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Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina.

Overbey EG, da Silveira WA, Stanbouly S, Nishiyama NC, Roque-Torres GD, Pecaut MJ, Zawieja DC, Wang C, Willey JS, Delp MD, Hardiman G, Mao XW.

Sci Rep. 2019 Sep 16;9(1):13304. doi: 10.1038/s41598-019-49453-x.


Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.

Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T, Drew A, Sridharan V, Boerma M, Tackett AJ, Zawieja D, Willey JS, Delp M, Pecaut MJ.

Sci Rep. 2019 Jun 3;9(1):8215. doi: 10.1038/s41598-019-44696-0.


Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis.

Mao XW, Byrum S, Nishiyama NC, Pecaut MJ, Sridharan V, Boerma M, Tackett AJ, Shiba D, Shirakawa M, Takahashi S, Delp MD.

Int J Mol Sci. 2018 Aug 28;19(9). pii: E2546. doi: 10.3390/ijms19092546.


The G protein-coupled estrogen receptor agonist, G-1, attenuates BK channel activation in cerebral arterial smooth muscle cells.

Evanson KW, Goldsmith JA, Ghosh P, Delp MD.

Pharmacol Res Perspect. 2018 Jun 21;6(4):e00409. doi: 10.1002/prp2.409. eCollection 2018 Jul.


Drivers overtaking bicyclists-An examination using naturalistic driving data.

Feng F, Bao S, Hampshire RC, Delp M.

Accid Anal Prev. 2018 Jun;115:98-109. doi: 10.1016/j.aap.2018.03.010. Epub 2018 Mar 15.


Effects of age and exercise training on coronary microvascular smooth muscle phenotype and function.

Muller-Delp JM, Hotta K, Chen B, Behnke BJ, Maraj JJ, Delp MD, Lucero TR, Bramy JA, Alarcon DB, Morgan HE, Cowan MR, Haynes AD.

J Appl Physiol (1985). 2018 Jan 1;124(1):140-149. doi: 10.1152/japplphysiol.00459.2017. Epub 2017 Oct 12.


The central effects of alpha-melanocyte stimulating hormone (α-MSH) in chicks involve changes in gene expression of neuropeptide Y and other factors in distinct hypothalamic nuclei.

Delp MS, Cline MA, Gilbert ER.

Neurosci Lett. 2017 Jun 9;651:52-56. doi: 10.1016/j.neulet.2017.04.064. Epub 2017 May 1.


Exercise training reverses age-induced diastolic dysfunction and restores coronary microvascular function.

Hotta K, Chen B, Behnke BJ, Ghosh P, Stabley JN, Bramy JA, Sepulveda JL, Delp MD, Muller-Delp JM.

J Physiol. 2017 Jun 15;595(12):3703-3719. doi: 10.1113/JP274172. Epub 2017 May 23.


Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium.

Delp MD, Charvat JM, Limoli CL, Globus RK, Ghosh P.

Sci Rep. 2016 Jul 28;6:29901. doi: 10.1038/srep29901.


Effects of High-LET Radiation Exposure and Hindlimb Unloading on Skeletal Muscle Resistance Artery Vasomotor Properties and Cancellous Bone Microarchitecture in Mice.

Ghosh P, Behnke BJ, Stabley JN, Kilar CR, Park Y, Narayanan A, Alwood JS, Shirazi-Fard Y, Schreurs AS, Globus RK, Delp MD.

Radiat Res. 2016 Mar;185(3):257-66. doi: 10.1667/RR4308.1. Epub 2016 Mar 1.


Anorexia is Associated with Stress-Dependent Orexigenic Responses to Exogenous Neuropeptide Y.

Yi J, Delp MS, Gilbert ER, Siegel PB, Cline MA.

J Neuroendocrinol. 2016 May;28(5). doi: 10.1111/jne.12378.


Reply to Zhang.

Delp MD, Vinogradova OL, Tarasova OS.

J Appl Physiol (1985). 2015 Nov 15;119(10):1244. doi: 10.1152/japplphysiol.00743.2015. No abstract available.


Effects of spaceflight on the murine mandible: Possible factors mediating skeletal changes in non-weight bearing bones of the head.

Ghosh P, Stabley JN, Behnke BJ, Allen MR, Delp MD.

Bone. 2016 Feb;83:156-161. doi: 10.1016/j.bone.2015.11.001. Epub 2015 Nov 9.


Effects of hindlimb unloading and ionizing radiation on skeletal muscle resistance artery vasodilation and its relation to cancellous bone in mice.

Prisby RD, Alwood JS, Behnke BJ, Stabley JN, McCullough DJ, Ghosh P, Globus RK, Delp MD.

J Appl Physiol (1985). 2016 Jan 15;120(2):97-106. doi: 10.1152/japplphysiol.00423.2015. Epub 2015 Oct 15.


The functional and structural changes in the basilar artery due to overpressure blast injury.

Toklu HZ, Muller-Delp J, Yang Z, Oktay Ş, Sakarya Y, Strang K, Ghosh P, Delp MD, Scarpace PJ, Wang KK, Tümer N.

J Cereb Blood Flow Metab. 2015 Dec;35(12):1950-6. doi: 10.1038/jcbfm.2015.151. Epub 2015 Jun 24.


Type 2 diabetes alters bone and marrow blood flow and vascular control mechanisms in the ZDF rat.

Stabley JN, Prisby RD, Behnke BJ, Delp MD.

J Endocrinol. 2015 Apr;225(1):47-58. doi: 10.1530/JOE-14-0514.


Effects of skeletal unloading on the vasomotor properties of the rat femur principal nutrient artery.

Prisby RD, Behnke BJ, Allen MR, Delp MD.

J Appl Physiol (1985). 2015 Apr 15;118(8):980-8. doi: 10.1152/japplphysiol.00576.2014. Epub 2015 Jan 29.


Exercise training reverses aging-induced impairment of myogenic constriction in skeletal muscle arterioles.

Ghosh P, Mora Solis FR, Dominguez JM 2nd, Spier SA, Donato AJ, Delp MD, Muller-Delp JM.

J Appl Physiol (1985). 2015 Apr 1;118(7):904-11. doi: 10.1152/japplphysiol.00277.2014. Epub 2015 Jan 29.


Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice.

Sofronova SI, Tarasova OS, Gaynullina D, Borzykh AA, Behnke BJ, Stabley JN, McCullough DJ, Maraj JJ, Hanna M, Muller-Delp JM, Vinogradova OL, Delp MD.

J Appl Physiol (1985). 2015 Apr 1;118(7):830-8. doi: 10.1152/japplphysiol.00976.2014. Epub 2015 Jan 15. Erratum in: J Appl Physiol (1985). 2016 May 15;120(10):1267.


Structural remodeling of coronary resistance arteries: effects of age and exercise training.

Hanna MA, Taylor CR, Chen B, La HS, Maraj JJ, Kilar CR, Behnke BJ, Delp MD, Muller-Delp JM.

J Appl Physiol (1985). 2014 Sep 15;117(6):616-23. doi: 10.1152/japplphysiol.01296.2013. Epub 2014 Jul 24.


The effects of aging on the functional and structural properties of the rat basilar artery.

Tümer N, Toklu HZ, Muller-Delp JM, Oktay S, Ghosh P, Strang K, Delp MD, Scarpace PJ.

Physiol Rep. 2014 Jun 6;2(6). pii: e12031. doi: 10.14814/phy2.12031. Print 2014 Jun 1.


Exercise training augments regional bone and marrow blood flow during exercise.

Stabley JN, Moningka NC, Behnke BJ, Delp MD.

Med Sci Sports Exerc. 2014 Nov;46(11):2107-12. doi: 10.1249/MSS.0000000000000342.


Chronic skeletal unloading of the rat femur: mechanisms and functional consequences of vascular remodeling.

Stabley JN, Prisby RD, Behnke BJ, Delp MD.

Bone. 2013 Dec;57(2):355-60. doi: 10.1016/j.bone.2013.09.003. Epub 2013 Sep 19.


Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressure.

Taylor CR, Hanna M, Behnke BJ, Stabley JN, McCullough DJ, Davis RT 3rd, Ghosh P, Papadopoulos A, Muller-Delp JM, Delp MD.

FASEB J. 2013 Jun;27(6):2282-92. doi: 10.1096/fj.12-222687. Epub 2013 Mar 1.


Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation.

Davis RT 3rd, Stabley JN, Dominguez JM 2nd, Ramsey MW, McCullough DJ, Lesniewski LA, Delp MD, Behnke BJ.

J Appl Physiol (1985). 2013 Mar 15;114(6):808-15. doi: 10.1152/japplphysiol.01358.2012. Epub 2013 Jan 24.


Age and exercise training alter signaling through reactive oxygen species in the endothelium of skeletal muscle arterioles.

Sindler AL, Reyes R, Chen B, Ghosh P, Gurovich AN, Kang LS, Cardounel AJ, Delp MD, Muller-Delp JM.

J Appl Physiol (1985). 2013 Mar 1;114(5):681-93. doi: 10.1152/japplphysiol.00341.2012. Epub 2013 Jan 3.


Aging and estrogen status: a possible endothelium-dependent vascular coupling mechanism in bone remodeling.

Prisby RD, Dominguez JM 2nd, Muller-Delp J, Allen MR, Delp MD.

PLoS One. 2012;7(11):e48564. doi: 10.1371/journal.pone.0048564. Epub 2012 Nov 20.


Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice.

Behnke BJ, Stabley JN, McCullough DJ, Davis RT 3rd, Dominguez JM 2nd, Muller-Delp JM, Delp MD.

FASEB J. 2013 Jan;27(1):399-409. doi: 10.1096/fj.12-218503. Epub 2012 Oct 25.


Effects of aging and exercise training on skeletal muscle blood flow and resistance artery morphology.

Behnke BJ, Ramsey MW, Stabley JN, Dominguez JM 2nd, Davis RT 3rd, McCullough DJ, Muller-Delp JM, Delp MD.

J Appl Physiol (1985). 2012 Dec 1;113(11):1699-708. doi: 10.1152/japplphysiol.01025.2012. Epub 2012 Oct 4.


Spaceflight reduces vasoconstrictor responsiveness of skeletal muscle resistance arteries in mice.

Stabley JN, Dominguez JM 2nd, Dominguez CE, Mora Solis FR, Ahlgren J, Behnke BJ, Muller-Delp JM, Delp MD.

J Appl Physiol (1985). 2012 Nov;113(9):1439-45. doi: 10.1152/japplphysiol.00772.2012. Epub 2012 Sep 13.


Effects of aging, TNF-α, and exercise training on angiotensin II-induced vasoconstriction of rat skeletal muscle arterioles.

Park Y, Prisby RD, Behnke BJ, Dominguez JM 2nd, Lesniewski LA, Donato AJ, Muller-Delp J, Delp MD.

J Appl Physiol (1985). 2012 Oct;113(7):1091-100. doi: 10.1152/japplphysiol.00292.2012. Epub 2012 Aug 23.


Adrenergic control of vascular resistance varies in muscles composed of different fiber types: influence of the vascular endothelium.

Behnke BJ, Armstrong RB, Delp MD.

Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R783-90. doi: 10.1152/ajpregu.00205.2011. Epub 2011 Jun 15.


Increased nitric oxide-mediated vasodilation of bone resistance arteries is associated with increased trabecular bone volume after endurance training in rats.

Dominguez JM 2nd, Prisby RD, Muller-Delp JM, Allen MR, Delp MD.

Bone. 2010 Mar;46(3):813-9. doi: 10.1016/j.bone.2009.10.029. Epub 2009 Nov 3.


Aging blunts the dynamics of vasodilation in isolated skeletal muscle resistance vessels.

Behnke BJ, Delp MD.

J Appl Physiol (1985). 2010 Jan;108(1):14-20. doi: 10.1152/japplphysiol.00970.2009. Epub 2009 Oct 1.


Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles.

Sindler AL, Delp MD, Reyes R, Wu G, Muller-Delp JM.

J Physiol. 2009 Aug 1;587(Pt 15):3885-97. doi: 10.1113/jphysiol.2009.172221. Epub 2009 Jun 15.


Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs.

Fogarty JA, Delp MD, Muller-Delp JM, Laine GA, Parker JL, Heaps CL.

J Vasc Res. 2009;46(2):152-61. doi: 10.1159/000152351. Epub 2008 Sep 4.


Altered bone mass, geometry and mechanical properties during the development and progression of type 2 diabetes in the Zucker diabetic fatty rat.

Prisby RD, Swift JM, Bloomfield SA, Hogan HA, Delp MD.

J Endocrinol. 2008 Dec;199(3):379-88. doi: 10.1677/JOE-08-0046. Epub 2008 Aug 28.


Unraveling the complex web of impaired wound healing with mechanical unloading and physical deconditioning.

Delp MD.

J Appl Physiol (1985). 2008 May;104(5):1262-3. doi: 10.1152/japplphysiol.90393.2008. Epub 2008 Mar 20. No abstract available.


Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca(2+) release mechanism.

Colleran PN, Behnke BJ, Wilkerson MK, Donato AJ, Delp MD.

Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1577-85. doi: 10.1152/ajpregu.00084.2008. Epub 2008 Mar 19.


Age, gender, and hormonal status modulate the vascular toxicity of the diesel exhaust extract phenanthraquinone.

Prisby RD, Muller-Delp J, Delp MD, Nurkiewicz TR.

J Toxicol Environ Health A. 2008;71(7):464-70. doi: 10.1080/15287390701839349.


Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension.

Lesniewski LA, Donato AJ, Behnke BJ, Woodman CR, Laughlin MH, Ray CA, Delp MD.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1840-50. doi: 10.1152/ajpheart.00692.2007. Epub 2008 Feb 1.


Diminished mesenteric vaso- and venoconstriction and elevated plasma ANP and BNP with simulated microgravity.

Behnke BJ, Zawieja DC, Gashev AA, Ray CA, Delp MD.

J Appl Physiol (1985). 2008 May;104(5):1273-80. doi: 10.1152/japplphysiol.00954.2006. Epub 2008 Jan 24.


Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles.

Delp MD, Behnke BJ, Spier SA, Wu G, Muller-Delp JM.

J Physiol. 2008 Feb 15;586(4):1161-8. Epub 2007 Dec 6.


Effects of aging on adipose resistance artery vasoconstriction: possible implications for orthostatic blood pressure regulation.

Ramsey MW, Behnke BJ, Prisby RD, Delp MD.

J Appl Physiol (1985). 2007 Nov;103(5):1636-43. Epub 2007 Sep 20.


Aging potentiates the effect of congestive heart failure on muscle microvascular oxygenation.

Behnke BJ, Delp MD, Poole DC, Musch TI.

J Appl Physiol (1985). 2007 Nov;103(5):1757-63. Epub 2007 Aug 30.


Chronic ethanol increases fetal cerebral blood flow specific to the ethanol-sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model.

Parnell SE, Ramadoss J, Delp MD, Ramsey MW, Chen WJ, West JR, Cudd TA.

Exp Physiol. 2007 Sep;92(5):933-43. Epub 2007 May 25.


Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and NO bioavailability in rats.

Prisby RD, Ramsey MW, Behnke BJ, Dominguez JM 2nd, Donato AJ, Allen MR, Delp MD.

J Bone Miner Res. 2007 Aug;22(8):1280-8.


Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide.

Spier SA, Delp MD, Stallone JN, Dominguez JM 2nd, Muller-Delp JM.

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3119-27. Epub 2007 Mar 2.


Arterial adaptations in microgravity contribute to orthostatic tolerance.

Delp MD.

J Appl Physiol (1985). 2007 Mar;102(3):836. Epub 2006 Dec 14. No abstract available.


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