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Dissolution of lipids from mucus: a possible mechanism for prompt disruption of gut barrier function by alcohol.

Qin X, Deitch EA.

Toxicol Lett. 2015 Jan 22;232(2):356-62. doi: 10.1016/j.toxlet.2014.11.027. Epub 2014 Nov 25.


A sphingosine-1 phosphate agonist (FTY720) limits trauma/hemorrhagic shock-induced multiple organ dysfunction syndrome.

Bonitz JA, Son JY, Chandler B, Tomaio JN, Qin Y, Prescott LM, Feketeova E, Deitch EA.

Shock. 2014 Nov;42(5):448-55. doi: 10.1097/SHK.0000000000000227.


The intestinal mucus layer is a critical component of the gut barrier that is damaged during acute pancreatitis.

Fishman JE, Levy G, Alli V, Zheng X, Mole DJ, Deitch EA.

Shock. 2014 Sep;42(3):264-70. doi: 10.1097/SHK.0000000000000209.


Intraluminal nonbacterial intestinal components control gut and lung injury after trauma hemorrhagic shock.

Fishman JE, Sheth SU, Levy G, Alli V, Lu Q, Xu D, Qin Y, Qin X, Deitch EA.

Ann Surg. 2014 Dec;260(6):1112-20. doi: 10.1097/SLA.0000000000000631.


Oral pretreatment with recombinant human lactoferrin limits trauma-hemorrhagic shock-induced gut injury and the biological activity of mesenteric lymph.

Son JY, Chandler B, Feketova E, Qin Y, Quackenbush EJ, Deitch EA.

J Surg Res. 2014 Mar;187(1):270-7. doi: 10.1016/j.jss.2013.10.026. Epub 2013 Oct 19.


Trauma-hemorrhagic shock induces a CD36-dependent RBC endothelial-adhesive phenotype.

Deitch EA, Condon M, Feketeova E, Machiedo GW, Mason L, Vinluan GM, Alli VA, Neal MD, Tomaio JN, Fishman JE, Durán WN, Spolarics Z.

Crit Care Med. 2014 Mar;42(3):e200-10. doi: 10.1097/CCM.0000000000000119.


Does recombinant factor XIII eliminate early manifestations of multiple-organ injury after experimental burn similarly to gut ischemia-reperfusion injury or trauma-hemorrhagic shock?

Zaets SB, Xu DZ, Lu Q, Feketova E, Berezina TL, Malinina IV, Deitch EA, Olsen EH.

J Burn Care Res. 2014 Jul-Aug;35(4):328-36. doi: 10.1097/BCR.0b013e3182a228ee.


IRAK1-dependent signaling mediates mortality in polymicrobial sepsis.

Chandra R, Federici S, Bishwas T, Németh ZH, Deitch EA, Thomas JA, Spolarics Z.

Inflammation. 2013 Dec;36(6):1503-12. doi: 10.1007/s10753-013-9692-1.


Early trauma-hemorrhage-induced splenic and thymic apoptosis is gut-mediated and toll-like receptor 4-dependent.

Tiesi G, Reino D, Mason L, Palange D, Tomaio JN, Deitch EA.

Shock. 2013 Jun;39(6):507-13. doi: 10.1097/SHK.0b013e318293d020.


Cellular basis of burn-induced cardiac dysfunction and prevention by mesenteric lymph duct ligation.

Sambol J, Deitch EA, Takimoto K, Dosi G, Yatani A.

J Surg Res. 2013 Aug;183(2):678-85. doi: 10.1016/j.jss.2013.01.065. Epub 2013 Feb 22.


Preexisting mental illness and risk for developing a new disorder after hurricane Katrina.

Sullivan G, Vasterling JJ, Han X, Tharp AT, Davis T, Deitch EA, Constans JI.

J Nerv Ment Dis. 2013 Feb;201(2):161-6. doi: 10.1097/NMD.0b013e31827f636d.


Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock.

Levy G, Fishman JE, Xu D, Chandler BT, Feketova E, Dong W, Qin Y, Alli V, Ulloa L, Deitch EA.

Shock. 2013 Jan;39(1):39-44. doi: 10.1097/SHK.0b013e31827b450d.


Oxidative modification of the intestinal mucus layer is a critical but unrecognized component of trauma hemorrhagic shock-induced gut barrier failure.

Fishman JE, Levy G, Alli V, Sheth S, Lu Q, Deitch EA.

Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G57-63. doi: 10.1152/ajpgi.00170.2012. Epub 2012 Nov 1.


Role of lipase-generated free fatty acids in converting mesenteric lymph from a noncytotoxic to a cytotoxic fluid.

Qin X, Dong W, Sharpe SM, Sheth SU, Palange DC, Rider T, Jandacek R, Tso P, Deitch EA.

Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15;303(8):G969-78. doi: 10.1152/ajpgi.00290.2012. Epub 2012 Aug 16.


Vagal nerve stimulation modulates gut injury and lung permeability in trauma-hemorrhagic shock.

Levy G, Fishman JE, Xu DZ, Dong W, Palange D, Vida G, Mohr A, Ulloa L, Deitch EA.

J Trauma Acute Care Surg. 2012 Aug;73(2):338-42; discussion 342. doi: 10.1097/TA.0b013e31825debd3.


Systemic inflammatory response does not correlate with acute lung injury associated with mechanical ventilation strategies in normal lungs.

Hong CM, Xu DZ, Lu Q, Cheng Y, Pisarenko V, Doucet D, Brown M, Zhang C, Deitch EA, Delphin E.

Anesth Analg. 2012 Jul;115(1):118-21. doi: 10.1213/ANE.0b013e3182554337. Epub 2012 May 14.


Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming.

Reino DC, Palange D, Feketeova E, Bonitz RP, Xu DZ, Lu Q, Sheth SU, Peña G, Ulloa L, De Maio A, Feinman R, Deitch EA.

Shock. 2012 Jul;38(1):107-14. doi: 10.1097/SHK.0b013e318257123a.


Gut-origin sepsis: evolution of a concept.

Deitch EA.

Surgeon. 2012 Dec;10(6):350-6. doi: 10.1016/j.surge.2012.03.003. Epub 2012 Apr 23. Review.


Testosterone depletion or blockade in male rats protects against trauma hemorrhagic shock-induced distant organ injury by limiting gut injury and subsequent production of biologically active mesenteric lymph.

Sheth SU, Palange D, Xu DZ, Wei D, Feketeova E, Lu Q, Reino DC, Qin X, Deitch EA.

J Trauma. 2011 Dec;71(6):1652-8. doi: 10.1097/TA.0b013e31823a06ea.


Effects of pre- and post-Katrina nonviolent and violent experiences on male veterans' psychological functioning.

Tharp AT, Vasterling JJ, Sullivan G, Han X, Davis T, Deitch EA, Constans J.

Disaster Med Public Health Prep. 2011 Sep;5 Suppl 2:S227-34. doi: 10.1001/dmp.2011.47.


Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis.

Haskó G, Csóka B, Koscsó B, Chandra R, Pacher P, Thompson LF, Deitch EA, Spolarics Z, Virág L, Gergely P, Rolandelli RH, Németh ZH.

J Immunol. 2011 Oct 15;187(8):4256-67. doi: 10.4049/jimmunol.1003379. Epub 2011 Sep 14.


β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system.

Vida G, Peña G, Kanashiro A, Thompson-Bonilla Mdel R, Palange D, Deitch EA, Ulloa L.

FASEB J. 2011 Dec;25(12):4476-85. doi: 10.1096/fj.11-191007. Epub 2011 Aug 12.


Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice.

Reino DC, Pisarenko V, Palange D, Doucet D, Bonitz RP, Lu Q, Colorado I, Sheth SU, Chandler B, Kannan KB, Ramanathan M, Xu DZ, Deitch EA, Feinman R.

PLoS One. 2011;6(8):e14829. doi: 10.1371/journal.pone.0014829. Epub 2011 Aug 4.


Mesenteric lymph from rats with trauma-hemorrhagic shock causes abnormal cardiac myocyte function and induces myocardial contractile dysfunction.

Sambol JT, Lee MA, Jiang M, Dosi G, Dong W, Deitch EA, Yatani A.

J Appl Physiol (1985). 2011 Sep;111(3):799-807. doi: 10.1152/japplphysiol.00100.2011. Epub 2011 Jun 23.


Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis.

Peña G, Cai B, Ramos L, Vida G, Deitch EA, Ulloa L.

J Immunol. 2011 Jul 15;187(2):718-25. doi: 10.4049/jimmunol.1100013. Epub 2011 Jun 10.


Anticoagulants influence the in vitro activity and composition of shock lymph but not its in vivo activity.

Deitch EA, Qin X, Sheth SU, Tiesi G, Palange D, Dong W, Lu Q, Xu D, Feketeova E, Feinman R.

Shock. 2011 Aug;36(2):177-83. doi: 10.1097/SHK.0b013e3182205c30.


Female X-chromosome mosaicism for NOX2 deficiency presents unique inflammatory phenotype and improves outcome in polymicrobial sepsis.

Chandra R, Federici S, Németh ZH, Horváth B, Pacher P, Haskó G, Deitch EA, Spolarics Z.

J Immunol. 2011 Jun 1;186(11):6465-73. doi: 10.4049/jimmunol.1100205. Epub 2011 Apr 18.


α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.

Vida G, Peña G, Deitch EA, Ulloa L.

J Immunol. 2011 Apr 1;186(7):4340-6. doi: 10.4049/jimmunol.1003722. Epub 2011 Feb 21.


Intravenous injection of mesenteric lymph produced during hemorrhagic shock decreases RBC deformability in the rat.

Condon M, Senthil M, Xu DZ, Mason L, Sheth SU, Spolarics Z, Feketova E, Machiedo GW, Deitch EA.

J Trauma. 2011 Feb;70(2):489-95. doi: 10.1097/TA.0b013e31820329d8.


Recombinant factor XIII mitigates hemorrhagic shock-induced organ dysfunction.

Zaets SB, Xu DZ, Lu Q, Feketova E, Berezina TL, Malinina IV, Deitch EA, Olsen EH.

J Surg Res. 2011 Apr;166(2):e135-42. doi: 10.1016/j.jss.2010.12.001. Epub 2010 Dec 31.


Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury.

Kannan KB, Colorado I, Reino D, Palange D, Lu Q, Qin X, Abungu B, Watkins A, Caputo FJ, Xu DZ, Semenza GL, Deitch EA, Feinman R.

Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G853-61. doi: 10.1152/ajpgi.00459.2010. Epub 2010 Dec 23.


Heparin use in a rat hemorrhagic shock model induces biologic activity in mesenteric lymph separate from shock.

Qin Y, Prescott LM, Deitch EA, Kaiser VL.

Shock. 2011 Apr;35(4):411-21. doi: 10.1097/SHK.0b013e31820239ee.


Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction.

Deitch EA.

Ann N Y Acad Sci. 2010 Oct;1207 Suppl 1:E103-11. doi: 10.1111/j.1749-6632.2010.05713.x. Review.


The mucus layer is critical in protecting against ischemia-reperfusion-mediated gut injury and in the restitution of gut barrier function.

Qin X, Sheth SU, Sharpe SM, Dong W, Lu Q, Xu D, Deitch EA.

Shock. 2011 Mar;35(3):275-81. doi: 10.1097/SHK.0b013e3181f6aaf1.


Gender differences in glucose variability after severe trauma.

Mohr AM, Lavery RF, Sifri ZC, Anjaria DJ, Koernig R, Deitch EA, Livingston DH.

Am Surg. 2010 Aug;76(8):896-902.


Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis.

Peña G, Cai B, Liu J, van der Zanden EP, Deitch EA, de Jonge WJ, Ulloa L.

Eur J Immunol. 2010 Sep;40(9):2580-9. doi: 10.1002/eji.201040540.


HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury.

Feinman R, Deitch EA, Watkins AC, Abungu B, Colorado I, Kannan KB, Sheth SU, Caputo FJ, Lu Q, Ramanathan M, Attan S, Badami CD, Doucet D, Barlos D, Bosch-Marce M, Semenza GL, Xu DZ.

Am J Physiol Gastrointest Liver Physiol. 2010 Oct;299(4):G833-43. doi: 10.1152/ajpgi.00065.2010. Epub 2010 Aug 5.


The anatomic sites of disruption of the mucus layer directly correlate with areas of trauma/hemorrhagic shock-induced gut injury.

Lu Q, Xu DZ, Sharpe S, Doucet D, Pisarenko V, Lee M, Deitch EA.

J Trauma. 2011 Mar;70(3):630-5. doi: 10.1097/TA.0b013e3181e1221b.


Female X-chromosome mosaicism for gp91phox expression diversifies leukocyte responses during endotoxemia.

Chandra R, Federici S, Haskó G, Deitch EA, Spolarics Z.

Crit Care Med. 2010 Oct;38(10):2003-10. doi: 10.1097/CCM.0b013e3181eb9ed6.


Novel insights for systemic inflammation in sepsis and hemorrhage.

Cai B, Deitch EA, Ulloa L.

Mediators Inflamm. 2010;2010:642462. doi: 10.1155/2010/642462. Epub 2010 Jun 8. Review.


Fat and the gut: more than empty calories.

Deitch EA, Ulloa L.

Crit Care Med. 2010 Jul;38(7):1608-9. doi: 10.1097/CCM.0b013e3181e4baea. No abstract available.


Mast cell stabilization improves survival by preventing apoptosis in sepsis.

Ramos L, Peña G, Cai B, Deitch EA, Ulloa L.

J Immunol. 2010 Jul 1;185(1):709-16. doi: 10.4049/jimmunol.1000273. Epub 2010 Jun 2.


A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation.

Csóka B, Németh ZH, Rosenberger P, Eltzschig HK, Spolarics Z, Pacher P, Selmeczy Z, Koscsó B, Himer L, Vizi ES, Blackburn MR, Deitch EA, Haskó G.

J Immunol. 2010 Jul 1;185(1):542-50. doi: 10.4049/jimmunol.0901295. Epub 2010 May 26.


Prevalence and characteristics of Staphylococcus aureus colonization among healthcare professionals in an urban teaching hospital.

Elie-Turenne MC, Fernandes H, Mediavilla JR, Rosenthal M, Mathema B, Singh A, Cohen TR, Pawar KA, Shahidi H, Kreiswirth BN, Deitch EA.

Infect Control Hosp Epidemiol. 2010 Jun;31(6):574-80. doi: 10.1086/652525.


JAK2 inhibition prevents innate immune responses and rescues animals from sepsis.

Peña G, Cai B, Deitch EA, Ulloa L.

J Mol Med (Berl). 2010 Aug;88(8):851-9. doi: 10.1007/s00109-010-0628-z.


Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death.

Himer L, Csóka B, Selmeczy Z, Koscsó B, Pócza T, Pacher P, Németh ZH, Deitch EA, Vizi ES, Cronstein BN, Haskó G.

FASEB J. 2010 Aug;24(8):2631-40. doi: 10.1096/fj.10-155192. Epub 2010 Apr 6.


Loss of the intestinal mucus layer in the normal rat causes gut injury but not toxic mesenteric lymph nor lung injury.

Sharpe SM, Qin X, Lu Q, Feketeova E, Palange DC, Dong W, Sheth SU, Lee MA, Reino D, Xu DZ, Deitch EA.

Shock. 2010 Nov;34(5):475-81. doi: 10.1097/SHK.0b013e3181dc3ff5.


Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats.

Doucet D, Badami C, Palange D, Bonitz RP, Lu Q, Xu DZ, Kannan KB, Colorado I, Feinman R, Deitch EA.

PLoS One. 2010 Feb 25;5(2):e9421. doi: 10.1371/journal.pone.0009421.


Survival and inflammatory responses in experimental models of hemorrhage.

Cai B, Dong W, Sharpe S, Deitch EA, Ulloa L.

J Surg Res. 2011 Aug;169(2):257-66. doi: 10.1016/j.jss.2009.11.712. Epub 2009 Dec 9.


Intestinal mucus layer preservation in female rats attenuates gut injury after trauma-hemorrhagic shock.

Sheth SU, Lu Q, Twelker K, Sharpe SM, Qin X, Reino DC, Lee MA, Xu DZ, Deitch EA.

J Trauma. 2010 Feb;68(2):279-88. doi: 10.1097/TA.0b013e3181caa6bd.

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