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Items: 16

1.

Preclinical evaluation of the maximum tolerated dose and toxicokinetics of enteric-coated lantibiotic OG253 capsules.

Rajeshkumar NV, Kers JA, Moncrief S, Defusco AW, Park JH, Handfield M.

Toxicol Appl Pharmacol. 2019 Jul 1;374:32-40. doi: 10.1016/j.taap.2019.04.019. Epub 2019 Apr 26.

PMID:
31034929
2.

Pharmacological, Toxicological, and Dose Range Assessment of OG716, a Novel Lantibiotic for the Treatment of Clostridium difficile-Associated Infection.

Pulse ME, Weiss WJ, Kers JA, DeFusco AW, Park JH, Handfield M.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01904-18. doi: 10.1128/AAC.01904-18. Print 2019 Apr.

3.

Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome.

Torrey H, Khodadoust M, Tran L, Baum D, Defusco A, Kim YH, Faustman DL.

Leukemia. 2019 May;33(5):1206-1218. doi: 10.1038/s41375-018-0292-9. Epub 2018 Oct 24.

4.

Blueprints for the rational design of therapeutic mutacin 1140 variants.

Kers JA, Sharp RE, Muley S, Mayo M, Colbeck J, Zhu Y, DeFusco AW, Park JH, Handfield M.

Chem Biol Drug Des. 2018 Dec;92(6):1940-1953. doi: 10.1111/cbdd.13365. Epub 2018 Aug 18.

PMID:
30010233
5.

Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations.

Kühtreiber WM, Tran L, Kim T, Dybala M, Nguyen B, Plager S, Huang D, Janes S, Defusco A, Baum D, Zheng H, Faustman DL.

NPJ Vaccines. 2018 Jun 21;3:23. doi: 10.1038/s41541-018-0062-8. eCollection 2018.

6.

OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infections.

Kers JA, DeFusco AW, Park JH, Xu J, Pulse ME, Weiss WJ, Handfield M.

PLoS One. 2018 Jun 12;13(6):e0197467. doi: 10.1371/journal.pone.0197467. eCollection 2018.

7.

Mutacin 1140 Lantibiotic Variants Are Efficacious Against Clostridium difficile Infection.

Kers JA, Sharp RE, Defusco AW, Park JH, Xu J, Pulse ME, Weiss WJ, Handfield M.

Front Microbiol. 2018 Mar 16;9:415. doi: 10.3389/fmicb.2018.00415. eCollection 2018.

8.

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs.

Torrey H, Butterworth J, Mera T, Okubo Y, Wang L, Baum D, Defusco A, Plager S, Warden S, Huang D, Vanamee E, Foster R, Faustman DL.

Sci Signal. 2017 Jan 17;10(462). pii: eaaf8608. doi: 10.1126/scisignal.aaf8608.

PMID:
28096513
9.

Interfacing the Ab initio multiple spawning method with electronic structure methods in GAMESS: Photodecay of trans-azomethane.

Gaenko A, DeFusco A, Varganov SA, Martínez TJ, Gordon MS.

J Phys Chem A. 2014 Nov 20;118(46):10902-8. doi: 10.1021/jp508242j. Epub 2014 Nov 6.

PMID:
25329724
10.

Solvent-induced shifts in electronic spectra of uracil.

DeFusco A, Ivanic J, Schmidt MW, Gordon MS.

J Phys Chem A. 2011 May 12;115(18):4574-82. doi: 10.1021/jp112230f. Epub 2011 Apr 14.

PMID:
21491886
11.

Solvent-induced frequency shifts: configuration interaction singles combined with the effective fragment potential method.

Arora P, Slipchenko LV, Webb SP, DeFusco A, Gordon MS.

J Phys Chem A. 2010 Jul 1;114(25):6742-50. doi: 10.1021/jp101780r.

PMID:
20527868
12.

Model potential approaches for describing the interaction of excess electrons with water clusters: incorporation of long-range correlation effects.

Sommerfeld T, DeFusco A, Jordan KD.

J Phys Chem A. 2008 Nov 6;112(44):11021-35. doi: 10.1021/jp806077h.

PMID:
18959395
13.

Low-lying isomers and finite temperature behavior of (H2O)6 -.

Sommerfeld T, Gardner SD, DeFusco A, Jordan KD.

J Chem Phys. 2006 Nov 7;125(17):174301.

PMID:
17100433
14.

Direct measurement of the energy thresholds to conformational isomerization in tryptamine: experiment and theory.

Clarkson JR, Dian BC, Moriggi L, DeFusco A, McCarthy V, Jordan KD, Zwier TS.

J Chem Phys. 2005 Jun 1;122(21):214311.

PMID:
15974742
15.

Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection.

Hung CS, Bouckaert J, Hung D, Pinkner J, Widberg C, DeFusco A, Auguste CG, Strouse R, Langermann S, Waksman G, Hultgren SJ.

Mol Microbiol. 2002 May;44(4):903-15.

16.

Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli.

Langermann S, Möllby R, Burlein JE, Palaszynski SR, Auguste CG, DeFusco A, Strouse R, Schenerman MA, Hultgren SJ, Pinkner JS, Winberg J, Guldevall L, Söderhäll M, Ishikawa K, Normark S, Koenig S.

J Infect Dis. 2000 Feb;181(2):774-8.

PMID:
10669375

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