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The meningococcal vaccine antigen GNA2091 is an analogue of YraP and plays key roles in outer membrane stability and virulence.

Seib KL, Haag AF, Oriente F, Fantappiè L, Borghi S, Semchenko EA, Schulz BL, Ferlicca F, Taddei AR, Giuliani MM, Pizza M, Delany I.

FASEB J. 2019 Aug 23:fj201900669R. doi: 10.1096/fj.201900669R. [Epub ahead of print]


Absence of Protein A Expression Is Associated With Higher Capsule Production in Staphylococcal Isolates.

Brignoli T, Manetti AGO, Rosini R, Haag AF, Scarlato V, Bagnoli F, Delany I.

Front Microbiol. 2019 May 10;10:863. doi: 10.3389/fmicb.2019.00863. eCollection 2019.


Neisseria Heparin Binding Antigen is targeted by the human alternative pathway C3-convertase.

Di Fede M, Biagini M, Cartocci E, Parillo C, Greco A, Martinelli M, Marchi S, Pezzicoli A, Delany I, Rossi Paccani S.

PLoS One. 2018 Mar 26;13(3):e0194662. doi: 10.1371/journal.pone.0194662. eCollection 2018.


Outer Membrane Vesicles (OMV)-based and Proteomics-driven Antigen Selection Identifies Novel Factors Contributing to Bordetella pertussis Adhesion to Epithelial Cells.

Gasperini G, Biagini M, Arato V, Gianfaldoni C, Vadi A, Norais N, Bensi G, Delany I, Pizza M, Aricò B, Leuzzi R.

Mol Cell Proteomics. 2018 Feb;17(2):205-215. doi: 10.1074/mcp.RA117.000045. Epub 2017 Dec 4.


In Vivo Analysis of Staphylococcus aureus-Infected Mice Reveals Differential Temporal and Spatial Expression Patterns of fhuD2.

Bacconi M, Haag AF, Chiarot E, Donato P, Bagnoli F, Delany I, Bensi G.

Infect Immun. 2017 Sep 20;85(10). pii: e00270-17. doi: 10.1128/IAI.00270-17. Print 2017 Oct.


Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1.

Marini A, Rossi O, Aruta MG, Micoli F, Rondini S, Guadagnuolo S, Delany I, Henderson IR, Cunningham AF, Saul A, MacLennan CA, Koeberling O.

PLoS One. 2017 Jul 25;12(7):e0181508. doi: 10.1371/journal.pone.0181508. eCollection 2017.


Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells.

Vacca I, Del Tordello E, Gasperini G, Pezzicoli A, Di Fede M, Rossi Paccani S, Marchi S, Mubaiwa TD, Hartley-Tassell LE, Jennings MP, Seib KL, Masignani V, Pizza M, Serruto D, Aricò B, Delany I.

PLoS One. 2016 Oct 25;11(10):e0162878. doi: 10.1371/journal.pone.0162878. eCollection 2016.


The Phosphocarrier Protein HPr Contributes to Meningococcal Survival during Infection.

Antunes A, Derkaoui M, Terrade A, Denizon M, Deghmane AE, Deutscher J, Delany I, Taha MK.

PLoS One. 2016 Sep 21;11(9):e0162434. doi: 10.1371/journal.pone.0162434. eCollection 2016.


Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA.

Liguori A, Malito E, Lo Surdo P, Fagnocchi L, Cantini F, Haag AF, Brier S, Pizza M, Delany I, Bottomley MJ.

PLoS Pathog. 2016 Apr 22;12(4):e1005557. doi: 10.1371/journal.ppat.1005557. eCollection 2016 Apr.


Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.

Biagini M, Spinsanti M, De Angelis G, Tomei S, Ferlenghi I, Scarselli M, Rigat F, Messuti N, Biolchi A, Muzzi A, Anderloni G, Brunelli B, Cartocci E, Buricchi F, Tani C, Stella M, Moschioni M, Del Tordello E, Colaprico A, Savino S, Giuliani MM, Delany I, Pizza M, Costantino P, Norais N, Rappuoli R, Masignani V.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2714-9. doi: 10.1073/pnas.1521142113. Epub 2016 Feb 17.


A stable luciferase reporter plasmid for in vivo imaging in murine models of Staphylococcus aureus infections.

Bacconi M, Haag AF, Torre A, Castagnetti A, Chiarot E, Delany I, Bensi G.

Appl Microbiol Biotechnol. 2016 Apr;100(7):3197-206. doi: 10.1007/s00253-015-7229-2. Epub 2015 Dec 21.


HexR Controls Glucose-Responsive Genes and Central Carbon Metabolism in Neisseria meningitidis.

Antunes A, Golfieri G, Ferlicca F, Giuliani MM, Scarlato V, Delany I.

J Bacteriol. 2015 Dec 7;198(4):644-54. doi: 10.1128/JB.00659-15.


Global transcriptome analysis reveals small RNAs affecting Neisseria meningitidis bacteremia.

Fagnocchi L, Bottini S, Golfieri G, Fantappiè L, Ferlicca F, Antunes A, Guadagnuolo S, Del Tordello E, Siena E, Serruto D, Scarlato V, Muzzi A, Delany I.

PLoS One. 2015 May 7;10(5):e0126325. doi: 10.1371/journal.pone.0126325. eCollection 2015.


Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein.

Donnarumma D, Golfieri G, Brier S, Castagnini M, Veggi D, Bottomley MJ, Delany I, Norais N.

FASEB J. 2015 Jun;29(6):2260-7. doi: 10.1096/fj.14-263954. Epub 2015 Feb 20.


Vaccines for the 21st century.

Delany I, Rappuoli R, De Gregorio E.

EMBO Mol Med. 2014 Jun;6(6):708-20. doi: 10.1002/emmm.201403876. Epub 2014 Apr 6. Review.


Vaccines, reverse vaccinology, and bacterial pathogenesis.

Delany I, Rappuoli R, Seib KL.

Cold Spring Harb Perspect Med. 2013 May 1;3(5):a012476. doi: 10.1101/cshperspect.a012476.


Transcriptional regulation of the nadA gene in Neisseria meningitidis impacts the prediction of coverage of a multicomponent meningococcal serogroup B vaccine.

Fagnocchi L, Biolchi A, Ferlicca F, Boccadifuoco G, Brunelli B, Brier S, Norais N, Chiarot E, Bensi G, Kroll JS, Pizza M, Donnelly J, Giuliani MM, Delany I.

Infect Immun. 2013 Feb;81(2):560-9. doi: 10.1128/IAI.01085-12. Epub 2012 Dec 10.


Structural insight into the mechanism of DNA-binding attenuation of the Neisserial adhesin repressor NadR by the small natural ligand 4-hydroxyphenylacetic acid.

Brier S, Fagnocchi L, Donnarumma D, Scarselli M, Rappuoli R, Nissum M, Delany I, Norais N.

Biochemistry. 2012 Aug 28;51(34):6738-52. Epub 2012 Aug 15.


In the NadR regulon, adhesins and diverse meningococcal functions are regulated in response to signals in human saliva.

Fagnocchi L, Pigozzi E, Scarlato V, Delany I.

J Bacteriol. 2012 Jan;194(2):460-74. doi: 10.1128/JB.06161-11. Epub 2011 Nov 11.


The Streptococcus pneumoniae pilus-1 displays a biphasic expression pattern.

De Angelis G, Moschioni M, Muzzi A, Pezzicoli A, Censini S, Delany I, Lo Sapio M, Sinisi A, Donati C, Masignani V, Barocchi MA.

PLoS One. 2011;6(6):e21269. doi: 10.1371/journal.pone.0021269. Epub 2011 Jun 22.


A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44.

Seib KL, Pigozzi E, Muzzi A, Gawthorne JA, Delany I, Jennings MP, Rappuoli R.

FASEB J. 2011 Oct;25(10):3622-33. doi: 10.1096/fj.11-183590. Epub 2011 Jun 16.


Identification of the in vitro target of an iron-responsive AraC-like protein from Neisseria meningitidis that is in a regulatory cascade with Fur.

Fantappiè L, Scarlato V, Delany I.

Microbiology. 2011 Aug;157(Pt 8):2235-47. doi: 10.1099/mic.0.048033-0. Epub 2011 May 20.


A novel Hfq-dependent sRNA that is under FNR control and is synthesized in oxygen limitation in Neisseria meningitidis.

Fantappiè L, Oriente F, Muzzi A, Serruto D, Scarlato V, Delany I.

Mol Microbiol. 2011 Apr;80(2):507-23. doi: 10.1111/j.1365-2958.2011.07592.x. Epub 2011 Mar 7.


Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection.

Seib KL, Oriente F, Adu-Bobie J, Montanari P, Ferlicca F, Giuliani MM, Rappuoli R, Pizza M, Delany I.

Vaccine. 2010 Mar 11;28(12):2416-27. doi: 10.1016/j.vaccine.2009.12.082. Epub 2010 Jan 10.


A novel phase variation mechanism in the meningococcus driven by a ligand-responsive repressor and differential spacing of distal promoter elements.

Metruccio MM, Pigozzi E, Roncarati D, Berlanda Scorza F, Norais N, Hill SA, Scarlato V, Delany I.

PLoS Pathog. 2009 Dec;5(12):e1000710. doi: 10.1371/journal.ppat.1000710. Epub 2009 Dec 24.


Expression of factor H binding protein of meningococcus responds to oxygen limitation through a dedicated FNR-regulated promoter.

Oriente F, Scarlato V, Delany I.

J Bacteriol. 2010 Feb;192(3):691-701. doi: 10.1128/JB.01308-09. Epub 2009 Nov 30.


Growth phase and metal-dependent transcriptional regulation of the fecA genes in Helicobacter pylori.

Danielli A, Romagnoli S, Roncarati D, Costantino L, Delany I, Scarlato V.

J Bacteriol. 2009 Jun;191(11):3717-25. doi: 10.1128/JB.01741-08. Epub 2009 Apr 3.


The RNA chaperone Hfq is involved in stress response and virulence in Neisseria meningitidis and is a pleiotropic regulator of protein expression.

Fantappiè L, Metruccio MM, Seib KL, Oriente F, Cartocci E, Ferlicca F, Giuliani MM, Scarlato V, Delany I.

Infect Immun. 2009 May;77(5):1842-53. doi: 10.1128/IAI.01216-08. Epub 2009 Feb 17.


The Hfq-dependent small noncoding RNA NrrF directly mediates Fur-dependent positive regulation of succinate dehydrogenase in Neisseria meningitidis.

Metruccio MM, Fantappiè L, Serruto D, Muzzi A, Roncarati D, Donati C, Scarlato V, Delany I.

J Bacteriol. 2009 Feb;191(4):1330-42. doi: 10.1128/JB.00849-08. Epub 2008 Dec 5.


OxyR tightly regulates catalase expression in Neisseria meningitidis through both repression and activation mechanisms.

Ieva R, Roncarati D, Metruccio MM, Seib KL, Scarlato V, Delany I.

Mol Microbiol. 2008 Dec;70(5):1152-65. doi: 10.1111/j.1365-2958.2008.06468.x.


Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37.

Seib KL, Serruto D, Oriente F, Delany I, Adu-Bobie J, Veggi D, Aricò B, Rappuoli R, Pizza M.

Infect Immun. 2009 Jan;77(1):292-9. doi: 10.1128/IAI.01071-08. Epub 2008 Oct 13.


Transcriptional regulation of stress response and motility functions in Helicobacter pylori is mediated by HspR and HrcA.

Roncarati D, Danielli A, Spohn G, Delany I, Scarlato V.

J Bacteriol. 2007 Oct;189(20):7234-43. Epub 2007 Aug 10.


Expression, purification and characterization of the membrane-associated HrcA repressor protein of Helicobacter pylori.

Roncarati D, Spohn G, Tango N, Danielli A, Delany I, Scarlato V.

Protein Expr Purif. 2007 Feb;51(2):267-75. Epub 2006 Aug 17.


In vivo dissection of the Helicobacter pylori Fur regulatory circuit by genome-wide location analysis.

Danielli A, Roncarati D, Delany I, Chiarini V, Rappuoli R, Scarlato V.

J Bacteriol. 2006 Jul;188(13):4654-62.


Effect of Neisseria meningitidis fur mutations on global control of gene transcription.

Delany I, Grifantini R, Bartolini E, Rappuoli R, Scarlato V.

J Bacteriol. 2006 Apr;188(7):2483-92.


In vitro analysis of protein-operator interactions of the NikR and fur metal-responsive regulators of coregulated genes in Helicobacter pylori.

Delany I, Ieva R, Soragni A, Hilleringmann M, Rappuoli R, Scarlato V.

J Bacteriol. 2005 Nov;187(22):7703-15.


Phosphate flow in the chemotactic response system of Helicobacter pylori.

Jiménez-Pearson MA, Delany I, Scarlato V, Beier D.

Microbiology. 2005 Oct;151(Pt 10):3299-311.


CrgA is an inducible LysR-type regulator of Neisseria meningitidis, acting both as a repressor and as an activator of gene transcription.

Ieva R, Alaimo C, Delany I, Spohn G, Rappuoli R, Scarlato V.

J Bacteriol. 2005 May;187(10):3421-30.


Characterization of a novel Neisseria meningitidis Fur and iron-regulated operon required for protection from oxidative stress: utility of DNA microarray in the assignment of the biological role of hypothetical genes.

Grifantini R, Frigimelica E, Delany I, Bartolini E, Giovinazzi S, Balloni S, Agarwal S, Galli G, Genco C, Grandi G.

Mol Microbiol. 2004 Nov;54(4):962-79.


Dual control of Helicobacter pylori heat shock gene transcription by HspR and HrcA.

Spohn G, Danielli A, Roncarati D, Delany I, Rappuoli R, Scarlato V.

J Bacteriol. 2004 May;186(10):2956-65.


The iron-responsive regulator fur is transcriptionally autoregulated and not essential in Neisseria meningitidis.

Delany I, Ieva R, Alaimo C, Rappuoli R, Scarlato V.

J Bacteriol. 2003 Oct;185(20):6032-41.


Autoregulation of Helicobacter pylori Fur revealed by functional analysis of the iron-binding site.

Delany I, Spohn G, Pacheco AB, Ieva R, Alaimo C, Rappuoli R, Scarlato V.

Mol Microbiol. 2002 Nov;46(4):1107-22.


Characterization of the HspR-mediated stress response in Helicobacter pylori.

Spohn G, Delany I, Rappuoli R, Scarlato V.

J Bacteriol. 2002 Jun;184(11):2925-30.

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