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Terminally Differentiated Effector Memory CD8+ T Cells Identify Kidney Transplant Recipients at High Risk of Graft Failure.

Jacquemont L, Tilly G, Yap M, Doan-Ngoc TM, Danger R, Guérif P, Delbos F, Martinet B, Giral M, Foucher Y, Brouard S, Degauque N.

J Am Soc Nephrol. 2020 Apr;31(4):876-891. doi: 10.1681/ASN.2019080847. Epub 2020 Mar 12.


CXCR5+PD1+ICOS+ Circulating T Follicular Helpers Are Associated With de novo Donor-Specific Antibodies After Renal Transplantation.

Danger R, Chesneau M, Delbos F, Le Bot S, Kerleau C, Chenouard A, Ville S, Degauque N, Conchon S, Cesbron A, Giral M, Brouard S.

Front Immunol. 2019 Sep 10;10:2071. doi: 10.3389/fimmu.2019.02071. eCollection 2019.


Cytotoxic CD8+ T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons.

Coque E, Salsac C, Espinosa-Carrasco G, Varga B, Degauque N, Cadoux M, Crabé R, Virenque A, Soulard C, Fierle JK, Brodovitch A, Libralato M, Végh AG, Venteo S, Scamps F, Boucraut J, Laplaud D, Hernandez J, Gergely C, Vincent T, Raoul C.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2312-2317. doi: 10.1073/pnas.1815961116. Epub 2019 Jan 23.


Dampening of CD8+ T Cell Response by B Cell Depletion Therapy in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Néel A, Bucchia M, Néel M, Tilly G, Caristan A, Yap M, Rimbert M, Bruneau S, Cadoux M, Agard C, Hourmant M, Godmer P, Brouard S, Bressollette C, Hamidou M, Josien R, Fakhouri F, Degauque N.

Arthritis Rheumatol. 2019 Apr;71(4):641-650. doi: 10.1002/art.40766. Epub 2019 Mar 8.


IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates.

Belarif L, Mary C, Jacquemont L, Mai HL, Danger R, Hervouet J, Minault D, Thepenier V, Nerrière-Daguin V, Nguyen E, Pengam S, Largy E, Delobel A, Martinet B, Le Bas-Bernardet S, Brouard S, Soulillou JP, Degauque N, Blancho G, Vanhove B, Poirier N.

Nat Commun. 2018 Oct 26;9(1):4483. doi: 10.1038/s41467-018-06804-y.


Regulation of the Immune Response by the Inflammatory Metabolic Microenvironment in the Context of Allotransplantation.

Degauque N, Brosseau C, Brouard S.

Front Immunol. 2018 Jun 25;9:1465. doi: 10.3389/fimmu.2018.01465. eCollection 2018. Review.


Corrigendum: Broad Impairment of Natural Killer Cells From Operationally Tolerant Kidney Transplanted Patients.

Dugast E, David G, Oger R, Danger R, Judor JP, Gagne K, Chesneau M, Degauque N, Soulillou JP, Paul P, Picard C, Guerif P, Conchon S, Giral M, Gervois N, Retière C, Brouard S.

Front Immunol. 2018 Mar 26;9:589. doi: 10.3389/fimmu.2018.00589. eCollection 2018.


High circulating CD4+CD25hiFOXP3+ T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome.

Durand M, Lacoste P, Danger R, Jacquemont L, Brosseau C, Durand E, Tilly G, Loy J, Foureau A, Royer PJ, Tissot A, Roux A, Reynaud-Gaubert M, Kessler R, Mussot S, Dromer C, Brugière O, Mornex JF, Guillemain R, Claustre J, Degauque N, Magnan A, Brouard S; COLT and SysCLAD Consortia.

J Heart Lung Transplant. 2018 Jun;37(6):770-781. doi: 10.1016/j.healun.2018.01.1306. Epub 2018 Mar 20.


Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance.

Durand M, Dubois F, Dejou C, Durand E, Danger R, Chesneau M, Brosseau C, Guerif P, Soulillou JP, Degauque N, Eliaou JF, Giral M, Bonnefoy N, Brouard S.

Kidney Int. 2018 May;93(5):1154-1164. doi: 10.1016/j.kint.2017.12.004. Epub 2018 Feb 15.


Broad Impairment of Natural Killer Cells from Operationally Tolerant Kidney Transplanted Patients.

Dugast E, David G, Oger R, Danger R, Judor JP, Gagne K, Chesneau M, Degauque N, Soulillou JP, Paul P, Picard C, Guerif P, Conchon S, Giral M, Gervois N, Retière C, Brouard S.

Front Immunol. 2017 Dec 11;8:1721. doi: 10.3389/fimmu.2017.01721. eCollection 2017. Erratum in: Front Immunol. 2018 Mar 26;9:589.


An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8+ T cells involved in multiple sclerosis.

Nicol B, Salou M, Vogel I, Garcia A, Dugast E, Morille J, Kilens S, Charpentier E, Donnart A, Nedellec S, Jacq-Foucher M, Le Frère F, Wiertlewski S, Bourreille A, Brouard S, Michel L, David L, Gourraud PA, Degauque N, Nicot AB, Berthelot L, Laplaud DA.

J Autoimmun. 2018 Mar;88:61-74. doi: 10.1016/j.jaut.2017.10.005. Epub 2017 Oct 18.


Fate of transplanted lungs is controlled by immune cells encounter within pulmonary allografts.

Degauque N.

Am J Transplant. 2018 Jan;18(1):9-10. doi: 10.1111/ajt.14487. Epub 2017 Sep 26. No abstract available.


IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients.

Tilly G, Doan-Ngoc TM, Yap M, Caristan A, Jacquemont L, Danger R, Cadoux M, Bruneau S, Giral M, Guerif P, Nicol B, Garcia A, Laplaud DA, Brouard S, Pecqueur Hellman C, Degauque N.

Front Immunol. 2017 Jun 30;8:778. doi: 10.3389/fimmu.2017.00778. eCollection 2017.


Blood biomarkers of kidney transplant rejection, an endless search?

Jacquemont L, Soulillou JP, Degauque N.

Expert Rev Mol Diagn. 2017 Jul;17(7):687-697. doi: 10.1080/14737159.2017.1337512. Epub 2017 Jun 7. Review.


Renal Operational Tolerance Is Associated With a Defect of Blood Tfh Cells That Exhibit Impaired B Cell Help.

Chenouard A, Chesneau M, Bui Nguyen L, Le Bot S, Cadoux M, Dugast E, Paul C, Malard-Castagnet S, Ville S, Guérif P, Soulillou JP, Degauque N, Danger R, Giral M, Brouard S.

Am J Transplant. 2017 Jun;17(6):1490-1501. doi: 10.1111/ajt.14142. Epub 2017 Jan 19.


Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis.

Salou M, Nicol B, Garcia A, Baron D, Michel L, Elong-Ngono A, Hulin P, Nedellec S, Jacq-Foucher M, Le Frère F, Jousset N, Bourreille A, Wiertlewski S, Soulillou JP, Brouard S, Nicot AB, Degauque N, Laplaud DA.

Clin Immunol. 2016 May;166-167:1-11. doi: 10.1016/j.clim.2016.03.014. Epub 2016 Apr 2.


Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation.

Degauque N, Brouard S, Soulillou JP.

Front Immunol. 2016 Mar 24;7:89. doi: 10.3389/fimmu.2016.00089. eCollection 2016. Review.


Benefits of Using CD45RA and CD28 to Investigate CD8 Subsets in Kidney Transplant Recipients.

Yap M, Tilly G, Giral M, Brouard S, Degauque N.

Am J Transplant. 2016 Mar;16(3):999-1006. doi: 10.1111/ajt.13581. Epub 2016 Jan 28.


Targeting CD8 T-Cell Metabolism in Transplantation.

Yap M, Brouard S, Pecqueur C, Degauque N.

Front Immunol. 2015 Oct 23;6:547. doi: 10.3389/fimmu.2015.00547. eCollection 2015. Review.


Sialylation of antibodies in kidney recipients with de novo donor specific antibody, with or without antibody mediated rejection.

Malard-Castagnet S, Dugast E, Degauque N, Pallier A, Soulillou JP, Cesbron A, Giral M, Harb J, Brouard S.

Hum Immunol. 2016 Nov;77(11):1076-1083. doi: 10.1016/j.humimm.2015.10.021. Epub 2015 Nov 10.


Regulatory T Cells in Kidney Transplantation: New Directions?

Braza F, Durand M, Degauque N, Brouard S.

Am J Transplant. 2015 Sep;15(9):2288-300. doi: 10.1111/ajt.13395. Epub 2015 Jul 31. Review.


Peripheral phenotype and gene expression profiles of combined liver-kidney transplant patients.

Dumontet E, Danger R, Vagefi PA, Londoño MC, Pallier A, Lozano JJ, Giral M, Degauque N, Soulillou JP, Martínez-Llordella M, Lee H, Latournerie M, Boudjema K, Dulong J, Tarte K, Sanchez-Fueyo A, Feng S, Brouard S, Conchon S.

Liver Int. 2016 Mar;36(3):401-9. doi: 10.1111/liv.12917. Epub 2015 Aug 8.


Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis.

Salou M, Garcia A, Michel L, Gainche-Salmon A, Loussouarn D, Nicol B, Guillot F, Hulin P, Nedellec S, Baron D, Ramstein G, Soulillou JP, Brouard S, Nicot AB, Degauque N, Laplaud DA.

Ann Clin Transl Neurol. 2015 Jun;2(6):609-22. doi: 10.1002/acn3.199. Epub 2015 Apr 28.


Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis.

Elong Ngono A, Lepetit M, Reindl M, Garcia A, Guillot F, Genty A, Chesneau M, Salou M, Michel L, Lefrere F, Schanda K, Imbert-Marcille BM, Degauque N, Nicot A, Brouard S, Laplaud DA, Soulillou JP.

J Immunol Res. 2015;2015:673503. doi: 10.1155/2015/673503. Epub 2015 May 18.


Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties.

Chesneau M, Michel L, Dugast E, Chenouard A, Baron D, Pallier A, Durand J, Braza F, Guerif P, Laplaud DA, Soulillou JP, Giral M, Degauque N, Chiffoleau E, Brouard S.

J Am Soc Nephrol. 2015 Oct;26(10):2588-98. doi: 10.1681/ASN.2014040404. Epub 2015 Feb 2.


A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft.

Baron D, Ramstein G, Chesneau M, Echasseriau Y, Pallier A, Paul C, Degauque N, Hernandez-Fuentes MP, Sanchez-Fueyo A, Newell KA, Giral M, Soulillou JP, Houlgatte R, Brouard S.

Kidney Int. 2015 May;87(5):984-95. doi: 10.1038/ki.2014.395. Epub 2015 Jan 28.


Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance.

Braza F, Dugast E, Panov I, Paul C, Vogt K, Pallier A, Chesneau M, Baron D, Guerif P, Lei H, Laplaud DA, Volk HD, Degauque N, Giral M, Soulillou JP, Sawitzki B, Brouard S.

J Am Soc Nephrol. 2015 Aug;26(8):1795-805. doi: 10.1681/ASN.2014050480. Epub 2015 Jan 2.


Unaltered regulatory B-cell frequency and function in patients with multiple sclerosis.

Michel L, Chesneau M, Manceau P, Genty A, Garcia A, Salou M, Elong Ngono A, Pallier A, Jacq-Foucher M, Lefrère F, Wiertlewski S, Soulillou JP, Degauque N, Laplaud DA, Brouard S.

Clin Immunol. 2014 Dec;155(2):198-208. doi: 10.1016/j.clim.2014.09.011. Epub 2014 Sep 28.


Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory.

Thornley TB, Fang Z, Balasubramanian S, Larocca RA, Gong W, Gupta S, Csizmadia E, Degauque N, Kim BS, Koulmanda M, Kuchroo VK, Strom TB.

J Clin Invest. 2014 Aug;124(8):3443-54. doi: 10.1172/JCI73527. Epub 2014 Jul 1.


Expansion of highly differentiated cytotoxic terminally differentiated effector memory CD8+ T cells in a subset of clinically stable kidney transplant recipients: a potential marker for late graft dysfunction.

Yap M, Boeffard F, Clave E, Pallier A, Danger R, Giral M, Dantal J, Foucher Y, Guillot-Gueguen C, Toubert A, Soulillou JP, Brouard S, Degauque N.

J Am Soc Nephrol. 2014 Aug;25(8):1856-68. doi: 10.1681/ASN.2013080848. Epub 2014 Mar 20.


Regulatory B cells and tolerance in transplantation: from animal models to human.

Chesneau M, Michel L, Degauque N, Brouard S.

Front Immunol. 2013 Dec 31;4:497. doi: 10.3389/fimmu.2013.00497. Review.


Characterization of antigen-specific B cells using nominal antigen-coated flow-beads.

Degauque N, Elong Ngono A, Akl A, Lepetit M, Crochette R, Giral M, Lepourry J, Pallier A, Castagnet S, Dugast E, Guillot-Gueguen C, Jacq-Foucher M, Saulquin X, Cesbron A, Laplaud D, Nicot A, Brouard S, Soulillou JP.

PLoS One. 2013 Dec 30;8(12):e84273. doi: 10.1371/journal.pone.0084273. eCollection 2013. Erratum in: PLoS One. 2014;9(7):e102845. Ngono, Annie Elong [corrected to Elong Ngono, Annie].


Unique B cell differentiation profile in tolerant kidney transplant patients.

Chesneau M, Pallier A, Braza F, Lacombe G, Le Gallou S, Baron D, Giral M, Danger R, Guerif P, Aubert-Wastiaux H, Néel A, Michel L, Laplaud DA, Degauque N, Soulillou JP, Tarte K, Brouard S.

Am J Transplant. 2014 Jan;14(1):144-55. doi: 10.1111/ajt.12508. Epub 2013 Nov 13.


Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity.

Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J.

Immunity. 2013 May 23;38(5):1063-72. doi: 10.1016/j.immuni.2013.01.015. Epub 2013 May 16.


Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection.

Danger R, Paul C, Giral M, Lavault A, Foucher Y, Degauque N, Pallier A, Durand M, Castagnet S, Duong Van Huyen JP, Delahousse M, Renaudin K, Soulillou JP, Brouard S.

PLoS One. 2013;8(4):e60702. doi: 10.1371/journal.pone.0060702. Epub 2013 Apr 5.


Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant.

Danger R, Pallier A, Giral M, Martínez-Llordella M, Lozano JJ, Degauque N, Sanchez-Fueyo A, Soulillou JP, Brouard S.

J Am Soc Nephrol. 2012 Apr;23(4):597-606. doi: 10.1681/ASN.2011060543. Epub 2012 Jan 26.


The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vb repertoire but with an unmodified phenotype.

Degauque N, Boeffard F, Foucher Y, Ballet C, Brouard S, Soulillou JP.

PLoS One. 2011;6(6):e21240. doi: 10.1371/journal.pone.0021240. Epub 2011 Jun 27.


Analysis of the peripheral T-cell repertoire in kidney transplant patients.

Miqueu P, Degauque N, Guillet M, Giral M, Ruiz C, Pallier A, Braudeau C, Roussey-Kesler G, Ashton-Chess J, Doré JC, Thervet E, Legendre C, Hernandez-Fuentes MP, Warrens AN, Goldman M, Volk HD, Janssen U, Wood KJ, Lechler RI, Bertrand D, Sébille V, Soulillou JP, Brouard S.

Eur J Immunol. 2010 Nov;40(11):3280-90. doi: 10.1002/eji.201040301. Epub 2010 Oct 27.


Cross-reactivity of herpesvirus-specific CD8 T cell lines toward allogeneic class I MHC molecules.

Morice A, Charreau B, Neveu B, Brouard S, Soulillou JP, Bonneville M, Houssaint E, Degauque N.

PLoS One. 2010 Aug 12;5(8):e12120. doi: 10.1371/journal.pone.0012120.


AKT1 leader gene and downstream targets are involved in a rat model of kidney allograft tolerance.

Jovanovic V, Giacomelli L, Sivozhelezov V, Degauque N, Lair D, Soulillou JP, Pechkova E, Nicolini C, Brouard S.

J Cell Biochem. 2010 Oct 15;111(3):709-19. doi: 10.1002/jcb.22757.


Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype.

Pallier A, Hillion S, Danger R, Giral M, Racapé M, Degauque N, Dugast E, Ashton-Chess J, Pettré S, Lozano JJ, Bataille R, Devys A, Cesbron-Gautier A, Braudeau C, Larrose C, Soulillou JP, Brouard S.

Kidney Int. 2010 Sep;78(5):503-13. doi: 10.1038/ki.2010.162. Epub 2010 Jun 9.


T cell recognition of self-antigen presenting cells by protein transfer assay reveals a high frequency of anti-myelin T cells in multiple sclerosis.

Bahbouhi B, Pettré S, Berthelot L, Garcia A, Elong Ngono A, Degauque N, Michel L, Wiertlewski S, Lefrère F, Meyniel C, Delcroix C, Brouard S, Laplaud DA, Soulillou JP.

Brain. 2010 Jun;133(Pt 6):1622-36. doi: 10.1093/brain/awq074. Epub 2010 Apr 30.


A novel subpopulation of B-1 cells is enriched with autoreactivity in normal and lupus-prone mice.

Zhong X, Lau S, Bai C, Degauque N, Holodick NE, Steven SJ, Tumang J, Gao W, Rothstein TL.

Arthritis Rheum. 2009 Dec;60(12):3734-43. doi: 10.1002/art.25015.


TIM-1: a new player in transplant immunity.

Mariat C, Degauque N, Strom TB.

Transplantation. 2009 May 15;87(9 Suppl):S84-6. doi: 10.1097/TP.0b013e3181a2ba83.


Indirect CD4+ TH1 response, antidonor antibodies and diffuse C4d graft deposits in long-term recipients conditioned by donor antigens priming.

Ballet C, Renaudin K, Degauque N, Mai HL, Boëffard F, Lair D, Berthelot L, Feng C, Smit H, Usal C, Heslan M, Josien R, Brouard S, Soulillou JP.

Am J Transplant. 2009 Apr;9(4):697-708. doi: 10.1111/j.1600-6143.2009.02556.x.


Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.

Mariat C, Degauque N, Balasubramanian S, Kenny J, DeKruyff RH, Umetsu DT, Kuchroo V, Zheng XX, Strom TB.

J Immunol. 2009 Feb 1;182(3):1379-85.


Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.

Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H Jr, Flier JS, Strom TB.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16242-7. doi: 10.1073/pnas.0808031105. Epub 2008 Oct 13.


The innate NK cells, allograft rejection, and a key role for IL-15.

Kroemer A, Xiao X, Degauque N, Edtinger K, Wei H, Demirci G, Li XC.

J Immunol. 2008 Jun 15;180(12):7818-26.


Implication of matrix metalloproteinase 7 and the noncanonical wingless-type signaling pathway in a model of kidney allograft tolerance induced by the administration of anti-donor class II antibodies.

Jovanovic V, Dugast AS, Heslan JM, Ashton-Chess J, Giral M, Degauque N, Moreau A, Pallier A, Chiffoleau E, Lair D, Usal C, Smit H, Vanhove B, Soulillou JP, Brouard S.

J Immunol. 2008 Feb 1;180(3):1317-25.


Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.

Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, Kuchroo V, Zheng XX, Strom TB.

J Clin Invest. 2008 Feb;118(2):735-41.

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