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Items: 9


Fighting bacterial persistence: Current and emerging anti-persister strategies and therapeutics.

Defraine V, Fauvart M, Michiels J.

Drug Resist Updat. 2018 May;38:12-26. doi: 10.1016/j.drup.2018.03.002. Epub 2018 Apr 10. Review.


1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage.

Defraine V, Liebens V, Loos E, Swings T, Weytjens B, Fierro C, Marchal K, Sharkey L, O'Neill AJ, Corbau R, Marchand A, Chaltin P, Fauvart M, Michiels J.

Front Microbiol. 2018 Feb 8;9:129. doi: 10.3389/fmicb.2018.00129. eCollection 2018.


Antibacterial Activity of 1-[(2,4-Dichlorophenethyl)amino]-3-Phenoxypropan-2-ol against Antibiotic-Resistant Strains of Diverse Bacterial Pathogens, Biofilms and in Pre-clinical Infection Models.

Defraine V, Verstraete L, Van Bambeke F, Anantharajah A, Townsend EM, Ramage G, Corbau R, Marchand A, Chaltin P, Fauvart M, Michiels J.

Front Microbiol. 2017 Dec 22;8:2585. doi: 10.3389/fmicb.2017.02585. eCollection 2017.


Identification of 1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol, a Novel Antibacterial Compound Active against Persisters of Pseudomonas aeruginosa.

Liebens V, Defraine V, Knapen W, Swings T, Beullens S, Corbau R, Marchand A, Chaltin P, Fauvart M, Michiels J.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00836-17. doi: 10.1128/AAC.00836-17. Print 2017 Sep.


Repurposing Toremifene for Treatment of Oral Bacterial Infections.

Gerits E, Defraine V, Vandamme K, De Cremer K, De Brucker K, Thevissen K, Cammue BP, Beullens S, Fauvart M, Verstraeten N, Michiels J.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e01846-16. doi: 10.1128/AAC.01846-16. Print 2017 Mar.


Efficacy of Artilysin Art-175 against Resistant and Persistent Acinetobacter baumannii.

Defraine V, Schuermans J, Grymonprez B, Govers SK, Aertsen A, Fauvart M, Michiels J, Lavigne R, Briers Y.

Antimicrob Agents Chemother. 2016 May 23;60(6):3480-8. doi: 10.1128/AAC.00285-16. Print 2016 Jun.


A Whole-Cell-Based High-Throughput Screening Method to Identify Molecules Targeting Pseudomonas aeruginosa Persister Cells.

Liebens V, Defraine V, Fauvart M.

Methods Mol Biol. 2016;1333:113-20. doi: 10.1007/978-1-4939-2854-5_10.


Art-175 is a highly efficient antibacterial against multidrug-resistant strains and persisters of Pseudomonas aeruginosa.

Briers Y, Walmagh M, Grymonprez B, Biebl M, Pirnay JP, Defraine V, Michiels J, Cenens W, Aertsen A, Miller S, Lavigne R.

Antimicrob Agents Chemother. 2014 Jul;58(7):3774-84. doi: 10.1128/AAC.02668-14. Epub 2014 Apr 21.


A putative de-N-acetylase of the PIG-L superfamily affects fluoroquinolone tolerance in Pseudomonas aeruginosa.

Liebens V, Defraine V, Van der Leyden A, De Groote VN, Fierro C, Beullens S, Verstraeten N, Kint C, Jans A, Frangipani E, Visca P, Marchal K, Versées W, Fauvart M, Michiels J.

Pathog Dis. 2014 Jun;71(1):39-54. doi: 10.1111/2049-632X.12174. Epub 2014 Apr 24.


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