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Items: 1 to 50 of 72

1.

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.

Zong G, Hu Z, O'Keefe S, Tranter D, Iannotti MJ, Baron L, Hall B, Corfield K, Paatero AO, Henderson MJ, Roboti P, Zhou J, Sun X, Govindarajan M, Rohde JM, Blanchard N, Simmonds R, Inglese J, Du Y, Demangel C, High S, Paavilainen VO, Shi WQ.

J Am Chem Soc. 2019 May 29;141(21):8450-8461. doi: 10.1021/jacs.8b13506. Epub 2019 May 15.

PMID:
31059257
2.

Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease.

Demangel C, High S.

Biol Cell. 2018 Nov;110(11):237-248. doi: 10.1111/boc.201800030. Epub 2018 Aug 14. Review.

PMID:
30055020
3.

Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature.

Morel JD, Paatero AO, Wei J, Yewdell JW, Guenin-Macé L, Van Haver D, Impens F, Pietrosemoli N, Paavilainen VO, Demangel C.

Mol Cell Proteomics. 2018 Sep;17(9):1750-1765. doi: 10.1074/mcp.RA118.000824. Epub 2018 Jun 18.

PMID:
29915147
4.

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages.

Oldenburg R, Mayau V, Prandi J, Arbues A, Astarie-Dequeker C, Guilhot C, Werts C, Winter N, Demangel C.

Front Immunol. 2018 Jan 19;9:2. doi: 10.3389/fimmu.2018.00002. eCollection 2018.

5.

Mycolactone displays anti-inflammatory effects on the nervous system.

Isaac C, Mauborgne A, Grimaldi A, Ade K, Pohl M, Limatola C, Boucher Y, Demangel C, Guenin-Macé L.

PLoS Negl Trop Dis. 2017 Nov 17;11(11):e0006058. doi: 10.1371/journal.pntd.0006058. eCollection 2017 Nov.

6.

Modular total syntheses of mycolactone A/B and its [2H]-isotopologue.

Saint-Auret S, Abdelkafi H, Le Nouen D, Guenin-Macé L, Demangel C, Bisseret P, Blanchard N.

Org Biomol Chem. 2017 Sep 20;15(36):7518-7522. doi: 10.1039/c7ob01943b.

7.

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export.

Grotzke JE, Kozik P, Morel JD, Impens F, Pietrosemoli N, Cresswell P, Amigorena S, Demangel C.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5910-E5919. doi: 10.1073/pnas.1705242114. Epub 2017 Jul 5.

8.

Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells.

Monel B, Compton AA, Bruel T, Amraoui S, Burlaud-Gaillard J, Roy N, Guivel-Benhassine F, Porrot F, Génin P, Meertens L, Sinigaglia L, Jouvenet N, Weil R, Casartelli N, Demangel C, Simon-Lorière E, Moris A, Roingeard P, Amara A, Schwartz O.

EMBO J. 2017 Jun 14;36(12):1653-1668. doi: 10.15252/embj.201695597. Epub 2017 May 4.

9.

Pathogenic and immunosuppressive properties of mycobacterial phenolic glycolipids.

Oldenburg R, Demangel C.

Biochimie. 2017 Oct;141:3-8. doi: 10.1016/j.biochi.2017.03.012. Epub 2017 Mar 18. Review.

10.

Mycolactone subverts immunity by selectively blocking the Sec61 translocon.

Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C.

J Exp Med. 2016 Dec 12;213(13):2885-2896. Epub 2016 Nov 7.

11.

Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease.

Niang F, Sarfo FS, Frimpong M, Guenin-Macé L, Wansbrough-Jones M, Stinear T, Phillips RO, Demangel C.

Sci Rep. 2015 Dec 4;5:17693. doi: 10.1038/srep17693.

12.

Electron Backscatter Diffraction and Transmission Kikuchi Diffraction Analysis of an Austenitic Stainless Steel Subjected to Surface Mechanical Attrition Treatment and Plasma Nitriding.

Proust G, Retraint D, Chemkhi M, Roos A, Demangel C.

Microsc Microanal. 2015 Aug;21(4):919-26. doi: 10.1017/S1431927615000793. Epub 2015 Jul 3.

PMID:
26139391
13.

Shaping mycolactone for therapeutic use against inflammatory disorders.

Guenin-Macé L, Baron L, Chany AC, Tresse C, Saint-Auret S, Jönsson F, Le Chevalier F, Bruhns P, Bismuth G, Hidalgo-Lucas S, Bisson JF, Blanchard N, Demangel C.

Sci Transl Med. 2015 May 27;7(289):289ra85. doi: 10.1126/scitranslmed.aab0458.

14.

Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins.

Chany AC, Veyron-Churlet R, Tresse C, Mayau V, Casarotto V, Le Chevalier F, Guenin-Macé L, Demangel C, Blanchard N.

J Med Chem. 2014 Sep 11;57(17):7382-95. doi: 10.1021/jm5008819. Epub 2014 Sep 2.

PMID:
25158122
15.

Adhesion of the ulcerative pathogen Mycobacterium ulcerans to DACC-coated dressings.

Geroult S, Phillips RO, Demangel C.

J Wound Care. 2014 Aug;23(8):417-8, 422-4. doi: 10.12968/jowc.2014.23.8.417. Erratum in: J Wound Care. 2014 Dec;23(12):642.

PMID:
25139600
16.

Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease.

Phillips RO, Sarfo FS, Landier J, Oldenburg R, Frimpong M, Wansbrough-Jones M, Abass K, Thompson W, Forson M, Fontanet A, Niang F, Demangel C.

PLoS Negl Trop Dis. 2014 Apr 10;8(4):e2786. doi: 10.1371/journal.pntd.0002786. eCollection 2014 Apr.

17.

Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens.

Guenin-Macé L, Oldenburg R, Chrétien F, Demangel C.

Cell Mol Life Sci. 2014 Jul;71(13):2443-50. doi: 10.1007/s00018-014-1561-z. Epub 2014 Jan 21. Review.

18.

Proteomic analysis of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) interactome in resting and activated primary mast cells [corrected].

Bounab Y, Hesse AM, Iannascoli B, Grieco L, Couté Y, Niarakis A, Roncagalli R, Lie E, Lam KP, Demangel C, Thieffry D, Garin J, Malissen B, Daëron M.

Mol Cell Proteomics. 2013 Oct;12(10):2874-89. doi: 10.1074/mcp.M112.025908. Epub 2013 Jul 2. Erratum in: Mol Cell Proteomics. 2013 Feb ;13(2):678.

19.

Microstructural characterization of Ti-6Al-4V alloy subjected to the duplex SMAT/plasma nitriding.

Pi Y, Faure J, Agoda-Tandjawa G, Andreazza C, Potiron S, Levesque A, Demangel C, Retraint D, Benhayoune H.

Microsc Res Tech. 2013 Sep;76(9):897-903. doi: 10.1002/jemt.22245. Epub 2013 Jun 14.

PMID:
23766242
20.

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.

Guenin-Macé L, Veyron-Churlet R, Thoulouze MI, Romet-Lemonne G, Hong H, Leadlay PF, Danckaert A, Ruf MT, Mostowy S, Zurzolo C, Bousso P, Chrétien F, Carlier MF, Demangel C.

J Clin Invest. 2013 Apr;123(4):1501-12. doi: 10.1172/JCI66576. Epub 2013 Mar 15.

21.

Surface nanocrystallization of Ti-6Al-4V alloy: microstructural and mechanical characterization.

Pi Y, Agoda-Tandjawa G, Potiron S, Demangel C, Retraint D, Benhayoune H.

J Nanosci Nanotechnol. 2012 Jun;12(6):4892-7.

PMID:
22905548
22.

Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer.

Biot C, Rentsch CA, Gsponer JR, Birkhäuser FD, Jusforgues-Saklani H, Lemaître F, Auriau C, Bachmann A, Bousso P, Demangel C, Peduto L, Thalmann GN, Albert ML.

Sci Transl Med. 2012 Jun 6;4(137):137ra72. doi: 10.1126/scitranslmed.3003586.

23.

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria.

Houben D, Demangel C, van Ingen J, Perez J, Baldeón L, Abdallah AM, Caleechurn L, Bottai D, van Zon M, de Punder K, van der Laan T, Kant A, Bossers-de Vries R, Willemsen P, Bitter W, van Soolingen D, Brosch R, van der Wel N, Peters PJ.

Cell Microbiol. 2012 Aug;14(8):1287-98. doi: 10.1111/j.1462-5822.2012.01799.x. Epub 2012 May 8.

PMID:
22524898
24.

A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins.

Chany AC, Casarotto V, Schmitt M, Tarnus C, Guenin-Macé L, Demangel C, Mirguet O, Eustache J, Blanchard N.

Chemistry. 2011 Dec 16;17(51):14413-9. doi: 10.1002/chem.201102542. Epub 2011 Nov 30.

PMID:
22127975
25.

Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring.

Sarfo FS, Le Chevalier F, Aka N, Phillips RO, Amoako Y, Boneca IG, Lenormand P, Dosso M, Wansbrough-Jones M, Veyron-Churlet R, Guenin-Macé L, Demangel C.

PLoS Negl Trop Dis. 2011 Jul;5(7):e1237. doi: 10.1371/journal.pntd.0001237. Epub 2011 Jul 19.

26.

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression.

Guenin-Macé L, Carrette F, Asperti-Boursin F, Le Bon A, Caleechurn L, Di Bartolo V, Fontanet A, Bismuth G, Demangel C.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12833-8. doi: 10.1073/pnas.1016496108. Epub 2011 Jul 18.

27.

Entrapment of intracytosolic bacteria by septin cage-like structures.

Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, Cossart P.

Cell Host Microbe. 2010 Nov 18;8(5):433-44. doi: 10.1016/j.chom.2010.10.009.

28.

Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes.

Tabouret G, Astarie-Dequeker C, Demangel C, Malaga W, Constant P, Ray A, Honoré N, Bello NF, Perez E, Daffé M, Guilhot C.

PLoS Pathog. 2010 Oct 21;6(10):e1001159. doi: 10.1371/journal.ppat.1001159.

29.

Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events.

Boulkroun S, Guenin-Macé L, Thoulouze MI, Monot M, Merckx A, Langsley G, Bismuth G, Di Bartolo V, Demangel C.

J Immunol. 2010 Feb 1;184(3):1436-44. doi: 10.4049/jimmunol.0902854. Epub 2009 Dec 30.

30.

Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with buruli ulcer disease.

Phillips R, Sarfo FS, Guenin-Macé L, Decalf J, Wansbrough-Jones M, Albert ML, Demangel C.

J Infect Dis. 2009 Dec 1;200(11):1675-84. doi: 10.1086/646615.

PMID:
19863437
31.

Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression.

Guenin-Macé L, Siméone R, Demangel C.

Transbound Emerg Dis. 2009 Aug;56(6-7):255-68. doi: 10.1111/j.1865-1682.2009.01072.x. Epub 2009 May 26. Review.

PMID:
19486312
32.

Buruli ulcer disease: prospects for a vaccine.

Huygen K, Adjei O, Affolabi D, Bretzel G, Demangel C, Fleischer B, Johnson RC, Pedrosa J, Phanzu DM, Phillips RO, Pluschke G, Siegmund V, Singh M, van der Werf TS, Wansbrough-Jones M, Portaels F.

Med Microbiol Immunol. 2009 May;198(2):69-77. doi: 10.1007/s00430-009-0109-6. Epub 2009 Feb 7. Review.

PMID:
19198877
33.

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans.

Demangel C, Stinear TP, Cole ST.

Nat Rev Microbiol. 2009 Jan;7(1):50-60. doi: 10.1038/nrmicro2077. Review.

PMID:
19079352
34.

Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs.

Hong H, Coutanceau E, Leclerc M, Caleechurn L, Leadlay PF, Demangel C.

PLoS Negl Trop Dis. 2008;2(10):e325. doi: 10.1371/journal.pntd.0000325. Epub 2008 Oct 22.

35.

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria.

Hong H, Demangel C, Pidot SJ, Leadlay PF, Stinear T.

Nat Prod Rep. 2008 Jun;25(3):447-54. doi: 10.1039/b803101k. Epub 2008 Apr 17. Review.

36.

A novel mycolactone toxin obtained by biosynthetic engineering.

Hong H, Stinear T, Porter J, Demangel C, Leadlay PF.

Chembiochem. 2007 Nov 23;8(17):2043-7. No abstract available.

37.

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone.

Coutanceau E, Decalf J, Martino A, Babon A, Winter N, Cole ST, Albert ML, Demangel C.

J Exp Med. 2007 Jun 11;204(6):1395-403. Epub 2007 May 21.

38.

Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence.

Saint-Joanis B, Demangel C, Jackson M, Brodin P, Marsollier L, Boshoff H, Cole ST.

J Bacteriol. 2006 Sep;188(18):6669-79.

39.

Towards an immunodiagnostic test for leprosy.

Aráoz R, Honoré N, Banu S, Demangel C, Cissoko Y, Arama C, Uddin MK, Hadi SK, Monot M, Cho SN, Ji B, Brennan PJ, Sow S, Cole ST.

Microbes Infect. 2006 Jul;8(8):2270-6. Epub 2006 May 26.

PMID:
16797206
40.

Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer.

Coutanceau E, Legras P, Marsollier L, Reysset G, Cole ST, Demangel C.

Microbes Infect. 2006 Jul;8(8):2075-81. Epub 2006 May 24.

PMID:
16781179
41.

Antigen discovery: a postgenomic approach to leprosy diagnosis.

Aráoz R, Honoré N, Cho S, Kim JP, Cho SN, Monot M, Demangel C, Brennan PJ, Cole ST.

Infect Immun. 2006 Jan;74(1):175-82.

42.

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.

Brodin P, Majlessi L, Marsollier L, de Jonge MI, Bottai D, Demangel C, Hinds J, Neyrolles O, Butcher PD, Leclerc C, Cole ST, Brosch R.

Infect Immun. 2006 Jan;74(1):88-98.

43.

Tuberculosis: from genome to vaccine.

de Jonge MI, Brosch R, Brodin P, Demangel C, Cole ST.

Expert Rev Vaccines. 2005 Aug;4(4):541-51. Review.

PMID:
16117711
44.

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin.

Coutanceau E, Marsollier L, Brosch R, Perret E, Goossens P, Tanguy M, Cole ST, Small PL, Demangel C.

Cell Microbiol. 2005 Aug;7(8):1187-96.

PMID:
16008585
45.

Single chain antibody fragments for the selective targeting of antigens to dendritic cells.

Demangel C, Zhou J, Choo AB, Shoebridge G, Halliday GM, Britton WJ.

Mol Immunol. 2005 May;42(8):979-85. Epub 2004 Dec 10.

PMID:
15829289
47.

[Use of the mycobacteria genome to develop new vaccines and therapeutic targets].

Demangel C, Brosch R, Marmiesse M, Cole ST.

Med Trop (Mars). 2004;64(3):221-3. French. No abstract available.

PMID:
15497318
48.
49.
50.

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis.

Pym AS, Brodin P, Majlessi L, Brosch R, Demangel C, Williams A, Griffiths KE, Marchal G, Leclerc C, Cole ST.

Nat Med. 2003 May;9(5):533-9. Epub 2003 Apr 14.

PMID:
12692540

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