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Items: 1 to 50 of 171

1.

Novel Human NKCC1 Mutations Cause Defects in Goblet Cells Mucus Secretion and Chronic Inflammation.

Koumangoye R, Omer S, Kabeer MH, Delpire E.

Cell Mol Gastroenterol Hepatol. 2019 Oct 23. pii: S2352-345X(19)30142-0. doi: 10.1016/j.jcmgh.2019.10.006. [Epub ahead of print]

2.

Cryo-EM structures of the human cation-chloride cotransporter KCC1.

Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J.

Science. 2019 Oct 25;366(6464):505-508. doi: 10.1126/science.aay3129.

PMID:
31649201
3.

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.

Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT.

Sci Signal. 2019 Oct 15;12(603). pii: eaaw9315. doi: 10.1126/scisignal.aaw9315.

PMID:
31615901
4.

De novo variants in SLC12A6 cause sporadic early-onset progressive sensorimotor neuropathy.

Park J, Flores BR, Scherer K, Kuepper H, Rossi M, Rupprich K, Rautenberg M, Deininger N, Weichselbaum A, Grimm A, Sturm M, Grasshoff U, Delpire E, Haack TB.

J Med Genet. 2019 Aug 22. pii: jmedgenet-2019-106273. doi: 10.1136/jmedgenet-2019-106273. [Epub ahead of print]

PMID:
31439721
5.

SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.

Jin SC, Furey CG, Zeng X, Allocco A, Nelson-Williams C, Dong W, Karimy JK, Wang K, Ma S, Delpire E, Kahle KT.

Mol Genet Genomic Med. 2019 Sep;7(9):e892. doi: 10.1002/mgg3.892. Epub 2019 Aug 8.

6.

A missense mutation in SLC6A1 associated with Lennox-Gastaut syndrome impairs GABA transporter 1 protein trafficking and function.

Cai K, Wang J, Eissman J, Wang J, Nwosu G, Shen W, Liang HC, Li XJ, Zhu HX, Yi YH, Song J, Xu D, Delpire E, Liao WP, Shi YW, Kang JQ.

Exp Neurol. 2019 Oct;320:112973. doi: 10.1016/j.expneurol.2019.112973. Epub 2019 Jun 6.

PMID:
31176687
7.

Sex-Dependent Modulation of Anxiety and Fear by 5-HT1A Receptors in the Bed Nucleus of the Stria Terminalis.

Marcinkiewcz CA, Bierlein-De La Rosa G, Dorrier CE, McKnight M, DiBerto JF, Pati D, Gianessi CA, Hon OJ, Tipton G, McElligott ZA, Delpire E, Kash TL.

ACS Chem Neurosci. 2019 Jul 17;10(7):3154-3166. doi: 10.1021/acschemneuro.8b00594. Epub 2019 Jun 17.

PMID:
31140276
8.

Enhanced Social Dominance and Altered Neuronal Excitability in the Prefrontal Cortex of Male KCC2b Mutant Mice.

Anacker AMJ, Moran JT, Santarelli S, Forsberg CG, Rogers TD, Stanwood GD, Hall BJ, Delpire E, Veenstra-VanderWeele J, Saxe MD.

Autism Res. 2019 May;12(5):732-743. doi: 10.1002/aur.2098. Epub 2019 Apr 12.

PMID:
30977597
9.

Functional Coupling of K+-Cl- Cotransporter (KCC) to GABA-Gated Cl- Channels in the Central Nervous System of Drosophila melanogaster Leads to Altered Drug Sensitivities.

Chen R, Prael FJ 3rd, Li Z, Delpire E, Weaver CD, Swale DR.

ACS Chem Neurosci. 2019 Jun 19;10(6):2765-2776. doi: 10.1021/acschemneuro.8b00697. Epub 2019 May 3.

PMID:
30942574
10.

A dileucine motif in the COOH-terminal domain of NKCC1 targets the cotransporter to the plasma membrane.

Koumangoye R, Omer S, Delpire E.

Am J Physiol Cell Physiol. 2019 Apr 1;316(4):C545-C558. doi: 10.1152/ajpcell.00023.2019. Epub 2019 Mar 13.

PMID:
30865516
11.

Elusive role of the Na-K-2Cl cotransporter in the choroid plexus.

Delpire E, Gagnon KB.

Am J Physiol Cell Physiol. 2019 Apr 1;316(4):C522-C524. doi: 10.1152/ajpcell.00490.2018. Epub 2018 Dec 21. No abstract available.

PMID:
30576234
12.

Agmatine preferentially antagonizes GluN2B-containing N-methyl-d-aspartate receptors in spinal cord.

Waataja JJ, Peterson CD, Verma H, Goracke-Postle CJ, Séguéla P, Delpire E, Wilcox GL, Fairbanks CA.

J Neurophysiol. 2019 Feb 1;121(2):662-671. doi: 10.1152/jn.00172.2018. Epub 2018 Nov 14.

PMID:
30427758
13.

Preface.

Levitan I, Delpire E.

Curr Top Membr. 2018;81:xv-xvii. doi: 10.1016/S1063-5823(18)30029-2. No abstract available.

PMID:
30243443
14.

Water Homeostasis and Cell Volume Maintenance and Regulation.

Delpire E, Gagnon KB.

Curr Top Membr. 2018;81:3-52. doi: 10.1016/bs.ctm.2018.08.001. Epub 2018 Aug 27. Review.

15.

Genetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses.

Joffe ME, Turner BD, Delpire E, Grueter BA.

Neuropsychopharmacology. 2018 Nov;43(12):2383-2389. doi: 10.1038/s41386-018-0131-8. Epub 2018 Jun 25.

16.

Mistargeting of a truncated Na-K-2Cl cotransporter in epithelial cells.

Koumangoye R, Omer S, Delpire E.

Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C258-C276. doi: 10.1152/ajpcell.00130.2018. Epub 2018 May 2.

17.

Na+ -K+ -2Cl- Cotransporter (NKCC) Physiological Function in Nonpolarized Cells and Transporting Epithelia.

Delpire E, Gagnon KB.

Compr Physiol. 2018 Mar 25;8(2):871-901. doi: 10.1002/cphy.c170018. Review.

PMID:
29687903
18.

Mechanism of Hyperkalemia-Induced Metabolic Acidosis.

Harris AN, Grimm PR, Lee HW, Delpire E, Fang L, Verlander JW, Welling PA, Weiner ID.

J Am Soc Nephrol. 2018 May;29(5):1411-1425. doi: 10.1681/ASN.2017111163. Epub 2018 Feb 26.

19.

A role for KCC3 in maintaining cell volume of peripheral nerve fibers.

Flores B, Schornak CC, Delpire E.

Neurochem Int. 2019 Feb;123:114-124. doi: 10.1016/j.neuint.2018.01.009. Epub 2018 Jan 31. Review.

20.

DNPEP is not the only peptidase that produces SPAK fragments in kidney.

Koumangoye R, Delpire E.

Physiol Rep. 2017 Nov;5(21). pii: e13479. doi: 10.14814/phy2.13479.

21.

AJP-Cell Physiology begins landmark reviews in cell physiology: an editorial from the senior editors of AJP-Cell Physiology.

Delpire E, Hamilton KL, Hawke TJ, Isenberg JS, Lotersztajn S, Yuan JX, Adams JC.

Am J Physiol Cell Physiol. 2018 Jan 1;314(1):C1-C2. doi: 10.1152/ajpcell.00256.2017. Epub 2017 Nov 14. No abstract available.

22.

Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function.

Markkanen M, Ludwig A, Khirug S, Pryazhnikov E, Soni S, Khiroug L, Delpire E, Rivera C, Airaksinen MS, Uvarov P.

Brain Res. 2017 Nov 15;1675:87-101. doi: 10.1016/j.brainres.2017.08.034. Epub 2017 Sep 6.

PMID:
28888841
23.

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.

Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT.

Nat Med. 2017 Aug;23(8):997-1003. doi: 10.1038/nm.4361. Epub 2017 Jul 10.

PMID:
28692063
24.

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.

Zhang J, Karimy JK, Delpire E, Kahle KT.

Expert Opin Ther Targets. 2017 Aug;21(8):795-804. doi: 10.1080/14728222.2017.1351949. Epub 2017 Jul 12. Review.

25.

KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects.

Bowerman M, Salsac C, Bernard V, Soulard C, Dionne A, Coque E, Benlefki S, Hince P, Dion PA, Butler-Browne G, Camu W, Bouchard JP, Delpire E, Rouleau GA, Raoul C, Scamps F.

Neurobiol Dis. 2017 Oct;106:35-48. doi: 10.1016/j.nbd.2017.06.013. Epub 2017 Jun 21.

PMID:
28647557
26.

Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules.

Grimm PR, Coleman R, Delpire E, Welling PA.

J Am Soc Nephrol. 2017 Sep;28(9):2597-2606. doi: 10.1681/ASN.2016090948. Epub 2017 Apr 25.

27.

Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.

Glykys J, Dzhala V, Egawa K, Kahle KT, Delpire E, Staley K.

Trends Neurosci. 2017 May;40(5):276-294. doi: 10.1016/j.tins.2017.03.006. Epub 2017 Apr 18. Review.

28.

WNK Kinase Signaling in Ion Homeostasis and Human Disease.

Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT.

Cell Metab. 2017 Feb 7;25(2):285-299. doi: 10.1016/j.cmet.2017.01.007. Review.

29.

Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptors subunit.

Radke AK, Jury NJ, Delpire E, Nakazawa K, Holmes A.

Alcohol. 2017 Feb;58:47-51. doi: 10.1016/j.alcohol.2016.07.005. Epub 2016 Aug 12.

30.

The mysterious role of the neuronal anion exchanger-3.

Delpire E.

J Physiol. 2017 Feb 1;595(3):601-602. doi: 10.1113/JP273033. Epub 2017 Jan 17. No abstract available.

31.

The KCC3 cotransporter as a therapeutic target for peripheral neuropathy.

Delpire E, Kahle KT.

Expert Opin Ther Targets. 2017 Feb;21(2):113-116. doi: 10.1080/14728222.2017.1275569. Epub 2017 Jan 5. No abstract available.

PMID:
28019725
32.

Challenges of Finding Novel Drugs Targeting the K-Cl Cotransporter.

Delpire E, Weaver CD.

ACS Chem Neurosci. 2016 Dec 21;7(12):1624-1627. Epub 2016 Nov 8.

33.

A patient with multisystem dysfunction carries a truncation mutation in human SLC12A2, the gene encoding the Na-K-2Cl cotransporter, NKCC1.

Delpire E, Wolfe L, Flores B, Koumangoye R, Schornak CC, Omer S, Pusey B, Lau C, Markello T, Adams DR.

Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001289.

34.

The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition.

Kahle KT, Khanna AR, Duan J, Staley KJ, Delpire E, Poduri A.

Neuroscientist. 2016 Dec;22(6):555-562. Epub 2016 Apr 29. Review.

PMID:
27130838
35.

KCC3 deficiency-induced disruption of paranodal loops and impairment of axonal excitability in the peripheral nervous system.

Sun YT, Tzeng SF, Lin TS, Hsu KS, Delpire E, Shen MR.

Neuroscience. 2016 Oct 29;335:91-102. doi: 10.1016/j.neuroscience.2016.08.031. Epub 2016 Aug 24.

PMID:
27568057
36.

Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.

Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E.

Sci Signal. 2016 Aug 2;9(439):ra77. doi: 10.1126/scisignal.aae0546.

37.

The Ste20 kinases SPAK and OSR1 travel between cells through exosomes.

Koumangoye R, Delpire E.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C43-53. doi: 10.1152/ajpcell.00080.2016. Epub 2016 Apr 27.

38.

STIM and Orai Proteins in Calcium Signaling: an AJP-Cell Physiology series of Themed Reviews.

Delpire E.

Am J Physiol Cell Physiol. 2016 Mar 15;310(6):C401. doi: 10.1152/ajpcell.C-zh0-7906-editorial.2016. No abstract available.

39.

Hyperpolarization-independent maturation and refinement of GABA/glycinergic connections in the auditory brain stem.

Lee H, Bach E, Noh J, Delpire E, Kandler K.

J Neurophysiol. 2016 Mar;115(3):1170-82. doi: 10.1152/jn.00926.2015. Epub 2015 Dec 9.

40.

Research antibodies: do not use them to stain your reputation.

Delpire E.

Am J Physiol Cell Physiol. 2015 Dec 1;309(11):C707-8. doi: 10.1152/ajpcell.zh0-7843-editorial.2015. No abstract available.

41.

Chronic intermittent alcohol disrupts the GluN2B-associated proteome and specifically regulates group I mGlu receptor-dependent long-term depression.

Wills TA, Baucum AJ 2nd, Holleran KM, Chen Y, Pasek JG, Delpire E, Tabb DL, Colbran RJ, Winder DG.

Addict Biol. 2017 Mar;22(2):275-290. doi: 10.1111/adb.12319. Epub 2015 Nov 8.

42.

Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.

Kahle KT, Delpire E.

J Neurophysiol. 2016 Jan 1;115(1):8-18. doi: 10.1152/jn.00865.2015. Epub 2015 Oct 28. Review.

43.

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis.

Üner A, Gonçalves GH, Li W, Porceban M, Caron N, Schönke M, Delpire E, Sakimura K, Bjørbæk C.

Mol Metab. 2015 Jul 6;4(10):678-91. doi: 10.1016/j.molmet.2015.06.010. eCollection 2015 Oct.

44.

K-Cl cotransporters, cell volume homeostasis, and neurological disease.

Kahle KT, Khanna AR, Alper SL, Adragna NC, Lauf PK, Sun D, Delpire E.

Trends Mol Med. 2015 Aug;21(8):513-23. doi: 10.1016/j.molmed.2015.05.008. Epub 2015 Jul 1. Review.

45.

Integrated compensatory network is activated in the absence of NCC phosphorylation.

Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA.

J Clin Invest. 2015 May;125(5):2136-50. doi: 10.1172/JCI78558. Epub 2015 Apr 20.

46.

Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase.

Mathieu V, Chantôme A, Lefranc F, Cimmino A, Miklos W, Paulitschke V, Mohr T, Maddau L, Kornienko A, Berger W, Vandier C, Evidente A, Delpire E, Kiss R.

Cell Mol Life Sci. 2015 Oct;72(19):3731-46. doi: 10.1007/s00018-015-1902-6. Epub 2015 Apr 14.

47.

Aldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway.

Feng X, Zhang Y, Shao N, Wang Y, Zhuang Z, Wu P, Lee MJ, Liu Y, Wang X, Zhuang J, Delpire E, Gu D, Cai H.

Am J Physiol Renal Physiol. 2015 May 15;308(10):F1119-27. doi: 10.1152/ajprenal.00543.2014. Epub 2015 Mar 11.

48.

SPAK-mediated NCC regulation in response to low-K+ diet.

Wade JB, Liu J, Coleman R, Grimm PR, Delpire E, Welling PA.

Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F923-31. doi: 10.1152/ajprenal.00388.2014. Epub 2015 Jan 28.

49.

Renal transporter activation during angiotensin-II hypertension is blunted in interferon-γ-/- and interleukin-17A-/- mice.

Kamat NV, Thabet SR, Xiao L, Saleh MA, Kirabo A, Madhur MS, Delpire E, Harrison DG, McDonough AA.

Hypertension. 2015 Mar;65(3):569-76. doi: 10.1161/HYPERTENSIONAHA.114.04975. Epub 2015 Jan 19.

50.

Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.

Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P.

Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):310-21. doi: 10.1167/iovs.14-15911.

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