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'Aberrant localisation of Annexin A1 is associated with metastatic outcome in thin melanomas'.

Romero P, Boudhraa Z, Carton M, Hassan A, Joubert-Zakeyh J, Pereira B, Dechelotte P, Rouanet J, Degoul F.

Australas J Dermatol. 2019 Oct 23. doi: 10.1111/ajd.13174. [Epub ahead of print] No abstract available.


Pretargeted radioimmunotherapy and SPECT imaging of peritoneal carcinomatosis using bioorthogonal click chemistry: probe selection and first proof-of-concept.

Rondon A, Schmitt S, Briat A, Ty N, Maigne L, Quintana M, Membreno R, Zeglis BM, Navarro-Teulon I, Pouget JP, Chezal JM, Miot-Noirault E, Moreau E, Degoul F.

Theranostics. 2019 Sep 19;9(22):6706-6718. doi: 10.7150/thno.35461. eCollection 2019.


TIP60 Inhibitor TH1834 Reduces Breast Cancer Progression in Xenografts in Mice.

Idrissou M, Judes G, Daures M, Sanchez A, El Ouardi D, Besse S, Degoul F, Penault-Llorca F, Bignon YJ, Bernard-Gallon D.

OMICS. 2019 Sep;23(9):457-459. doi: 10.1089/omi.2019.0126. No abstract available.


Targeted Radionuclide Therapy Decreases Melanoma Lung Invasion by Modifying Epithelial-Mesenchymal Transition-Like Mechanisms.

Akil H, Rouanet J, Viallard C, Besse S, Auzeloux P, Chezal JM, Miot-Noirault E, Quintana M, Degoul F.

Transl Oncol. 2019 Nov;12(11):1442-1452. doi: 10.1016/j.tranon.2019.07.015. Epub 2019 Aug 14.


Determination of eumelanin and pheomelanin in melanomas using solid-phase extraction and high performance liquid chromatography-diode array detection (HPLC-DAD) analysis.

Rioux B, Rouanet J, Akil H, Besse S, Debiton E, Bouchon B, Degoul F, Quintana M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Apr 15;1113:60-68. doi: 10.1016/j.jchromb.2019.03.010. Epub 2019 Mar 11.


Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029.

Bonnet M, Maisonial-Besset A, Zhu Y, Witkowski T, Roche G, Boucheix C, Greco C, Degoul F.

Cancers (Basel). 2019 Feb 3;11(2). pii: E179. doi: 10.3390/cancers11020179. Review.


TIP60: an actor in acetylation of H3K4 and tumor development in breast cancer.

Judes G, Dubois L, Rifaï K, Idrissou M, Mishellany F, Pajon A, Besse S, Daures M, Degoul F, Bignon YJ, Penault-Llorca F, Bernard-Gallon D.

Epigenomics. 2018 Nov;10(11):1415-1430. doi: 10.2217/epi-2018-0004. Epub 2018 Oct 16.


Radiation dosimetry of [131 I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment.

Jouberton E, Perrot Y, Dirat B, Billoux T, Auzeloux P, Cachin F, Chezal JM, Filaire M, Labarre P, Miot-Noirault E, Millardet C, Valla C, Vidal A, Degoul F, Maigne L.

Med Phys. 2018 Nov;45(11):5251-5262. doi: 10.1002/mp.13165. Epub 2018 Sep 24.


Proteoglycan-targeting applied to hypoxia-activated prodrug therapy in chondrosarcoma: first proof-of-concept.

Voissiere A, Weber V, Gerard Y, Rédini F, Raes F, Chezal JM, Degoul F, Peyrode C, Miot-Noirault E.

Oncotarget. 2017 Sep 27;8(56):95824-95840. doi: 10.18632/oncotarget.21337. eCollection 2017 Nov 10.


Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models.

Rondon A, Ty N, Bequignat JB, Quintana M, Briat A, Witkowski T, Bouchon B, Boucheix C, Miot-Noirault E, Pouget JP, Chezal JM, Navarro-Teulon I, Moreau E, Degoul F.

Sci Rep. 2017 Nov 2;7(1):14918. doi: 10.1038/s41598-017-15051-y.


Doxycycline and its quaternary ammonium derivative for adjuvant therapies of chondrosarcoma.

Miladi I, Vivier M, Dauplat MM, Chatard M, Besse S, Vidal A, Chassain K, Jean B, Forestier C, Chezal JM, Rédini F, Degoul F, Miot-Noirault E.

Cancer Chemother Pharmacol. 2017 Sep;80(3):517-526. doi: 10.1007/s00280-017-3377-7. Epub 2017 Jul 13.


Development and characterization of a human three-dimensional chondrosarcoma culture for in vitro drug testing.

Voissiere A, Jouberton E, Maubert E, Degoul F, Peyrode C, Chezal JM, Miot-Noirault É.

PLoS One. 2017 Jul 13;12(7):e0181340. doi: 10.1371/journal.pone.0181340. eCollection 2017.


A large-scale RNAi screen identifies LCMR1 as a critical regulator of Tspan8-mediated melanoma invasion.

Agaësse G, Barbollat-Boutrand L, Sulpice E, Bhajun R, El Kharbili M, Berthier-Vergnes O, Degoul F, de la Fouchardière A, Berger E, Voeltzel T, Lamartine J, Gidrol X, Masse I.

Oncogene. 2017 Aug 31;36(35):5084. doi: 10.1038/onc.2017.195. Epub 2017 Jun 19.


Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer.

Maisonial-Besset A, Witkowski T, Navarro-Teulon I, Berthier-Vergnes O, Fois G, Zhu Y, Besse S, Bawa O, Briat A, Quintana M, Pichard A, Bonnet M, Rubinstein E, Pouget JP, Opolon P, Maigne L, Miot-Noirault E, Chezal JM, Boucheix C, Degoul F.

Oncotarget. 2017 Mar 28;8(13):22034-22047. doi: 10.18632/oncotarget.15787.


Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.

El Kharbili M, Robert C, Witkowski T, Danty-Berger E, Barbollat-Boutrand L, Masse I, Gadot N, de la Fouchardière A, McDonald PC, Dedhar S, Le Naour F, Degoul F, Berthier-Vergnes O.

Oncotarget. 2017 Mar 7;8(10):17140-17155. doi: 10.18632/oncotarget.15084.


Theranostic Approach for Metastatic Pigmented Melanoma Using ICF15002, a Multimodal Radiotracer for Both PET Imaging and Targeted Radionuclide Therapy.

Rbah-Vidal L, Vidal A, Billaud EM, Besse S, Ranchon-Cole I, Mishellany F, Perrot Y, Maigne L, Moins N, Guerquin-Kern JL, Degoul F, Chezal JM, Auzeloux P, Miot-Noirault E.

Neoplasia. 2017 Jan;19(1):17-27. doi: 10.1016/j.neo.2016.11.001. Epub 2016 Dec 14.


Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept.

Peyrode C, Weber V, Voissière A, Maisonial-Besset A, Vidal A, Auzeloux P, Gaumet V, Borel M, Dauplat MM, Quintana M, Degoul F, Rédini F, Chezal JM, Miot-Noirault E.

Mol Cancer Ther. 2016 Nov;15(11):2575-2585. Epub 2016 Aug 29.


A large-scale RNAi screen identifies LCMR1 as a critical regulator of Tspan8-mediated melanoma invasion.

Agaësse G, Barbollat-Boutrand L, Sulpice E, Bhajun R, El Kharbili M, Berthier-Vergnes O, Degoul F, de la Fouchardière A, Berger E, Voeltzel T, Lamartine J, Gidrol X, Masse I.

Oncogene. 2017 Jan 26;36(4):446-457. doi: 10.1038/onc.2016.219. Epub 2016 Jul 4. Erratum in: Oncogene. 2017 Jun 19;:.


Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy.

Viallard C, Chezal JM, Mishellany F, Ranchon-Cole I, Pereira B, Herbette A, Besse S, Boudhraa Z, Jacquemot N, Cayre A, Miot-Noirault E, Sun JS, Dutreix M, Degoul F.

Oncotarget. 2016 Mar 15;7(11):12927-36. doi: 10.18632/oncotarget.7340.


Annexin A1 localization and its relevance to cancer.

Boudhraa Z, Bouchon B, Viallard C, D'Incan M, Degoul F.

Clin Sci (Lond). 2016 Feb;130(4):205-20. doi: 10.1042/CS20150415. Review.


Synthesis, radiolabeling and preliminary in vivo evaluation of multimodal radiotracers for PET imaging and targeted radionuclide therapy of pigmented melanoma.

Billaud EM, Maisonial-Besset A, Rbah-Vidal L, Vidal A, Besse S, Béquignat JB, Decombat C, Degoul F, Audin L, Deloye JB, Dollé F, Kuhnast B, Madelmont JC, Tarrit S, Galmier MJ, Borel M, Auzeloux P, Miot-Noirault E, Chezal JM.

Eur J Med Chem. 2015 Mar 6;92:818-38. doi: 10.1016/j.ejmech.2015.01.034. Epub 2015 Jan 21.


[¹²³I]ICF01012 melanoma imaging and [¹³¹I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models.

Viallard C, Perrot Y, Boudhraa Z, Jouberton E, Miot-Noirault E, Bonnet M, Besse S, Mishellany F, Cayre A, Maigne L, Rbah-Vidal L, D'Incan M, Cachin F, Chezal JM, Degoul F.

Eur J Dermatol. 2015 Jan-Feb;25(1):29-35. doi: 10.1684/ejd.2014.2481.


Characterization of pro-invasive mechanisms and N-terminal cleavage of ANXA1 in melanoma.

Boudhraa Z, Merle C, Mazzocut D, Chezal JM, Chambon C, Miot-Noirault E, Theisen M, Bouchon B, Degoul F.

Arch Dermatol Res. 2014 Dec;306(10):903-14. doi: 10.1007/s00403-014-1517-z. Epub 2014 Nov 2.


Annexin A1 in primary tumors promotes melanoma dissemination.

Boudhraa Z, Rondepierre F, Ouchchane L, Kintossou R, Trzeciakiewicz A, Franck F, Kanitakis J, Labeille B, Joubert-Zakeyh J, Bouchon B, Perrot JL, Mansard S, Papon J, Dechelotte P, Chezal JM, Miot-Noirault E, Bonnet M, D'Incan M, Degoul F.

Clin Exp Metastasis. 2014 Oct;31(7):749-60. doi: 10.1007/s10585-014-9665-2. Epub 2014 Jul 6.


Small rigid platforms functionalization with quaternary ammonium: targeting extracellular matrix of chondrosarcoma.

Miot-Noirault E, Vidal A, Morlieras J, Bonazza P, Auzeloux P, Besse S, Dauplat MM, Peyrode C, Degoul F, Billotey C, Lux F, Rédini F, Tillement O, Chezal JM, Kryza D, Janier M.

Nanomedicine. 2014 Nov;10(8):1887-95. doi: 10.1016/j.nano.2014.06.011. Epub 2014 Jun 25.


Internal dosimetry through GATE simulations of preclinical radiotherapy using a melanin-targeting ligand.

Perrot Y, Degoul F, Auzeloux P, Bonnet M, Cachin F, Chezal JM, Donnarieix D, Labarre P, Moins N, Papon J, Rbah-Vidal L, Vidal A, Miot-Noirault E, Maigne L.

Phys Med Biol. 2014 May 7;59(9):2183-98. doi: 10.1088/0031-9155/59/9/2183. Epub 2014 Apr 8.


Evaluation of two (125)I-radiolabeled acridine derivatives for Auger-electron radionuclide therapy of melanoma.

Gardette M, Viallard C, Paillas S, Guerquin-Kern JL, Papon J, Moins N, Labarre P, Desbois N, Wong-Wah-Chung P, Palle S, Wu TD, Pouget JP, Miot-Noirault E, Chezal JM, Degoul F.

Invest New Drugs. 2014 Aug;32(4):587-97. doi: 10.1007/s10637-014-0086-5. Epub 2014 Apr 2.


(123)I-BZA2 as a melanin-targeted radiotracer for the identification of melanoma metastases: results and perspectives of a multicenter phase III clinical trial.

Cachin F, Miot-Noirault E, Gillet B, Isnardi V, Labeille B, Payoux P, Meyer N, Cammilleri S, Gaudy C, Razzouk-Cadet M, Lacour JP, Granel-Brocard F, Tychyj C, Benbouzid F, Grange JD, Baulieu F, Kelly A, Merlin C, Mestas D, Gachon F, Chezal JM, Degoul F, D'Incan M.

J Nucl Med. 2014 Jan;55(1):15-22. doi: 10.2967/jnumed.113.123554. Epub 2013 Nov 21.


In vivo efficacy of melanoma internal radionuclide therapy with a 131I-labelled melanin-targeting heteroarylcarboxamide molecule.

Degoul F, Borel M, Jacquemot N, Besse S, Communal Y, Mishellany F, Papon J, Penault-Llorca F, Donnarieix D, Doly M, Maigne L, Miot-Noirault E, Cayre A, Cluzel J, Moins N, Chezal JM, Bonnet M.

Int J Cancer. 2013 Sep 1;133(5):1042-53. doi: 10.1002/ijc.28103. Epub 2013 Mar 18.


Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹⁰F]ICF01006, a highly promising melanoma PET tracer.

Rbah-Vidal L, Vidal A, Besse S, Cachin F, Bonnet M, Audin L, Askienazy S, Dollé F, Degoul F, Miot-Noirault E, Moins N, Auzeloux P, Chezal JM.

Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1449-61. doi: 10.1007/s00259-012-2168-y. Epub 2012 Jun 16.


Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40.

Trzeciakiewicz A, Fortin S, Moreau E, C-Gaudreault R, Lacroix J, Chambon C, Communal Y, Chezal JM, Miot-Noirault E, Bouchon B, Degoul F.

Biochem Pharmacol. 2011 May 1;81(9):1116-23. doi: 10.1016/j.bcp.2011.02.014. Epub 2011 Mar 1.


Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stability.

Fortin S, Bouchon B, Chambon C, Lacroix J, Moreau E, Chezal JM, Degoul F, C-Gaudreault R.

J Pharmacol Exp Ther. 2011 Feb;336(2):460-7. doi: 10.1124/jpet.110.171082. Epub 2010 Oct 26.


MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice.

Mansouri A, Tarhuni A, Larosche I, Reyl-Desmars F, Demeilliers C, Degoul F, Nahon P, Sutton A, Moreau R, Fromenty B, Pessayre D.

Dig Dis. 2010;28(6):756-75. doi: 10.1159/000324284. Epub 2011 Apr 27. Review.


B16 melanoma secretomes and in vitro invasiveness: syntenin as an invasion modulator.

Rondepierre F, Bouchon B, Bonnet M, Moins N, Chezal JM, D'Incan M, Degoul F.

Melanoma Res. 2010 Apr;20(2):77-84. doi: 10.1097/CMR.0b013e32833279f2.


Proteomic studies of B16 lines: involvement of annexin A1 in melanoma dissemination.

Rondepierre F, Bouchon B, Papon J, Bonnet-Duquennoy M, Kintossou R, Moins N, Maublant J, Madelmont JC, D'Incan M, Degoul F.

Biochim Biophys Acta. 2009 Jan;1794(1):61-9. doi: 10.1016/j.bbapap.2008.09.014. Epub 2008 Oct 8.


Alkylation of prohibitin by cyclohexylphenyl-chloroethyl urea on an aspartyl residue is associated with cell cycle G(1) arrest in B16 cells.

Bouchon B, Papon J, Communal Y, Madelmont JC, Degoul F.

Br J Pharmacol. 2007 Oct;152(4):449-55. Epub 2007 Aug 20.


N-(4-iodophenyl)-N'-(2-chloroethyl)urea as a microtubule disrupter: in vitro and in vivo profiling of antitumoral activity on CT-26 murine colon carcinoma cell line cultured and grafted to mice.

Borel M, Degoul F, Communal Y, Mounetou E, Bouchon B, C-Gaudreault R, Madelmont JC, Miot-Noirault E.

Br J Cancer. 2007 Jun 4;96(11):1684-91. Epub 2007 May 8.


Alkylation of beta-tubulin on Glu 198 by a microtubule disrupter.

Bouchon B, Chambon C, Mounetou E, Papon J, Miot-Noirault E, Gaudreault RC, Madelmont JC, Degoul F.

Mol Pharmacol. 2005 Nov;68(5):1415-22. Epub 2005 Aug 12.


The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability.

Sutton A, Imbert A, Igoudjil A, Descatoire V, Cazanave S, Pessayre D, Degoul F.

Pharmacogenet Genomics. 2005 May;15(5):311-9.


Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death.

Nahon P, Sutton A, Pessayre D, Rufat P, Degoul F, Ganne-Carrie N, Ziol M, Charnaux N, N'kontchou G, Trinchet JC, Gattegno L, Beaugrand M.

Clin Gastroenterol Hepatol. 2005 Mar;3(3):292-8.


Antineoplastic potency of arylchloroethylurea derivatives in murine colon carcinoma.

Miot-Noirault E, Legault J, Cachin F, Mounetou E, Degoul F, Gaudreault RC, Moins N, Madelmont JC.

Invest New Drugs. 2004 Nov;22(4):369-78.


The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria.

Sutton A, Khoury H, Prip-Buus C, Cepanec C, Pessayre D, Degoul F.

Pharmacogenetics. 2003 Mar;13(3):145-57.


Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease.

Degoul F, Sutton A, Mansouri A, Cepanec C, Degott C, Fromenty B, Beaugrand M, Valla D, Pessayre D.

Gastroenterology. 2001 May;120(6):1468-74.


[Ageing, alcohol and mitochondria].

Fromenty B, Mansouri A, Degoul F, Demeilliers C, Gaou I, Pessayre D.

Gastroenterol Clin Biol. 2000 Mar;24(3):349-58. Review. French. No abstract available.


The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA.

Helm M, Brulé H, Degoul F, Cepanec C, Leroux JP, Giegé R, Florentz C.

Nucleic Acids Res. 1998 Apr 1;26(7):1636-43.


A case of mitochondrial encephalomyopathy associated with a muscle coenzyme Q10 deficiency.

Boitier E, Degoul F, Desguerre I, Charpentier C, François D, Ponsot G, Diry M, Rustin P, Marsac C.

J Neurol Sci. 1998;156(1):41-6.


Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene.

Degoul F, Brulé H, Cepanec C, Helm M, Marsac C, Leroux J, Giegé R, Florentz C.

Hum Mol Genet. 1998 Mar;7(3):347-54.


A near homoplasmic T8993G mtDNA mutation in a patient with atypic Leigh syndrome not present in the mother's tissues.

Degoul F, François D, Diry M, Ponsot G, Desguerre I, Héron B, Marsac C, Moutard ML.

J Inherit Metab Dis. 1997 Mar;20(1):49-53.


Third International Congress on Human Mitochondrial Pathology (Euromit III): towards a better understanding of energy metabolism disorders.

Possekel S, Boitier E, Marsac C, Degoul F.

Neuromuscul Disord. 1996 May;6(3):215-8. No abstract available.


Intrafamilial heterogeneous clinical presentation of the mitochondrial 3243 MELAS mutation; molecular investigations among four generations.

Degoul F, Diry M, Viader F, Boitier E, Marsac C, Eymard B, Romero N, Delisle MB, Lechevalier B, Chapon F.

Eur J Neurol. 1995 Dec;2(6):573-9. doi: 10.1111/j.1468-1331.1995.tb00177.x.


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