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Items: 1 to 50 of 144

1.

A Role for the VPS Retromer in Brucella Intracellular Replication Revealed by Genomewide siRNA Screening.

Casanova A, Low SH, Québatte M, Sedzicki J, Tschon T, Ketterer M, Smith K, Emmenlauer M, Ben-Tekaya H, Dehio C.

mSphere. 2019 Jun 26;4(3). pii: e00380-19. doi: 10.1128/mSphere.00380-19.

2.

Bartonella gene transfer agent: Evolution, function, and proposed role in host adaptation.

Québatte M, Dehio C.

Cell Microbiol. 2019 Jun 24:e13068. doi: 10.1111/cmi.13068. [Epub ahead of print] Review.

PMID:
31231937
3.

Versatility of the BID Domain: Conserved Function as Type-IV-Secretion-Signal and Secondarily Evolved Effector Functions Within Bartonella-Infected Host Cells.

Wagner A, Tittes C, Dehio C.

Front Microbiol. 2019 May 3;10:921. doi: 10.3389/fmicb.2019.00921. eCollection 2019. Review.

4.

Publisher Correction: Definitions and guidelines for research on antibiotic persistence.

Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A.

Nat Rev Microbiol. 2019 Jul;17(7):460. doi: 10.1038/s41579-019-0207-4.

PMID:
31036919
5.

Definitions and guidelines for research on antibiotic persistence.

Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A.

Nat Rev Microbiol. 2019 Jul;17(7):441-448. doi: 10.1038/s41579-019-0196-3. Review. Erratum in: Nat Rev Microbiol. 2019 Apr 29;:.

PMID:
30980069
6.

Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains.

Cunrath O, Meinel DM, Maturana P, Fanous J, Buyck JM, Saint Auguste P, Seth-Smith HMB, Körner J, Dehio C, Trebosc V, Kemmer C, Neher R, Egli A, Bumann D.

EBioMedicine. 2019 Mar;41:479-487. doi: 10.1016/j.ebiom.2019.02.061. Epub 2019 Mar 7.

7.

Multi-omic measurements of heterogeneity in HeLa cells across laboratories.

Liu Y, Mi Y, Mueller T, Kreibich S, Williams EG, Van Drogen A, Borel C, Frank M, Germain PL, Bludau I, Mehnert M, Seifert M, Emmenlauer M, Sorg I, Bezrukov F, Bena FS, Zhou H, Dehio C, Testa G, Saez-Rodriguez J, Antonarakis SE, Hardt WD, Aebersold R.

Nat Biotechnol. 2019 Mar;37(3):314-322. doi: 10.1038/s41587-019-0037-y. Epub 2019 Feb 18.

PMID:
30778230
8.

Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species.

Wagner A, Dehio C.

Cell Microbiol. 2019 Mar;21(3):e13004. doi: 10.1111/cmi.13004. Epub 2019 Feb 6. Review.

9.

Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition.

Daga N, Eicher S, Kannan A, Casanova A, Low SH, Kreibich S, Andritschke D, Emmenlauer M, Jenkins JL, Hardt WD, Greber UF, Dehio C, von Mering C.

Nucleic Acids Res. 2018 Oct 12;46(18):9309-9320. doi: 10.1093/nar/gky798.

10.

Improved pathway reconstruction from RNA interference screens by exploiting off-target effects.

Srivatsa S, Kuipers J, Schmich F, Eicher S, Emmenlauer M, Dehio C, Beerenwinkel N.

Bioinformatics. 2018 Jul 1;34(13):i519-i527. doi: 10.1093/bioinformatics/bty240.

11.

Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria.

Lobet E, Willemart K, Ninane N, Demazy C, Sedzicki J, Lelubre C, De Bolle X, Renard P, Raes M, Dehio C, Letesson JJ, Arnould T.

Sci Rep. 2018 Mar 26;8(1):5173. doi: 10.1038/s41598-018-23483-3.

12.

3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum.

Sedzicki J, Tschon T, Low SH, Willemart K, Goldie KN, Letesson JJ, Stahlberg H, Dehio C.

J Cell Sci. 2018 Feb 22;131(4). pii: jcs210799. doi: 10.1242/jcs.210799.

13.

Editorial overview: Bacterial systems biology.

Dehio C, Bumann D.

Curr Opin Microbiol. 2017 Oct;39:viii-xi. doi: 10.1016/j.mib.2017.11.024. No abstract available.

PMID:
29241558
14.

An integrative strategy to identify the entire protein coding potential of prokaryotic genomes by proteogenomics.

Omasits U, Varadarajan AR, Schmid M, Goetze S, Melidis D, Bourqui M, Nikolayeva O, Québatte M, Patrignani A, Dehio C, Frey JE, Robinson MD, Wollscheid B, Ahrens CH.

Genome Res. 2017 Dec;27(12):2083-2095. doi: 10.1101/gr.218255.116. Epub 2017 Nov 15.

15.

A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella.

Harms A, Liesch M, Körner J, Québatte M, Engel P, Dehio C.

PLoS Genet. 2017 Oct 26;13(10):e1007077. doi: 10.1371/journal.pgen.1007077. eCollection 2017 Oct.

16.

Systems-level interference strategies to decipher host factors involved in bacterial pathogen interaction: from RNAi to CRISPRi.

Québatte M, Dehio C.

Curr Opin Microbiol. 2017 Oct;39:34-41. doi: 10.1016/j.mib.2017.08.002. Epub 2017 Sep 1. Review.

PMID:
28858701
17.

Gene Transfer Agent Promotes Evolvability within the Fittest Subpopulation of a Bacterial Pathogen.

Québatte M, Christen M, Harms A, Körner J, Christen B, Dehio C.

Cell Syst. 2017 Jun 28;4(6):611-621.e6. doi: 10.1016/j.cels.2017.05.011. Epub 2017 Jun 14.

18.

The Conjugative Relaxase TrwC Promotes Integration of Foreign DNA in the Human Genome.

González-Prieto C, Gabriel R, Dehio C, Schmidt M, Llosa M.

Appl Environ Microbiol. 2017 May 31;83(12). pii: e00207-17. doi: 10.1128/AEM.00207-17. Print 2017 Jun 15.

19.

Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella.

Harms A, Segers FH, Quebatte M, Mistl C, Manfredi P, Körner J, Chomel BB, Kosoy M, Maruyama S, Engel P, Dehio C.

Genome Biol Evol. 2017 Mar 1;9(3):761-776. doi: 10.1093/gbe/evx042.

20.

Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results.

Riba A, Emmenlauer M, Chen A, Sigoillot F, Cong F, Dehio C, Jenkins J, Zavolan M.

Cell Syst. 2017 Feb 22;4(2):182-193.e4. doi: 10.1016/j.cels.2017.01.011. Epub 2017 Feb 15.

21.

Type IV Effector Secretion and Subversion of Host Functions by Bartonella and Brucella Species.

Dehio C, Tsolis RM.

Curr Top Microbiol Immunol. 2017;413:269-295. doi: 10.1007/978-3-319-75241-9_11.

PMID:
29536363
22.

The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook.

Stanger FV, de Beer TAP, Dranow DM, Schirmer T, Phan I, Dehio C.

Structure. 2017 Jan 3;25(1):203-211. doi: 10.1016/j.str.2016.10.010. Epub 2016 Nov 23.

23.

Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin.

Stanger FV, Harms A, Dehio C, Schirmer T.

PLoS One. 2016 Sep 22;11(9):e0163654. doi: 10.1371/journal.pone.0163654. eCollection 2016.

24.

A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion.

Andritschke D, Dilling S, Emmenlauer M, Welz T, Schmich F, Misselwitz B, Rämö P, Rottner K, Kerkhoff E, Wada T, Penninger JM, Beerenwinkel N, Horvath P, Dehio C, Hardt WD.

PLoS One. 2016 Sep 14;11(9):e0161965. doi: 10.1371/journal.pone.0161965. eCollection 2016.

25.

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells.

Casanova A, Low SH, Emmenlauer M, Conde-Alvarez R, Salcedo SP, Gorvel JP, Dehio C.

J Vis Exp. 2016 Aug 5;(114). doi: 10.3791/54263.

26.

Biological Diversity and Molecular Plasticity of FIC Domain Proteins.

Harms A, Stanger FV, Dehio C.

Annu Rev Microbiol. 2016 Sep 8;70:341-60. doi: 10.1146/annurev-micro-102215-095245. Epub 2016 Jul 8. Review.

PMID:
27482742
27.

Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification.

Stanger FV, Burmann BM, Harms A, Aragão H, Mazur A, Sharpe T, Dehio C, Hiller S, Schirmer T.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E529-37. doi: 10.1073/pnas.1516930113. Epub 2016 Jan 19.

28.

Autophagy Proteins Promote Repair of Endosomal Membranes Damaged by the Salmonella Type Three Secretion System 1.

Kreibich S, Emmenlauer M, Fredlund J, Rämö P, Münz C, Dehio C, Enninga J, Hardt WD.

Cell Host Microbe. 2015 Nov 11;18(5):527-37. doi: 10.1016/j.chom.2015.10.015.

29.

Erratum to: gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens.

Schmich F, Szczurek E, Kreibich S, Dilling S, Andritschke D, Casanova A, Low SH, Eicher S, Muntwiler S, Emmenlauer M, Rämo P, Conde-Alvarez R, von Mering C, Hardt WD, Dehio C, Beerenwinkel N.

Genome Biol. 2015 Oct 21;16:233. doi: 10.1186/s13059-015-0807-x. No abstract available.

30.

gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens.

Schmich F, Szczurek E, Kreibich S, Dilling S, Andritschke D, Casanova A, Low SH, Eicher S, Muntwiler S, Emmenlauer M, Rämö P, Conde-Alvarez R, von Mering C, Hardt WD, Dehio C, Beerenwinkel N.

Genome Biol. 2015 Oct 7;16:220. doi: 10.1186/s13059-015-0783-1. Erratum in: Genome Biol. 2015;16:233.

31.

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology.

Harms A, Stanger FV, Scheu PD, de Jong IG, Goepfert A, Glatter T, Gerdes K, Schirmer T, Dehio C.

Cell Rep. 2015 Sep 1;12(9):1497-507. doi: 10.1016/j.celrep.2015.07.056. Epub 2015 Aug 20.

32.
33.

NEMix: single-cell nested effects models for probabilistic pathway stimulation.

Siebourg-Polster J, Mudrak D, Emmenlauer M, Rämö P, Dehio C, Greber U, Fröhlich H, Beerenwinkel N.

PLoS Comput Biol. 2015 Apr 16;11(4):e1004078. doi: 10.1371/journal.pcbi.1004078. eCollection 2015 Apr.

34.

Simultaneous analysis of large-scale RNAi screens for pathogen entry.

Rämö P, Drewek A, Arrieumerlou C, Beerenwinkel N, Ben-Tekaya H, Cardel B, Casanova A, Conde-Alvarez R, Cossart P, Csúcs G, Eicher S, Emmenlauer M, Greber U, Hardt WD, Helenius A, Kasper C, Kaufmann A, Kreibich S, Kühbacher A, Kunszt P, Low SH, Mercer J, Mudrak D, Muntwiler S, Pelkmans L, Pizarro-Cerdá J, Podvinec M, Pujadas E, Rinn B, Rouilly V, Schmich F, Siebourg-Polster J, Snijder B, Stebler M, Studer G, Szczurek E, Truttmann M, von Mering C, Vonderheit A, Yakimovich A, Bühlmann P, Dehio C.

BMC Genomics. 2014 Dec 22;15:1162. doi: 10.1186/1471-2164-15-1162.

35.

New insights into the role of Bartonella effector proteins in pathogenesis.

Siamer S, Dehio C.

Curr Opin Microbiol. 2015 Feb;23:80-5. doi: 10.1016/j.mib.2014.11.007. Epub 2014 Nov 26. Review.

PMID:
25461577
36.

Does playing pay? The fitness-effect of free play during childhood.

Greve W, Thomsen T, Dehio C.

Evol Psychol. 2014 Apr 29;12(2):434-47.

PMID:
25299888
37.

Structure of the N-terminal Gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis.

Stanger FV, Dehio C, Schirmer T.

PLoS One. 2014 Sep 9;9(9):e107289. doi: 10.1371/journal.pone.0107289. eCollection 2014.

38.

A translocated effector required for Bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors.

Okujava R, Guye P, Lu YY, Mistl C, Polus F, Vayssier-Taussat M, Halin C, Rolink AG, Dehio C.

PLoS Pathog. 2014 Jun 19;10(6):e1004187. doi: 10.1371/journal.ppat.1004187. eCollection 2014 Jun.

39.

An experimental strategy for the identification of AMPylation targets from complex protein samples.

Pieles K, Glatter T, Harms A, Schmidt A, Dehio C.

Proteomics. 2014 May;14(9):1048-52. doi: 10.1002/pmic.201300470. Epub 2014 Mar 20.

PMID:
24677795
40.

Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens.

Franceschini A, Meier R, Casanova A, Kreibich S, Daga N, Andritschke D, Dilling S, Rämö P, Emmenlauer M, Kaufmann A, Conde-Álvarez R, Low SH, Pelkmans L, Helenius A, Hardt WD, Dehio C, von Mering C.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4548-53. doi: 10.1073/pnas.1402353111. Epub 2014 Mar 10.

41.

Proteome-wide identification of predominant subcellular protein localizations in a bacterial model organism.

Stekhoven DJ, Omasits U, Quebatte M, Dehio C, Ahrens CH.

J Proteomics. 2014 Mar 17;99:123-37. doi: 10.1016/j.jprot.2014.01.015. Epub 2014 Jan 28.

PMID:
24486812
42.

Multi-scale Gaussian representation and outline-learning based cell image segmentation.

Farhan M, Ruusuvuori P, Emmenlauer M, Rämö P, Dehio C, Yli-Harja O.

BMC Bioinformatics. 2013;14 Suppl 10:S6. doi: 10.1186/1471-2105-14-S10-S6. Epub 2013 Aug 12.

43.

Imaging InlC secretion to investigate cellular infection by the bacterial pathogen Listeria monocytogenes.

Kühbacher A, Gouin E, Mercer J, Emmenlauer M, Dehio C, Cossart P, Pizarro-Cerdá J.

J Vis Exp. 2013 Sep 19;(79):e51043. doi: 10.3791/51043. Erratum in: J Vis Exp. 2014 Jun 25; (88): e5414, 10.3791/5414..

44.

Dual input control: activation of the Bartonella henselae VirB/D4 type IV secretion system by the stringent sigma factor RpoH1 and the BatR/BatS two-component system.

Québatte M, Dick MS, Kaever V, Schmidt A, Dehio C.

Mol Microbiol. 2013 Nov;90(4):756-75. doi: 10.1111/mmi.12396. Epub 2013 Oct 4.

45.

A translocation motif in relaxase TrwC specifically affects recruitment by its conjugative type IV secretion system.

Alperi A, Larrea D, Fernández-González E, Dehio C, Zechner EL, Llosa M.

J Bacteriol. 2013 Nov;195(22):4999-5006. doi: 10.1128/JB.00367-13. Epub 2013 Aug 30.

46.

Bartonella and Brucella--weapons and strategies for stealth attack.

Ben-Tekaya H, Gorvel JP, Dehio C.

Cold Spring Harb Perspect Med. 2013 Aug 1;3(8). pii: a010231. doi: 10.1101/cshperspect.a010231.

47.

Directed shotgun proteomics guided by saturated RNA-seq identifies a complete expressed prokaryotic proteome.

Omasits U, Quebatte M, Stekhoven DJ, Fortes C, Roschitzki B, Robinson MD, Dehio C, Ahrens CH.

Genome Res. 2013 Nov;23(11):1916-27. doi: 10.1101/gr.151035.112. Epub 2013 Jul 22.

48.

Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with Fic fold.

Goepfert A, Stanger FV, Dehio C, Schirmer T.

PLoS One. 2013 May 30;8(5):e64901. doi: 10.1371/journal.pone.0064901. Print 2013.

49.

Partial disruption of translational and posttranslational machinery reshapes growth rates of Bartonella birtlesii.

Rolain JM, Vayssier-Taussat M, Saisongkorh W, Merhej V, Gimenez G, Robert C, Le Rhun D, Dehio C, Raoult D.

MBio. 2013 Apr 23;4(2):e00115-13. doi: 10.1128/mBio.00115-13.

50.

Systems-level analysis of host-pathogen interaction using RNA interference.

Eicher SC, Dehio C.

N Biotechnol. 2013 Mar 25;30(3):308-13. doi: 10.1016/j.nbt.2013.01.008. Epub 2013 Feb 5. Review.

PMID:
23395778

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