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Items: 23

1.

Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.

Holzer S, Degliesposti G, Kilkenny ML, Maslen SL, Matak-Vinkovíc D, Skehel M, Pellegrini L.

Nucleic Acids Res. 2019 Nov 22. pii: gkz1116. doi: 10.1093/nar/gkz1116. [Epub ahead of print] No abstract available.

PMID:
31754694
2.

Structure of the Fanconi anaemia monoubiquitin ligase complex.

Shakeel S, Rajendra E, Alcón P, O'Reilly F, Chorev DS, Maslen S, Degliesposti G, Russo CJ, He S, Hill CH, Skehel JM, Scheres SHW, Patel KJ, Rappsilber J, Robinson CV, Passmore LA.

Nature. 2019 Nov;575(7781):234-237. doi: 10.1038/s41586-019-1703-4. Epub 2019 Oct 30.

PMID:
31666700
3.

Architecture of the mycobacterial type VII secretion system.

Famelis N, Rivera-Calzada A, Degliesposti G, Wingender M, Mietrach N, Skehel JM, Fernandez-Leiro R, Böttcher B, Schlosser A, Llorca O, Geibel S.

Nature. 2019 Oct 9. doi: 10.1038/s41586-019-1633-1. [Epub ahead of print]

PMID:
31597161
4.

Structures of Respiratory Supercomplex I+III2 Reveal Functional and Conformational Crosstalk.

Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA.

Mol Cell. 2019 Sep 19;75(6):1131-1146.e6. doi: 10.1016/j.molcel.2019.07.022. Epub 2019 Sep 3.

PMID:
31492636
5.

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.

Iacobucci C, Piotrowski C, Aebersold R, Amaral BC, Andrews P, Bernfur K, Borchers C, Brodie NI, Bruce JE, Cao Y, Chaignepain S, Chavez JD, Claverol S, Cox J, Davis T, Degliesposti G, Dong MQ, Edinger N, Emanuelsson C, Gay M, Götze M, Gomes-Neto F, Gozzo FC, Gutierrez C, Haupt C, Heck AJR, Herzog F, Huang L, Hoopmann MR, Kalisman N, Klykov O, Kukačka Z, Liu F, MacCoss MJ, Mechtler K, Mesika R, Moritz RL, Nagaraj N, Nesati V, Neves-Ferreira AGC, Ninnis R, Novák P, O'Reilly FJ, Pelzing M, Petrotchenko E, Piersimoni L, Plasencia M, Pukala T, Rand KD, Rappsilber J, Reichmann D, Sailer C, Sarnowski CP, Scheltema RA, Schmidt C, Schriemer DC, Shi Y, Skehel JM, Slavin M, Sobott F, Solis-Mezarino V, Stephanowitz H, Stengel F, Stieger CE, Trabjerg E, Trnka M, Vilaseca M, Viner R, Xiang Y, Yilmaz S, Zelter A, Ziemianowicz D, Leitner A, Sinz A.

Anal Chem. 2019 Jun 4;91(11):6953-6961. doi: 10.1021/acs.analchem.9b00658. Epub 2019 May 22.

6.

Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex.

Hill CH, Boreikaitė V, Kumar A, Casañal A, Kubík P, Degliesposti G, Maslen S, Mariani A, von Loeffelholz O, Girbig M, Skehel M, Passmore LA.

Mol Cell. 2019 Mar 21;73(6):1217-1231.e11. doi: 10.1016/j.molcel.2018.12.023. Epub 2019 Feb 5.

7.

Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O.

Nat Commun. 2018 Jul 31;9(1):3063. doi: 10.1038/s41467-018-05546-1.

8.

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O.

Nat Commun. 2018 Apr 16;9(1):1501. doi: 10.1038/s41467-018-03942-1. Erratum in: Nat Commun. 2018 Jul 31;9(1):3063.

9.

Architecture of eukaryotic mRNA 3'-end processing machinery.

Casañal A, Kumar A, Hill CH, Easter AD, Emsley P, Degliesposti G, Gordiyenko Y, Santhanam B, Wolf J, Wiederhold K, Dornan GL, Skehel M, Robinson CV, Passmore LA.

Science. 2017 Nov 24;358(6366):1056-1059. doi: 10.1126/science.aao6535. Epub 2017 Oct 26.

10.

The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System.

Rivera-Calzada A, Pal M, Muñoz-Hernández H, Luque-Ortega JR, Gil-Carton D, Degliesposti G, Skehel JM, Prodromou C, Pearl LH, Llorca O.

Structure. 2017 Jul 5;25(7):1145-1152.e4. doi: 10.1016/j.str.2017.05.016. Epub 2017 Jun 22.

11.

Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.

Holzer S, Degliesposti G, Kilkenny ML, Maslen SL, Matak-Vinkovíc D, Skehel M, Pellegrini L.

Nucleic Acids Res. 2017 May 19;45(9):5555-5563. doi: 10.1093/nar/gkx139.

12.

Atomic structure of the entire mammalian mitochondrial complex I.

Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA.

Nature. 2016 Oct 20;538(7625):406-410. doi: 10.1038/nature19794. Epub 2016 Sep 5.

13.

Purification of Ovine Respiratory Complex I Results in a Highly Active and Stable Preparation.

Letts JA, Degliesposti G, Fiedorczuk K, Skehel M, Sazanov LA.

J Biol Chem. 2016 Nov 18;291(47):24657-24675. Epub 2016 Sep 26.

14.

BEAR, a novel virtual screening methodology for drug discovery.

Degliesposti G, Portioli C, Parenti MD, Rastelli G.

J Biomol Screen. 2011 Jan;16(1):129-33. doi: 10.1177/1087057110388276. Epub 2010 Nov 17.

PMID:
21084717
15.

Exploring the binding site of C-terminal hsp90 inhibitors.

Sgobba M, Forestiero R, Degliesposti G, Rastelli G.

J Chem Inf Model. 2010 Sep 27;50(9):1522-8. doi: 10.1021/ci1001857.

PMID:
20828111
16.

A computational workflow for the design of irreversible inhibitors of protein kinases.

Del Rio A, Sgobba M, Parenti MD, Degliesposti G, Forestiero R, Percivalle C, Conte PF, Freccero M, Rastelli G.

J Comput Aided Mol Des. 2010 Mar;24(3):183-94. doi: 10.1007/s10822-010-9324-x. Epub 2010 Mar 21.

PMID:
20306284
17.

Fast and accurate predictions of binding free energies using MM-PBSA and MM-GBSA.

Rastelli G, Del Rio A, Degliesposti G, Sgobba M.

J Comput Chem. 2010 Mar;31(4):797-810. doi: 10.1002/jcc.21372.

PMID:
19569205
18.

Design and discovery of plasmepsin II inhibitors using an automated workflow on large-scale grids.

Degliesposti G, Kasam V, Da Costa A, Kang HK, Kim N, Kim DW, Breton V, Kim D, Rastelli G.

ChemMedChem. 2009 Jul;4(7):1164-73. doi: 10.1002/cmdc.200900111.

PMID:
19437467
19.

WISDOM-II: screening against multiple targets implicated in malaria using computational grid infrastructures.

Kasam V, Salzemann J, Botha M, Dacosta A, Degliesposti G, Isea R, Kim D, Maass A, Kenyon C, Rastelli G, Hofmann-Apitius M, Breton V.

Malar J. 2009 May 1;8:88. doi: 10.1186/1475-2875-8-88.

20.

Binding estimation after refinement, a new automated procedure for the refinement and rescoring of docked ligands in virtual screening.

Rastelli G, Degliesposti G, Del Rio A, Sgobba M.

Chem Biol Drug Des. 2009 Mar;73(3):283-6. doi: 10.1111/j.1747-0285.2009.00780.x.

PMID:
19207463
21.

Structural models and binding site prediction of the C-terminal domain of human Hsp90: a new target for anticancer drugs.

Sgobba M, Degliesposti G, Ferrari AM, Rastelli G.

Chem Biol Drug Des. 2008 May;71(5):420-433. doi: 10.1111/j.1747-0285.2008.00650.x. Epub 2008 Mar 25.

PMID:
18373550
22.

In vitro effects of Plasmodium falciparum dihydrofolate reductase inhibitors on normal and cancer cell proliferation.

Rossi T, Coppi A, Bruni E, Sgobba M, Degliesposti G, Rastelli G.

ChemMedChem. 2008 Mar;3(3):421-4. No abstract available.

PMID:
17973282
23.

Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.

Ferrari AM, Degliesposti G, Sgobba M, Rastelli G.

Bioorg Med Chem. 2007 Dec 15;15(24):7865-77. Epub 2007 Aug 22.

PMID:
17870536

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