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Items: 10


Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression.

Rogers TJ, Christenson JL, Greene LI, O'Neill KI, Williams MM, Gordon MA, Nemkov T, D'Alessandro A, Degala GD, Shin J, Tan AC, Cittelly DM, Lambert JR, Richer JK.

Mol Cancer Res. 2019 Jan;17(1):30-41. doi: 10.1158/1541-7786.MCR-18-0246. Epub 2018 Sep 13.


Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth.

Gari HH, DeGala GD, Lucia MS, Lambert JR.

Oncogenesis. 2016 Aug 15;5(8):e255. doi: 10.1038/oncsis.2016.50.


PRL-3 engages the focal adhesion pathway in triple-negative breast cancer cells to alter actin structure and substrate adhesion properties critical for cell migration and invasion.

Gari HH, DeGala GD, Ray R, Lucia MS, Lambert JR.

Cancer Lett. 2016 Oct 1;380(2):505-12. doi: 10.1016/j.canlet.2016.07.017. Epub 2016 Jul 21.


Genome-wide functional genetic screen with the anticancer agent AMPI-109 identifies PRL-3 as an oncogenic driver in triple-negative breast cancers.

Gari HH, Gearheart CM, Fosmire S, DeGala GD, Fan Z, Torkko KC, Edgerton SM, Lucia MS, Ray R, Thor AD, Porter CC, Lambert JR.

Oncotarget. 2016 Mar 29;7(13):15757-71. doi: 10.18632/oncotarget.7462.


Dissecting Steroid Receptor Function by Analytical Ultracentrifugation.

Bain DL, De Angelis RW, Connaghan KD, Yang Q, Degala GD, Lambert JR.

Methods Enzymol. 2015;562:363-89. doi: 10.1016/bs.mie.2015.04.005. Epub 2015 Jun 12.


Steroid receptor-DNA interactions: toward a quantitative connection between energetics and transcriptional regulation.

Bain DL, Connaghan KD, Maluf NK, Yang Q, Miura MT, De Angelis RW, Degala GD, Lambert JR.

Nucleic Acids Res. 2014 Jan;42(2):691-700. doi: 10.1093/nar/gkt859. Epub 2013 Sep 24. Review.


Glucocorticoid receptor-DNA interactions: binding energetics are the primary determinant of sequence-specific transcriptional activity.

Bain DL, Yang Q, Connaghan KD, Robblee JP, Miura MT, Degala GD, Lambert JR, Maluf NK.

J Mol Biol. 2012 Sep 7;422(1):18-32. doi: 10.1016/j.jmb.2012.06.005. Epub 2012 Jun 11.


Expression and characterization of two pathogenic mutations in human electron transfer flavoprotein.

Salazar D, Zhang L, deGala GD, Frerman FE.

J Biol Chem. 1997 Oct 17;272(42):26425-33.

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