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Items: 31


The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic health.

Zhao XY, Li S, DelProposto JL, Liu T, Mi L, Porsche C, Peng X, Lumeng CN, Lin JD.

Mol Metab. 2018 Jun 8. pii: S2212-8778(18)30490-3. doi: 10.1016/j.molmet.2018.06.005. [Epub ahead of print]


Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages.

Muir LA, Kiridena S, Griffin C, DelProposto JB, Geletka L, Martinez-SantibaƱez G, Zamarron BF, Lucas H, Singer K, O' Rourke RW, Lumeng CN.

J Leukoc Biol. 2018 Apr;103(4):615-628. doi: 10.1002/JLB.3HI1017-422R. Epub 2018 Mar 1.


Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery.

Muir LA, Baker NA, Washabaugh AR, Neeley CK, Flesher CG, DelProposto JB, Geletka LM, Ghaferi AA, Finks JF, Singer K, Varban OA, Lumeng CN, O'Rourke RW.

Adipocyte. 2017 Apr 3;6(2):134-140. doi: 10.1080/21623945.2017.1287639. Epub 2017 Jan 27.


Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice.

Zamarron BF, Mergian TA, Cho KW, Martinez-Santibanez G, Luan D, Singer K, DelProposto JL, Geletka LM, Muir LA, Lumeng CN.

Diabetes. 2017 Feb;66(2):392-406. doi: 10.2337/db16-0500. Epub 2016 Nov 8.


Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.

Yang CY, Phillips JG, Stuckey JA, Bai L, Sun H, Delproposto J, Brown WC, Chinnaswamy K.

ACS Med Chem Lett. 2016 Sep 13;7(12):1092-1096. eCollection 2016 Dec 8.


D3R grand challenge 2015: Evaluation of protein-ligand pose and affinity predictions.

Gathiaka S, Liu S, Chiu M, Yang H, Stuckey JA, Kang YN, Delproposto J, Kubish G, Dunbar JB Jr, Carlson HA, Burley SK, Walters WP, Amaro RE, Feher VA, Gilson MK.

J Comput Aided Mol Des. 2016 Sep;30(9):651-668. Epub 2016 Sep 30.


Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance.

Cho KW, Zamarron BF, Muir LA, Singer K, Porsche CE, DelProposto JB, Geletka L, Meyer KA, O'Rourke RW, Lumeng CN.

J Immunol. 2016 Nov 1;197(9):3650-3661. Epub 2016 Sep 28.


Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity.

Muir LA, Neeley CK, Meyer KA, Baker NA, Brosius AM, Washabaugh AR, Varban OA, Finks JF, Zamarron BF, Flesher CG, Chang JS, DelProposto JB, Geletka L, Martinez-Santibanez G, Kaciroti N, Lumeng CN, O'Rourke RW.

Obesity (Silver Spring). 2016 Mar;24(3):597-605. doi: 10.1002/oby.21377.


Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 Ectodomain.

Yang CY, Delproposto J, Chinnaswamy K, Brown WC, Wang S, Stuckey JA, Wang X.

PLoS One. 2016 Jan 6;11(1):e0146522. doi: 10.1371/journal.pone.0146522. eCollection 2016.


CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity.

Morris DL, Oatmen KE, Mergian TA, Cho KW, DelProposto JL, Singer K, Evans-Molina C, O'Rourke RW, Lumeng CN.

J Leukoc Biol. 2016 Jun;99(6):1107-19. doi: 10.1189/jlb.3A0115-009R. Epub 2015 Dec 11.


Obesity-induced remodeling of the adipose tissue elastin network is independent of the metalloelastase MMP-12.

Martinez-Santibanez G, Singer K, Cho KW, DelProposto JL, Mergian T, Lumeng CN.

Adipocyte. 2015 Apr 20;4(4):264-72. doi: 10.1080/21623945.2015.1027848. eCollection 2015 Oct-Dec.


CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge.

Smith RD, Damm-Ganamet KL, Dunbar JB Jr, Ahmed A, Chinnaswamy K, Delproposto JE, Kubish GM, Tinberg CE, Khare SD, Dou J, Doyle L, Stuckey JA, Baker D, Carlson HA.

J Chem Inf Model. 2016 Jun 27;56(6):1022-31. doi: 10.1021/acs.jcim.5b00387. Epub 2015 Oct 9.


The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein.

Morgan CE, Meagher JL, Levengood JD, Delproposto J, Rollins C, Stuckey JA, Tolbert BS.

J Mol Biol. 2015 Oct 9;427(20):3241-3257. doi: 10.1016/j.jmb.2015.05.009. Epub 2015 May 21.


Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet-induced Obesity.

Singer K, Maley N, Mergian T, DelProposto J, Cho KW, Zamarron BF, Martinez-Santibanez G, Geletka L, Muir L, Wachowiak P, Demirjian C, Lumeng CN.

J Biol Chem. 2015 May 22;290(21):13250-62. doi: 10.1074/jbc.M114.634568. Epub 2015 Apr 13.


An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation.

Cho KW, Morris DL, DelProposto JL, Geletka L, Zamarron B, Martinez-Santibanez G, Meyer KA, Singer K, O'Rourke RW, Lumeng CN.

Cell Rep. 2014 Oct 23;9(2):605-17. doi: 10.1016/j.celrep.2014.09.004. Epub 2014 Oct 9.


Obesity-Related Hormones in Low-Income Preschool-Age Children: Implications for School Readiness.

Miller AL, Lumeng CN, Delproposto J, Florek B, Wendorf K, Lumeng JC.

Mind Brain Educ. 2013 Dec;7(4):246-255.


Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells.

Singer K, DelProposto J, Morris DL, Zamarron B, Mergian T, Maley N, Cho KW, Geletka L, Subbaiah P, Muir L, Martinez-Santibanez G, Lumeng CN.

Mol Metab. 2014 Jul 10;3(6):664-75. doi: 10.1016/j.molmet.2014.06.005. eCollection 2014 Sep.


Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.

Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, Ning X, Bree AJ, Schell B, Broome DT, Soliman SS, DelProposto JL, Lumeng CN, Mitra A, Pandit SV, Gallagher KA, Miller JD, Krishnan V, Hui SK, Bredella MA, Fazeli PK, Klibanski A, Horowitz MC, Rosen CJ, MacDougald OA.

Cell Metab. 2014 Aug 5;20(2):368-375. doi: 10.1016/j.cmet.2014.06.003. Epub 2014 Jul 3.


Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.

Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, DelProposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL.

Science. 2014 Feb 21;343(6173):881-5. doi: 10.1126/science.1247749. Epub 2014 Feb 6.


CSAR data set release 2012: ligands, affinities, complexes, and docking decoys.

Dunbar JB Jr, Smith RD, Damm-Ganamet KL, Ahmed A, Esposito EX, Delproposto J, Chinnaswamy K, Kang YN, Kubish G, Gestwicki JE, Stuckey JA, Carlson HA.

J Chem Inf Model. 2013 Aug 26;53(8):1842-52. doi: 10.1021/ci4000486. Epub 2013 May 10.


Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice.

Morris DL, Cho KW, Delproposto JL, Oatmen KE, Geletka LM, Martinez-Santibanez G, Singer K, Lumeng CN.

Diabetes. 2013 Aug;62(8):2762-72. doi: 10.2337/db12-1404. Epub 2013 Mar 14.


Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation.

Singer K, Morris DL, Oatmen KE, Wang T, DelProposto J, Mergian T, Cho KW, Lumeng CN.

PLoS One. 2013;8(3):e57929. doi: 10.1371/journal.pone.0057929. Epub 2013 Mar 5. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/c2432ace-1dd7-4b02-8980-e4e6c085beba.


CX3CR1 deficiency does not influence trafficking of adipose tissue macrophages in mice with diet-induced obesity.

Morris DL, Oatmen KE, Wang T, DelProposto JL, Lumeng CN.

Obesity (Silver Spring). 2012 Jun;20(6):1189-99. doi: 10.1038/oby.2012.7. Epub 2012 Jan 17.


Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue.

Lumeng CN, Liu J, Geletka L, Delaney C, Delproposto J, Desai A, Oatmen K, Martinez-Santibanez G, Julius A, Garg S, Yung RL.

J Immunol. 2011 Dec 15;187(12):6208-16. doi: 10.4049/jimmunol.1102188. Epub 2011 Nov 9.


New ligation-independent cloning vectors compatible with a high-throughput platform for parallel construct expression evaluation using baculovirus-infected insect cells.

Brown WC, DelProposto J, Rubin JR, Lamiman K, Carless J, Smith JL.

Protein Expr Purif. 2011 May;77(1):34-45. doi: 10.1016/j.pep.2011.01.007. Epub 2011 Jan 22.


MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity.

Westcott DJ, Delproposto JB, Geletka LM, Wang T, Singer K, Saltiel AR, Lumeng CN.

J Exp Med. 2009 Dec 21;206(13):3143-56. doi: 10.1084/jem.20091333. Epub 2009 Dec 7.


The protein kinase IKKepsilon regulates energy balance in obese mice.

Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR.

Cell. 2009 Sep 4;138(5):961-75. doi: 10.1016/j.cell.2009.06.046.


A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis.

McQuade TJ, Shallop AD, Sheoran A, Delproposto JE, Tsodikov OV, Garneau-Tsodikova S.

Anal Biochem. 2009 Mar 15;386(2):244-50. doi: 10.1016/j.ab.2008.12.014. Epub 2008 Dec 24.


Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes.

Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR.

Diabetes. 2008 Dec;57(12):3239-46. doi: 10.2337/db08-0872. Epub 2008 Oct 1.


Mocr: a novel fusion tag for enhancing solubility that is compatible with structural biology applications.

DelProposto J, Majmudar CY, Smith JL, Brown WC.

Protein Expr Purif. 2009 Jan;63(1):40-9. doi: 10.1016/j.pep.2008.08.011. Epub 2008 Sep 12.


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