caramalho I, Moraes-Fontes MF, Rebelo M, Demengeot J.

Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4091-6. Epub 2005 Mar 7.

45.

Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2.

Vilanova M, Teixeira L, Caramalho I, Torrado E, Marques A, Madureira P, Ribeiro A, Ferreira P, Gama M, Demengeot J.

Immunology. 2004 Mar;111(3):334-42.

46.

Keeping hopes high.

Demengeot J, Hori S.

EMBO Rep. 2003 Nov;4(11):1033-7. Epub 2003 Oct 24. Review. No abstract available.

47.

Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice.

Braun D, Geraldes P, Demengeot J.

J Autoimmun. 2003 Feb;20(1):15-25.

PMID:
12604309
48.

Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide.

Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J.

J Exp Med. 2003 Feb 17;197(4):403-11.

49.

Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice.

Hori S, Haury M, Lafaille JJ, Demengeot J, Coutinho A.

Eur J Immunol. 2002 Dec;32(12):3729-35.

50.

A new statistical method for quantitative analyses: application to the precise quantification of T cell receptor repertoires.

Hori S, Collette A, Demengeot J, Stewart J.

J Immunol Methods. 2002 Oct 15;268(2):159-70.

PMID:
12215384

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