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Ethical Issues in Pragmatic Cluster-Randomized Trials in Dialysis Facilities.

Goldstein CE, Weijer C, Taljaard M, Al-Jaishi AA, Basile E, Brehaut J, Cook CL, Grimshaw JM, Lacson E Jr, Lindsay C, Jardine M, Dember LM, Garg AX.

Am J Kidney Dis. 2019 Jun 18. pii: S0272-6386(19)30739-5. doi: 10.1053/j.ajkd.2019.04.019. [Epub ahead of print]


Addressing guideline and policy changes during pragmatic clinical trials.

Curtis LH, Dember LM, Vazquez MA, Murray D, DeBar L, Staman KL, Septimus E, Mor V, Volandes A, Wells BL, Huang SS, Green BB, Coronado G, Meyers CM, Tuzzio L, Hernandez AF, Sugarman J.

Clin Trials. 2019 May 14:1740774519845682. doi: 10.1177/1740774519845682. [Epub ahead of print]


A Pragmatic Step Forward: AKI and Beyond.

Dember LM.

J Am Soc Nephrol. 2019 Mar;30(3):371-372. doi: 10.1681/ASN.2019010076. Epub 2019 Feb 21. No abstract available.


The TiME Trial: A Fully Embedded, Cluster-Randomized, Pragmatic Trial of Hemodialysis Session Duration.

Dember LM, Lacson E Jr, Brunelli SM, Hsu JY, Cheung AK, Daugirdas JT, Greene T, Kovesdy CP, Miskulin DC, Thadhani RI, Winkelmayer WC, Ellenberg SS, Cifelli D, Madigan R, Young A, Angeletti M, Wingard RL, Kahn C, Nissenson AR, Maddux FW, Abbott KC, Landis JR.

J Am Soc Nephrol. 2019 May;30(5):890-903. doi: 10.1681/ASN.2018090945. Epub 2019 Apr 18.


Mineral Metabolism Disturbances and Arteriovenous Fistula Maturation.

Kubiak RW, Zelnick LR, Hoofnagle AN, Alpers CE, Terry CM, Shiu YT, Cheung AK, de Boer IH, Robinson-Cohen C, Allon M, Dember LM, Feldman HI, Himmelfarb J, Huber TS, Roy-Chaudhury P, Vazquez MA, Kusek JW, Beck GJ, Imrey PB, Kestenbaum B; Hemodialysis Fistula Maturation Study Group.

Eur J Vasc Endovasc Surg. 2019 May;57(5):719-728. doi: 10.1016/j.ejvs.2019.01.022. Epub 2019 Apr 15.


Dialysis initiation, modality choice, access, and prescription: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Chan CT, Blankestijn PJ, Dember LM, Gallieni M, Harris DCH, Lok CE, Mehrotra R, Stevens PE, Wang AY, Cheung M, Wheeler DC, Winkelmayer WC, Pollock CA; Conference Participants.

Kidney Int. 2019 Jul;96(1):37-47. doi: 10.1016/j.kint.2019.01.017. Epub 2019 Apr 13.


Comparative Efficacy of Therapies for Treatment of Depression for Patients Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial.

Mehrotra R, Cukor D, Unruh M, Rue T, Heagerty P, Cohen SD, Dember LM, Diaz-Linhart Y, Dubovsky A, Greene T, Grote N, Kutner N, Trivedi MH, Quinn DK, Ver Halen N, Weisbord SD, Young BA, Kimmel PL, Hedayati SS.

Ann Intern Med. 2019 Feb 26. doi: 10.7326/M18-2229. [Epub ahead of print]


The home hemodialysis patient experience: A qualitative assessment of modality use and discontinuation.

Seshasai RK, Wong T, Glickman JD, Shea JA, Dember LM.

Hemodial Int. 2019 Apr;23(2):139-150. doi: 10.1111/hdi.12713. Epub 2019 Feb 11.


Cultivating a Research-Ready Dialysis Community.

Flythe JE, Narendra JH, Hilliard T, Frazier K, Ikeler K, Amolegbe A, Mitchell D, Dorough A, Lee SD, Ordish A, Wilkie C, Dember LM; Building Research Capacity in the Dialysis Community at the Local Level Stakeholder Workshop Participants.

J Am Soc Nephrol. 2019 Feb 8. pii: ASN.2018101059. doi: 10.1681/ASN.2018101059. [Epub ahead of print] No abstract available.


The authors reply.

Hogan JJ, Weiss BM, Dember LM.

Kidney Int. 2019 Feb;95(2):468. doi: 10.1016/j.kint.2018.11.005. No abstract available.


Safety and cardiovascular efficacy of spironolactone in dialysis-dependent ESRD (SPin-D): a randomized, placebo-controlled, multiple dosage trial.

Charytan DM, Himmelfarb J, Ikizler TA, Raj DS, Hsu JY, Landis JR, Anderson AH, Hung AM, Mehrotra R, Sharma S, Weiner DE, Williams M, DiCarli M, Skali H, Kimmel PL, Kliger AS, Dember LM; Hemodialysis Novel Therapies Consortium.

Kidney Int. 2019 Apr;95(4):973-982. doi: 10.1016/j.kint.2018.08.034. Epub 2018 Nov 23.


Prediction of Arteriovenous Fistula Clinical Maturation from Postoperative Ultrasound Measurements: Findings from the Hemodialysis Fistula Maturation Study.

Robbin ML, Greene T, Allon M, Dember LM, Imrey PB, Cheung AK, Himmelfarb J, Huber TS, Kaufman JS, Radeva MK, Roy-Chaudhury P, Shiu YT, Vazquez MA, Umphrey HR, Alexander L, Abts C, Beck GJ, Kusek JW, Feldman HI; Hemodialysis Fistula Maturation Study Group.

J Am Soc Nephrol. 2018 Nov;29(11):2735-2744. doi: 10.1681/ASN.2017111225. Epub 2018 Oct 11.


Effect of Anti-Hypertensive Medication History on Arteriovenous Fistula Maturation Outcomes.

Wang K, Zelnick LR, Imrey PB, deBoer IH, Himmelfarb J, Allon MD, Cheung AK, Dember LM, Roy-Chaudhury P, Vazquez MA, Kusek JW, Feldman HI, Beck GJ, Kestenbaum B; the Hemodialysis Fistula Maturation Study Group.

Am J Nephrol. 2018;48(1):56-64. doi: 10.1159/000491828. Epub 2018 Aug 2.


Local Adipose-Associated Mediators and Adaptations Following Arteriovenous Fistula Creation.

Sharma G, Kuppler C, He Y, Tao M, Ding K, Longchamp A, Dember LM, Ozaki CK, Berceli SA.

Kidney Int Rep. 2018 Mar 2;3(4):970-978. doi: 10.1016/j.ekir.2018.02.008. eCollection 2018 Jul.


Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop.

Zuk A, Palevsky PM, Fried L, Harrell FE Jr, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman JS, Thompson BT, Agarwal A, Greene T, Okusa MD, Bonventre JV, Dember LM, Liu KD, Humphreys BD, Gossett D, Xie Y, Norton JM, Kimmel PL, Star RA.

Clin J Am Soc Nephrol. 2018 Jul 6;13(7):1113-1123. doi: 10.2215/CJN.06820617. Epub 2018 Mar 9.


Clinical Trial End Points for Hemodialysis Vascular Access: Background, Rationale, and Definitions.

Shenoy S, Allon M, Beathard G, Brouwer-Maier D, Dember LM, Glickman M, Lee C, Litchfield T, Lok C, Huber T, Roy-Chaudhury P, Work J, West M, Wasse H.

Clin J Am Soc Nephrol. 2018 Mar 7;13(3):490-494. doi: 10.2215/CJN.13321216. Epub 2018 Feb 27. No abstract available.


Relationships Between Clinical Processes and Arteriovenous Fistula Cannulation and Maturation: A Multicenter Prospective Cohort Study.

Allon M, Imrey PB, Cheung AK, Radeva M, Alpers CE, Beck GJ, Dember LM, Farber A, Greene T, Himmelfarb J, Huber TS, Kaufman JS, Kusek JW, Roy-Chaudhury P, Robbin ML, Vazquez MA, Feldman HI; Hemodialysis Fistula Maturation (HFM) Study Group.

Am J Kidney Dis. 2018 May;71(5):677-689. doi: 10.1053/j.ajkd.2017.10.027. Epub 2018 Feb 2.


Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans.

Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC.

J Am Soc Nephrol. 2018 Mar;29(3):1063-1072. doi: 10.1681/ASN.2017080929. Epub 2018 Jan 17.


Perspectives on Research Participation and Facilitation Among Dialysis Patients, Clinic Personnel, and Medical Providers: A Focus Group Study.

Flythe JE, Narendra JH, Dorough A, Oberlander J, Ordish A, Wilkie C, Dember LM.

Am J Kidney Dis. 2018 Jul;72(1):93-103. doi: 10.1053/j.ajkd.2017.10.011. Epub 2017 Dec 27.


Willingness to participate in pragmatic dialysis trials: the importance of physician decisional autonomy and consent approach.

Courtright KR, Halpern SD, Joffe S, Ellenberg SS, Karlawish J, Madden V, Gabler NB, Szymanski S, Yadav KN, Dember LM.

Trials. 2017 Oct 11;18(1):474. doi: 10.1186/s13063-017-2217-8.


Data Sharing and Embedded Research.

Simon GE, Coronado G, DeBar LL, Dember LM, Green BB, Huang SS, Jarvik JG, Mor V, Ramsberg J, Septimus EJ, Staman KL, Vazquez MA, Vollmer WM, Zatzick D, Hernandez AF, Platt R.

Ann Intern Med. 2017 Nov 7;167(9):668-670. doi: 10.7326/M17-0863. Epub 2017 Oct 3. No abstract available.


Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory.

Weinfurt KP, Hernandez AF, Coronado GD, DeBar LL, Dember LM, Green BB, Heagerty PJ, Huang SS, James KT, Jarvik JG, Larson EB, Mor V, Platt R, Rosenthal GE, Septimus EJ, Simon GE, Staman KL, Sugarman J, Vazquez M, Zatzick D, Curtis LH.

BMC Med Res Methodol. 2017 Sep 18;17(1):144. doi: 10.1186/s12874-017-0420-7.


Patient and Kidney Allograft Survival in Recipients With End-Stage Renal Disease From Amyloidosis.

Sawinski D, Lim MA, Cohen JB, Locke JE, Weiss B, Hogan JJ, Dember LM.

Transplantation. 2018 Feb;102(2):300-309. doi: 10.1097/TP.0000000000001930.


High-Dose Melphalan and Stem Cell Transplantation in Patients on Dialysis Due to Immunoglobulin Light-Chain Amyloidosis and Monoclonal Immunoglobulin Deposition Disease.

Batalini F, Econimo L, Quillen K, Sloan JM, Sarosiek S, Brauneis D, Havasi A, Stern L, Dember LM, Sanchorawala V.

Biol Blood Marrow Transplant. 2018 Jan;24(1):127-132. doi: 10.1016/j.bbmt.2017.08.031. Epub 2017 Sep 1.


Smooth Muscle Nitric Oxide Responsiveness and Clinical Maturation of Hemodialysis Arteriovenous Fistulae.

Tong X, Hou X, Wason C, Kopel T, Cohen RA, Dember LM.

Am J Pathol. 2017 Sep;187(9):2095-2101. doi: 10.1016/j.ajpath.2017.05.006. Epub 2017 Aug 17.


Endothelium-Dependent and -Independent Vascular Function in Advanced Chronic Kidney Disease.

Kopel T, Kaufman JS, Hamburg N, Sampalis JS, Vita JA, Dember LM.

Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1588-1594. doi: 10.2215/CJN.12811216. Epub 2017 Aug 7.


Histopathology of Veins Obtained at Hemodialysis Arteriovenous Fistula Creation Surgery.

Alpers CE, Imrey PB, Hudkins KL, Wietecha TA, Radeva M, Allon M, Cheung AK, Dember LM, Roy-Chaudhury P, Shiu YT, Terry CM, Farber A, Beck GJ, Feldman HI, Kusek JW, Himmelfarb J; Hemodialysis Fistula Maturation Study Group.

J Am Soc Nephrol. 2017 Oct;28(10):3076-3088. doi: 10.1681/ASN.2016050598. Epub 2017 Jul 19.


Intimal Hyperplasia, Stenosis, and Arteriovenous Fistula Maturation Failure in the Hemodialysis Fistula Maturation Study.

Cheung AK, Imrey PB, Alpers CE, Robbin ML, Radeva M, Larive B, Shiu YT, Allon M, Dember LM, Greene T, Himmelfarb J, Roy-Chaudhury P, Terry CM, Vazquez MA, Kusek JW, Feldman HI; Hemodialysis Fistula Maturation Study Group.

J Am Soc Nephrol. 2017 Oct;28(10):3005-3013. doi: 10.1681/ASN.2016121355. Epub 2017 Jul 14.


The Use of a Multidimensional Measure of Dialysis Adequacy-Moving beyond Small Solute Kinetics.

Perl J, Dember LM, Bargman JM, Browne T, Charytan DM, Flythe JE, Hickson LJ, Hung AM, Jadoul M, Lee TC, Meyer KB, Moradi H, Shafi T, Teitelbaum I, Wong LP, Chan CT; American Society of Nephrology Dialysis Advisory Group.

Clin J Am Soc Nephrol. 2017 May 8;12(5):839-847. doi: 10.2215/CJN.08460816. Epub 2017 Mar 17. Review.


Patient and Physician Views about Protocolized Dialysis Treatment in Randomized Trials and Clinical Care.

Kraybill A, Dember LM, Joffe S, Karlawish J, Ellenberg SS, Madden V, Halpern SD.

AJOB Empir Bioeth. 2016;7(2):106-115. Epub 2015 Oct 23.


Trials without tribulations: Minimizing the burden of pragmatic research on healthcare systems.

Larson EB, Tachibana C, Thompson E, Coronado GD, DeBar L, Dember LM, Honda S, Huang SS, Jarvik JG, Nelson C, Septimus E, Simon G, Johnson KE.

Healthc (Amst). 2016 Sep;4(3):138-41. doi: 10.1016/j.hjdsi.2015.07.005. Epub 2015 Jul 29.


A Randomized Trial of Expanding Choice Sets to Motivate Advance Directive Completion.

Courtright KR, Madden V, Gabler NB, Cooney E, Kim J, Herbst N, Burgoon L, Whealdon J, Dember LM, Halpern SD.

Med Decis Making. 2017 Jul;37(5):544-554. doi: 10.1177/0272989X16663709. Epub 2016 Aug 10.


Vascular Function at Baseline in the Hemodialysis Fistula Maturation Study.

Dember LM, Imrey PB, Duess MA, Hamburg NM, Larive B, Radeva M, Himmelfarb J, Kraiss LW, Kusek JW, Roy-Chaudhury P, Terry CM, Vazquez MA, Vongpatanasin W, Beck GJ, Vita JA; Hemodialysis Fistula Maturation Study GroupFeldmanH.FarberA.KaufmanJ.SternL.LeSageP.KivorkC.SoaresD.MalikovaM.AllonM.YoungC.TaylorM.WoodardL.MangadiK.MundaR.LeeT.AllowayR.El‐KhatibM.CanaanT.PflumA.ThiekenL.Campos‐NaciffB.HuberT.BerceliS.JansenM.McCaslinG.TrahanY.DavidsonI.HwangC.LightfootT.LivingstonC.ValenciaA.DolmatchB.FenvesA.HawkinsN.CheungA.KinikiniD.TreimanG.IhnatD.SarfatiM.LavasaniI.MaloneyM.SchlotfeldtL.BuchananC.ClarkC.CrawfordC.HamlettJ.KundzinsJ.ManahanL.WiseJ.GassmanJ.GreeneT.LiL.

J Am Heart Assoc. 2016 Jul 22;5(7). pii: e003227. doi: 10.1161/JAHA.116.003227.


Pragmatic Trials in Maintenance Dialysis: Perspectives from the Kidney Health Initiative.

Dember LM, Archdeacon P, Krishnan M, Lacson E Jr, Ling SM, Roy-Chaudhury P, Smith KA, Flessner MF.

J Am Soc Nephrol. 2016 Oct;27(10):2955-2963. Epub 2016 Jul 11. Review.


Patient and Other Stakeholder Engagement in Patient-Centered Outcomes Research Institute Funded Studies of Patients with Kidney Diseases.

Cukor D, Cohen LM, Cope EL, Ghahramani N, Hedayati SS, Hynes DM, Shah VO, Tentori F, Unruh M, Bobelu J, Cohen S, Dember LM, Faber T, Fischer MJ, Gallardo R, Germain MJ, Ghahate D, Grote N, Hartwell L, Heagerty P, Kimmel PL, Kutner N, Lawson S, Marr L, Nelson RG, Porter AC, Sandy P, Struminger BB, Subramanian L, Weisbord S, Young B, Mehrotra R.

Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1703-12. doi: 10.2215/CJN.09780915. Epub 2016 May 19. Review.


Association between Preoperative Vascular Function and Postoperative Arteriovenous Fistula Development.

Allon M, Greene T, Dember LM, Vita JA, Cheung AK, Hamburg NM, Imrey PB, Kaufman JS, Robbin ML, Shiu YT, Terry CM, Umphrey HR, Feldman HI; Hemodialysis Fistula Maturation Study Group.

J Am Soc Nephrol. 2016 Dec;27(12):3788-3795. Epub 2016 May 9.


Honoring Patient Preferences in Initiation of Dialysis: Problems, Proposals, and a Path Forward.

Potluri VS, Dember LM, Reese PP.

JAMA Intern Med. 2016 Feb;176(2):236-7. doi: 10.1001/jamainternmed.2015.7796. No abstract available.


Use of PRECIS ratings in the National Institutes of Health (NIH) Health Care Systems Research Collaboratory.

Johnson KE, Neta G, Dember LM, Coronado GD, Suls J, Chambers DA, Rundell S, Smith DH, Liu B, Taplin S, Stoney CM, Farrell MM, Glasgow RE.

Trials. 2016 Jan 16;17:32. doi: 10.1186/s13063-016-1158-y.


Factors Associated With Discontinuation of Home Hemodialysis.

Seshasai RK, Mitra N, Chaknos CM, Li J, Wirtalla C, Negoianu D, Glickman JD, Dember LM.

Am J Kidney Dis. 2016 Apr;67(4):629-37. doi: 10.1053/j.ajkd.2015.11.003. Epub 2015 Dec 18.


Rationale and design of A Trial of Sertraline vs. Cognitive Behavioral Therapy for End-stage Renal Disease Patients with Depression (ASCEND).

Hedayati SS, Daniel DM, Cohen S, Comstock B, Cukor D, Diaz-Linhart Y, Dember LM, Dubovsky A, Greene T, Grote N, Heagerty P, Katon W, Kimmel PL, Kutner N, Linke L, Quinn D, Rue T, Trivedi MH, Unruh M, Weisbord S, Young BA, Mehrotra R.

Contemp Clin Trials. 2016 Mar;47:1-11. doi: 10.1016/j.cct.2015.11.020. Epub 2015 Nov 24.


The effect of location and configuration on forearm and upper arm hemodialysis arteriovenous grafts.

Farber A, Tan TW, Hu B, Dember LM, Beck GJ, Dixon BS, Kusek JW, Feldman HI; Dialysis Access Consortium (DAC) Study Group; Dialysis Access Consortium DAC Study Group.

J Vasc Surg. 2015 Nov;62(5):1258-64. doi: 10.1016/j.jvs.2015.06.132. Epub 2015 Aug 6.


Healthy lifestyle and risk of kidney disease progression, atherosclerotic events, and death in CKD: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.

Ricardo AC, Anderson CA, Yang W, Zhang X, Fischer MJ, Dember LM, Fink JC, Frydrych A, Jensvold NG, Lustigova E, Nessel LC, Porter AC, Rahman M, Wright Nunes JA, Daviglus ML, Lash JP; CRIC Study Investigators.

Am J Kidney Dis. 2015 Mar;65(3):412-24. doi: 10.1053/j.ajkd.2014.09.016. Epub 2014 Nov 20.


A guide to research partnerships for pragmatic clinical trials.

Johnson KE, Tachibana C, Coronado GD, Dember LM, Glasgow RE, Huang SS, Martin PJ, Richards J, Rosenthal G, Septimus E, Simon GE, Solberg L, Suls J, Thompson E, Larson EB.

BMJ. 2014 Dec 1;349:g6826. doi: 10.1136/bmj.g6826. No abstract available.


The kidney research national dialogue: gearing up to move forward.

Bonventre JV, Boulware LE, Dember LM, Freedman BI, Furth SL, Holzman LB, Ketchum CJ, Little MH, Mehrotra R, Moe SM, Sands JM, Sedor JR, Somlo S, Star RA, Rys-Sikora KE; Kidney Research National Dialogue (KRND).

Clin J Am Soc Nephrol. 2014 Oct 7;9(10):1806-11. doi: 10.2215/CJN.07310714. Epub 2014 Sep 15. Review.


Human type I pancreatic elastase treatment of arteriovenous fistulas in patients with chronic kidney disease.

Hye RJ, Peden EK, O'Connor TP, Browne BJ, Dixon BS, Schanzer AS, Jensik SC, Dember LM, Jaff MR, Burke SK.

J Vasc Surg. 2014 Aug;60(2):454-461.e1. doi: 10.1016/j.jvs.2014.02.037. Epub 2014 Mar 27.


Notch ties a knot on fistula maturation.

Dember LM, Susztak K.

J Am Soc Nephrol. 2014 Apr;25(4):648-50. doi: 10.1681/ASN.2014010005. Epub 2014 Jan 30. No abstract available.


Novel therapies for hemodialysis vascular access dysfunction: myth or reality?

Terry CM, Dember LM.

Clin J Am Soc Nephrol. 2013 Dec;8(12):2202-12. doi: 10.2215/CJN.07360713. Epub 2013 Nov 14. Review.


Objectives and design of the hemodialysis fistula maturation study.

Dember LM, Imrey PB, Beck GJ, Cheung AK, Himmelfarb J, Huber TS, Kusek JW, Roy-Chaudhury P, Vazquez MA, Alpers CE, Robbin ML, Vita JA, Greene T, Gassman JJ, Feldman HI; Hemodialysis Fistula Maturation Study Group.

Am J Kidney Dis. 2014 Jan;63(1):104-12. doi: 10.1053/j.ajkd.2013.06.024. Epub 2013 Aug 28.


Can frequent hemodialysis be too frequent?

Berns JS, Dember LM.

J Am Soc Nephrol. 2013 Feb;24(3):334-6. doi: 10.1681/ASN.2013010007. Epub 2013 Feb 14. No abstract available.


Relationship of plasma galectin-3 to renal function in patients with heart failure: effects of clinical status, pathophysiology of heart failure, and presence or absence of heart failure.

Gopal DM, Kommineni M, Ayalon N, Koelbl C, Ayalon R, Biolo A, Dember LM, Downing J, Siwik DA, Liang CS, Colucci WS.

J Am Heart Assoc. 2012 Oct;1(5):e000760. doi: 10.1161/JAHA.112.000760. Epub 2012 Oct 25. Erratum in: J Am Heart Assoc. 2013 Jun;2(3):e000194.

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