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Items: 1 to 50 of 53

1.

The N-Terminal Domain of NPHP1 Folds into a Monomeric Left-Handed Antiparallel Three-Stranded Coiled Coil with Anti-apoptotic Function.

Mannella V, Quilici G, Nigro EA, Lampis M, Minici C, Degano M, Boletta A, Musco G.

ACS Chem Biol. 2019 Aug 16;14(8):1845-1854. doi: 10.1021/acschembio.9b00582. Epub 2019 Aug 5.

PMID:
31345020
2.

ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation.

Barzaghi F, Minniti F, Mauro M, Bortoli M, Balter R, Bonetti E, Zaccaron A, Vitale V, Omrani M, Zoccolillo M, Brigida I, Cicalese MP, Degano M, Hershfield MS, Aiuti A, Bondarenko AV, Chinello M, Cesaro S.

Front Immunol. 2019 Jan 14;9:2767. doi: 10.3389/fimmu.2018.02767. eCollection 2018.

3.

Type 1 Diabetes in STAT Protein Family Mutations: Regulating the Th17/Treg Equilibrium and Beyond.

Fabbri M, Frixou M, Degano M, Fousteri G.

Diabetes. 2019 Feb;68(2):258-265. doi: 10.2337/db18-0627.

4.

T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency.

Brigida I, Zoccolillo M, Cicalese MP, Pfajfer L, Barzaghi F, Scala S, Oleaga-Quintas C, Álvarez-Álvarez JA, Sereni L, Giannelli S, Sartirana C, Dionisio F, Pavesi L, Benavides-Nieto M, Basso-Ricci L, Capasso P, Mazzi B, Rosain J, Marcus N, Lee YN, Somech R, Degano M, Raiola G, Caorsi R, Picco P, Moncada Velez M, Khourieh J, Arias AA, Bousfiha A, Issekutz T, Issekutz A, Boisson B, Dobbs K, Villa A, Lombardo A, Neven B, Moshous D, Casanova JL, Franco JL, Notarangelo LD, Scielzo C, Volpi S, Dupré L, Bustamante J, Gattorno M, Aiuti A.

Blood. 2018 Nov 29;132(22):2362-2374. doi: 10.1182/blood-2018-07-863431. Epub 2018 Sep 25.

PMID:
30254128
5.

Role of Disputed Mutations in the rpoB Gene in Interpretation of Automated Liquid MGIT Culture Results for Rifampin Susceptibility Testing of Mycobacterium tuberculosis.

Miotto P, Cabibbe AM, Borroni E, Degano M, Cirillo DM.

J Clin Microbiol. 2018 Apr 25;56(5). pii: e01599-17. doi: 10.1128/JCM.01599-17. Print 2018 May.

6.

IL-27, but not IL-35, inhibits neuroinflammation through modulating GM-CSF expression.

Casella G, Finardi A, Descamps H, Colombo F, Maiorino C, Ruffini F, Patrone M, Degano M, Martino G, Muzio L, Becher B, Furlan R.

Sci Rep. 2017 Nov 29;7(1):16547. doi: 10.1038/s41598-017-16702-w.

7.

Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.

Minici C, Gounari M, Übelhart R, Scarfò L, Dühren-von Minden M, Schneider D, Tasdogan A, Alkhatib A, Agathangelidis A, Ntoufa S, Chiorazzi N, Jumaa H, Stamatopoulos K, Ghia P, Degano M.

Nat Commun. 2017 Jun 9;8:15746. doi: 10.1038/ncomms15746.

8.

Exploring growth-defence trade-offs in Arabidopsis: phytochrome B inactivation requires JAZ10 to suppress plant immunity but not to trigger shade-avoidance responses.

Cerrudo I, Caliri-Ortiz ME, Keller MM, Degano ME, Demkura PV, Ballaré CL.

Plant Cell Environ. 2017 May;40(5):635-644. doi: 10.1111/pce.12877. Epub 2017 Mar 20.

PMID:
27943325
9.

Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome.

Berardi A, Quilici G, Spiliotopoulos D, Corral-Rodriguez MA, Martin-Garcia F, Degano M, Tonon G, Ghitti M, Musco G.

Nucleic Acids Res. 2016 Apr 20;44(7):3448-63. doi: 10.1093/nar/gkw103. Epub 2016 Feb 20.

10.

Direct and high throughput (HT) interactions on the ribosomal surface by iRIA.

Pesce E, Minici C, Baβler J, Hurt E, Degano M, Calamita P, Biffo S.

Sci Rep. 2015 Oct 21;5:15401. doi: 10.1038/srep15401.

11.

Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study.

Miotto P, Cabibbe AM, Feuerriegel S, Casali N, Drobniewski F, Rodionova Y, Bakonyte D, Stakenas P, Pimkina E, Augustynowicz-Kopeć E, Degano M, Ambrosi A, Hoffner S, Mansjö M, Werngren J, Rüsch-Gerdes S, Niemann S, Cirillo DM.

MBio. 2014 Oct 21;5(5):e01819-14. doi: 10.1128/mBio.01819-14.

12.

Progressive quality control of secretory proteins in the early secretory compartment by ERp44.

Sannino S, Anelli T, Cortini M, Masui S, Degano M, Fagioli C, Inaba K, Sitia R.

J Cell Sci. 2014 Oct 1;127(Pt 19):4260-9. doi: 10.1242/jcs.153239. Epub 2014 Aug 5.

13.

Characterization of inosine-uridine nucleoside hydrolase (RihC) from Escherichia coli.

Arivett B, Farone M, Masiragani R, Burden A, Judge S, Osinloye A, Minici C, Degano M, Robinson M, Kline P.

Biochim Biophys Acta. 2014 Mar;1844(3):656-62. doi: 10.1016/j.bbapap.2014.01.010. Epub 2014 Jan 25.

PMID:
24473221
14.

Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor.

Giannese F, Berg M, Van der Veken P, Castagna V, Tornaghi P, Augustyns K, Degano M.

Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1553-66. doi: 10.1107/S0907444913010792. Epub 2013 Jul 20.

PMID:
23897478
15.

A pH-regulated quality control cycle for surveillance of secretory protein assembly.

Vavassori S, Cortini M, Masui S, Sannino S, Anelli T, Caserta IR, Fagioli C, Mossuto MF, Fornili A, van Anken E, Degano M, Inaba K, Sitia R.

Mol Cell. 2013 Jun 27;50(6):783-92. doi: 10.1016/j.molcel.2013.04.016. Epub 2013 May 16.

16.

Disease-associated mutations in the coil 2B domain of human lamin A/C affect structural properties that mediate dimerization and intermediate filament formation.

Gangemi F, Degano M.

J Struct Biol. 2013 Jan;181(1):17-28. doi: 10.1016/j.jsb.2012.10.016. Epub 2012 Nov 7.

PMID:
23142632
17.

New determinants in the catalytic mechanism of nucleoside hydrolases from the structures of two isozymes from Sulfolobus solfataricus.

Minici C, Cacciapuoti G, De Leo E, Porcelli M, Degano M.

Biochemistry. 2012 Jun 5;51(22):4590-9. Epub 2012 May 21.

PMID:
22551416
18.

Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications.

Bikos V, Darzentas N, Hadzidimitriou A, Davis Z, Hockley S, Traverse-Glehen A, Algara P, Santoro A, Gonzalez D, Mollejo M, Dagklis A, Gangemi F, Bosler DS, Bourikas G, Anagnostopoulos A, Tsaftaris A, Iannitto E, Ponzoni M, Felman P, Berger F, Belessi C, Ghia P, Papadaki T, Dogan A, Degano M, Matutes E, Piris MA, Oscier D, Stamatopoulos K.

Leukemia. 2012 Jul;26(7):1638-46. doi: 10.1038/leu.2012.3. Epub 2012 Jan 6.

PMID:
22222599
19.

An αß T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 1996. 274: 209-219.

Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA.

J Immunol. 2010 Dec 1;185(11):6402-12. No abstract available.

20.

Energy landscapes associated with macromolecular conformational changes from endpoint structures.

Fornili A, Giabbai B, Garau G, Degano M.

J Am Chem Soc. 2010 Dec 15;132(49):17570-7. doi: 10.1021/ja107640u. Epub 2010 Nov 17.

PMID:
21082835
21.

Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei.

Vandemeulebroucke A, Minici C, Bruno I, Muzzolini L, Tornaghi P, Parkin DW, Versées W, Steyaert J, Degano M.

Biochemistry. 2010 Oct 19;49(41):8999-9010. doi: 10.1021/bi100697d.

PMID:
20825170
22.

Active site plasticity revealed from the structure of the enterobacterial N-ribohydrolase RihA bound to a competitive inhibitor.

Garau G, Muzzolini L, Tornaghi P, Degano M.

BMC Struct Biol. 2010 Jun 8;10:14. doi: 10.1186/1472-6807-10-14.

23.

Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis.

Berg M, Kohl L, Van der Veken P, Joossens J, Al-Salabi MI, Castagna V, Giannese F, Cos P, Versées W, Steyaert J, Grellier P, Haemers A, Degano M, Maes L, de Koning HP, Augustyns K.

Antimicrob Agents Chemother. 2010 May;54(5):1900-8. doi: 10.1128/AAC.01787-09. Epub 2010 Mar 1.

24.

Dynamic features of the selective pressure on the human immunodeficiency virus type 1 (HIV-1) gp120 CD4-binding site in a group of long term non progressor (LTNP) subjects.

Canducci F, Marinozzi MC, Sampaolo M, Berrè S, Bagnarelli P, Degano M, Gallotta G, Mazzi B, Lemey P, Burioni R, Clementi M.

Retrovirology. 2009 Jan 15;6:4. doi: 10.1186/1742-4690-6-4.

25.

Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail.

Wang L, Wang L, Vavassori S, Li S, Ke H, Anelli T, Degano M, Ronzoni R, Sitia R, Sun F, Wang CC.

EMBO Rep. 2008 Jul;9(7):642-7. doi: 10.1038/embor.2008.88. Epub 2008 Jun 13.

26.

Structural basis for substrate specificity in group I nucleoside hydrolases.

Iovane E, Giabbai B, Muzzolini L, Matafora V, Fornili A, Minici C, Giannese F, Degano M.

Biochemistry. 2008 Apr 15;47(15):4418-26. doi: 10.1021/bi702448s. Epub 2008 Mar 25.

PMID:
18361502
27.

Accurate description of nitrogenous base flexibility in classical molecular dynamics simulations of nucleotides bound to proteins.

Fornili A, Sironi M, Degano M.

J Phys Chem B. 2007 Jun 14;111(23):6297-302. Epub 2007 May 18.

PMID:
17508739
28.

Phenotypic clustering of lamin A/C mutations in neuromuscular patients.

Benedetti S, Menditto I, Degano M, Rodolico C, Merlini L, D'Amico A, Palmucci L, Berardinelli A, Pegoraro E, Trevisan CP, Morandi L, Moroni I, Galluzzi G, Bertini E, Toscano A, Olivè M, Bonne G, Mari F, Caldara R, Fazio R, Mammì I, Carrera P, Toniolo D, Comi G, Quattrini A, Ferrari M, Previtali SC.

Neurology. 2007 Sep 18;69(12):1285-92. Epub 2007 Mar 21.

PMID:
17377071
29.

IGHV gene insertions and deletions in chronic lymphocytic leukemia: "CLL-biased" deletions in a subset of cases with stereotyped receptors.

Belessi CJ, Davi FB, Stamatopoulos KE, Degano M, Andreou TM, Moreno C, Merle-Béral H, Crespo M, Laoutaris NP, Montserrat E, Caligaris-Cappio F, Anagnostopoulos AZ, Ghia P.

Eur J Immunol. 2006 Jul;36(7):1963-74.

30.

New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product.

Muzzolini L, Versées W, Tornaghi P, Van Holsbeke E, Steyaert J, Degano M.

Biochemistry. 2006 Jan 24;45(3):773-82.

PMID:
16411753
31.

Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen- or tumour-derived synthetic peptides.

Moro M, Cecconi V, Martinoli C, Dallegno E, Giabbai B, Degano M, Glaichenhaus N, Protti MP, Dellabona P, Casorati G.

BMC Immunol. 2005 Dec 5;6:24.

32.

Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation.

Giabbai B, Sidobre S, Crispin MD, Sanchez-Ruìz Y, Bachi A, Kronenberg M, Wilson IA, Degano M.

J Immunol. 2005 Jul 15;175(2):977-84.

34.

Cloning, purification, crystallization and X-ray analysis of the Escherichia coli pyrimidine nucleoside hydrolase YeiK.

Giabbai B, Degano M.

Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):524-7. Epub 2004 Feb 25.

PMID:
14993681
35.

Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier.

Marković-Housley Z, Degano M, Lamba D, von Roepenack-Lahaye E, Clemens S, Susani M, Ferreira F, Scheiner O, Breiteneder H.

J Mol Biol. 2003 Jan 3;325(1):123-33.

PMID:
12473456
36.

Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex.

Grant EP, Beckman EM, Behar SM, Degano M, Frederique D, Besra GS, Wilson IA, Porcelli SA, Furlong ST, Brenner MB.

J Immunol. 2002 Apr 15;168(8):3933-40.

37.

Emerging principles for T cell receptor recognition of antigen in cellular immunity.

Garcia KC, Degano M, Speir JA, Wilson IA.

Rev Immunogenet. 1999;1(1):75-90. Review.

PMID:
11256574
38.

The A' and F' pockets of human CD1b are both required for optimal presentation of lipid antigens to T cells.

Niazi K, Chiu M, Mendoza R, Degano M, Khurana S, Moody D, Melián A, Wilson I, Kronenberg M, Porcelli S, Modlin R.

J Immunol. 2001 Feb 15;166(4):2562-70.

39.

A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.

Degano M, Garcia KC, Apostolopoulos V, Rudolph MG, Teyton L, Wilson IA.

Immunity. 2000 Mar;12(3):251-61.

40.

Structural requirements for antigen presentation by mouse CD1.

Burdin N, Brossay L, Degano M, Iijima H, Gui M, Wilson IA, Kronenberg M.

Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10156-61.

41.

Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold.

Wingren C, Crowley MP, Degano M, Chien Y, Wilson IA.

Science. 2000 Jan 14;287(5451):310-4.

42.

Molecular recognition of lipid antigens by T cell receptors.

Grant EP, Degano M, Rosat JP, Stenger S, Modlin RL, Wilson IA, Porcelli SA, Brenner MB.

J Exp Med. 1999 Jan 4;189(1):195-205.

43.

Probing the activation requirements for naive CD8+ T cells with Drosophila cell transfectants as antigen presenting cells.

Cai Z, Brunmark AB, Luxembourg AT, Garcia KC, Degano M, Teyton L, Wilson I, Peterson PA, Sprent J, Jackson MR.

Immunol Rev. 1998 Oct;165:249-65. Review.

PMID:
9850865
44.

Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor.

Degano M, Almo SC, Sacchettini JC, Schramm VL.

Biochemistry. 1998 May 5;37(18):6277-85.

PMID:
9572842
45.

Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes.

Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA.

Immunity. 1998 May;8(5):553-62.

46.

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.

Garcia KC, Degano M, Pease LR, Huang M, Peterson PA, Teyton L, Wilson IA.

Science. 1998 Feb 20;279(5354):1166-72.

47.

Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization.

Garcia KC, Tallquist MD, Pease LR, Brunmark A, Scott CA, Degano M, Stura EA, Peterson PA, Wilson IA, Teyton L.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13838-43.

48.

An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex.

Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA.

Science. 1996 Oct 11;274(5285):209-19.

PMID:
8824178
49.

Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata.

Degano M, Gopaul DN, Scapin G, Schramm VL, Sacchettini JC.

Biochemistry. 1996 May 14;35(19):5971-81.

PMID:
8634238
50.

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