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Items: 1 to 50 of 93


The Zebrafish Xenograft Platform-A Novel Tool for Modeling KSHV-Associated Diseases.

Pringle ES, Wertman J, Melong N, Coombs AJ, Young AL, O'Leary D, Veinotte C, Robinson CA, Ha MN, Dellaire G, Druley TE, McCormick C, Berman JN.

Viruses. 2019 Dec 20;12(1). pii: E12. doi: 10.3390/v12010012.


Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity.

Rajan V, Melong N, Wong WH, King B, Tong RS, Mahajan N, Gaston D, Lund T, Rittenberg D, Dellaire G, Campbell CJV, Druley T, Berman JN.

Haematologica. 2019 Dec 19. pii: haematol.2019.223040. doi: 10.3324/haematol.2019.223040. [Epub ahead of print]


Dominant negative Gfi1b mutations cause moderate thrombocytopenia and an impaired stress thrombopoiesis associated with mild erythropoietic abnormalities in mice.

Beauchemin H, Shooshtharizadeh P, Pinder J, Dellaire G, Möröy T.

Haematologica. 2019 Nov 21. pii: haematol.2019.222596. doi: 10.3324/haematol.2019.222596. [Epub ahead of print]


NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.

Darracq A, Pak H, Bourgoin V, Zmiri F, Dellaire G, Affar EB, Milot E.

PLoS Genet. 2019 Nov 1;15(11):e1008463. doi: 10.1371/journal.pgen.1008463. eCollection 2019 Nov.


PML isoform expression and DNA break location relative to PML nuclear bodies impacts the efficiency of homologous recombination.

Attwood KM, Salsman J, Chung D, Mathavarajah S, Van Iderstine C, Dellaire G.

Biochem Cell Biol. 2019 Oct 31. doi: 10.1139/bcb-2019-0115. [Epub ahead of print]


A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor.

Rodrigue A, Margaillan G, Torres Gomes T, Coulombe Y, Montalban G, da Costa E Silva Carvalho S, Milano L, Ducy M, De-Gregoriis G, Dellaire G, Araújo da Silva W Jr, Monteiro AN, Carvalho MA, Simard J, Masson JY.

Nucleic Acids Res. 2019 Nov 18;47(20):10662-10677. doi: 10.1093/nar/gkz780.


DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer.

George VC, Ansari SA, Chelakkot VS, Chelakkot AL, Chelakkot C, Menon V, Ramadan W, Ethiraj KR, El-Awady R, Mantso T, Mitsiogianni M, Panagiotidis MI, Dellaire G, Vasantha Rupasinghe HP.

Mutat Res. 2019 Apr - Jun;780:92-105. doi: 10.1016/j.mrrev.2018.06.001. Epub 2018 Jun 19. Review.


Inhibition of neddylation induces mitotic defects and alters MKLP1 accumulation at the midbody during cytokinesis.

Chung D, Salsman J, Dellaire G.

Cell Cycle. 2019 May;18(10):1135-1153. doi: 10.1080/15384101.2019.1612696. Epub 2019 May 5.


Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells.

Deveryshetty J, Peterlini T, Ryzhikov M, Brahiti N, Dellaire G, Masson JY, Korolev S.

Elife. 2019 Apr 29;8. pii: e44063. doi: 10.7554/eLife.44063.


An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis.

Mathavarajah S, Salsman J, Dellaire G.

Cytokine Growth Factor Rev. 2019 Dec;50:43-51. doi: 10.1016/j.cytogfr.2019.04.003. Epub 2019 Apr 2.


A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.

Castroviejo-Bermejo M, Cruz C, Llop-Guevara A, Gutiérrez-Enríquez S, Ducy M, Ibrahim YH, Gris-Oliver A, Pellegrino B, Bruna A, Guzmán M, Rodríguez O, Grueso J, Bonache S, Moles-Fernández A, Villacampa G, Viaplana C, Gómez P, Vidal M, Peg V, Serres-Créixams X, Dellaire G, Simard J, Nuciforo P, Rubio IT, Dienstmann R, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Déas O, Jonkers J, Masson JY, Cairo S, Judde JG, O'Connor MJ, Díez O, Balmaña J, Serra V.

EMBO Mol Med. 2018 Dec;10(12). pii: e9172. doi: 10.15252/emmm.201809172.


Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival.

Martin LTP, Nachtigal MW, Selman T, Nguyen E, Salsman J, Dellaire G, Dupré DJ.

Mol Cell Biochem. 2019 Apr;454(1-2):203-214. doi: 10.1007/s11010-018-3464-z. Epub 2018 Oct 22.


Angels and Devils: Dilemmas in Dual-Use Biotechnology.

Getz LJ, Dellaire G.

Trends Biotechnol. 2018 Dec;36(12):1202-1205. doi: 10.1016/j.tibtech.2018.07.016. Epub 2018 Aug 10.


Genomics and Epigenetics of Malignant Mesothelioma.

Sage AP, Martinez VD, Minatel BC, Pewarchuk ME, Marshall EA, MacAulay GM, Hubaux R, Pearson DD, Goodarzi AA, Dellaire G, Lam WL.

High Throughput. 2018 Jul 27;7(3). pii: E20. doi: 10.3390/ht7030020. Review.


Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis.

Stairs CW, Eme L, Muñoz-Gómez SA, Cohen A, Dellaire G, Shepherd JN, Fawcett JP, Roger AJ.

Elife. 2018 Apr 26;7. pii: e34292. doi: 10.7554/eLife.34292.


GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, Frank D, Khandanpour C, Hébert J, Dellaire G, Côté JF, Richard S, Orthwein A, Drobetsky E, Möröy T.

Nat Commun. 2018 Apr 12;9(1):1418. doi: 10.1038/s41467-018-03817-5.


The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

Baranes-Bachar K, Levy-Barda A, Oehler J, Reid DA, Soria-Bretones I, Voss TC, Chung D, Park Y, Liu C, Yoon JB, Li W, Dellaire G, Misteli T, Huertas P, Rothenberg E, Ramadan K, Ziv Y, Shiloh Y.

Mol Cell. 2018 Mar 1;69(5):866-878.e7. doi: 10.1016/j.molcel.2018.02.002.


Editorial: CRISPR Medicine: From Bench to Bedside.

Dellaire G.

Curr Gene Ther. 2017;17(4):261-262. doi: 10.2174/156652321704180104153508. No abstract available.


CRISPR/Cas9 Gene Editing: From Basic Mechanisms to Improved Strategies for Enhanced Genome Engineering In Vivo.

Salsman J, Masson JY, Orthwein A, Dellaire G.

Curr Gene Ther. 2017;17(4):263-274. doi: 10.2174/1566523217666171122094629. Review.


Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia.

Melong N, Steele S, MacDonald M, Holly A, Collins CC, Zoubeidi A, Berman JN, Dellaire G.

Sci Rep. 2017 Oct 31;7(1):14698. doi: 10.1038/s41598-017-14413-w.


Natural Killer T-cell Immunotherapy in Combination with Chemotherapy-Induced Immunogenic Cell Death Targets Metastatic Breast Cancer.

Gebremeskel S, Lobert L, Tanner K, Walker B, Oliphant T, Clarke LE, Dellaire G, Johnston B.

Cancer Immunol Res. 2017 Dec;5(12):1086-1097. doi: 10.1158/2326-6066.CIR-17-0229. Epub 2017 Oct 20.


TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.

Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM.

Cancer Discov. 2017 Nov;7(11):1336-1353. doi: 10.1158/2159-8290.CD-17-0267. Epub 2017 Oct 3.


Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking.

Corkery DP, Clarke LE, Gebremeskel S, Salsman J, Pinder J, Le Page C, Meunier L, Xu Z, Mes-Masson AM, Berman JN, Johnston B, Dellaire G.

Oncogene. 2018 Jan 11;37(2):174-184. doi: 10.1038/onc.2017.318. Epub 2017 Sep 11.


Marker-free coselection for CRISPR-driven genome editing in human cells.

Agudelo D, Duringer A, Bozoyan L, Huard CC, Carter S, Loehr J, Synodinou D, Drouin M, Salsman J, Dellaire G, Laganière J, Doyon Y.

Nat Methods. 2017 Jun;14(6):615-620. doi: 10.1038/nmeth.4265. Epub 2017 Apr 17.


Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres.

Salsman J, Rapkin LM, Margam NN, Duncan R, Bazett-Jones DP, Dellaire G.

Cell Death Dis. 2017 Mar 30;8(3):e2724. doi: 10.1038/cddis.2017.151.


PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4.

Salsman J, Stathakis A, Parker E, Chung D, Anthes LE, Koskowich KL, Lahsaee S, Gaston D, Kukurba KR, Smith KS, Chute IC, Léger D, Frost LD, Montgomery SB, Lewis SM, Eskiw C, Dellaire G.

Sci Rep. 2017 Mar 23;7:45038. doi: 10.1038/srep45038.


Precision genome editing in the CRISPR era.

Salsman J, Dellaire G.

Biochem Cell Biol. 2017 Apr;95(2):187-201. doi: 10.1139/bcb-2016-0137. Epub 2016 Sep 29. Review.


Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif.

Pauty J, Couturier AM, Rodrigue A, Caron MC, Coulombe Y, Dellaire G, Masson JY.

Nucleic Acids Res. 2017 Mar 17;45(5):2644-2657. doi: 10.1093/nar/gkx011.


The DNA repair function of CUX1 contributes to radioresistance.

Ramdzan ZM, Ginjala V, Pinder JB, Chung D, Donovan CM, Kaur S, Leduy L, Dellaire G, Ganesan S, Nepveu A.

Oncotarget. 2017 Mar 21;8(12):19021-19038. doi: 10.18632/oncotarget.14875.


Coupling of Homologous Recombination and the Checkpoint by ATR.

Buisson R, Niraj J, Rodrigue A, Ho CK, Kreuzer J, Foo TK, Hardy EJ, Dellaire G, Haas W, Xia B, Masson JY, Zou L.

Mol Cell. 2017 Jan 19;65(2):336-346. doi: 10.1016/j.molcel.2016.12.007. Epub 2017 Jan 12.


Plant flavonoids in cancer chemoprevention: role in genome stability.

George VC, Dellaire G, Rupasinghe HPV.

J Nutr Biochem. 2017 Jul;45:1-14. doi: 10.1016/j.jnutbio.2016.11.007. Epub 2016 Nov 28. Review.


Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.

Couturier AM, Fleury H, Patenaude AM, Bentley VL, Rodrigue A, Coulombe Y, Niraj J, Pauty J, Berman JN, Dellaire G, Di Noia JM, Mes-Masson AM, Masson JY.

Nucleic Acids Res. 2016 Dec 15;44(22):10879-10897. Epub 2016 Oct 24.


ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells.

Khan IA, Yoo BH, Masson O, Baron S, Corkery D, Dellaire G, Attardi LD, Rosen KV.

Oncogene. 2016 Nov 3;35(44):5759-5769. doi: 10.1038/onc.2016.109. Epub 2016 Apr 25.


Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models.

Rajan V, Dellaire G, Berman JN.

Methods Mol Biol. 2016;1451:171-89. doi: 10.1007/978-1-4939-3771-4_12.


The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool.

Wertman J, Veinotte CJ, Dellaire G, Berman JN.

Adv Exp Med Biol. 2016;916:289-314. doi: 10.1007/978-3-319-30654-4_13. Review.


Estrogen receptor alpha (ESR1)-signaling regulates the expression of the taxane-response biomarker PRP4K.

Lahsaee S, Corkery DP, Anthes LE, Holly A, Dellaire G.

Exp Cell Res. 2016 Jan 1;340(1):125-31. doi: 10.1016/j.yexcr.2015.12.013. Epub 2015 Dec 19.


A mechanism for the suppression of homologous recombination in G1 cells.

Orthwein A, Noordermeer SM, Wilson MD, Landry S, Enchev RI, Sherker A, Munro M, Pinder J, Salsman J, Dellaire G, Xia B, Peter M, Durocher D.

Nature. 2015 Dec 17;528(7582):422-6. doi: 10.1038/nature16142. Epub 2015 Dec 9.


The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair.

Chung D, Dellaire G.

Biomolecules. 2015 Sep 30;5(4):2388-416. doi: 10.3390/biom5042388. Review.


Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing.

Pinder J, Salsman J, Dellaire G.

Nucleic Acids Res. 2015 Oct 30;43(19):9379-92. doi: 10.1093/nar/gkv993. Epub 2015 Oct 1.


Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response.

Corkery DP, Holly AC, Lahsaee S, Dellaire G.

Nucleus. 2015;6(4):279-88. doi: 10.1080/19491034.2015.1062194. Epub 2015 Jun 22. Review.


Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.

El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH.

Cancer Cell. 2015 May 11;27(5):682-97. doi: 10.1016/j.ccell.2015.04.003.


Shigella infection interferes with SUMOylation and increases PML-NB number.

Sidik SM, Salsman J, Dellaire G, Rohde JR.

PLoS One. 2015 Apr 7;10(4):e0122585. doi: 10.1371/journal.pone.0122585. eCollection 2015.


The nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin.

Kalousi A, Hoffbeck AS, Selemenakis PN, Pinder J, Savage KI, Khanna KK, Brino L, Dellaire G, Gorgoulis VG, Soutoglou E.

Cell Rep. 2015 Apr 7;11(1):149-63. doi: 10.1016/j.celrep.2015.03.005. Epub 2015 Mar 26.


PRP4K is a HER2-regulated modifier of taxane sensitivity.

Corkery DP, Le Page C, Meunier L, Provencher D, Mes-Masson AM, Dellaire G.

Cell Cycle. 2015;14(7):1059-69. doi: 10.1080/15384101.2015.1007775.


Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair.

Klement K, Luijsterburg MS, Pinder JB, Cena CS, Del Nero V, Wintersinger CM, Dellaire G, van Attikum H, Goodarzi AA.

J Cell Biol. 2014 Dec 22;207(6):717-33. doi: 10.1083/jcb.201405077.


Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.

Liu Y, Asnani A, Zou L, Bentley VL, Yu M, Wang Y, Dellaire G, Sarkar KS, Dai M, Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W, Peterson RT.

Sci Transl Med. 2014 Dec 10;6(266):266ra170. doi: 10.1126/scitranslmed.3010189.


Nuclear position dictates DNA repair pathway choice.

Lemaître C, Grabarz A, Tsouroula K, Andronov L, Furst A, Pankotai T, Heyer V, Rogier M, Attwood KM, Kessler P, Dellaire G, Klaholz B, Reina-San-Martin B, Soutoglou E.

Genes Dev. 2014 Nov 15;28(22):2450-63. doi: 10.1101/gad.248369.114. Epub 2014 Nov 3.


Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia.

Bentley VL, Veinotte CJ, Corkery DP, Pinder JB, LeBlanc MA, Bedard K, Weng AP, Berman JN, Dellaire G.

Haematologica. 2015 Jan;100(1):70-6. doi: 10.3324/haematol.2014.110742. Epub 2014 Oct 3.


Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era.

Veinotte CJ, Dellaire G, Berman JN.

Dis Model Mech. 2014 Jul;7(7):745-54. doi: 10.1242/dmm.015784. Review.


A SUF Fe-S cluster biogenesis system in the mitochondrion-related organelles of the anaerobic protist Pygsuia.

Stairs CW, Eme L, Brown MW, Mutsaers C, Susko E, Dellaire G, Soanes DM, van der Giezen M, Roger AJ.

Curr Biol. 2014 Jun 2;24(11):1176-86. doi: 10.1016/j.cub.2014.04.033. Epub 2014 May 22.

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