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Items: 1 to 50 of 370

1.

Endothelial β-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression.

Martowicz A, Trusohamn M, Jensen N, Wisniewska-Kruk J, Corada M, Chenfei Ning F, Kele J, Dejana E, Nyqvist D.

Arterioscler Thromb Vasc Biol. 2019 Sep 19:ATVBAHA119312749. doi: 10.1161/ATVBAHA.119.312749. [Epub ahead of print]

PMID:
31533473
2.

Endothelial cell clonal expansion in the development of cerebral cavernous malformations.

Malinverno M, Maderna C, Abu Taha A, Corada M, Orsenigo F, Valentino M, Pisati F, Fusco C, Graziano P, Giannotta M, Yu QC, Zeng YA, Lampugnani MG, Magnusson PU, Dejana E.

Nat Commun. 2019 Jun 24;10(1):2761. doi: 10.1038/s41467-019-10707-x.

3.

Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells.

Ferraro DA, Patella F, Zanivan S, Donato C, Aceto N, Giannotta M, Dejana E, Diepenbruck M, Christofori G, Buess M.

BMC Cancer. 2019 Apr 4;19(1):312. doi: 10.1186/s12885-019-5521-8.

4.

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing.

Angiolini F, Belloni E, Giordano M, Campioni M, Forneris F, Paronetto MP, Lupia M, Brandas C, Pradella D, Di Matteo A, Giampietro C, Jodice G, Luise C, Bertalot G, Freddi S, Malinverno M, Irimia M, Moulton JD, Summerton J, Chiapparino A, Ghilardi C, Giavazzi R, Nyqvist D, Gabellini D, Dejana E, Cavallaro U, Ghigna C.

Elife. 2019 Mar 4;8. pii: e44305. doi: 10.7554/eLife.44305.

5.

CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression.

Castro M, Laviña B, Ando K, Álvarez-Aznar A, Abu Taha A, Brakebusch C, Dejana E, Betsholtz C, Gaengel K.

Circ Res. 2019 Apr 12;124(8):1240-1252. doi: 10.1161/CIRCRESAHA.118.314300.

PMID:
30732528
6.

Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier.

Corada M, Orsenigo F, Bhat GP, Conze LL, Breviario F, Cunha SI, Claesson-Welsh L, Beznoussenko GV, Mironov AA, Bacigaluppi M, Martino G, Pitulescu ME, Adams RH, Magnusson P, Dejana E.

Circ Res. 2019 Feb 15;124(4):511-525. doi: 10.1161/CIRCRESAHA.118.313316.

7.

Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease: A Review.

Chohan MO, Marchiò S, Morrison LA, Sidman RL, Cavenee WK, Dejana E, Yonas H, Pasqualini R, Arap W.

JAMA Neurol. 2019 Apr 1;76(4):492-500. doi: 10.1001/jamaneurol.2018.3634.

PMID:
30476961
8.

Endothelial cell transitions.

Dejana E, Lampugnani MG.

Science. 2018 Nov 16;362(6416):746-747. doi: 10.1126/science.aas9432. No abstract available.

PMID:
30442789
9.

Resident Endothelial Progenitors Make Themselves at Home.

Hirschi KK, Dejana E.

Cell Stem Cell. 2018 Aug 2;23(2):153-155. doi: 10.1016/j.stem.2018.07.014.

10.

CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis.

Lugano R, Vemuri K, Yu D, Bergqvist M, Smits A, Essand M, Johansson S, Dejana E, Dimberg A.

J Clin Invest. 2018 Aug 1;128(8):3280-3297. doi: 10.1172/JCI97459. Epub 2018 Jun 25.

11.

Endothelial trans-differentiation in glioblastoma recurring after radiotherapy.

De Pascalis I, Morgante L, Pacioni S, D'Alessandris QG, Giannetti S, Martini M, Ricci-Vitiani L, Malinverno M, Dejana E, Larocca LM, Pallini R.

Mod Pathol. 2018 Sep;31(9):1361-1366. doi: 10.1038/s41379-018-0046-2. Epub 2018 Apr 30.

12.

Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.

Krispin S, Stratman AN, Melick CH, Stan RV, Malinverno M, Gleklen J, Castranova D, Dejana E, Weinstein BM.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):353-362. doi: 10.1161/ATVBAHA.117.309571. Epub 2017 Dec 28.

13.

VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression.

Morini MF, Giampietro C, Corada M, Pisati F, Lavarone E, Cunha SI, Conze LL, O'Reilly N, Joshi D, Kjaer S, George R, Nye E, Ma A, Jin J, Mitter R, Lupia M, Cavallaro U, Pasini D, Calado DP, Dejana E, Taddei A.

Circ Res. 2018 Jan 19;122(2):231-245. doi: 10.1161/CIRCRESAHA.117.312392. Epub 2017 Dec 12.

14.

Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development doi: 10.1242/dev.146241.

Chiang IK, Fritzsche M, Pichol-Thievend C, Neal A, Holmes K, Lagendijk A, Overman J, D'Angelo D, Omini A, Hermkens D, Lesieur E, Fossat N, Radziewic T, Liu K, Ratnayaka I, Corada M, Bou-Gharios G, Tam PPL, Carroll J, Dejana E, Schulte-Merker S, Hogan BM, Beltrame M, De Val S, Francois M.

Development. 2017 Oct 15;144(20):3847-3848. doi: 10.1242/dev.159715. No abstract available.

15.

Corrigendum: Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease.

Lampugnani MG, Dejana E, Giampietro C.

Cold Spring Harb Perspect Biol. 2017 Oct 3;9(10). pii: a033720. doi: 10.1101/cshperspect.a033720. No abstract available.

16.

Deregulated TGF-β/BMP Signaling in Vascular Malformations.

Cunha SI, Magnusson PU, Dejana E, Lampugnani MG.

Circ Res. 2017 Sep 29;121(8):981-999. doi: 10.1161/CIRCRESAHA.117.309930. Review.

PMID:
28963191
17.

VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.

Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA.

Curr Biol. 2017 Sep 11;27(17):2727. doi: 10.1016/j.cub.2017.08.064. No abstract available.

18.

Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease.

Lampugnani MG, Dejana E, Giampietro C.

Cold Spring Harb Perspect Biol. 2018 Oct 1;10(10). pii: a029322. doi: 10.1101/cshperspect.a029322. Review. Erratum in: Cold Spring Harb Perspect Biol. 2017 Oct 3;9(10 ):.

PMID:
28851747
19.

Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis.

Erba BG, Gruppi C, Corada M, Pisati F, Rosti V, Bartalucci N, Villeval JL, Vannucchi AM, Barosi G, Balduini A, Dejana E.

Am J Pathol. 2017 Aug;187(8):1879-1892. doi: 10.1016/j.ajpath.2017.04.006.

20.

VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.

Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA.

Curr Biol. 2017 Jul 24;27(14):2219-2225.e5. doi: 10.1016/j.cub.2017.06.020. Epub 2017 Jul 14. Erratum in: Curr Biol. 2017 Sep 11;27(17):2727.

21.

Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell-Mediated Immunotherapy.

Zhao Y, Ting KK, Li J, Cogger VC, Chen J, Johansson-Percival A, Ngiow SF, Holst J, Grau G, Goel S, Muller T, Dejana E, McCaughan G, Smyth MJ, Ganss R, Vadas MA, Gamble JR.

Cancer Res. 2017 Aug 15;77(16):4434-4447. doi: 10.1158/0008-5472.CAN-16-3129. Epub 2017 Jun 27. Erratum in: Cancer Res. 2018 Oct 1;78(19):5718.

22.

SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development.

Chiang IK, Fritzsche M, Pichol-Thievend C, Neal A, Holmes K, Lagendijk A, Overman J, D'Angelo D, Omini A, Hermkens D, Lesieur E, Liu K, Ratnayaka I, Corada M, Bou-Gharios G, Carroll J, Dejana E, Schulte-Merker S, Hogan B, Beltrame M, De Val S, Francois M.

Development. 2017 Jul 15;144(14):2629-2639. doi: 10.1242/dev.146241. Epub 2017 Jun 15. Erratum in: Development. 2017 Oct 15;144(20):3847-3848.

23.

Endothelial cell disease: emerging knowledge from cerebral cavernous malformations.

Lampugnani MG, Malinverno M, Dejana E, Rudini N.

Curr Opin Hematol. 2017 May;24(3):256-264. doi: 10.1097/MOH.0000000000000338. Review.

PMID:
28212190
24.

The molecular basis of endothelial cell plasticity.

Dejana E, Hirschi KK, Simons M.

Nat Commun. 2017 Feb 9;8:14361. doi: 10.1038/ncomms14361. Review. No abstract available.

25.

Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors.

Malinverno M, Corada M, Ferrarini L, Formicola L, Marazzi G, Sassoon D, Dejana E.

Stem Cells. 2017 May;35(5):1328-1340. doi: 10.1002/stem.2566. Epub 2017 Feb 5.

26.

β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function.

Ziegler N, Awwad K, Fisslthaler B, Reis M, Devraj K, Corada M, Minardi SP, Dejana E, Plate KH, Fleming I, Liebner S.

J Neurosci. 2016 Aug 24;36(34):8921-35. doi: 10.1523/JNEUROSCI.0148-16.2016.

27.

Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice.

Gertz K, Kronenberg G, Uhlemann R, Prinz V, Marquina R, Corada M, Dejana E, Endres M.

BMC Neurol. 2016 Aug 18;16(1):144. doi: 10.1186/s12883-016-0670-8.

28.

Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells.

Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, Corada M, Dejana E, Zhou B, Adams RH.

Nat Commun. 2016 Aug 12;7:12422. doi: 10.1038/ncomms12422.

29.

Glycolytic regulation of cell rearrangement in angiogenesis.

Cruys B, Wong BW, Kuchnio A, Verdegem D, Cantelmo AR, Conradi LC, Vandekeere S, Bouché A, Cornelissen I, Vinckier S, Merks RM, Dejana E, Gerhardt H, Dewerchin M, Bentley K, Carmeliet P.

Nat Commun. 2016 Jul 20;7:12240. doi: 10.1038/ncomms12240.

30.

The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation.

Gordon EJ, Fukuhara D, Weström S, Padhan N, Sjöström EO, van Meeteren L, He L, Orsenigo F, Dejana E, Bentley K, Spurkland A, Claesson-Welsh L.

Sci Signal. 2016 Jul 19;9(437):ra72. doi: 10.1126/scisignal.aad9256.

PMID:
27436360
31.

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread.

Li X, Padhan N, Sjöström EO, Roche FP, Testini C, Honkura N, Sáinz-Jaspeado M, Gordon E, Bentley K, Philippides A, Tolmachev V, Dejana E, Stan RV, Vestweber D, Ballmer-Hofer K, Betsholtz C, Pietras K, Jansson L, Claesson-Welsh L.

Nat Commun. 2016 Mar 23;7:11017. doi: 10.1038/ncomms11017.

32.

Endothelial Cells Lining Sporadic Cerebral Cavernous Malformation Cavernomas Undergo Endothelial-to-Mesenchymal Transition.

Bravi L, Malinverno M, Pisati F, Rudini N, Cuttano R, Pallini R, Martini M, Larocca LM, Locatelli M, Levi V, Bertani GA, Dejana E, Lampugnani MG.

Stroke. 2016 Mar;47(3):886-90. doi: 10.1161/STROKEAHA.115.011867. Epub 2016 Feb 2.

PMID:
26839352
33.

NEURODEVELOPMENT. Oligodendrocytes follow blood vessel trails in the brain.

Dejana E, Betsholtz C.

Science. 2016 Jan 22;351(6271):341-2. doi: 10.1126/science.aaf1139. No abstract available.

PMID:
26798001
34.

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.

Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E.

J Cell Biol. 2015 Dec 21;211(6):1177-92. doi: 10.1083/jcb.201501089. Epub 2015 Dec 14.

35.

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.

Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, Morini MF, Maddaluno L, Baeyens N, Adams RH, Jain MK, Owens GK, Schwartz M, Lampugnani MG, Dejana E.

EMBO Mol Med. 2016 Jan 1;8(1):6-24. doi: 10.15252/emmm.201505433.

36.

A gut-vascular barrier controls the systemic dissemination of bacteria.

Spadoni I, Zagato E, Bertocchi A, Paolinelli R, Hot E, Di Sabatino A, Caprioli F, Bottiglieri L, Oldani A, Viale G, Penna G, Dejana E, Rescigno M.

Science. 2015 Nov 13;350(6262):830-4. doi: 10.1126/science.aad0135.

37.

The alternative splicing factor Nova2 regulates vascular development and lumen formation.

Giampietro C, Deflorian G, Gallo S, Di Matteo A, Pradella D, Bonomi S, Belloni E, Nyqvist D, Quaranta V, Confalonieri S, Bertalot G, Orsenigo F, Pisati F, Ferrero E, Biamonti G, Fredrickx E, Taveggia C, Wyatt CD, Irimia M, Di Fiore PP, Blencowe BJ, Dejana E, Ghigna C.

Nat Commun. 2015 Oct 8;6:8479. doi: 10.1038/ncomms9479.

38.

Defective autophagy is a key feature of cerebral cavernous malformations.

Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E, Retta SF, Pinton P.

EMBO Mol Med. 2015 Nov;7(11):1403-17. doi: 10.15252/emmm.201505316.

39.

Lessons from the first ecancer symposium on angiogenesis in gastric cancer.

Nailor A, Dejana E, Reynolds AR, Punwani S, Curigliano G, Bertolini F, Shah M, Danesi R, Kerbel R, McVie G.

Ecancermedicalscience. 2015 Jul 21;9:553. doi: 10.3332/ecancer.2015.553. eCollection 2015.

40.

Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice.

Bravi L, Rudini N, Cuttano R, Giampietro C, Maddaluno L, Ferrarini L, Adams RH, Corada M, Boulday G, Tournier-Lasserve E, Dejana E, Lampugnani MG.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8421-6. doi: 10.1073/pnas.1501352112. Epub 2015 Jun 24.

41.

New insights in the control of vascular permeability: vascular endothelial-cadherin and other players.

Trani M, Dejana E.

Curr Opin Hematol. 2015 May;22(3):267-72. doi: 10.1097/MOH.0000000000000137. Review.

PMID:
25767951
42.

Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion.

Tacconi C, Correale C, Gandelli A, Spinelli A, Dejana E, D'Alessio S, Danese S.

Gastroenterology. 2015 Jun;148(7):1438-51.e8. doi: 10.1053/j.gastro.2015.03.005. Epub 2015 Mar 6.

43.

PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence.

Bonfanti C, Rossi G, Tedesco FS, Giannotta M, Benedetti S, Tonlorenzi R, Antonini S, Marazzi G, Dejana E, Sassoon D, Cossu G, Messina G.

Nat Commun. 2015 Mar 9;6:6364. doi: 10.1038/ncomms7364.

44.

The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling.

Birdsey GM, Shah AV, Dufton N, Reynolds LE, Osuna Almagro L, Yang Y, Aspalter IM, Khan ST, Mason JC, Dejana E, Göttgens B, Hodivala-Dilke K, Gerhardt H, Adams RH, Randi AM.

Dev Cell. 2015 Jan 12;32(1):82-96. doi: 10.1016/j.devcel.2014.11.016.

45.

The role of microvascular endothelial WNT signaling the formation of the blood brain barrier.

Lampugnani MG, Bravi L, Dejana E.

Springerplus. 2015 Jun 12;4(Suppl 1):L47. doi: 10.1186/2193-1801-4-S1-L47. eCollection 2015. No abstract available.

46.

Signaling pathways in the specification of arteries and veins.

Corada M, Morini MF, Dejana E.

Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2372-7. doi: 10.1161/ATVBAHA.114.303218. Epub 2014 Aug 28. Review.

PMID:
25169934
47.

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization.

Magrini E, Villa A, Angiolini F, Doni A, Mazzarol G, Rudini N, Maddaluno L, Komuta M, Topal B, Prenen H, Schachner M, Confalonieri S, Dejana E, Bianchi F, Mazzone M, Cavallaro U.

J Clin Invest. 2014 Oct;124(10):4335-50. doi: 10.1172/JCI70683. Epub 2014 Aug 26.

48.

Tumor vessel normalization by chloroquine independent of autophagy.

Maes H, Kuchnio A, Peric A, Moens S, Nys K, De Bock K, Quaegebeur A, Schoors S, Georgiadou M, Wouters J, Vinckier S, Vankelecom H, Garmyn M, Vion AC, Radtke F, Boulanger C, Gerhardt H, Dejana E, Dewerchin M, Ghesquière B, Annaert W, Agostinis P, Carmeliet P.

Cancer Cell. 2014 Aug 11;26(2):190-206. doi: 10.1016/j.ccr.2014.06.025.

49.

Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.

Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG, Alitalo K.

Genes Dev. 2014 Jul 15;28(14):1592-603. doi: 10.1101/gad.237677.114.

50.

An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions.

Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG.

J Cell Sci. 2014 Sep 1;127(Pt 17):3768-81. doi: 10.1242/jcs.149518. Epub 2014 Jul 2.

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