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Items: 1 to 50 of 60

1.

Duration and magnitude of hypotension and monocyte deactivation in patients with community-acquired pneumonia.

Simon PM, Delude RL, Lee M, Kong L, Guzik LJ, Huang DT, Angus DC, Kellum JA; GenIMS Investigators.

Shock. 2011 Dec;36(6):553-9. doi: 10.1097/SHK.0b013e318235331e.

2.

Understanding the potential role of statins in pneumonia and sepsis.

Yende S, Milbrandt EB, Kellum JA, Kong L, Delude RL, Weissfeld LA, Angus DC.

Crit Care Med. 2011 Aug;39(8):1871-8. doi: 10.1097/CCM.0b013e31821b8290.

3.

Characterizing accelerated capture of deoligomerized TNF within hemoadsorption beads used to treat sepsis.

Kimmel JD, Lacko CS, Delude RL, Federspiel WJ.

J Biomed Mater Res B Appl Biomater. 2011 Jul;98(1):47-53. doi: 10.1002/jbm.b.31830. Epub 2011 Apr 18.

PMID:
21504054
4.

Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line.

Aneja RK, Sjodin H, Gefter JV, Zingarelli B, Delude RL.

J Inflamm (Lond). 2011 Feb 23;8:3. doi: 10.1186/1476-9255-8-3.

5.

Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation.

Miki K, Kumar A, Yang R, Killeen ME, Delude RL.

Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G840-8. doi: 10.1152/ajpgi.90716.2008. Epub 2009 Aug 27.

6.

Comparison of distinct protein isoforms of the receptor for advanced glycation end-products expressed in murine tissues and cell lines.

Gefter JV, Shaufl AL, Fink MP, Delude RL.

Cell Tissue Res. 2009 Jul;337(1):79-89. doi: 10.1007/s00441-009-0791-0. Epub 2009 May 5.

PMID:
19415334
7.

Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia.

Huang DT, Angus DC, Kellum JA, Pugh NA, Weissfeld LA, Struck J, Delude RL, Rosengart MR, Yealy DM.

Chest. 2009 Sep;136(3):823-831. doi: 10.1378/chest.08-1981. Epub 2009 Apr 10.

8.

Breathing normobaric oxygen protects against splanchnic ischemic injury: how does it work?

Delude RL.

Crit Care Med. 2009 Mar;37(3):1162-4. doi: 10.1097/CCM.0b013e318194bde1. No abstract available.

PMID:
19237951
9.

Would you like your colloid straight or with a twist of an anti-inflammatory antioxidant?

Delude RL.

Crit Care Med. 2009 Mar;37(3):1133-4. doi: 10.1097/CCM.0b013e3181987309. No abstract available.

PMID:
19237932
10.

Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance.

Aneja RK, Tsung A, Sjodin H, Gefter JV, Delude RL, Billiar TR, Fink MP.

J Leukoc Biol. 2008 Nov;84(5):1326-34. doi: 10.1189/jlb.0108030. Epub 2008 Aug 7.

11.

Drag-reducing hyaluronic acid increases survival in profoundly hemorrhaged rats.

Cotoia A, Kameneva MV, Marascalco PJ, Fink MP, Delude RL.

Shock. 2009 Mar;31(3):258-61. doi: 10.1097/SHK.0b013e31817fc434.

PMID:
18650778
12.

Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants.

Fink MP, Macias CA, Xiao J, Tyurina YY, Delude RL, Greenberger JS, Kagan VE, Wipf P.

Crit Care Med. 2007 Sep;35(9 Suppl):S461-7. Review.

PMID:
17713394
13.

Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study.

Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC; GenIMS Investigators.

Arch Intern Med. 2007 Aug 13-27;167(15):1655-63.

14.

Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants.

Fink MP, Macias CA, Xiao J, Tyurina YY, Jiang J, Belikova N, Delude RL, Greenberger JS, Kagan VE, Wipf P.

Biochem Pharmacol. 2007 Sep 15;74(6):801-9. Epub 2007 May 29. Review.

PMID:
17601494
15.

Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis.

Angus DC, Yang L, Kong L, Kellum JA, Delude RL, Tracey KJ, Weissfeld L; GenIMS Investigators.

Crit Care Med. 2007 Apr;35(4):1061-7.

PMID:
17334246
16.

Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock.

Macias CA, Chiao JW, Xiao J, Arora DS, Tyurina YY, Delude RL, Wipf P, Kagan VE, Fink MP.

Ann Surg. 2007 Feb;245(2):305-14.

17.

LPS increases hepatic HIF-1alpha protein and expression of the HIF-1-dependent gene aldolase A in rats.

Scharte M, Han X, Uchiyama T, Tawadrous Z, Delude RL, Fink MP.

J Surg Res. 2006 Oct;135(2):262-7. Epub 2006 Aug 23.

PMID:
16930621
18.

The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells.

Killeen ME, Englert JA, Stolz DB, Song M, Han Y, Delude RL, Kellum JA, Fink MP.

J Pharmacol Exp Ther. 2006 Mar;316(3):1070-9. Epub 2005 Dec 28.

PMID:
16382025
19.

Flow cytometry.

Delude RL.

Crit Care Med. 2005 Dec;33(12 Suppl):S426-8. Review. No abstract available.

PMID:
16340412
20.

HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers.

Liu S, Stolz DB, Sappington PL, Macias CA, Killeen ME, Tenhunen JJ, Delude RL, Fink MP.

Am J Physiol Cell Physiol. 2006 Apr;290(4):C990-9. Epub 2005 Nov 9.

21.

The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro.

Sappington PL, Cruz RJ Jr, Harada T, Yang R, Han Y, Englert JA, Ajami AA, Killeen ME, Delude RL, Fink MP.

Biochem Pharmacol. 2005 Nov 25;70(11):1579-92. Epub 2005 Oct 13.

PMID:
16226725
22.

Ethyl pyruvate ameliorates ileus induced by bowel manipulation in mice.

Harada T, Moore BA, Yang R, Cruz RJ Jr, Delude RL, Fink MP.

Surgery. 2005 Sep;138(3):530-7.

PMID:
16213909
23.
24.

Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway.

Han Y, Englert JA, Delude RL, Fink MP.

Shock. 2005 Jan;23(1):45-53.

PMID:
15614131
25.

Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65.

Han Y, Englert JA, Yang R, Delude RL, Fink MP.

J Pharmacol Exp Ther. 2005 Mar;312(3):1097-105. Epub 2004 Nov 3.

PMID:
15525791
26.

Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis.

Yang R, Uchiyama T, Alber SM, Han X, Watkins SK, Delude RL, Fink MP.

Crit Care Med. 2004 Jul;32(7):1453-9.

PMID:
15241088
27.
28.

Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice.

Yang R, Han X, Delude RL, Fink MP.

J Lab Clin Med. 2003 Nov;142(5):322-31.

PMID:
14647036
29.

Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction.

Sappington PL, Fink ME, Yang R, Delude RL, Fink MP.

Shock. 2003 Dec;20(6):521-8.

PMID:
14625476
30.

NAD+ ameliorates inflammation-induced epithelial barrier dysfunction in cultured enterocytes and mouse ileal mucosa.

Han X, Uchiyama T, Sappington PL, Yaguchi A, Yang R, Fink MP, Delude RL.

J Pharmacol Exp Ther. 2003 Nov;307(2):443-9. Epub 2003 Sep 15.

PMID:
12975482
31.

Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion.

Uchiyama T, Delude RL, Fink MP.

Intensive Care Med. 2003 Nov;29(11):2050-8. Epub 2003 Sep 3.

PMID:
12955182
32.

Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice.

Han X, Fink MP, Uchiyama T, Yang R, Delude RL.

Am J Physiol Gastrointest Liver Physiol. 2004 Jan;286(1):G126-36. Epub 2003 Aug 28.

33.

Increased iNOS activity is essential for pulmonary epithelial tight junction dysfunction in endotoxemic mice.

Han X, Fink MP, Uchiyama T, Yang R, Delude RL.

Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L259-67. Epub 2003 Aug 1.

34.

IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice.

Yang R, Han X, Uchiyama T, Watkins SK, Yaguchi A, Delude RL, Fink MP.

Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G621-9. Epub 2003 May 28.

35.

Proinflammatory cytokines increase the rate of glycolysis and adenosine-5'-triphosphate turnover in cultured rat enterocytes.

Berg S, Sappington PL, Guzik LJ, Delude RL, Fink MP.

Crit Care Med. 2003 Apr;31(4):1203-12.

PMID:
12682494
37.

Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers.

Sappington PL, Han X, Yang R, Delude RL, Fink MP.

J Pharmacol Exp Ther. 2003 Jan;304(1):464-76.

PMID:
12490623
38.

Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes.

Scharte M, Han X, Bertges DJ, Fink MP, Delude RL.

Am J Physiol Gastrointest Liver Physiol. 2003 Mar;284(3):G373-84. Epub 2002 Oct 2.

39.

Effect of hemorrhagic shock on gut barrier function and expression of stress-related genes in normal and gnotobiotic mice.

Yang R, Gallo DJ, Baust JJ, Watkins SK, Delude RL, Fink MP.

Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1263-74.

40.

HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice.

Sappington PL, Yang R, Yang H, Tracey KJ, Delude RL, Fink MP.

Gastroenterology. 2002 Sep;123(3):790-802.

PMID:
12198705
41.

Regulation of hypoxia-inducible factor 1 in enterocytic cells.

Bertges DJ, Berg S, Fink MP, Delude RL.

J Surg Res. 2002 Jul;106(1):157-65.

PMID:
12127821
43.

Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock.

Yang R, Gallo DJ, Baust JJ, Uchiyama T, Watkins SK, Delude RL, Fink MP.

Am J Physiol Gastrointest Liver Physiol. 2002 Jul;283(1):G212-21.

44.

Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells.

Khan AU, Delude RL, Han YY, Sappington PL, Han X, Carcillo JA, Fink MP.

Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L1082-91.

45.

Extremely low doses of tissue factor pathway inhibitor decrease mortality in a rabbit model of septic shock.

Matyal R, Vin Y, Delude RL, Lee C, Creasey AA, Fink MP.

Intensive Care Med. 2001 Aug;27(8):1274-80.

PMID:
11511939
46.

Hypoxic signal transduction in critical illness.

Bertges DJ, Fink MP, Delude RL.

Crit Care Med. 2000 Apr;28(4 Suppl):N78-86. Review.

PMID:
10807319
47.

Polarized transport of hydrophilic compounds across rat colonic mucosa from serosa to mucosa is temperature dependent.

Tomita M, Menconi MJ, Delude RL, Fink MP.

Gastroenterology. 2000 Mar;118(3):535-43.

PMID:
10702204
48.
49.

Effect of mesenteric ischemia and reperfusion or hemorrhagic shock on intestinal mucosal permeability and ATP content in rats.

Wattanasirichaigoon S, Menconi MJ, Delude RL, Fink MP.

Shock. 1999 Aug;12(2):127-33.

PMID:
10446893
50.

Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411.

Heine H, Delude RL, Monks BG, Espevik T, Golenbock DT.

J Biol Chem. 1999 Jul 23;274(30):21049-55.

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