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Items: 42


Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy.

Mcilroy GD, Mitchell SE, Han W, Delibegović M, Rochford JJ.

Dis Model Mech. 2020 Jan 17;13(1). pii: dmm042655. doi: 10.1242/dmm.042655.


Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia.

Hull C, Dekeryte R, Koss DJ, Crouch B, Buchanan H, Delibegovic M, Platt B.

Mol Neurobiol. 2020 Jan;57(1):539-550. doi: 10.1007/s12035-019-01722-6. Epub 2019 Aug 8.


Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice.

Dekeryte R, Hull C, Plucińska K, Khan S, Kamli-Salino S, Mody N, Morrice N, McLaughlin C, Gault V, Platt B, Delibegovic M.

Biochem Pharmacol. 2019 Aug;166:222-230. doi: 10.1016/j.bcp.2019.05.020. Epub 2019 May 16.


Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet.

Mcilroy GD, Mitchell SE, Han W, Delibegović M, Rochford JJ.

Sci Rep. 2018 Dec 14;8(1):17863. doi: 10.1038/s41598-018-36078-9.


Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease.

Mcilroy GD, Suchacki K, Roelofs AJ, Yang W, Fu Y, Bai B, Wallace RJ, De Bari C, Cawthorn WP, Han W, Delibegović M, Rochford JJ.

Mol Metab. 2018 Apr;10:55-65. doi: 10.1016/j.molmet.2018.01.019. Epub 2018 Jan 31.


Response to comment by Moxon et al.

Thompson D, Morrice N, Grant L, Le Sommer S, Lees EK, Mody N, Wilson HM, Delibegovic M.

Clin Sci (Lond). 2018 Jan 2;132(1):39-41. doi: 10.1042/CS20171555. Print 2018 Jan 16. No abstract available.


Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia.

Le Sommer S, Morrice N, Pesaresi M, Thompson D, Vickers MA, Murray GI, Mody N, Neel BG, Bence KK, Wilson HM, Delibegović M.

Cancer Res. 2018 Jan 1;78(1):75-87. doi: 10.1158/0008-5472.CAN-17-0946. Epub 2017 Nov 9.


Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis.

Thompson D, Morrice N, Grant L, Le Sommer S, Lees EK, Mody N, Wilson HM, Delibegovic M.

Clin Sci (Lond). 2017 Sep 28;131(20):2489-2501. doi: 10.1042/CS20171066. Print 2017 Oct 1.


Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice.

Lees EK, Banks R, Cook C, Hill S, Morrice N, Grant L, Mody N, Delibegovic M.

Sci Rep. 2017 Aug 30;7(1):9977. doi: 10.1038/s41598-017-10381-3.


Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKα pathway.

Thompson D, Morrice N, Grant L, Le Sommer S, Ziegler K, Whitfield P, Mody N, Wilson HM, Delibegović M.

Mol Metab. 2017 Jun 13;6(8):845-853. doi: 10.1016/j.molmet.2017.06.003. eCollection 2017 Aug.


Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.

Morrice N, Mcilroy GD, Tammireddy SR, Reekie J, Shearer KD, Doherty MK, Delibegović M, Whitfield PD, Mody N.

Sci Rep. 2017 Mar 3;7:43782. doi: 10.1038/srep43782.


Methionine restriction improves renal insulin signalling in aged kidneys.

Grant L, Lees EK, Forney LA, Mody N, Gettys T, Brown PA, Wilson HM, Delibegovic M.

Mech Ageing Dev. 2016 Jul;157:35-43. doi: 10.1016/j.mad.2016.07.003. Epub 2016 Jul 21.


Neuronal human BACE1 knockin induces systemic diabetes in mice.

Plucińska K, Dekeryte R, Koss D, Shearer K, Mody N, Whitfield PD, Doherty MK, Mingarelli M, Welch A, Riedel G, Delibegovic M, Platt B.

Diabetologia. 2016 Jul;59(7):1513-1523. doi: 10.1007/s00125-016-3960-1. Epub 2016 May 2.


Photoperiod- and Triiodothyronine-dependent Regulation of Reproductive Neuropeptides, Proinflammatory Cytokines, and Peripheral Physiology in Siberian Hamsters (Phodopus sungorus).

Banks R, Delibegovic M, Stevenson TJ.

J Biol Rhythms. 2016 Jun;31(3):299-307. doi: 10.1177/0748730416637707. Epub 2016 Mar 16.


Executive functions predict conceptual learning of science.

Rhodes SM, Booth JN, Palmer LE, Blythe RA, Delibegovic M, Wheate NJ.

Br J Dev Psychol. 2016 Jun;34(2):261-75. doi: 10.1111/bjdp.12129. Epub 2016 Jan 11.


Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue.

Mcilroy GD, Tammireddy SR, Maskrey BH, Grant L, Doherty MK, Watson DG, Delibegović M, Whitfield PD, Mody N.

Biochem Pharmacol. 2016 Jan 15;100:86-97. doi: 10.1016/j.bcp.2015.11.017. Epub 2015 Nov 22.


Intramural Haemorrhage and Haematoma as the Cause of Ileus of the Small Intestine in a Haemophiliac.

Delibegovic M, Alispahic A, Gazija J, Mehmedovic Z, Mehmedovic M.

Med Arch. 2015 Jun;69(3):206-7. doi: 10.5455/medarh.2015.69.206-207. Epub 2015 Jun 10.


Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen signaling.

Shearer KD, Morrice N, Henderson C, Reekie J, Mcilroy GD, McCaffery PJ, Delibegovic M, Mody N.

Obesity (Silver Spring). 2015 Aug;23(8):1655-62. doi: 10.1002/oby.21164. Epub 2015 Jul 14.


A key role for PTP1B in dendritic cell maturation, migration, and T cell activation.

Martin-Granados C, Prescott AR, Le Sommer S, Klaska IP, Yu T, Muckersie E, Giuraniuc CV, Grant L, Delibegovic M, Forrester JV.

J Mol Cell Biol. 2015 Dec;7(6):517-28. doi: 10.1093/jmcb/mjv032. Epub 2015 Jun 10.


Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice.

Lees EK, Krol E, Shearer K, Mody N, Gettys TW, Delibegovic M.

Metabolism. 2015 Feb;64(2):305-14. doi: 10.1016/j.metabol.2014.10.038. Epub 2014 Nov 5.


Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction.

Agouni A, Tual-Chalot S, Chalopin M, Duluc L, Mody N, Martinez MC, Andriantsitohaina R, Delibegović M.

Biochem Pharmacol. 2014 Dec 15;92(4):607-17. doi: 10.1016/j.bcp.2014.10.008. Epub 2014 Oct 30.


Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B.

Owen C, Lees EK, Mody N, Delibegović M.

Diabetes Metab. 2015 Feb;41(1):95-101. doi: 10.1016/j.diabet.2014.02.008. Epub 2014 Jun 16.


Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.

Lees EK, Król E, Grant L, Shearer K, Wyse C, Moncur E, Bykowska AS, Mody N, Gettys TW, Delibegovic M.

Aging Cell. 2014 Oct;13(5):817-27. doi: 10.1111/acel.12238. Epub 2014 Jun 17.


Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism.

Grant L, Shearer KD, Czopek A, Lees EK, Owen C, Agouni A, Workman J, Martin-Granados C, Forrester JV, Wilson HM, Mody N, Delibegovic M.

Diabetes. 2014 Feb;63(2):456-70. doi: 10.2337/db13-0885. Epub 2013 Nov 1.


Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice.

Owen C, Lees EK, Grant L, Zimmer DJ, Mody N, Bence KK, Delibegović M.

Diabetologia. 2013 Oct;56(10):2286-96. doi: 10.1007/s00125-013-2992-z. Epub 2013 Jul 6.


Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus.

Mcilroy GD, Delibegovic M, Owen C, Stoney PN, Shearer KD, McCaffery PJ, Mody N.

Diabetes. 2013 Mar;62(3):825-36. doi: 10.2337/db12-0458. Epub 2012 Nov 27.


Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.

Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Göransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegović M.

PLoS One. 2012;7(2):e32700. doi: 10.1371/journal.pone.0032700. Epub 2012 Feb 28.


Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice.

Agouni A, Ducluzeau PH, Benameur T, Faure S, Sladkova M, Duluc L, Leftheriotis G, Pechanova O, Delibegovic M, Martinez MC, Andriantsitohaina R.

PLoS One. 2011;6(11):e27809. doi: 10.1371/journal.pone.0027809. Epub 2011 Nov 15.


Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress.

Agouni A, Mody N, Owen C, Czopek A, Zimmer D, Bentires-Alj M, Bence KK, Delibegović M.

Biochem J. 2011 Sep 1;438(2):369-78. doi: 10.1042/BJ20110373.


Non-invasive ultrasound guided compression repair of post puncture femoral pseudoaneurysm.

Latic A, Delibegovic M, Pudic I, Latic F, Samardzic J, Karmela R.

Med Arh. 2011;65(2):113-4.


Succcessful laparoscopic treatment of cholecystoduodenal fistula.

Latic A, Latic F, Delibegovic M, Samardzic J, Kraljik D, Delibegovic S.

Med Arh. 2010;64(6):379-80.


Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2.

Matsuo K, Delibegovic M, Matsuo I, Nagata N, Liu S, Bettaieb A, Xi Y, Araki K, Yang W, Kahn BB, Neel BG, Haj FG.

J Biol Chem. 2010 Dec 17;285(51):39750-8. doi: 10.1074/jbc.M110.153734. Epub 2010 Sep 14.


In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues.

Agouni A, Owen C, Czopek A, Mody N, Delibegovic M.

Biochem Biophys Res Commun. 2010 Oct 8;401(1):104-11. doi: 10.1016/j.bbrc.2010.09.018. Epub 2010 Sep 15.


Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.

Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB.

Mol Cell Biol. 2009 Aug;29(16):4563-73. doi: 10.1128/MCB.01914-08. Epub 2009 Jun 15.


Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.

Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK.

Diabetes. 2009 Mar;58(3):590-9. doi: 10.2337/db08-0913. Epub 2008 Dec 15.


Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG.

Mol Cell Biol. 2007 Nov;27(21):7727-34. Epub 2007 Aug 27.


Neuronal PTP1B regulates body weight, adiposity and leptin action.

Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB.

Nat Med. 2006 Aug;12(8):917-24. Epub 2006 Jul 16. Erratum in: Nat Med. 2010 Feb;16(2):237.


Assay of protein phosphatase 1 complexes.

Cohen PT, Browne GJ, Delibegovic M, Munro S.

Methods Enzymol. 2003;366:135-44. No abstract available.


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