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Endolymphatic hydrops induced by different mechanisms responds differentially to spironolactone: a rationale for understanding the diversity of treatment responses in hydropic inner ear disease.

Degerman E, In 't Zandt R, Pålbrink A, Magnusson M.

Acta Otolaryngol. 2019 Aug;139(8):685-691. doi: 10.1080/00016489.2019.1616819. Epub 2019 May 30.


Insulin induces Thr484 phosphorylation and stabilization of SIK2 in adipocytes.

Säll J, Negoita F, Hansson B, Kopietz F, Linder W, Pettersson AML, Ekelund M, Laurencikiene J, Degerman E, Stenkula KG, Göransson O.

Cell Signal. 2019 Mar;55:73-80. doi: 10.1016/j.cellsig.2018.12.011. Epub 2018 Dec 23.


AMPK activation by A-769662 and 991 does not affect catecholamine-induced lipolysis in human adipocytes.

Kopietz F, Berggreen C, Larsson S, Säll J, Ekelund M, Sakamoto K, Degerman E, Holm C, Göransson O.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E1075-E1085. doi: 10.1152/ajpendo.00110.2018. Epub 2018 Sep 25.


β-Sarcoglycan Deficiency Reduces Atherosclerotic Plaque Development in ApoE-Null Mice.

Murugesan V, Degerman E, Holmen-Pålbrink AK, Duner P, Knutsson A, Hultgårdh-Nilsson A, Rauch U.

J Vasc Res. 2017;54(4):235-245. doi: 10.1159/000478014. Epub 2017 Jul 29.


White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function.

Chung YW, Ahmad F, Tang Y, Hockman SC, Kee HJ, Berger K, Guirguis E, Choi YH, Schimel DM, Aponte AM, Park S, Degerman E, Manganiello VC.

Sci Rep. 2017 Jan 13;7:40445. doi: 10.1038/srep40445.


Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes.

Heimann E, Nyman M, Pålbrink AK, Lindkvist-Petersson K, Degerman E.

Adipocyte. 2016 Oct 28;5(4):359-368. eCollection 2016 Oct-Dec.


Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes.

Säll J, Pettersson AM, Björk C, Henriksson E, Wasserstrom S, Linder W, Zhou Y, Hansson O, Andersson DP, Ekelund M, Degerman E, Stenkula KG, Laurencikiene J, Göransson O.

Diabetologia. 2017 Feb;60(2):314-323. doi: 10.1007/s00125-016-4141-y. Epub 2016 Nov 2.


Inhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI.

Degerman E, In 't Zandt R, Pålbrink A, Eliasson L, Cayé-Thomasen P, Magnusson M.

Acta Otolaryngol. 2017 Jan;137(1):8-15. Epub 2016 Aug 15.


Parathyroid hormone induces adipocyte lipolysis via PKA-mediated phosphorylation of hormone-sensitive lipase.

Larsson S, Jones HA, Göransson O, Degerman E, Holm C.

Cell Signal. 2016 Mar;28(3):204-213. doi: 10.1016/j.cellsig.2015.12.012. Epub 2015 Dec 23.


Propionic acid and butyric acid inhibit lipolysis and de novo lipogenesis and increase insulin-stimulated glucose uptake in primary rat adipocytes.

Heimann E, Nyman M, Degerman E.

Adipocyte. 2014 Nov 14;4(2):81-8. doi: 10.4161/21623945.2014.960694. eCollection 2015 Apr-Jun.


Vasopressin induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4 T MRI.

Degerman E, In 't Zandt R, Pålbrink AK, Magnusson M.

Hear Res. 2015 Dec;330(Pt A):119-24. doi: 10.1016/j.heares.2015.05.008. Epub 2015 Jun 3.


Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.

Ahmad F, Shen W, Vandeput F, Szabo-Fresnais N, Krall J, Degerman E, Goetz F, Klussmann E, Movsesian M, Manganiello V.

J Biol Chem. 2015 Mar 13;290(11):6763-76. doi: 10.1074/jbc.M115.638585. Epub 2015 Jan 15.


SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes.

Henriksson E, Säll J, Gormand A, Wasserstrom S, Morrice NA, Fritzen AM, Foretz M, Campbell DG, Sakamoto K, Ekelund M, Degerman E, Stenkula KG, Göransson O.

J Cell Sci. 2015 Feb 1;128(3):472-86.


Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.

Ahmad F, Murata T, Shimizu K, Degerman E, Maurice D, Manganiello V.

Oral Dis. 2015 Jan;21(1):e25-50. doi: 10.1111/odi.12275. Epub 2014 Sep 12. Review.


Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism.

Banke E, Rödström K, Ekelund M, Dalla-Riva J, Lagerstedt JO, Nilsson S, Degerman E, Lindkvist-Petersson K, Nilson B.

Metabolism. 2014 Jun;63(6):831-40. doi: 10.1016/j.metabol.2014.03.004. Epub 2014 Mar 11.


A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice.

Guirguis E, Hockman S, Chung YW, Ahmad F, Gavrilova O, Raghavachari N, Yang Y, Niu G, Chen X, Yu ZX, Liu S, Degerman E, Manganiello V.

Endocrinology. 2013 Sep;154(9):3152-67. doi: 10.1210/en.2012-2185. Epub 2013 Jun 13.


Expression of insulin signalling components in the sensory epithelium of the human saccule.

Degerman E, Rauch U, Lindberg S, Caye-Thomasen P, Hultgårdh A, Magnusson M.

Cell Tissue Res. 2013 Jun;352(3):469-78. doi: 10.1007/s00441-013-1614-x. Epub 2013 Apr 16.


Evidence-based knowledge versus negotiated indicators for assessment of ecological sustainability: the Swedish Forest Stewardship Council standard as a case study.

Angelstam P, Roberge JM, Axelsson R, Elbakidze M, Bergman KO, Dahlberg A, Degerman E, Eggers S, Esseen PA, Hjältén J, Johansson T, Müller J, Paltto H, Snäll T, Soloviy I, Törnblom J.

Ambio. 2013 Mar;42(2):229-40. doi: 10.1007/s13280-012-0377-z.


Social and cultural sustainability: criteria, indicators, verifier variables for measurement and maps for visualization to support planning.

Axelsson R, Angelstam P, Degerman E, Teitelbaum S, Andersson K, Elbakidze M, Drotz MK.

Ambio. 2013 Mar;42(2):215-28. doi: 10.1007/s13280-012-0376-0.


Protected area as an indicator of ecological sustainability? A century of development in Europe's boreal forest.

Elbakidze M, Angelstam P, Sobolev N, Degerman E, Andersson K, Axelsson R, Höjer O, Wennberg S.

Ambio. 2013 Mar;42(2):201-14. doi: 10.1007/s13280-012-0375-1.


Learning about the history of landscape use for the future: consequences for ecological and social systems in Swedish Bergslagen.

Angelstam P, Andersson K, Isacson M, Gavrilov DV, Axelsson R, Bäckström M, Degerman E, Elbakidze M, Kazakova-Apkarimova EY, Sartz L, Sädbom S, Törnblom J.

Ambio. 2013 Mar;42(2):146-59. doi: 10.1007/s13280-012-0369-z.


Link between GIP and osteopontin in adipose tissue and insulin resistance.

Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, Pihlajamäki J, Wierup N, Vaag A, Groop L, Lyssenko V.

Diabetes. 2013 Jun;62(6):2088-94. doi: 10.2337/db12-0976. Epub 2013 Jan 24.


Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.

Banke E, Riva M, Shcherbina L, Wierup N, Degerman E.

Regul Pept. 2013 Mar 10;182:35-40. doi: 10.1016/j.regpep.2012.12.011. Epub 2013 Jan 11.


Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.

Tian G, Sågetorp J, Xu Y, Shuai H, Degerman E, Tengholm A.

J Cell Sci. 2012 Nov 1;125(Pt 21):5084-95. doi: 10.1242/jcs.107201. Epub 2012 Sep 3.


Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.

Andersson SA, Olsson AH, Esguerra JL, Heimann E, Ladenvall C, Edlund A, Salehi A, Taneera J, Degerman E, Groop L, Ling C, Eliasson L.

Mol Cell Endocrinol. 2012 Nov 25;364(1-2):36-45. doi: 10.1016/j.mce.2012.08.009. Epub 2012 Aug 23.


Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B.

Omar B, Banke E, Guirguis E, Åkesson L, Manganiello V, Lyssenko V, Groop L, Gomez MF, Degerman E.

Biochem Biophys Res Commun. 2012 Sep 7;425(4):812-7. doi: 10.1016/j.bbrc.2012.07.157. Epub 2012 Aug 7.


Cyclic nucleotide phosphodiesterase 3 signaling complexes.

Ahmad F, Degerman E, Manganiello VC.

Horm Metab Res. 2012 Sep;44(10):776-85. doi: 10.1055/s-0032-1312646. Epub 2012 Jun 12. Review. Erratum in: Horm Metab Res. 2012 Nov;44(12):930.


Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.

Nilsson J, Shteinman AA, Degerman E, Enyedy EA, Kiss T, Behrens U, Rehder D, Nordlander E.

J Inorg Biochem. 2011 Dec;105(12):1795-800. doi: 10.1016/j.jinorgbio.2011.09.022. Epub 2011 Sep 22.


From PDE3B to the regulation of energy homeostasis.

Degerman E, Ahmad F, Chung YW, Guirguis E, Omar B, Stenson L, Manganiello V.

Curr Opin Pharmacol. 2011 Dec;11(6):676-82. doi: 10.1016/j.coph.2011.09.015. Epub 2011 Oct 14. Review.


Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity.

Andersson U, Dey ES, Holm C, Degerman E.

Mol Nutr Food Res. 2011 Sep;55 Suppl 2:S290-3. doi: 10.1002/mnfr.201100231. Epub 2011 Sep 2.


Identification of new signaling components in the sensory epithelium of human saccule.

Degerman E, Rauch U, Göransson O, Lindberg S, Hultgårdh A, Magnusson M.

Front Neurol. 2011 Aug 5;2:48. doi: 10.3389/fneur.2011.00048. eCollection 2011.


Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current.

Jin Z, Jin Y, Kumar-Mendu S, Degerman E, Groop L, Birnir B.

PLoS One. 2011 Jan 14;6(1):e16188. doi: 10.1371/journal.pone.0016188.


Alterations in cyclic nucleotide phosphodiesterase activities in omental and subcutaneous adipose tissues in human obesity.

Omar B, Banke E, Ekelund M, Frederiksen S, Degerman E.

Nutr Diabetes. 2011 Aug 8;1:e13. doi: 10.1038/nutd.2011.9.


Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.

Heimann E, Jones HA, Resjö S, Manganiello VC, Stenson L, Degerman E.

PLoS One. 2010 Dec 1;5(12):e14191. doi: 10.1371/journal.pone.0014191.


Cell-cell communication between adipocytes and pancreatic beta-cells in acoustically levitated droplets.

Santesson S, Degerman E, Rorsman P, Johansson T, Lemos S, Nilsson S.

Integr Biol (Camb). 2009 Oct;1(10):595-601. doi: 10.1039/b907834g. Epub 2009 Aug 19.


Bis- and tris(pyridyl)amine-oxidovanadium complexes: characteristics and insulin-mimetic potential.

Nilsson J, Degerman E, Haukka M, Lisensky GC, Garribba E, Yoshikawa Y, Sakurai H, Enyedy EA, Kiss T, Esbak H, Rehder D, Nordlander E.

Dalton Trans. 2009 Oct 14;(38):7902-11. doi: 10.1039/b903456k. Epub 2009 Aug 5.


Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes.

Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, Strålfors P, Degerman E, Manganiello VC.

Biochem J. 2009 Dec 10;424(3):399-410. doi: 10.1042/BJ20090842.


Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.

Berger K, Lindh R, Wierup N, Zmuda-Trzebiatowska E, Lindqvist A, Manganiello VC, Degerman E.

PLoS One. 2009;4(3):e4671. doi: 10.1371/journal.pone.0004671. Epub 2009 Mar 5.


Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis.

Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O, Degerman E.

Cell Signal. 2009 May;21(5):760-6. doi: 10.1016/j.cellsig.2009.01.015. Epub 2009 Jan 8.


Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes.

Berggreen C, Gormand A, Omar B, Degerman E, Göransson O.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E635-46. doi: 10.1152/ajpendo.90596.2008. Epub 2009 Jan 21.


Increased cAMP signaling can ameliorate the hypertensive condition in spontaneously hypertensive rats.

Berg T, Degerman E, Tasken K.

J Vasc Res. 2009;46(1):25-35. doi: 10.1159/000135662. Epub 2008 May 31.


Macroporous gel particles as robust macroporous matrices for cell immobilization.

Plieva FM, Oknianska A, Degerman E, Mattiasson B.

Biotechnol J. 2008 Mar;3(3):410-7.


Perilipin and adipophilin expression in lipid loaded macrophages.

Persson J, Degerman E, Nilsson J, Lindholm MW.

Biochem Biophys Res Commun. 2007 Nov 30;363(4):1020-6. Epub 2007 Sep 29.


Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.

Walz HA, Wierup N, Vikman J, Manganiello VC, Degerman E, Eliasson L, Holst LS.

Cell Signal. 2007 Jul;19(7):1505-13. Epub 2007 Feb 12.


Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B.

Lindh R, Ahmad F, Resjö S, James P, Yang JS, Fales HM, Manganiello V, Degerman E.

Biochim Biophys Acta. 2007 Apr;1773(4):584-92. Epub 2007 Jan 27.


Re-discovering PDE3 inhibitors--new opportunities for a long neglected target.

Thompson PE, Manganiello V, Degerman E.

Curr Top Med Chem. 2007;7(4):421-36. Review.


Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes.

Oknianska A, Zmuda-Trzebiatowska E, Manganiello V, Degerman E.

Biochem Biophys Res Commun. 2007 Feb 23;353(4):1080-5. Epub 2006 Dec 28.


Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice.

Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC.

J Clin Invest. 2006 Dec;116(12):3240-51.


Novel mechanisms of the regulation of protein kinase B in adipocytes; implications for protein kinase A, Epac, phosphodiesterases 3 and 4.

Zmuda-Trzebiatowska E, Manganiello V, Degerman E.

Cell Signal. 2007 Jan;19(1):81-6. Epub 2006 Jun 7.


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