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Highly Variable Sialylation Status of Donor-Specific Antibodies Does Not Impact Humoral Rejection Outcomes.

Barba T, Harb J, Ducreux S, Koenig A, Mathias V, Rabeyrin M, Pouliquen E, Sicard A, Chartoire D, Dugast E, Defrance T, Morelon E, Brouard S, Dubois V, Thaunat O.

Front Immunol. 2019 Mar 20;10:513. doi: 10.3389/fimmu.2019.00513. eCollection 2019.


Residual Activatability of Circulating Tfh17 Predicts Humoral Response to Thymodependent Antigens in Patients on Therapeutic Immunosuppression.

Dahdal S, Saison C, Valette M, Bachy E, Pallet N, Lina B, Koenig A, Monneret G, Defrance T, Morelon E, Thaunat O.

Front Immunol. 2019 Feb 5;9:3178. doi: 10.3389/fimmu.2018.03178. eCollection 2018.


CD4+ T Cell Help Is Mandatory for Naive and Memory Donor-Specific Antibody Responses: Impact of Therapeutic Immunosuppression.

Chen CC, Koenig A, Saison C, Dahdal S, Rigault G, Barba T, Taillardet M, Chartoire D, Ovize M, Morelon E, Defrance T, Thaunat O.

Front Immunol. 2018 Feb 19;9:275. doi: 10.3389/fimmu.2018.00275. eCollection 2018.


Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection.

Chen CC, Pouliquen E, Broisat A, Andreata F, Racapé M, Bruneval P, Kessler L, Ahmadi M, Bacot S, Saison-Delaplace C, Marcaud M, Van Huyen JD, Loupy A, Villard J, Demuylder-Mischler S, Berney T, Morelon E, Tsai MK, Kolopp-Sarda MN, Koenig A, Mathias V, Ducreux S, Ghezzi C, Dubois V, Nicoletti A, Defrance T, Thaunat O.

J Clin Invest. 2018 Jan 2;128(1):219-232. doi: 10.1172/JCI93542. Epub 2017 Nov 20.


Evaluation of the Immunomodulatory Properties of Streptococcus suis and Group B Streptococcus Capsular Polysaccharides on the Humoral Response.

Calzas C, Taillardet M, Fourati IS, Roy D, Gottschalk M, Soudeyns H, Defrance T, Segura M.

Pathogens. 2017 Apr 20;6(2). pii: E16. doi: 10.3390/pathogens6020016.


Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge.

Blanc P, Moro-Sibilot L, Barthly L, Jagot F, This S, de Bernard S, Buffat L, Dussurgey S, Colisson R, Hobeika E, Fest T, Taillardet M, Thaunat O, Sicard A, Mondière P, Genestier L, Nutt SL, Defrance T.

Nat Commun. 2016 Dec 7;7:13600. doi: 10.1038/ncomms13600.


Mouse and Human Liver Contain Immunoglobulin A-Secreting Cells Originating From Peyer's Patches and Directed Against Intestinal Antigens.

Moro-Sibilot L, Blanc P, Taillardet M, Bardel E, Couillault C, Boschetti G, Traverse-Glehen A, Defrance T, Kaiserlian D, Dubois B.

Gastroenterology. 2016 Aug;151(2):311-23. doi: 10.1053/j.gastro.2016.04.014. Epub 2016 Apr 27.


CD1d-restricted peripheral T cell lymphoma in mice and humans.

Bachy E, Urb M, Chandra S, Robinot R, Bricard G, de Bernard S, Traverse-Glehen A, Gazzo S, Blond O, Khurana A, Baseggio L, Heavican T, Ffrench M, Crispatzu G, Mondière P, Schrader A, Taillardet M, Thaunat O, Martin N, Dalle S, Le Garff-Tavernier M, Salles G, Lachuer J, Hermine O, Asnafi V, Roussel M, Lamy T, Herling M, Iqbal J, Buffat L, Marche PN, Gaulard P, Kronenberg M, Defrance T, Genestier L.

J Exp Med. 2016 May 2;213(5):841-57. doi: 10.1084/jem.20150794. Epub 2016 Apr 11.


B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform To Generate Antigen-Specific Helper T Cells for Cell Therapy.

Sicard A, Koenig A, Graff-Dubois S, Dussurgey S, Rouers A, Dubois V, Blanc P, Chartoire D, Errazuriz-Cerda E, Paidassi H, Taillardet M, Morelon E, Moris A, Defrance T, Thaunat O.

Nano Lett. 2016 Jan 13;16(1):297-308. doi: 10.1021/acs.nanolett.5b03801. Epub 2015 Dec 16.


Plasmacytoid dendritic cells are dispensable for noninfectious intestinal IgA responses in vivo.

Moro-Sibilot L, This S, Blanc P, Sanlaville A, Sisirak V, Bardel E, Boschetti G, Bendriss-Vermare N, Defrance T, Dubois B, Kaiserlian D.

Eur J Immunol. 2016 Feb;46(2):354-9. doi: 10.1002/eji.201545977. Epub 2015 Nov 23.


A Lentiviral Vector Allowing Physiologically Regulated Membrane-anchored and Secreted Antibody Expression Depending on B-cell Maturation Status.

Fusil F, Calattini S, Amirache F, Mancip J, Costa C, Robbins JB, Douam F, Lavillette D, Law M, Defrance T, Verhoeyen E, Cosset FL.

Mol Ther. 2015 Nov;23(11):1734-1747. doi: 10.1038/mt.2015.148. Epub 2015 Aug 18.


Cell therapy to induce allograft tolerance: time to switch to plan B?

Sicard A, Koenig A, Morelon E, Defrance T, Thaunat O.

Front Immunol. 2015 Apr 7;6:149. doi: 10.3389/fimmu.2015.00149. eCollection 2015. Review.


The origin of the plasma-cell heterogeneity.

Pellat-Deceunynck C, Defrance T.

Front Immunol. 2015 Jan 23;6:5. doi: 10.3389/fimmu.2015.00005. eCollection 2015. No abstract available.


Coronary CT angiography versus standard of care strategies to evaluate patients with potential coronary artery disease; effect on long term clinical outcomes.

Budoff MJ, Liu S, Chow D, Flores F, Hsieh B, Gebow D, DeFrance T, Ahmadi N.

Atherosclerosis. 2014 Dec;237(2):494-8. doi: 10.1016/j.atherosclerosis.2014.09.038. Epub 2014 Oct 18.


Usefulness of noninvasive fractional flow reserve computed from coronary computed tomographic angiograms for intermediate stenoses confirmed by quantitative coronary angiography.

Min JK, Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, Dunning AM, Defrance T, Lansky A, Leipsic J.

Am J Cardiol. 2012 Oct 1;110(7):971-6. doi: 10.1016/j.amjcard.2012.05.033. Epub 2012 Jun 29.


Effect of image quality on diagnostic accuracy of noninvasive fractional flow reserve: results from the prospective multicenter international DISCOVER-FLOW study.

Min JK, Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, Dunning A, Defrance T, Leipsic J.

J Cardiovasc Comput Tomogr. 2012 May-Jun;6(3):191-9. doi: 10.1016/j.jcct.2012.04.010. Epub 2012 Apr 27.


CT stress myocardial perfusion imaging using multidetector CT--A review.

Ko BS, Cameron JD, Defrance T, Seneviratne SK.

J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):345-56. doi: 10.1016/j.jcct.2011.10.005. Epub 2011 Oct 24. Review.


Compromising the unfolded protein response induces autophagy-mediated cell death in multiple myeloma cells.

Michallet AS, Mondiere P, Taillardet M, Leverrier Y, Genestier L, Defrance T.

PLoS One. 2011;6(10):e25820. doi: 10.1371/journal.pone.0025820. Epub 2011 Oct 18.


Computed tomography stress myocardial perfusion imaging in patients considered for revascularization: a comparison with fractional flow reserve.

Ko BS, Cameron JD, Meredith IT, Leung M, Antonis PR, Nasis A, Crossett M, Hope SA, Lehman SJ, Troupis J, DeFrance T, Seneviratne SK.

Eur Heart J. 2012 Jan;33(1):67-77. doi: 10.1093/eurheartj/ehr268. Epub 2011 Aug 2.


T cell-independent B cell memory.

Defrance T, Taillardet M, Genestier L.

Curr Opin Immunol. 2011 Jun;23(3):330-6. doi: 10.1016/j.coi.2011.03.004. Epub 2011 Apr 7. Review.


Classic images: coronary computed tomographic angiography.

Shriki JE, Talkin B, DeFrance T, Wilcox A.

Curr Probl Cardiol. 2010 Dec;35(12):599-632. doi: 10.1016/j.cpcardiol.2010.09.004. Review.


Toll-like receptor agonists allow generation of long-lasting antipneumococcal humoral immunity in response to a plain polysaccharidic vaccine.

Taillardet M, Haffar G, Mondière P, Asensio MJ, Pléau-Pison T, Burdin N, Defrance T, Genestier L.

J Infect Dis. 2010 Aug 15;202(3):470-9. doi: 10.1086/653739.


Am"B"valent: anti-CD20 antibodies unravel the dual role of B cells in immunopathogenesis.

Thaunat O, Morelon E, Defrance T.

Blood. 2010 Jul 29;116(4):515-21. doi: 10.1182/blood-2010-01-266668. Epub 2010 Mar 25. Review.


Effects of organic-farming-compatible insecticides on four aphid natural enemy species.

Jansen JP, Defrance T, Warnier AM.

Pest Manag Sci. 2010 Jun;66(6):650-6. doi: 10.1002/ps.1924.


Helical prospective ECG-gating in cardiac computed tomography: radiation dose and image quality.

DeFrance T, Dubois E, Gebow D, Ramirez A, Wolf F, Feuchtner GM.

Int J Cardiovasc Imaging. 2010 Jan;26(1):99-107. doi: 10.1007/s10554-009-9522-6. Epub 2009 Nov 7.


The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells.

Taillardet M, Haffar G, Mondière P, Asensio MJ, Gheit H, Burdin N, Defrance T, Genestier L.

Blood. 2009 Nov 12;114(20):4432-40. doi: 10.1182/blood-2009-01-200014. Epub 2009 Sep 18.


The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fate.

De Luca K, Frances-Duvert V, Asensio MJ, Ihsani R, Debien E, Taillardet M, Verhoeyen E, Bella C, Lantheaume S, Genestier L, Defrance T.

Leukemia. 2009 Nov;23(11):2063-74. doi: 10.1038/leu.2009.155. Epub 2009 Jul 30.


SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography.

Raff GL, Abidov A, Achenbach S, Berman DS, Boxt LM, Budoff MJ, Cheng V, DeFrance T, Hellinger JC, Karlsberg RP; Society of Cardiovascular Computed Tomography.

J Cardiovasc Comput Tomogr. 2009 Mar-Apr;3(2):122-36. doi: 10.1016/j.jcct.2009.01.001. Epub 2009 Jan 29. No abstract available.


Multiple imaging assessment of chest pain in a case of apical hypertrophic cardiomyopathy: clinical, electrocardiographic, computed tomography angiography, and cardiac magnetic resonance imaging findings.

de la Pena-Almaguer E, Madrid-Viteri X, Zamarripa-Morales R, DeFrance T.

J Cardiovasc Comput Tomogr. 2008 Mar-Apr;2(2):126-8. doi: 10.1016/j.jcct.2008.02.004. Epub 2008 Feb 8. No abstract available.


Culicoides trapping with Rothamsted suction traps before and during the bluetongue epidemic of 2006 in Belgium.

Fassotte C, Delécolle JC, Cors R, Defrance T, De Deken R, Haubruge E, Losson B.

Prev Vet Med. 2008 Oct 15;87(1-2):74-83. doi: 10.1016/j.prevetmed.2008.06.007. Epub 2008 Jul 21.


Distribution of potential bluetongue vectors on Belgium farms.

Zimmer JY, Haubruge E, Francis F, Bortels J, Joie E, Simonon G, De Deken R, De Deken G, Deblauwe I, Madder M, Fassotte C, Cors R, Defrance T, Saegerman C, Thiry E, Mignon B, Paternostre J, Losson B, Kirschvink N.

Vet Rec. 2008 May 24;162(21):700. No abstract available.


Breeding sites of bluetongue vectors in northern Europe.

Zimmer JY, Haubruge E, Francis F, Bortels J, Simonon G, Losson B, Mignon B, Paternostre J, De Deken R, De Deken G, Deblauwe I, Fassotte C, Cors R, Defrance T.

Vet Rec. 2008 Jan 26;162(4):131. No abstract available.


Fusion of multislice computed tomography and electroanatomical mapping data for 3D navigation of left and right atrial catheter ablation.

Feuchtner GM, Dichtl W, DeFrance T, Stühlinger M, Klauser A, Berger T, Junker D, Spuller K, Pachinger O, zur Nedden D, Hintringer F.

Eur J Radiol. 2008 Dec;68(3):456-64. Epub 2007 Oct 29.


TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses.

Genestier L, Taillardet M, Mondiere P, Gheit H, Bella C, Defrance T.

J Immunol. 2007 Jun 15;178(12):7779-86.


Biting midges overwintering in Belgium.

Losson B, Mignon B, Paternostre J, Madder M, De Deken R, De Deken G, Deblauwe I, Fassotte C, Cors R, Defrance T, Delécolle JC, Baldet T, Haubruge E, Frédéric F, Bortels J, Simonon G.

Vet Rec. 2007 Mar 31;160(13):451-2. No abstract available.


The endoplasmic reticulum is a key component of the plasma cell death pathway.

Pelletier N, Casamayor-Pallejà M, De Luca K, Mondière P, Saltel F, Jurdic P, Bella C, Genestier L, Defrance T.

J Immunol. 2006 Feb 1;176(3):1340-7.


Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter.

Cases-Thomas MJ, Masters JJ, Walter MW, Campbell G, Haughton L, Gallagher PT, Dobson DR, Mancuso V, Bonnier B, Giard T, Defrance T, Vanmarsenille M, Ledgard A, White C, Ouwerkerk-Mahadevan S, Brunelle FJ, Dezutter NA, Herbots CA, Lienard JY, Findlay J, Hayhurst L, Boot J, Thompson LK, Hemrick-Luecke S.

Bioorg Med Chem Lett. 2006 Apr 1;16(7):2022-5. Epub 2006 Jan 18.


Mature B cells: apoptosis checkpoints.

Defrance T.

Transplantation. 2005 Feb 15;79(3 Suppl):S4-7. Review.


Analysis of B-lymphocyte differentiation in patients infected with hepatitis C virus.

Fournillier A, Freida D, Defrance T, Merle P, Trépo C, Inchauspé G.

J Med Virol. 2004 Apr;72(4):566-74.


Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.

Kern C, Cornuel JF, Billard C, Tang R, Rouillard D, Stenou V, Defrance T, Ajchenbaum-Cymbalista F, Simonin PY, Feldblum S, Kolb JP.

Blood. 2004 Jan 15;103(2):679-88. Epub 2003 Sep 22.


Potential role of soluble CD40 in the humoral immune response impairment of uraemic patients.

Contin C, Pitard V, Delmas Y, Pelletier N, Defrance T, Moreau JF, Merville P, Déchanet-Merville J.

Immunology. 2003 Sep;110(1):131-40.


The life and death of a B cell.

Defrance T, Casamayor-Pallejà M, Krammer PH.

Adv Cancer Res. 2002;86:195-225. Review.


BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentially.

Casamayor-Pallejà M, Mondière P, Verschelde C, Bella C, Defrance T.

Blood. 2002 Mar 15;99(6):1913-21.


Death-receptor contribution to the germinal-center reaction.

van Eijk M, Defrance T, Hennino A, de Groot C.

Trends Immunol. 2001 Dec;22(12):677-82. Review.


Correlation between apoptosis microarray gene expression profiling and histopathological lymph node lesions.

Dales JP, Plumas J, Palmerini F, Devilard E, Defrance T, Lajmanovich A, Pradel V, Birg F, Xerri L.

Mol Pathol. 2001 Feb;54(1):17-23.


FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis.

Hennino A, Bérard M, Krammer PH, Defrance T.

J Exp Med. 2001 Feb 19;193(4):447-58.


Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomas.

Xerri L, Palmerini F, Devilard E, Defrance T, Bouabdallah R, Hassoun J, Birg F.

J Pathol. 2000 Oct;192(2):194-202.


Regulation of the Fas death pathway by FLICE-inhibitory protein in primary human B cells.

Hennino A, Berard M, Casamayor-Pallejà M, Krammer PH, Defrance T.

J Immunol. 2000 Sep 15;165(6):3023-30.

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