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Chymase uptake by cardiomyocytes results in myosin degradation in cardiac volume overload.

Powell PC, Wei CC, Fu L, Pat B, Bradley WE, Collawn JF, Dell'Italia LJ.

Heliyon. 2019 Apr 4;5(4):e01397. doi: 10.1016/j.heliyon.2019.e01397. eCollection 2019 Apr.


Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension.

Butts B, Calhoun DA, Denney TS Jr, Lloyd SG, Gupta H, Gaddam KK, Aban I, Oparil S, Sanders PW, Patel R, Collawn JF, Dell'Italia LJ.

Free Radic Biol Med. 2019 Jan 26;134:343-349. doi: 10.1016/j.freeradbiomed.2019.01.029. [Epub ahead of print]


Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats.

Ahmad S, Masjoan Juncos JX, Ahmad A, Zaky A, Wei CC, Bradley WE, Zafar I, Powell P, Mariappan N, Vetal N, Louch WE, Ford DA, Doran SF, Matalon S, Dell'Italia LJ.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H212-H223. doi: 10.1152/ajpheart.00652.2017. Epub 2018 Oct 31.


Novel Noninvasive Assessment of Pulmonary Arterial Stiffness Using Velocity Transfer Function.

Gupta A, Sharifov OF, Lloyd SG, Tallaj JA, Aban I, Dell'italia LJ, Denney TS Jr, Gupta H.

J Am Heart Assoc. 2018 Sep 18;7(18):e009459. doi: 10.1161/JAHA.118.009459.


AKT-independent activation of p38 MAP kinase promotes vascular calcification.

Yang Y, Sun Y, Chen J, Bradley WE, Dell'Italia LJ, Wu H, Chen Y.

Redox Biol. 2018 Jun;16:97-103. doi: 10.1016/j.redox.2018.02.009. Epub 2018 Feb 21.


Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling.

Dell'Italia LJ, Collawn JF, Ferrario CM.

Circ Res. 2018 Jan 19;122(2):319-336. doi: 10.1161/CIRCRESAHA.117.310978. Review.


Left Ventricular Torsion Shear Angle Volume Approach for Noninvasive Evaluation of Diastolic Dysfunction in Preserved Ejection Fraction.

Sharifov OF, Schiros CG, Aban I, Perry GJ, Dell'italia LJ, Lloyd SG, Denney TS Jr, Gupta H.

J Am Heart Assoc. 2017 Dec 29;7(1). pii: e007039. doi: 10.1161/JAHA.117.007039.


Increased Inflammation in Pericardial Fluid Persists 48 Hours After Cardiac Surgery.

Butts B, Goeddel LA, George DJ, Steele C, Davies JE, Wei CC, Varagic J, George JF, Ferrario CM, Melby SJ, Dell'Italia LJ.

Circulation. 2017 Dec 5;136(23):2284-2286. doi: 10.1161/CIRCULATIONAHA.117.029589. No abstract available.


Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice.

Voit A, Patel V, Pachon R, Shah V, Bakhutma M, Kohlbrenner E, McArdle JJ, Dell'Italia LJ, Mendell JR, Xie LH, Hajjar RJ, Duan D, Fraidenraich D, Babu GJ.

Nat Commun. 2017 Oct 20;8(1):1068. doi: 10.1038/s41467-017-01146-7.


Dietary potassium regulates vascular calcification and arterial stiffness.

Sun Y, Byon CH, Yang Y, Bradley WE, Dell'Italia LJ, Sanders PW, Agarwal A, Wu H, Chen Y.

JCI Insight. 2017 Oct 5;2(19). pii: 94920. doi: 10.1172/jci.insight.94920.


Randomized, four-arm, dose-response clinical trial to optimize resistance exercise training for older adults with age-related muscle atrophy.

Stec MJ, Thalacker-Mercer A, Mayhew DL, Kelly NA, Tuggle SC, Merritt EK, Brown CJ, Windham ST, Dell'Italia LJ, Bickel CS, Roberts BM, Vaughn KM, Isakova-Donahue I, Many GM, Bamman MM.

Exp Gerontol. 2017 Dec 1;99:98-109. doi: 10.1016/j.exger.2017.09.018. Epub 2017 Sep 28.


Impact of VA Research on Health Care for All: Contributions Over Nine Decades and Counting.

Dell'Italia LJ.

Circ Res. 2017 Jun 23;121(1):16-18. doi: 10.1161/CIRCRESAHA.117.311152. Review. No abstract available.


Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.

Guichard JL, Rogowski M, Agnetti G, Fu L, Powell P, Wei CC, Collawn J, Dell'Italia LJ.

Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H32-H45. doi: 10.1152/ajpheart.00027.2017. Epub 2017 Apr 28.


Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease.

Reyes S, Varagic J, Ahmad S, VonCannon J, Kon ND, Wang H, Groban L, Cheng CP, Dell'Italia LJ, Ferrario CM.

Curr Hypertens Rep. 2017 Feb;19(2):16. doi: 10.1007/s11906-017-0708-3. Review.


Novel Paradigms of Salt and Hypertension.

Feng W, Dell'Italia LJ, Sanders PW.

J Am Soc Nephrol. 2017 May;28(5):1362-1369. doi: 10.1681/ASN.2016080927. Epub 2017 Feb 20. Review.


Catheter-directed treatment for acute pulmonary embolism: Systematic review and single-arm meta-analyses.

Bajaj NS, Kalra R, Arora P, Ather S, Guichard JL, Lancaster WJ, Patel N, Raman F, Arora G, Al Solaiman F, Clark DT 3rd, Dell'Italia LJ, Leesar MA, Davies JE, McGiffin DC, Ahmed MI.

Int J Cardiol. 2016 Dec 15;225:128-139. doi: 10.1016/j.ijcard.2016.09.036. Epub 2016 Sep 20. Review.


Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.

Li M, Tejada T, Lambert JP, Nicholson CK, Yahiro E, Ambai VT, Ali SF, Bradley EW, Graham RM, Dell'Italia LJ, Calvert JW, Naqvi N.

Am J Cardiovasc Dis. 2016 Sep 15;6(3):118-28. eCollection 2016.


Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme.

Ahmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CM.

Biochem Biophys Res Commun. 2016 Sep 16;478(2):559-64. doi: 10.1016/j.bbrc.2016.07.100. Epub 2016 Jul 25.


Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function.

Ahmed MI, Guichard JL, Soorappan RN, Ahmad S, Mariappan N, Litovsky S, Gupta H, Lloyd SG, Denney TS, Powell PC, Aban I, Collawn J, Davies JE, McGiffin DC, Dell'Italia LJ.

J Thorac Cardiovasc Surg. 2016 Oct;152(4):1059-1070.e2. doi: 10.1016/j.jtcvs.2016.06.017. Epub 2016 Jun 25.


A graph theoretic approach for computing 3D+time biventricular cardiac strain from tagged MRI data.

Li M, Gupta H, Lloyd SG, Dell'Italia LJ, Denney TS Jr.

Med Image Anal. 2017 Jan;35:46-57. doi: 10.1016/ Epub 2016 Jun 11.


TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.

Chen J, Young ME, Chatham JC, Crossman DK, Dell'Italia LJ, Shalev A.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H64-75. doi: 10.1152/ajpheart.00151.2016. Epub 2016 May 3.


Regional Heterogeneity in 3D Myocardial Shortening in Hypertensive Left Ventricular Hypertrophy: A Cardiovascular CMR Tagging Substudy to the Life Study.

Biederman RW, Young AA, Doyle M, Devereux RB, Kortright E, Perry G, Bella JN, Oparil S, Calhoun D, Pohost GM, Dell'Italia LJ.

J Biomed Sci Eng. 2015 Mar 1;8(3):213-225. Epub 2015 Mar 26.


Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene.

Ferrario CM, VonCannon J, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic J.

Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H995-1002. doi: 10.1152/ajpheart.00833.2015. Epub 2016 Feb 12.


Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload.

Fu L, Wei CC, Powell PC, Bradley WE, Ahmad S, Ferrario CM, Collawn JF, Dell'Italia LJ.

J Mol Cell Cardiol. 2016 Mar;92:1-9. doi: 10.1016/j.yjmcc.2016.01.019. Epub 2016 Jan 22.


TLR4 regulates pulmonary vascular homeostasis and remodeling via redox signaling.

Ma L, Ambalavanan N, Liu H, Sun Y, Jhala N, Bradley WE, Dell'Italia LJ, Michalek S, Wu H, Steele C, Benza RL, Chen Y.

Front Biosci (Landmark Ed). 2016 Jan 1;21:397-409.


Inhaled matters of the heart.

Zaky A, Ahmad A, Dell'Italia LJ, Jahromi L, Reisenberg LA, Matalon S, Ahmad S.

Cardiovasc Regen Med. 2015;2. pii: e997. Epub 2015 Sep 20.


Mitral Annular Kinetics, Left Atrial, and Left Ventricular Diastolic Function Post Mitral Valve Repair in Degenerative Mitral Regurgitation.

Schiros CG, Ahmed MI, McGiffin DC, Zhang X, Lloyd SG, Aban I, Denney TS Jr, Dell'Italia LJ, Gupta H.

Front Cardiovasc Med. 2015 Aug 17;2:31. doi: 10.3389/fcvm.2015.00031. eCollection 2015.


Improved Right Ventricular Performance with Increased Tricuspid Annular Excursion in Athlete's Heart.

Zha W, Schiros CG, Reddy G, Feng W, Denney TS Jr, Lloyd SG, Dell'Italia LJ, Gupta H.

Front Cardiovasc Med. 2015 Apr 30;2:8. doi: 10.3389/fcvm.2015.00008. eCollection 2015.


Volume overload induces autophagic degradation of procollagen in cardiac fibroblasts.

Fu L, Wei CC, Powell PC, Bradley WE, Collawn JF, Dell'Italia LJ.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):241-250. doi: 10.1016/j.yjmcc.2015.10.027. Epub 2015 Oct 24.


Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes.

Goh KY, Qu J, Hong H, Liu T, Dell'Italia LJ, Wu Y, O'Rourke B, Zhou L.

Cardiovasc Res. 2016 Jan 1;109(1):79-89. doi: 10.1093/cvr/cvv230. Epub 2015 Oct 3.


Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients.

Kramer PA, Chacko BK, George DJ, Zhi D, Wei CC, Dell'Italia LJ, Melby SJ, George JF, Darley-Usmar VM.

Biosci Rep. 2015 Jul 1;35(4). pii: e00237. doi: 10.1042/BSR20150161.


Chlorine inhalation-induced myocardial depression and failure.

Zaky A, Bradley WE, Lazrak A, Zafar I, Doran S, Ahmad A, White CW, Dell'Italia LJ, Matalon S, Ahmad S.

Physiol Rep. 2015 Jun;3(6). pii: e12439. doi: 10.14814/phy2.12439.


Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.

Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM.

Ther Adv Cardiovasc Dis. 2015 Aug;9(4):168-80. doi: 10.1177/1753944715589717. Epub 2015 Jun 16.


Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary disease.

Wells JM, Iyer AS, Rahaghi FN, Bhatt SP, Gupta H, Denney TS, Lloyd SG, Dell'Italia LJ, Nath H, Estepar RS, Washko GR, Dransfield MT.

Circ Cardiovasc Imaging. 2015 Apr;8(4). pii: e002546. doi: 10.1161/CIRCIMAGING.114.002546.


Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload.

Yancey DM, Guichard JL, Ahmed MI, Zhou L, Murphy MP, Johnson MS, Benavides GA, Collawn J, Darley-Usmar V, Dell'Italia LJ.

Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H651-63. doi: 10.1152/ajpheart.00638.2014. Epub 2015 Jan 16.


3D+time left ventricular strain by unwrapping harmonic phase with graph cuts.

Li M, Gupta H, Lloyd SG, Dell'Italia LJ, Denney TS.

Med Image Comput Comput Assist Interv. 2014;17(Pt 2):578-85.


Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy.

Trappanese DM, Liu Y, McCormick RC, Cannavo A, Nanayakkara G, Baskharoun MM, Jarrett H, Woitek FJ, Tillson DM, Dillon AR, Recchia FA, Balligand JL, Houser SR, Koch WJ, Dell'Italia LJ, Tsai EJ.

Basic Res Cardiol. 2015 Jan;110(1):456. doi: 10.1007/s00395-014-0456-3. Epub 2014 Dec 6.


Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patients.

Kramer PA, Chacko BK, Ravi S, Johnson MS, Mitchell T, Barnes S, Arabshahi A, Dell'Italia LJ, George DJ, Steele C, George JF, Darley-Usmar VM, Melby SJ.

Lab Invest. 2015 Feb;95(2):132-41. doi: 10.1038/labinvest.2014.144. Epub 2014 Dec 1.


Left ventricular twist and shear in patients with primary mitral regurgitation.

Reyhan M, Wang Z, Li M, Kim HJ, Gupta H, Lloyd SG, Dell'Italia LJ, Denney T, Ennis DB.

J Magn Reson Imaging. 2015 Aug;42(2):400-6. doi: 10.1002/jmri.24811. Epub 2014 Nov 19.


Left ventricular torsion shear angle volume analysis in patients with hypertension: a global approach for LV diastolic function.

Schiros CG, Desai RV, Venkatesh BA, Gaddam KK, Agarwal S, Lloyd SG, Calhoun DA, Denney TS Jr, Dell'italia LJ, Gupta H.

J Cardiovasc Magn Reson. 2014 Sep 26;16:70. doi: 10.1186/s12968-014-0070-4.


Early exposure to hyperoxia or hypoxia adversely impacts cardiopulmonary development.

Ramani M, Bradley WE, Dell'Italia LJ, Ambalavanan N.

Am J Respir Cell Mol Biol. 2015 May;52(5):594-602. doi: 10.1165/rcmb.2013-0491OC.


Effect of spironolactone on diastolic function in hypertensive left ventricular hypertrophy.

Gupta A, Schiros CG, Gaddam KK, Aban I, Denney TS, Lloyd SG, Oparil S, Dell'Italia LJ, Calhoun DA, Gupta H.

J Hum Hypertens. 2015 Apr;29(4):241-6. doi: 10.1038/jhh.2014.83. Epub 2014 Sep 18.


High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats.

Liu J, Wang P, Zou L, Qu J, Litovsky S, Umeda P, Zhou L, Chatham J, Marsh SA, Dell'Italia LJ, Lloyd SG.

Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H598-608. doi: 10.1152/ajpheart.00058.2014. Epub 2014 Jun 13.


The multiple mechanistic faces of a pure volume overload: implications for therapy.

Barnes J, DellʼItalia LJ.

Am J Med Sci. 2014 Oct;348(4):337-46. doi: 10.1097/MAJ.0000000000000255. Review.


Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature.

Honavar J, Bradley E, Bradley K, Oh JY, Vallejo MO, Kelley EE, Cantu-Medellin N, Doran S, Dell'italia LJ, Matalon S, Patel RP.

Toxicology. 2014 Jul 3;321:96-102. doi: 10.1016/j.tox.2014.04.005. Epub 2014 Apr 24.


Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog.

Zheng J, Wei CC, Hase N, Shi K, Killingsworth CR, Litovsky SH, Powell PC, Kobayashi T, Ferrario CM, Rab A, Aban I, Collawn JF, Dell'Italia LJ.

PLoS One. 2014 Apr 14;9(4):e94732. doi: 10.1371/journal.pone.0094732. eCollection 2014.


Whole-genome profiling highlights the molecular complexity underlying eccentric cardiac hypertrophy.

Barnes J, Pat B, Chen YW, Powell PC, Bradley WE, Zheng J, Karki A, Cui X, Guichard J, Wei CC, Collawn J, Dell'Italia LJ.

Ther Adv Cardiovasc Dis. 2014 Jun 1;8(3):97-118. Epub 2014 Mar 31.


Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate.

Ahmad S, Varagic J, Groban L, Dell'Italia LJ, Nagata S, Kon ND, Ferrario CM.

Curr Hypertens Rep. 2014 May;16(5):429. doi: 10.1007/s11906-014-0429-9. Review.


Activation of AKT by O-linked N-acetylglucosamine induces vascular calcification in diabetes mellitus.

Heath JM, Sun Y, Yuan K, Bradley WE, Litovsky S, Dell'Italia LJ, Chatham JC, Wu H, Chen Y.

Circ Res. 2014 Mar 28;114(7):1094-102. doi: 10.1161/CIRCRESAHA.114.302968. Epub 2014 Feb 13.


An evolving story of angiotensin-II-forming pathways in rodents and humans.

Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJ.

Clin Sci (Lond). 2014 Apr;126(7):461-9. doi: 10.1042/CS20130400. Review.

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