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Items: 6

1.

Late-occurring and Long-circulating Metabolites of GABAAα2,3 Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance.

Gu C, Artelsmair M, Elmore CS, Lewis RJ, Davis P, Hall JE, Dembofsky BT, Christoph G, Smith MA, Chapdelaine M, Sunzel M.

Drug Metab Dispos. 2018 Mar;46(3):303-315. doi: 10.1124/dmd.117.078873. Epub 2018 Jan 8.

PMID:
29311137
2.

Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.

Brown DG, Bernstein PR, Wu Y, Urbanek RA, Becker CW, Throner SR, Dembofsky BT, Steelman GB, Lazor LA, Scott CW, Wood MW, Wesolowski SS, Nugiel DA, Koch S, Yu J, Pivonka DE, Li S, Thompson C, Zacco A, Elmore CS, Schroeder P, Liu J, Hurley CA, Ward S, Hunt HJ, Williams K, McLaughlin J, Hoesch V, Sydserff S, Maier D, Aharony D.

ACS Med Chem Lett. 2012 Nov 12;4(1):46-51. doi: 10.1021/ml300262e. eCollection 2013 Jan 10.

3.

Development and SAR of functionally selective allosteric modulators of GABAA receptors.

Alhambra C, Becker C, Blake T, Chang AH, Damewood JR Jr, Daniels T, Dembofsky BT, Gurley DA, Hall JE, Herzog KJ, Horchler CL, Ohnmacht CJ, Schmiesing RJ, Dudley A, Ribadeneira MD, Knappenberger KS, Maciag C, Stein MM, Chopra M, Liu XF, Christian EP, Arriza JL, Chapdelaine MJ.

Bioorg Med Chem. 2011 May 1;19(9):2927-38. doi: 10.1016/j.bmc.2011.03.035. Epub 2011 Mar 29.

PMID:
21498079
4.

Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists.

Ohnmacht CJ, Albert JS, Bernstein PR, Rumsey WL, Masek BB, Dembofsky BT, Koether GM, Andisik DW, Aharony D.

Bioorg Med Chem. 2004 May 15;12(10):2653-69.

PMID:
15110847
5.

Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity.

Albert JS, Aharony D, Andisik D, Barthlow H, Bernstein PR, Bialecki RA, Dedinas R, Dembofsky BT, Hill D, Kirkland K, Koether GM, Kosmider BJ, Ohnmacht C, Palmer W, Potts W, Rumsey W, Shen L, Shenvi A, Sherwood S, Warwick PJ, Russell K.

J Med Chem. 2002 Aug 29;45(18):3972-83.

PMID:
12190319
6.

Discovery of novel, orally active dual NK1/NK2 antagonists.

Bernstein PR, Aharony D, Albert JS, Andisik D, Barthlow HG, Bialecki R, Davenport T, Dedinas RF, Dembofsky BT, Koether G, Kosmider BJ, Kirkland K, Ohnmacht CJ, Potts W, Rumsey WL, Shen L, Shenvi A, Sherwood S, Stollman D, Russell K.

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2769-73.

PMID:
11591520

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