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The generation of enlarged eroded pores upon existing intracortical canals is a major contributor to endocortical trabecularization.

Andreasen CM, Bakalova LP, Brüel A, Hauge EM, Kiil BJ, Delaisse JM, Kersh ME, Thomsen JS, Andersen TL.

Bone. 2019 Nov 2;130:115127. doi: 10.1016/j.bone.2019.115127. [Epub ahead of print]


Coordination of Fusion and Trafficking of Pre-osteoclasts at the Marrow-Bone Interface.

Søe K, Andersen TL, Hinge M, Rolighed L, Marcussen N, Delaisse JM.

Calcif Tissue Int. 2019 Oct;105(4):430-445. doi: 10.1007/s00223-019-00575-4. Epub 2019 Jun 25.


An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice.

Panwar P, Xue L, Søe K, Srivastava K, Law S, Delaisse JM, Brömme D.

J Bone Miner Res. 2019 Apr;34(4):777-778. doi: 10.1002/jbmr.3687. Epub 2019 Mar 25. No abstract available.


Catabolic activity of osteoblast lineage cells contributes to osteoclastic bone resorption in vitro.

Pirapaharan DC, Olesen JB, Andersen TL, Christensen SB, Kjærsgaard-Andersen P, Delaisse JM, Søe K.

J Cell Sci. 2019 May 15;132(10). pii: jcs229351. doi: 10.1242/jcs.229351.


Innervation is higher above Bone Remodeling Surfaces and in Cortical Pores in Human Bone: Lessons from patients with primary hyperparathyroidism.

Sayilekshmy M, Hansen RB, Delaissé JM, Rolighed L, Andersen TL, Heegaard AM.

Sci Rep. 2019 Mar 29;9(1):5361. doi: 10.1038/s41598-019-41779-w.


Understanding age-induced cortical porosity in women: Is a negative BMU balance in quiescent osteons a major contributor?

Andreasen CM, Delaisse JM, van der Eerden BCJ, van Leeuwen JPTM, Ding M, Andersen TL.

Bone. 2018 Dec;117:70-82. doi: 10.1016/j.bone.2018.09.011. Epub 2018 Sep 18.


A Mild Inhibition of Cathepsin K Paradoxically Stimulates the Resorptive Activity of Osteoclasts in Culture.

Pirapaharan DC, Søe K, Panwar P, Madsen JS, Bergmann ML, Overgaard M, Brömme D, Delaisse JM.

Calcif Tissue Int. 2019 Jan;104(1):92-101. doi: 10.1007/s00223-018-0472-7. Epub 2018 Sep 7.


Septins are critical regulators of osteoclastic bone resorption.

Møller AMJ, Füchtbauer EM, Brüel A, Andersen TL, Borggaard XG, Pavlos NJ, Thomsen JS, Pedersen FS, Delaisse JM, Søe K.

Sci Rep. 2018 Aug 29;8(1):13016. doi: 10.1038/s41598-018-31159-1.


Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone.

Bakalova LP, Andreasen CM, Thomsen JS, Brüel A, Hauge EM, Kiil BJ, Delaisse JM, Andersen TL, Kersh ME.

J Bone Miner Res. 2018 Dec;33(12):2177-2185. doi: 10.1002/jbmr.3561. Epub 2018 Aug 29.


Understanding Age-Induced Cortical Porosity in Women: The Accumulation and Coalescence of Eroded Cavities Upon Existing Intracortical Canals Is the Main Contributor.

Andreasen CM, Delaisse JM, van der Eerden BC, van Leeuwen JP, Ding M, Andersen TL.

J Bone Miner Res. 2018 Apr;33(4):606-620. doi: 10.1002/jbmr.3354. Epub 2018 Jan 4.


An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice.

Panwar P, Xue L, Søe K, Srivastava K, Law S, Delaisse JM, Brömme D.

J Bone Miner Res. 2017 Dec;32(12):2415-2430. doi: 10.1002/jbmr.3227. Epub 2017 Aug 25. Erratum in: J Bone Miner Res. 2019 Apr;34(4):777-778.


Time-lapse reveals that osteoclasts can move across the bone surface while resorbing.

Søe K, Delaissé JM.

J Cell Sci. 2017 Jun 15;130(12):2026-2035. doi: 10.1242/jcs.202036. Epub 2017 May 4.


Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs.

Lassen NE, Andersen TL, Pløen GG, Søe K, Hauge EM, Harving S, Eschen GET, Delaisse JM.

J Bone Miner Res. 2017 Jul;32(7):1395-1405. doi: 10.1002/jbmr.3091. Epub 2017 Feb 28.


Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis.

Jafari A, Qanie D, Andersen TL, Zhang Y, Chen L, Postert B, Parsons S, Ditzel N, Khosla S, Johansen HT, Kjærsgaard-Andersen P, Delaisse JM, Abdallah BM, Hesselson D, Solberg R, Kassem M.

Stem Cell Reports. 2017 Feb 14;8(2):373-386. doi: 10.1016/j.stemcr.2017.01.003. Epub 2017 Feb 2.


CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling.

Abdallah BM, Figeac F, Larsen KH, Ditzel N, Keshari P, Isa A, Jafari A, Andersen TL, Delaisse JM, Goshima Y, Ohshima T, Kassem M.

J Bone Miner Res. 2017 May;32(5):913-926. doi: 10.1002/jbmr.3069. Epub 2017 Feb 2.


Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity.

Møller AM, Delaissé JM, Søe K.

J Cell Physiol. 2017 Jun;232(6):1396-1403. doi: 10.1002/jcp.25633. Epub 2016 Oct 19.


Erratum: Pit- and trench-forming osteoclasts: a distinction that matters.

Merrild DM, Pirapaharan DC, Andreasen CM, Kjærsgaard-Andersen P, Møller AM, Ding M, Delaissé JM, Søe K.

Bone Res. 2016 Mar 22;4:16006. eCollection 2016.


Early reversal cells in adult human bone remodeling: osteoblastic nature, catabolic functions and interactions with osteoclasts.

Abdelgawad ME, Delaisse JM, Hinge M, Jensen PR, Alnaimi RW, Rolighed L, Engelholm LH, Marcussen N, Andersen TL.

Histochem Cell Biol. 2016 Jun;145(6):603-15. doi: 10.1007/s00418-016-1414-y. Epub 2016 Feb 9.


Pit- and trench-forming osteoclasts: a distinction that matters.

Merrild DM, Pirapaharan DC, Andreasen CM, Kjærsgaard-Andersen P, Møller AM, Ding M, Delaissé JM, Søe K.

Bone Res. 2015 Dec 1;3:15032. doi: 10.1038/boneres.2015.32. eCollection 2015. Erratum in: Bone Res. 2016 Mar 22;4:16006.


A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K.

Panwar P, Søe K, Guido RV, Bueno RV, Delaisse JM, Brömme D.

Br J Pharmacol. 2016 Jan;173(2):396-410. doi: 10.1111/bph.13383. Epub 2015 Dec 16.


High-dose therapy improves the bone remodelling compartment canopy coverage and bone formation in multiple myeloma.

Hinge M, Delaisse JM, Plesner T, Clasen-Linde E, Salomo M, Andersen TL.

Br J Haematol. 2015 Nov;171(3):355-65. doi: 10.1111/bjh.13584. Epub 2015 Jul 27.


The elementary fusion modalities of osteoclasts.

Søe K, Hobolt-Pedersen AS, Delaisse JM.

Bone. 2015 Apr;73:181-9. doi: 10.1016/j.bone.2014.12.010. Epub 2014 Dec 16.


A joined role of canopy and reversal cells in bone remodeling--lessons from glucocorticoid-induced osteoporosis.

Jensen PR, Andersen TL, Hauge EM, Bollerslev J, Delaissé JM.

Bone. 2015 Apr;73:16-23. doi: 10.1016/j.bone.2014.12.004. Epub 2014 Dec 10.


The reversal phase of the bone-remodeling cycle: cellular prerequisites for coupling resorption and formation.

Delaisse JM.

Bonekey Rep. 2014 Aug 6;3:561. doi: 10.1038/bonekey.2014.56. eCollection 2014. Review. Erratum in: Bonekey Rep. 2016 Nov 30;5:856.


Does collagen trigger the recruitment of osteoblasts into vacated bone resorption lacunae during bone remodeling?

Abdelgawad ME, Søe K, Andersen TL, Merrild DM, Christiansen P, Kjærsgaard-Andersen P, Delaisse JM.

Bone. 2014 Oct;67:181-8. doi: 10.1016/j.bone.2014.07.012. Epub 2014 Jul 11.


Osteoclast fusion is based on heterogeneity between fusion partners.

Hobolt-Pedersen AS, Delaissé JM, Søe K.

Calcif Tissue Int. 2014 Jul;95(1):73-82. doi: 10.1007/s00223-014-9864-5. Epub 2014 May 27.


Correlation between absence of bone remodeling compartment canopies, reversal phase arrest, and deficient bone formation in post-menopausal osteoporosis.

Andersen TL, Hauge EM, Rolighed L, Bollerslev J, Kjærsgaard-Andersen P, Delaisse JM.

Am J Pathol. 2014 Apr;184(4):1142-1151. doi: 10.1016/j.ajpath.2013.12.005. Epub 2014 Feb 5.


Osteoblast recruitment routes in human cancellous bone remodeling.

Kristensen HB, Andersen TL, Marcussen N, Rolighed L, Delaisse JM.

Am J Pathol. 2014 Mar;184(3):778-89. doi: 10.1016/j.ajpath.2013.11.022. Epub 2014 Jan 9.


A supra-cellular model for coupling of bone resorption to formation during remodeling: lessons from two bone resorption inhibitors affecting bone formation differently.

Jensen PR, Andersen TL, Pennypacker BL, Duong LT, Engelholm LH, Delaissé JM.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):694-9. doi: 10.1016/j.bbrc.2013.12.036. Epub 2013 Dec 12.


Initial experience with robotic retropubic urethropexy compared to open retropubic urethropexy.

Patel PR, Borahay MA, Puentes AR, Rodriguez AM, Delaisse J, Kilic GS.

Obstet Gynecol Int. 2013;2013:315680. doi: 10.1155/2013/315680. Epub 2013 Sep 8.


Dosing related effects of zoledronic acid on bone markers and creatinine clearance in patients with multiple myeloma and metastatic breast cancer.

Søe K, Delaissé JM, Jakobsen EH, Hansen CT, Plesner T.

Acta Oncol. 2014 Apr;53(4):547-56. doi: 10.3109/0284186X.2013.844358. Epub 2013 Oct 28.


The bone resorption inhibitors odanacatib and alendronate affect post-osteoclastic events differently in ovariectomized rabbits.

Jensen PR, Andersen TL, Pennypacker BL, Duong LT, Delaissé JM.

Calcif Tissue Int. 2014 Feb;94(2):212-22. doi: 10.1007/s00223-013-9800-0. Epub 2013 Oct 2.


The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis.

Harbo M, Delaisse JM, Kjaersgaard-Andersen P, Soerensen FB, Koelvraa S, Bendix L.

Mech Ageing Dev. 2013 Sep;134(9):367-72. doi: 10.1016/j.mad.2013.07.002. Epub 2013 Jul 18.


Steering the osteoclast through the demineralization-collagenolysis balance.

Søe K, Merrild DM, Delaissé JM.

Bone. 2013 Sep;56(1):191-8. doi: 10.1016/j.bone.2013.06.007. Epub 2013 Jun 15.


Understanding coupling between bone resorption and formation: are reversal cells the missing link?

Andersen TL, Abdelgawad ME, Kristensen HB, Hauge EM, Rolighed L, Bollerslev J, Kjærsgaard-Andersen P, Delaisse JM.

Am J Pathol. 2013 Jul;183(1):235-46. doi: 10.1016/j.ajpath.2013.03.006. Epub 2013 Jun 6.


Is retention of zoledronic acid onto bone different in multiple myeloma and breast cancer patients with bone metastasis?

Søe K, Plesner T, Jakobsen EH, Hansen CT, Jørgensen HB, Delaissé JM.

J Bone Miner Res. 2013 Aug;28(8):1738-50. doi: 10.1002/jbmr.1897.


Glucocorticoid-induced changes in the geometry of osteoclast resorption cavities affect trabecular bone stiffness.

Vanderoost J, Søe K, Merrild DM, Delaissé JM, van Lenthe GH.

Calcif Tissue Int. 2013 Mar;92(3):240-50. doi: 10.1007/s00223-012-9674-6. Epub 2012 Nov 28.


Increased presence of capillaries next to remodeling sites in adult human cancellous bone.

Kristensen HB, Andersen TL, Marcussen N, Rolighed L, Delaisse JM.

J Bone Miner Res. 2013 Mar;28(3):574-85. doi: 10.1002/jbmr.1760.


The distribution pattern of critically short telomeres in human osteoarthritic knees.

Harbo M, Bendix L, Bay-Jensen AC, Graakjaer J, Søe K, Andersen TL, Kjaersgaard-Andersen P, Koelvraa S, Delaisse JM.

Arthritis Res Ther. 2012 Jan 18;14(1):R12. doi: 10.1186/ar3687.


Premature loss of bone remodeling compartment canopies is associated with deficient bone formation: a study of healthy individuals and patients with Cushing's syndrome.

Jensen PR, Andersen TL, Søe K, Hauge EM, Bollerslev J, Amling M, Barvencik F, Delaissé JM.

J Bone Miner Res. 2012 Apr;27(4):770-80. doi: 10.1002/jbmr.1490.


OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.

Barrow AD, Raynal N, Andersen TL, Slatter DA, Bihan D, Pugh N, Cella M, Kim T, Rho J, Negishi-Koga T, Delaisse JM, Takayanagi H, Lorenzo J, Colonna M, Farndale RW, Choi Y, Trowsdale J.

J Clin Invest. 2011 Sep;121(9):3505-16. doi: 10.1172/JCI45913. Epub 2011 Aug 15.


Estrogen inhibits Dlk1/FA1 production: a potential mechanism for estrogen effects on bone turnover.

Abdallah BM, Bay-Jensen AC, Srinivasan B, Tabassi NC, Garnero P, Delaissé JM, Khosla S, Kassem M.

J Bone Miner Res. 2011 Oct;26(10):2548-51. doi: 10.1002/jbmr.444.


Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity.

Ågren MS, Andersen TL, Andersen L, Schiødt CB, Surve V, Andreassen TT, Risteli J, Franzén LE, Delaissé JM, Heegaard AM, Jorgensen LN.

Int J Colorectal Dis. 2011 Mar;26(3):329-37. doi: 10.1007/s00384-010-1106-3. Epub 2010 Dec 31.


Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion.

Søe K, Andersen TL, Hobolt-Pedersen AS, Bjerregaard B, Larsson LI, Delaissé JM.

Bone. 2011 Apr 1;48(4):837-46. doi: 10.1016/j.bone.2010.11.011. Epub 2010 Nov 24.


Potential of resveratrol analogues as antagonists of osteoclasts and promoters of osteoblasts.

Kupisiewicz K, Boissy P, Abdallah BM, Hansen FD, Erben RG, Savouret JF, Søe K, Andersen TL, Plesner T, Delaisse JM.

Calcif Tissue Int. 2010 Nov;87(5):437-49. doi: 10.1007/s00223-010-9399-3. Epub 2010 Sep 15.


Effect of withdrawal of zoledronic acid treatment on bone remodelling markers in multiple myeloma.

Lund T, Abildgaard N, Delaisse JM, Plesner T.

Br J Haematol. 2010 Oct;151(1):92-3. doi: 10.1111/j.1365-2141.2010.08293.x. Epub 2010 Jun 28. No abstract available.


First-line treatment with bortezomib rapidly stimulates both osteoblast activity and bone matrix deposition in patients with multiple myeloma, and stimulates osteoblast proliferation and differentiation in vitro.

Lund T, Søe K, Abildgaard N, Garnero P, Pedersen PT, Ormstrup T, Delaissé JM, Plesner T.

Eur J Haematol. 2010 Oct;85(4):290-9. doi: 10.1111/j.1600-0609.2010.01485.x. Epub 2010 Jul 22.


Glucocorticoids maintain human osteoclasts in the active mode of their resorption cycle.

Søe K, Delaissé JM.

J Bone Miner Res. 2010 Oct;25(10):2184-92. doi: 10.1002/jbmr.113.


Multiple myeloma: changes in serum C-terminal telopeptide of collagen type I and bone-specific alkaline phosphatase can be used in daily practice to detect imminent osteolysis.

Lund T, Abildgaard N, Andersen TL, Delaisse JM, Plesner T.

Eur J Haematol. 2010 May;84(5):412-20. doi: 10.1111/j.1600-0609.2010.01417.x. Epub 2010 Jan 13.

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