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Items: 1 to 50 of 172

1.

Hydrogen sulfide releasing aspirin, ACS14, attenuates high glucose-induced increased methylglyoxal and oxidative stress in cultured vascular smooth muscle cells.

Huang Q, Sparatore A, Del Soldato P, Wu L, Desai K.

PLoS One. 2014 Jun 4;9(6):e97315. doi: 10.1371/journal.pone.0097315. eCollection 2014.

2.

Therapeutic effect of hydrogen sulfide-releasing L-Dopa derivative ACS84 on 6-OHDA-induced Parkinson's disease rat model.

Xie L, Hu LF, Teo XQ, Tiong CX, Tazzari V, Sparatore A, Del Soldato P, Dawe GS, Bian JS.

PLoS One. 2013;8(4):e60200. doi: 10.1371/journal.pone.0060200. Epub 2013 Apr 3.

3.

Hydrogen sulfide-releasing aspirin derivative ACS14 exerts strong antithrombotic effects in vitro and in vivo.

Pircher J, Fochler F, Czermak T, Mannell H, Kraemer BF, Wörnle M, Sparatore A, Del Soldato P, Pohl U, Krötz F.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2884-91. doi: 10.1161/ATVBAHA.112.300627. Epub 2012 Sep 27.

PMID:
23023375
4.

Role of paraoxonase-1 in the protection of hydrogen sulfide-donating sildenafil (ACS6) against homocysteine-induced neurotoxicity.

Tang XQ, Chen RQ, Dong L, Ren YK, Del Soldato P, Sparatore A, Liao DF.

J Mol Neurosci. 2013 May;50(1):70-7. doi: 10.1007/s12031-012-9862-x. Epub 2012 Jul 29.

PMID:
22843253
5.

Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.

Switzer CH, Cheng RY, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB, Glynn SA, Ambs S, Wink DA.

Cancer Res. 2012 May 1;72(9):2394-404. doi: 10.1158/0008-5472.CAN-11-3115. Epub 2012 Mar 21.

6.

Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity.

Tesei A, Brigliadori G, Carloni S, Fabbri F, Ulivi P, Arienti C, Sparatore A, Del Soldato P, Pasini A, Amadori D, Silvestrini R, Zoli W.

J Cell Physiol. 2012 Oct;227(10):3389-96. doi: 10.1002/jcp.24039.

PMID:
22212895
7.

Therapeutic potential of new hydrogen sulfide-releasing hybrids.

Sparatore A, Santus G, Giustarini D, Rossi R, Del Soldato P.

Expert Rev Clin Pharmacol. 2011 Jan;4(1):109-21. doi: 10.1586/ecp.10.122. Review.

PMID:
22115352
8.

Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo.

Frantzias J, Logan JG, Mollat P, Sparatore A, Del Soldato P, Ralston SH, Idris AI.

Br J Pharmacol. 2012 Mar;165(6):1914-1925. doi: 10.1111/j.1476-5381.2011.01704.x.

9.

H2S releasing aspirin protects amyloid beta induced cell toxicity in BV-2 microglial cells.

Liu YY, Sparatore A, Del Soldato P, Bian JS.

Neuroscience. 2011 Oct 13;193:80-8. doi: 10.1016/j.neuroscience.2011.07.023. Epub 2011 Jul 18. Erratum in: Neuroscience. 2012 Sep 27;221:225.

PMID:
21784135
10.

ACS84, a novel hydrogen sulfide-releasing compound, protects against amyloid β-induced cell cytotoxicity.

Liu YY, Sparatore A, Del Soldato P, Bian JS.

Neurochem Int. 2011 Apr;58(5):591-8. doi: 10.1016/j.neuint.2011.01.023. Epub 2011 Feb 12. Erratum in: Neurochem Int. 2012 Aug;61(3):441.

PMID:
21300120
11.

Activity of a new hydrogen sulfide-releasing aspirin (ACS14) on pathological cardiovascular alterations induced by glutathione depletion in rats.

Rossoni G, Manfredi B, Tazzari V, Sparatore A, Trivulzio S, Del Soldato P, Berti F.

Eur J Pharmacol. 2010 Dec 1;648(1-3):139-45. doi: 10.1016/j.ejphar.2010.08.039. Epub 2010 Sep 15.

PMID:
20826133
12.

New aryldithiolethione derivatives as potent histone deacetylase inhibitors.

Tazzari V, Cappelletti G, Casagrande M, Perrino E, Renzi L, Del Soldato P, Sparatore A.

Bioorg Med Chem. 2010 Jun 15;18(12):4187-94. doi: 10.1016/j.bmc.2010.05.011. Epub 2010 May 7.

PMID:
20576572
13.

Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson disease.

Lee M, Tazzari V, Giustarini D, Rossi R, Sparatore A, Del Soldato P, McGeer E, McGeer PL.

J Biol Chem. 2010 Jun 4;285(23):17318-28. doi: 10.1074/jbc.M110.115261. Epub 2010 Apr 5.

14.

Modulation of thiol homeostasis induced by H2S-releasing aspirin.

Giustarini D, Del Soldato P, Sparatore A, Rossi R.

Free Radic Biol Med. 2010 May 1;48(9):1263-72. doi: 10.1016/j.freeradbiomed.2010.02.014. Epub 2010 Feb 17.

PMID:
20171274
15.

ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture.

Osborne NN, Ji D, Abdul Majid AS, Fawcett RJ, Sparatore A, Del Soldato P.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):284-94. doi: 10.1167/iovs.09-3999. Epub 2009 Aug 26.

PMID:
19710416
16.

Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity.

Switzer CH, Ridnour LA, Cheng RY, Sparatore A, Del Soldato P, Moody TW, Vitek MP, Roberts DD, Wink DA.

Oncogene. 2009 Oct 29;28(43):3837-46. doi: 10.1038/onc.2009.244. Epub 2009 Aug 24.

17.

Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

Moody TW, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A, Del Soldato P, Yeh GC, Roberts DD, Giaccone G, Wink DA.

Lung Cancer. 2010 May;68(2):154-60. doi: 10.1016/j.lungcan.2009.06.012. Epub 2009 Jul 23.

18.

Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation.

Lee M, Sparatore A, Del Soldato P, McGeer E, McGeer PL.

Glia. 2010 Jan 1;58(1):103-13. doi: 10.1002/glia.20905.

PMID:
19544392
19.

Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide.

Mancardi D, Penna C, Merlino A, Del Soldato P, Wink DA, Pagliaro P.

Biochim Biophys Acta. 2009 Jul;1787(7):864-72. doi: 10.1016/j.bbabio.2009.03.005. Epub 2009 Mar 13. Review.

20.

Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.

Bass SE, Sienkiewicz P, Macdonald CJ, Cheng RY, Sparatore A, Del Soldato P, Roberts DD, Moody TW, Wink DA, Yeh GC.

Clin Cancer Res. 2009 Mar 15;15(6):1964-72. doi: 10.1158/1078-0432.CCR-08-1870. Epub 2009 Mar 10.

21.

Effect of hydrogen sulphide-donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats.

Shukla N, Rossoni G, Hotston M, Sparatore A, Del Soldato P, Tazzari V, Persad R, Angelini GD, Jeremy JY.

BJU Int. 2009 Jun;103(11):1522-9. doi: 10.1111/j.1464-410X.2009.08415.x. Epub 2009 Mar 26.

22.

Pharmacological profile of a novel H(2)S-releasing aspirin.

Sparatore A, Perrino E, Tazzari V, Giustarini D, Rossi R, Rossoni G, Erdmann K, Schröder H, Del Soldato P.

Free Radic Biol Med. 2009 Mar 1;46(5):586-92. doi: 10.1016/j.freeradbiomed.2008.11.013. Epub 2008 Dec 6. Erratum in: Free Radic Biol Med. 2009 Dec 15;47(12):1781. Erdman, Kati [corrected to Erdmann, Kati].

PMID:
19100325
23.

H2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G.

Muzaffar S, Jeremy JY, Sparatore A, Del Soldato P, Angelini GD, Shukla N.

Br J Pharmacol. 2008 Dec;155(7):984-94. doi: 10.1038/bjp.2008.326. Epub 2008 Sep 1.

24.

Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation.

Baskar R, Sparatore A, Del Soldato P, Moore PK.

Eur J Pharmacol. 2008 Oct 10;594(1-3):1-8. doi: 10.1016/j.ejphar.2008.07.029. Epub 2008 Jul 21.

PMID:
18680741
25.

Addition of nitric oxide through nitric oxide-paracetamol enhances healing rat achilles tendon.

Murrell GA, Tang G, Appleyard RC, del Soldato P, Wang MX.

Clin Orthop Relat Res. 2008 Jul;466(7):1618-24. doi: 10.1007/s11999-008-0271-y. Epub 2008 May 8.

26.

Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells.

Muzaffar S, Shukla N, Bond M, Newby AC, Angelini GD, Sparatore A, Del Soldato P, Jeremy JY.

J Vasc Res. 2008;45(6):521-8. doi: 10.1159/000129686. Epub 2008 May 7.

PMID:
18463417
27.

New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity.

Perrino E, Cappelletti G, Tazzari V, Giavini E, Del Soldato P, Sparatore A.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. doi: 10.1016/j.bmcl.2008.02.007. Epub 2008 Feb 8.

PMID:
18294844
28.

The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart.

Rossoni G, Sparatore A, Tazzari V, Manfredi B, Del Soldato P, Berti F.

Br J Pharmacol. 2008 Jan;153(1):100-9. Epub 2007 Oct 29.

29.

Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

Isenberg JS, Jia Y, Field L, Ridnour LA, Sparatore A, Del Soldato P, Sowers AL, Yeh GC, Moody TW, Wink DA, Ramchandran R, Roberts DD.

Br J Pharmacol. 2007 May;151(1):63-72. Epub 2007 Mar 12.

30.

Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative.

Li L, Rossoni G, Sparatore A, Lee LC, Del Soldato P, Moore PK.

Free Radic Biol Med. 2007 Mar 1;42(5):706-19. Epub 2006 Dec 16.

PMID:
17291994
31.

Ultrastructural investigations on protective effects of NCX 4016 (nitroaspirin) on macrovascular endothelium in diabetic Wistar rats.

Ambrosini MV, Mariucci G, Rambotti MG, Tantucci M, Covarelli C, De Angelis L, Del Soldato P.

J Submicrosc Cytol Pathol. 2005 Aug;37(2):205-13.

PMID:
16335593
32.

Nitric oxide-releasing NSAIDs: GI-safe antithrombotics.

Wallace JL, Del Soldato P, Cirino G, Muscará MN.

IDrugs. 1999 Apr;2(4):321-6.

PMID:
16158351
33.

Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination.

De Santo C, Serafini P, Marigo I, Dolcetti L, Bolla M, Del Soldato P, Melani C, Guiducci C, Colombo MP, Iezzi M, Musiani P, Zanovello P, Bronte V.

Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4185-90. Epub 2005 Mar 7.

34.

Nitroaspirin plus clopidogrel versus aspirin plus clopidogrel against platelet thromboembolism and intimal thickening in mice.

Momi S, Pitchford SC, Alberti PF, Minuz P, Del Soldato P, Gresele P.

Thromb Haemost. 2005 Mar;93(3):535-43.

PMID:
15735806
35.

NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.

Zacharowski P, Breese E, Wood E, Del Soldato P, Warner T, Mitchell J.

Eur J Pharmacol. 2005 Jan 31;508(1-3):7-13. Epub 2004 Dec 28.

PMID:
15680249
36.

Positional isomerism markedly affects the growth inhibition of colon cancer cells by nitric oxide-donating aspirin in vitro and in vivo.

Kashfi K, Borgo S, Williams JL, Chen J, Gao J, Glekas A, Benedini F, Del Soldato P, Rigas B.

J Pharmacol Exp Ther. 2005 Mar;312(3):978-88. Epub 2004 Nov 4.

PMID:
15528453
37.

The effects and metabolic fate of nitroflurbiprofen in healthy volunteers.

Zacharowski P, Zacharowski K, Donnellan C, Johnston A, Vojnovic I, Forte P, Del Soldato P, Benjamin N, O'Byrne S.

Clin Pharmacol Ther. 2004 Oct;76(4):350-8.

PMID:
15470334
38.

Comparison of the antinociceptive activity of two new NO-releasing derivatives of the NSAID S-ketoprofen in rats.

Gaitan G, Ahuir FJ, Del Soldato P, Herrero JF.

Br J Pharmacol. 2004 Nov;143(5):533-40. Epub 2004 Sep 27.

39.

Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans.

Fiorucci S, Mencarelli A, Meneguzzi A, Lechi A, Renga B, del Soldato P, Morelli A, Minuz P.

J Am Coll Cardiol. 2004 Aug 4;44(3):635-41.

40.

Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice.

Fiorucci S, Antonelli E, Distrutti E, Mencarelli A, Farneti S, Del Soldato P, Morelli A.

Br J Pharmacol. 2004 Sep;143(1):33-42. Retraction in: Br J Pharmacol. 2009 Mar;156(5):868.

41.

Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia.

Emanueli C, Van Linthout S, Salis MB, Monopoli A, Del Soldato P, Ongini E, Madeddu P.

Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2082-7. Epub 2004 Sep 2.

PMID:
15345513
42.
43.

Nitric oxide regulates immune cell bioenergetic: a mechanism to understand immunomodulatory functions of nitric oxide-releasing anti-inflammatory drugs.

Fiorucci S, Mencarelli A, Distrutti E, Baldoni M, del Soldato P, Morelli A.

J Immunol. 2004 Jul 15;173(2):874-82.

44.

Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties.

Ongini E, Impagnatiello F, Bonazzi A, Guzzetta M, Govoni M, Monopoli A, Del Soldato P, Ignarro LJ.

Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8497-502.

45.

NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property?

Yeh RK, Chen J, Williams JL, Baluch M, Hundley TR, Rosenbaum RE, Kalala S, Traganos F, Benardini F, del Soldato P, Kashfi K, Rigas B.

Biochem Pharmacol. 2004 Jun 15;67(12):2197-205.

PMID:
15163551
46.

Enhanced anti-inflammatory potency of a nitric oxide-releasing derivative of flunisolide: role of nuclear factor-kappaB.

Wallace JL, Rizzo G, Cirino G, Del Soldato P, Fiorucci S.

J Pharmacol Exp Ther. 2004 Sep;310(3):1096-102. Epub 2004 May 5.

PMID:
15128863
47.

The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1.

Di Filippo C, Rossi F, Ongini E, Del Soldato P, Perretti M, D'Amico M.

J Pharmacol Exp Ther. 2004 Sep;310(3):1133-41. Epub 2004 Apr 27.

PMID:
15113846
48.

A nitric oxide-releasing salbutamol elicits potent relaxant and anti-inflammatory activities.

Lagente V, Naline E, Guenon I, Corbel M, Boichot E, Burgaud JL, Del Soldato P, Advenier C.

J Pharmacol Exp Ther. 2004 Jul;310(1):367-75. Epub 2004 Apr 14.

PMID:
15084649
49.

The nitric oxide-releasing naproxen derivative displays cardioprotection in perfused rabbit heart submitted to ischemia-reperfusion.

Rossoni G, Manfredi B, Del Soldato P, Berti F.

J Pharmacol Exp Ther. 2004 Aug;310(2):555-62. Epub 2004 Apr 13.

PMID:
15082750
50.

Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence.

Fiorucci S, Distrutti E, Mencarelli A, Rizzo G, Lorenzo AR, Baldoni M, Del Soldato P, Morelli A, Wallace JL.

J Pharmacol Exp Ther. 2004 Jun;309(3):1174-82. Epub 2004 Feb 4.

PMID:
14762100

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