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Items: 29


A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.

Johansen LM, DeWald LE, Shoemaker CJ, Hoffstrom BG, Lear-Rooney CM, Stossel A, Nelson E, Delos SE, Simmons JA, Grenier JM, Pierce LT, Pajouhesh H, Lehár J, Hensley LE, Glass PJ, White JM, Olinger GG.

Sci Transl Med. 2015 Jun 3;7(290):290ra89. doi: 10.1126/scitranslmed.aaa5597.


FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.

Johansen LM, Brannan JM, Delos SE, Shoemaker CJ, Stossel A, Lear C, Hoffstrom BG, Dewald LE, Schornberg KL, Scully C, Lehár J, Hensley LE, White JM, Olinger GG.

Sci Transl Med. 2013 Jun 19;5(190):190ra79. doi: 10.1126/scitranslmed.3005471.


Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection.

Shoemaker CJ, Schornberg KL, Delos SE, Scully C, Pajouhesh H, Olinger GG, Johansen LM, White JM.

PLoS One. 2013;8(2):e56265. doi: 10.1371/journal.pone.0056265. Epub 2013 Feb 18. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/76780c06-ac81-48a3-8cce-509da6858fe5.


Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change.

Brecher M, Schornberg KL, Delos SE, Fusco ML, Saphire EO, White JM.

J Virol. 2012 Jan;86(1):364-72. doi: 10.1128/JVI.05708-11. Epub 2011 Oct 26.


Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2.

Gregory SM, Harada E, Liang B, Delos SE, White JM, Tamm LK.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11211-6. doi: 10.1073/pnas.1104760108. Epub 2011 Jun 20.


Cell adhesion-dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entry.

Dube D, Schornberg KL, Shoemaker CJ, Delos SE, Stantchev TS, Clouse KA, Broder CC, White JM.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16637-42. doi: 10.1073/pnas.1008509107. Epub 2010 Sep 3.


Glycoprotein-dependent acidification of vesicular stomatitis virus enhances release of matrix protein.

Mire CE, Dube D, Delos SE, White JM, Whitt MA.

J Virol. 2009 Dec;83(23):12139-50. doi: 10.1128/JVI.00955-09. Epub 2009 Sep 23.


Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins.

Schornberg KL, Shoemaker CJ, Dube D, Abshire MY, Delos SE, Bouton AH, White JM.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):8003-8. doi: 10.1073/pnas.0807578106. Epub 2009 Apr 28.


The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding.

Dube D, Brecher MB, Delos SE, Rose SC, Park EW, Schornberg KL, Kuhn JH, White JM.

J Virol. 2009 Apr;83(7):2883-91. doi: 10.1128/JVI.01956-08. Epub 2009 Jan 14.


Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.

White JM, Delos SE, Brecher M, Schornberg K.

Crit Rev Biochem Mol Biol. 2008 May-Jun;43(3):189-219. doi: 10.1080/10409230802058320 . Review. Erratum in: Crit Rev Biochem Mol Biol. 2008 Jul-Aug;43(4):287-8.


Cell adhesion promotes Ebola virus envelope glycoprotein-mediated binding and infection.

Dube D, Schornberg KL, Stantchev TS, Bonaparte MI, Delos SE, Bouton AH, Broder CC, White JM.

J Virol. 2008 Jul;82(14):7238-42. doi: 10.1128/JVI.00425-08. Epub 2008 Apr 30.


Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency.

Delos SE, Brecher MB, Chen Z, Melder DC, Federspiel MJ, White JM.

J Virol. 2008 Mar;82(6):3131-4. doi: 10.1128/JVI.02266-07. Epub 2008 Jan 9.


The single ligand-binding repeat of Tva, a low density lipoprotein receptor-related protein, contains two ligand-binding surfaces.

Contreras-Alcantara S, Godby JA, Delos SE.

J Biol Chem. 2006 Aug 11;281(32):22827-38. Epub 2006 Jun 12.


The many mechanisms of viral membrane fusion proteins.

Earp LJ, Delos SE, Park HE, White JM.

Curr Top Microbiol Immunol. 2005;285:25-66. Review.


Receptor-activated binding of viral fusion proteins to target membranes.

Earp LJ, Hernandez LD, Delos SE, White JM.

Methods Enzymol. 2003;372:428-40. No abstract available.


Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex.

Ochsenbauer-Jambor C, Delos SE, Accavitti MA, White JM, Hunter E.

J Virol. 2002 Aug;76(15):7518-27.


The central proline of an internal viral fusion peptide serves two important roles.

Delos SE, Gilbert JM, White JM.

J Virol. 2000 Feb;74(4):1686-93.


Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein.

Hernandez LD, Peters RJ, Delos SE, Young JA, Agard DA, White JM.

J Cell Biol. 1997 Dec 15;139(6):1455-64.


In vivo and in vitro association of hsc70 with polyomavirus capsid proteins.

Cripe TP, Delos SE, Estes PA, Garcea RL.

J Virol. 1995 Dec;69(12):7807-13.


Polyomavirus VP1 phosphorylation: coexpression with the VP2 capsid protein modulates VP1 phosphorylation in Sf9 insect cells.

Li M, Delos SE, Montross L, Garcea RL.

Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5992-6.

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