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Items: 28

1.

Reliable genotypic tropism tests for the major HIV-1 subtypes.

Cashin K, Gray LR, Harvey KL, Perez-Bercoff D, Lee GQ, Sterjovski J, Roche M, Demarest JF, Drummond F, Harrigan PR, Churchill MJ, Gorry PR.

Sci Rep. 2015 Feb 25;5:8543. doi: 10.1038/srep08543.

2.

Genotypic analysis of the V3 region of HIV from virologic nonresponders to maraviroc-containing regimens reveals distinct patterns of failure.

Swenson LC, Chui CK, Brumme CJ, Chan D, Woods CK, Mo T, Dong W, Chapman D, Lewis M, Demarest JF, James I, Portsmouth S, Goodrich J, Heera J, Valdez H, Harrigan PR.

Antimicrob Agents Chemother. 2013 Dec;57(12):6122-30. doi: 10.1128/AAC.01534-13. Epub 2013 Sep 30.

3.

HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cells.

Pfaff JM, Wilen CB, Harrison JE, Demarest JF, Lee B, Doms RW, Tilton JC.

J Virol. 2010 Jul;84(13):6505-14. doi: 10.1128/JVI.00374-10. Epub 2010 Apr 21.

4.

HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry.

Tilton JC, Amrine-Madsen H, Miamidian JL, Kitrinos KM, Pfaff J, Demarest JF, Ray N, Jeffrey JL, Labranche CC, Doms RW.

AIDS Res Hum Retroviruses. 2010 Jan;26(1):13-24. doi: 10.1089/aid.2009.0132.

5.

Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope.

Kitrinos KM, Amrine-Madsen H, Irlbeck DM, Word JM, Demarest JF; CCR100136 Study Team.

Antimicrob Agents Chemother. 2009 Mar;53(3):1124-31. doi: 10.1128/AAC.01057-08. Epub 2008 Dec 15.

6.

Virologic failure in first-line human immunodeficiency virus therapy with a CCR5 entry inhibitor, aplaviroc, plus a fixed-dose combination of lamivudine-zidovudine: nucleoside reverse transcriptase inhibitor resistance regardless of envelope tropism.

Demarest JF, Amrine-Madsen H, Irlbeck DM, Kitrinos KM; CCR102881 Clinical Study Team.

Antimicrob Agents Chemother. 2009 Mar;53(3):1116-23. doi: 10.1128/AAC.01055-08. Epub 2008 Dec 15.

7.

In vitro and clinical investigation of the relationship between CCR5 receptor occupancy and anti-HIV activity of Aplaviroc.

Demarest JF, Sparks SS, Schell K, Shibayama S, McDanal CB, Fang L, Adkison KK, Shachoy-Clark A, Piscitelli SC.

J Clin Pharmacol. 2008 Oct;48(10):1179-88. doi: 10.1177/0091270008322178. Epub 2008 Aug 1.

PMID:
18676693
8.

Chemokine (C-C motif) receptor 5-using envelopes predominate in dual/mixed-tropic HIV from the plasma of drug-naive individuals.

Irlbeck DM, Amrine-Madsen H, Kitrinos KM, Labranche CC, Demarest JF.

AIDS. 2008 Jul 31;22(12):1425-31. doi: 10.1097/QAD.0b013e32830184ba.

PMID:
18614865
9.

Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease gene.

Karlsson AC, Deeks SG, Barbour JD, Heiken BD, Younger SR, Hoh R, Lane M, Sällberg M, Ortiz GM, Demarest JF, Liegler T, Grant RM, Martin JN, Nixon DF.

J Virol. 2003 Jun;77(12):6743-52.

10.

Immunologic and virologic analyses of an acutely HIV type 1-infected patient with extremely rapid disease progression.

Demarest JF, Jack N, Cleghorn FR, Greenberg ML, Hoffman TL, Ottinger JS, Fantry L, Edwards J, O'Brien TR, Cao K, Mahabir B, Blattner WA, Bartholomew C, Weinhold KJ.

AIDS Res Hum Retroviruses. 2001 Sep 20;17(14):1333-44.

PMID:
11602044
11.

Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T-cell receptor beta chain repertoire and reduces the level of T-cell oligoclonality.

Soudeyns H, Campi G, Rizzardi GP, Lenge C, Demarest JF, Tambussi G, Lazzarin A, Kaufmann D, Casorati G, Corey L, Pantaleo G.

Blood. 2000 Mar 1;95(5):1743-51.

12.

Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection.

Haynes BF, Hale LP, Weinhold KJ, Patel DD, Liao HX, Bressler PB, Jones DM, Demarest JF, Gebhard-Mitchell K, Haase AT, Bartlett JA.

J Clin Invest. 1999 Mar 15;103(6):921. No abstract available.

13.

Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection.

Haynes BF, Hale LP, Weinhold KJ, Patel DD, Liao HX, Bressler PB, Jones DM, Demarest JF, Gebhard-Mitchell K, Haase AT, Bartlett JA.

J Clin Invest. 1999 Feb;103(4):453-60. Erratum in: J Clin Invest 1999 Mar;103(6):921.

14.

Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection.

Pantaleo G, Soudeyns H, Demarest JF, Vaccarezza M, Graziosi C, Paolucci S, Daucher MB, Cohen OJ, Denis F, Biddison WE, Sekaly RP, Fauci AS.

Eur J Immunol. 1997 Dec;27(12):3166-73.

PMID:
9464802
15.

Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection.

Pantaleo G, Soudeyns H, Demarest JF, Vaccarezza M, Graziosi C, Paolucci S, Daucher M, Cohen OJ, Denis F, Biddison WE, Sekaly RP, Fauci AS.

Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9848-53.

16.

The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia.

Pantaleo G, Demarest JF, Schacker T, Vaccarezza M, Cohen OJ, Daucher M, Graziosi C, Schnittman SS, Quinn TC, Shaw GM, Perrin L, Tambussi G, Lazzarin A, Sekaly RP, Soudeyns H, Corey L, Fauci AS.

Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):254-8.

17.

Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.

Graziosi C, Gantt KR, Vaccarezza M, Demarest JF, Daucher M, Saag MS, Shaw GM, Quinn TC, Cohen OJ, Welbon CC, Pantaleo G, Fauci AS.

Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4386-91.

18.

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression.

Koenig S, Conley AJ, Brewah YA, Jones GM, Leath S, Boots LJ, Davey V, Pantaleo G, Demarest JF, Carter C, et al.

Nat Med. 1995 Apr;1(4):330-6.

PMID:
7585062
19.

Studies in subjects with long-term nonprogressive human immunodeficiency virus infection.

Pantaleo G, Menzo S, Vaccarezza M, Graziosi C, Cohen OJ, Demarest JF, Montefiori D, Orenstein JM, Fox C, Schrager LK, et al.

N Engl J Med. 1995 Jan 26;332(4):209-16.

20.

Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission.

Pantaleo G, Demarest JF, Vaccarezza M, Graziosi C, Bansal GP, Koenig S, Fauci AS.

Eur J Immunol. 1995 Jan;25(1):226-31.

PMID:
7843235
21.

Expression of a wide T cell receptor V beta repertoire in human T lymphocytes derived in vitro from embryonic liver cell precursors.

Poggi A, Demarest JF, Costa P, Biassoni R, Pella N, Pantaleo G, Mingari MC, Moretta L.

Eur J Immunol. 1994 Sep;24(9):2258-61.

PMID:
8088340
22.

Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV.

Pantaleo G, Demarest JF, Soudeyns H, Graziosi C, Denis F, Adelsberger JW, Borrow P, Saag MS, Shaw GM, Sekaly RP, et al.

Nature. 1994 Aug 11;370(6489):463-7.

PMID:
8047166
23.

Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection.

Pantaleo G, Graziosi C, Demarest JF, Cohen OJ, Vaccarezza M, Gantt K, Muro-Cacho C, Fauci AS.

Immunol Rev. 1994 Aug;140:105-30. Review.

PMID:
7821924
24.

Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.

Graziosi C, Pantaleo G, Gantt KR, Fortin JP, Demarest JF, Cohen OJ, Sékaly RP, Fauci AS.

Science. 1994 Jul 8;265(5169):248-52.

PMID:
8023143
25.

Analysis of the T-cell receptor beta-chain variable-region (V beta) repertoire in monozygotic twins discordant for human immunodeficiency virus: evidence for perturbations of specific V beta segments in CD4+ T cells of the virus-positive twins.

Rebai N, Pantaleo G, Demarest JF, Ciurli C, Soudeyns H, Adelsberger JW, Vaccarezza M, Walker RE, Sekaly RP, Fauci AS.

Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1529-33.

26.

HIV-1 infection in the lymphoid organs.

Graziosi C, Pantaleo G, Demarest JF, Cohen OJ, Vaccarezza M, Butini L, Montroni M, Fauci AS.

AIDS. 1993 Nov;7 Suppl 2:S53-8. Review.

PMID:
8161447
27.

Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection.

Graziosi C, Pantaleo G, Butini L, Demarest JF, Saag MS, Shaw GM, Fauci AS.

Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6405-9.

28.

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease.

Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS.

Nature. 1993 Mar 25;362(6418):355-8.

PMID:
8455722

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