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Items: 7


Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.

Kenny JR, Ramsden D, Buckley DB, Dallas S, Fung C, Mohutsky M, Einolf HJ, Chen L, Dekeyser JG, Fitzgerald M, Goosen TC, Siu YA, Walsky RL, Zhang G, Tweedie D, Hariparsad N.

Drug Metab Dispos. 2018 Sep;46(9):1285-1303. doi: 10.1124/dmd.118.081927. Epub 2018 Jun 29.


Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.

Hariparsad N, Ramsden D, Palamanda J, Dekeyser JG, Fahmi OA, Kenny JR, Einolf H, Mohutsky M, Pardon M, Siu YA, Chen L, Sinz M, Jones B, Walsky R, Dallas S, Balani SK, Zhang G, Buckley D, Tweedie D.

Drug Metab Dispos. 2017 Oct;45(10):1049-1059. doi: 10.1124/dmd.116.074567. Epub 2017 Jun 23.


Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.

DeKeyser JG, Laurenzana EM, Peterson EC, Chen T, Omiecinski CJ.

Toxicol Sci. 2011 Apr;120(2):381-91. doi: 10.1093/toxsci/kfq394. Epub 2011 Jan 12.


Bioassay-directed fractionation for discovery of bioactive neutral lipids guided by relative mass defect filtering and multiplexed collision-induced dissociation.

Stagliano MC, DeKeyser JG, Omiecinski CJ, Jones AD.

Rapid Commun Mass Spectrom. 2010 Dec 30;24(24):3578-84. doi: 10.1002/rcm.4796.


Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.

DeKeyser JG, Stagliano MC, Auerbach SS, Prabhu KS, Jones AD, Omiecinski CJ.

Mol Pharmacol. 2009 May;75(5):1005-13. doi: 10.1124/mol.108.053702. Epub 2009 Feb 11.


CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.

Auerbach SS, Dekeyser JG, Stoner MA, Omiecinski CJ.

Drug Metab Dispos. 2007 Mar;35(3):428-39. Epub 2006 Dec 28.


Studies on titin PEVK peptides and their interaction.

Duan Y, DeKeyser JG, Damodaran S, Greaser ML.

Arch Biochem Biophys. 2006 Oct 1;454(1):16-25. Epub 2006 Aug 15. Erratum in: Arch Biochem Biophys. 2006 Dec 15;456(2):232.

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