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Items: 1 to 50 of 152

1.

Kanechlor 500-mediated changes in serum and hepatic thyroxine levels primarily occur in a transthyretin-unrelated manner.

Kato Y, Tamaki S, Haraguchi K, Ikushiro SI, Fujii Y, Ohta C, Atobe K, Kimura O, Endo T, Koga N, Yamada S, Degawa M.

J Appl Toxicol. 2019 Dec;39(12):1701-1709. doi: 10.1002/jat.3895. Epub 2019 Sep 9.

PMID:
31498458
2.

Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats.

Kato Y, Fujii A, Haraguchi K, Fujii Y, Atobe K, Endo T, Kimura O, Koga N, Ohta C, Yamada S, Degawa M.

J Toxicol Sci. 2017;42(6):663-669. doi: 10.2131/jts.42.663.

3.

Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of food-flavouring substances uniquely used in Japan that belong to the class of aliphatic primary alcohols, aldehydes, carboxylic acids, acetals and esters containing additional oxygenated functional groups.

Saito K, Hasegawa-Baba Y, Sekiya F, Hayashi SM, Mirokuji Y, Okamura H, Maruyama S, Ono A, Nakajima M, Degawa M, Ozawa S, Shibutani M, Maitani T.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Sep;34(9):1474-1484. doi: 10.1080/19440049.2017.1333160. Epub 2017 Jul 19.

PMID:
28540764
4.

Aryl hydrocarbon receptor activation and CYP1A induction by cooked food-derived carcinogenic heterocyclic amines in human HepG2 cell lines.

Sekimoto M, Sumi H, Hosaka T, Umemura T, Nishikawa A, Degawa M.

Food Chem Toxicol. 2016 Nov;97:256-264. doi: 10.1016/j.fct.2016.09.021. Epub 2016 Sep 16.

PMID:
27644595
5.

Sex differences in constitutive mRNA levels of CYP2B22, CYP2C33, CYP2C49, CYP3A22, CYP3A29 and CYP3A46 in the pig liver: Comparison between Meishan and Landrace pigs.

Kojima M, Degawa M.

Drug Metab Pharmacokinet. 2016 Jun;31(3):185-92. doi: 10.1016/j.dmpk.2016.02.001. Epub 2016 Feb 17.

PMID:
27080814
6.

The Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan.

Okamura H, Abe H, Hasegawa-Baba Y, Saito K, Sekiya F, Hayashi SM, Mirokuji Y, Maruyama S, Ono A, Nakajima M, Degawa M, Ozawa S, Shibutani M, Maitani T.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(9):1384-96. doi: 10.1080/19440049.2015.1067927. Epub 2015 Aug 14. Review.

PMID:
26212670
7.

Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.

Kimura J, Nemoto K, Degawa M, Yokosuka A, Mimaki Y, Shimizu K, Oku N, Ohizumi Y.

Biol Pharm Bull. 2014;37(9):1555-8. Epub 2014 Jun 26.

8.

Usefulness of urinary kidney injury molecule-1 (Kim-1) as a biomarker for cisplatin-induced sub-chronic kidney injury.

Nan-Ya K, Kajihara M, Kojima N, Degawa M.

J Appl Toxicol. 2015 Feb;35(2):124-32. doi: 10.1002/jat.2999. Epub 2014 Apr 16.

PMID:
24737228
9.

Involvement of hepatic IL-1 in the strain-dependent sex differences in serum total cholesterol levels in rats.

Kumagai Y, Sekimoto M, Okamoto M, Kurita R, Kojima M, Degawa M.

Biol Pharm Bull. 2014;37(4):654-8.

10.

3,3',4,4'-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in C57BL/6 and DBA/2 mice occurs mainly through enhanced accumulation of thyroxine in the liver.

Kato Y, Haraguchi K, Onishi M, Ikushiro S, Endo T, Ohta C, Koga N, Yamada S, Degawa M.

Biol Pharm Bull. 2014;37(3):504-9. Epub 2013 Dec 17.

11.

The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan.

Mirokuji Y, Abe H, Okamura H, Saito K, Sekiya F, Hayashi SM, Maruyama S, Ono A, Nakajima M, Degawa M, Ozawa S, Shibutani M, Maitani T.

Food Chem Toxicol. 2014 Feb;64:314-21. doi: 10.1016/j.fct.2013.11.044. Epub 2013 Dec 2. Review.

PMID:
24309148
13.

Development of a saliva collection device for use in the field.

Takagi K, Ishikura Y, Hiramatsu M, Nakamura K, Degawa M.

Clin Chim Acta. 2013 Oct 21;425:181-5. doi: 10.1016/j.cca.2013.08.008. Epub 2013 Aug 16.

PMID:
23954838
14.

6-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells.

Kimura J, Nemoto K, Yokosuka A, Mimaki Y, Degawa M, Ohizumi Y.

Biol Pharm Bull. 2013;36(10):1646-9. Epub 2013 Aug 9.

15.

A possible mechanism for 2,3',4,4',5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level in mice.

Kato Y, Onishi M, Haraguchi K, Ikushiro S, Ohta C, Koga N, Endo T, Yamada S, Degawa M.

Biol Pharm Bull. 2013;36(10):1594-601. Epub 2013 Jul 23.

16.

Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver.

Nemoto K, Ikeda A, Tanaka T, Inoue K, Yoshida M, Nishikawa A, Gamou T, Habano W, Ozawa S, Degawa M.

J Toxicol Sci. 2013;38(4):611-7.

17.

Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells.

Ikeda A, Nemoto K, Yoshida C, Miyata S, Mori J, Soejima S, Yokosuka A, Mimaki Y, Ohizumi Y, Degawa M.

Neurosci Lett. 2013 Aug 9;549:135-9. doi: 10.1016/j.neulet.2013.06.004. Epub 2013 Jun 14.

PMID:
23774476
18.
19.

Different pathways of constitutive androstane receptor-mediated liver hypertrophy and hepatocarcinogenesis in mice treated with piperonyl butoxide or decabromodiphenyl ether.

Sakamoto Y, Inoue K, Takahashi M, Taketa Y, Kodama Y, Nemoto K, Degawa M, Gamou T, Ozawa S, Nishikawa A, Yoshida M.

Toxicol Pathol. 2013;41(8):1078-92. doi: 10.1177/0192623313482055. Epub 2013 Mar 26.

PMID:
23531792
20.
21.

Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.

Nemoto K, Ikeda A, Yoshida C, Kimura J, Mori J, Fujiwara H, Yokosuka A, Mimaki Y, Ohizumi Y, Degawa M.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):530-4. doi: 10.1016/j.bbrc.2013.01.024. Epub 2013 Jan 12.

PMID:
23321314
22.

Serum androgen level is determined by autosomal dominant inheritance and regulates sex-related CYP genes in pigs.

Kojima M, Degawa M.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):833-8. doi: 10.1016/j.bbrc.2012.11.060. Epub 2012 Nov 28.

PMID:
23200834
23.

Comparative study on 2,2',4,5,5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level between C57BL/6 and its transthyretin-deficient mice.

Kato Y, Tamaki S, Haraguchi K, Ikushiro S, Sekimoto M, Ohta C, Endo T, Koga N, Yamada S, Degawa M.

Toxicol Appl Pharmacol. 2012 Sep 15;263(3):323-9. doi: 10.1016/j.taap.2012.07.004. Epub 2012 Jul 16.

PMID:
22800508
24.

Establishment of a stable human cell line, HPL-A3, for use in reporter gene assays of cytochrome P450 3A inducers.

Sekimoto M, Sano S, Hosaka T, Nemoto K, Degawa M.

Biol Pharm Bull. 2012;35(5):677-85.

25.

Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats.

Fujimoto N, Inoue K, Yoshida M, Nishikawa A, Ozawa S, Gamou T, Nemoto K, Degawa M.

J Toxicol Sci. 2012;37(2):281-6.

26.

Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice.

Kojima M, Ashino T, Yoshida T, Iwakura Y, Degawa M.

Biol Pharm Bull. 2012;35(2):246-50.

27.

Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats.

Ozawa S, Gamou T, Habano W, Inoue K, Yoshida M, Nishikawa A, Nemoto K, Degawa M.

J Toxicol Sci. 2011 Oct;36(5):613-23.

28.

Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats.

Nemoto K, Tanaka T, Ikeda A, Ito S, Mizukami M, Hikida T, Gamou T, Habano W, Ozawa S, Inoue K, Yoshida M, Nishikawa A, Degawa M.

J Toxicol Sci. 2011 Oct;36(5):507-14.

29.
31.

A possible mechanism for 2,2',4,4',5,5'-hexachlorobiphenyl-mediated decrease in serum thyroxine level in mice.

Kato Y, Onishi M, Haraguchi K, Ikushiro S, Ohta C, Koga N, Endo T, Yamada S, Degawa M.

Toxicol Appl Pharmacol. 2011 Jul 1;254(1):48-55. doi: 10.1016/j.taap.2011.04.020. Epub 2011 May 4.

PMID:
21569787
32.
33.

A possible mechanism for the decrease in serum thyroxine level by phenobarbital in rodents.

Kato Y, Suzuki H, Haraguchi K, Ikushiro S, Ito Y, Uchida S, Yamada S, Degawa M.

Toxicol Appl Pharmacol. 2010 Dec 15;249(3):238-46. doi: 10.1016/j.taap.2010.09.024. Epub 2010 Oct 13.

PMID:
20932986
34.

Tube width fluctuations in F-actin solutions.

Glaser J, Chakraborty D, Kroy K, Lauter I, Degawa M, Kirchgessner N, Hoffmann B, Merkel R, Giesen M.

Phys Rev Lett. 2010 Jul 16;105(3):037801. Epub 2010 Jul 13.

PMID:
20867808
35.

Androgen-mediated down-regulation of CYP1A subfamily genes in the pig liver.

Kojima M, Sekimoto M, Degawa M.

J Endocrinol. 2010 Nov;207(2):203-11. doi: 10.1677/JOE-10-0160. Epub 2010 Aug 16.

PMID:
20713500
36.

Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine.

Hosaka T, Sekimoto M, Nemoto K, Degawa M.

Cancer Sci. 2010 Mar;101(3):652-7. doi: 10.1111/j.1349-7006.2009.01454.x. Epub 2009 Dec 4.

37.

Polychlorinated biphenyl-mediated decrease in serum thyroxine level in rodents.

Kato Y, Haraguchi K, Ito Y, Fujii A, Yamazaki T, Endo T, Koga N, Yamada S, Degawa M.

Drug Metab Dispos. 2010 Apr;38(4):697-704. doi: 10.1124/dmd.109.031153. Epub 2009 Dec 29.

PMID:
20040582
38.

Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells.

Umehara K, Nemoto K, Matsushita A, Terada E, Monthakantirat O, De-Eknamkul W, Miyase T, Warashina T, Degawa M, Noguchi H.

J Nat Prod. 2009 Dec;72(12):2163-8. doi: 10.1021/np900676y.

PMID:
19928832
39.

A possible mechanism for the decrease in serum thyroxine level by a 2,3,7,8-tetrachlorodibenzo-p-dioxin-like polychlorinated biphenyl congener, 3,3',4,4',5-pentachlorobiphenyl in mice.

Kato Y, Haraguchi K, Kubota M, Seto Y, Okura T, Ikushiro S, Koga N, Yamada S, Degawa M.

Drug Metab Dispos. 2010 Jan;38(1):150-6. doi: 10.1124/dmd.109.029348.

PMID:
19786508
40.

A capillary electrochromatography-electron spray ionization-mass spectrometry method for simultaneous analysis of charged and neutral constituents of a hepatocarcinoma cell metabolome.

Kato M, Onda Y, Sekimoto M, Degawa M, Toyo'oka T.

J Chromatogr A. 2009 Nov 20;1216(47):8277-82. doi: 10.1016/j.chroma.2009.06.074. Epub 2009 Jul 4.

PMID:
19616781
41.

4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl-mediated decrease in serum thyroxine level in mice occurs through increase in accumulation of thyroxine in the liver.

Kato Y, Haraguchi K, Kubota M, Seto Y, Ikushiro S, Sakaki T, Koga N, Yamada S, Degawa M.

Drug Metab Dispos. 2009 Oct;37(10):2095-102. doi: 10.1124/dmd.109.028621. Epub 2009 Jul 9.

PMID:
19589873
42.

IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice.

Kojima M, Ashino T, Yoshida T, Iwakura Y, Sekimoto M, Degawa M.

Biochem Biophys Res Commun. 2009 Feb 6;379(2):239-42. doi: 10.1016/j.bbrc.2008.12.032. Epub 2008 Dec 25.

PMID:
19101514
43.

Biased surface fluctuations due to current stress.

Bondarchuk O, Cullen WG, Degawa M, Williams ED, Bole T, Rous PJ.

Phys Rev Lett. 2007 Nov 16;99(20):206801. Epub 2007 Nov 12.

PMID:
18233173
44.

A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs.

Kojima M, Sekimoto M, Degawa M.

Biochem Pharmacol. 2008 Mar 1;75(5):1076-82. Epub 2007 Nov 7.

PMID:
18068149
45.

Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-16.

Ikari A, Okude C, Sawada H, Sasaki Y, Yamazaki Y, Sugatani J, Degawa M, Miwa M.

Biochim Biophys Acta. 2008 Jan;1778(1):283-90. Epub 2007 Oct 12.

46.

Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine in humans.

Kato Y, Ikushiro S, Emi Y, Tamaki S, Suzuki H, Sakaki T, Yamada S, Degawa M.

Drug Metab Dispos. 2008 Jan;36(1):51-5. Epub 2007 Oct 1.

PMID:
17908920
47.

pH-sensitive diamond field-effect transistors (FETs) with directly aminated channel surface.

Song KS, Nakamura Y, Sasaki Y, Degawa M, Yang JH, Kawarada H.

Anal Chim Acta. 2006 Jul 28;573-574:3-8. Epub 2006 Apr 29.

PMID:
17723497
48.

Estrogenic constituents of the heartwood of Dalbergia parviflora.

Umehara K, Nemoto K, Kimijima K, Matsushita A, Terada E, Monthakantirat O, De-Eknamkul W, Miyase T, Warashina T, Degawa M, Noguchi H.

Phytochemistry. 2008 Jan;69(2):546-52. Epub 2007 Aug 24.

PMID:
17719612
49.

A novel mechanism for polychlorinated biphenyl-induced decrease in serum thyroxine level in rats.

Kato Y, Ikushiro S, Takiguchi R, Haraguchi K, Koga N, Uchida S, Sakaki T, Yamada S, Kanno J, Degawa M.

Drug Metab Dispos. 2007 Oct;35(10):1949-55. Epub 2007 Jul 16.

PMID:
17639023
50.

Claudin-16 is directly phosphorylated by protein kinase A independently of a vasodilator-stimulated phosphoprotein-mediated pathway.

Ikari A, Ito M, Okude C, Sawada H, Harada H, Degawa M, Sakai H, Takahashi T, Sugatani J, Miwa M.

J Cell Physiol. 2008 Jan;214(1):221-9.

PMID:
17559069

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