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Lysine Methylation Regulators Moonlighting outside the Epigenome.

Cornett EM, Ferry L, Defossez PA, Rothbart SB.

Mol Cell. 2019 Sep 19;75(6):1092-1101. doi: 10.1016/j.molcel.2019.08.026. Review.


Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors.

Naciri I, Laisné M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, Kirsh O, Defossez PA.

Nucleic Acids Res. 2019 Apr 23;47(7):3407-3421. doi: 10.1093/nar/gkz080.


Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation.

Kori S, Ferry L, Matano S, Jimenji T, Kodera N, Tsusaka T, Matsumura R, Oda T, Sato M, Dohmae N, Ando T, Shinkai Y, Defossez PA, Arita K.

Structure. 2019 Mar 5;27(3):485-496.e7. doi: 10.1016/j.str.2018.11.012. Epub 2019 Jan 10.


Mechanisms of DNA Methyltransferase Recruitment in Mammals.

Laisné M, Gupta N, Kirsh O, Pradhan S, Defossez PA.

Genes (Basel). 2018 Dec 10;9(12). pii: E617. doi: 10.3390/genes9120617. Review.


Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation.

Marchal C, de Dieuleveult M, Saint-Ruf C, Guinot N, Ferry L, Olalla Saad ST, Lazarini M, Defossez PA, Miotto B.

Oncogenesis. 2018 Oct 11;7(10):82. doi: 10.1038/s41389-018-0092-0.


The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling.

Ma X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, Martin N, Bernard D.

Aging Cell. 2018 Dec;17(6):e12831. doi: 10.1111/acel.12831. Epub 2018 Sep 14.


Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.

Miotto B, Marchal C, Adelmant G, Guinot N, Xie P, Marto JA, Zhang L, Defossez PA.

Nucleic Acids Res. 2018 May 18;46(9):4392-4404. doi: 10.1093/nar/gky149.


[Unexpected roles for a methyl-binding protein in cancer].

Naciri I, Roussel-Gervais A, Defossez PA, Kirsh O.

Med Sci (Paris). 2017 Aug-Sep;33(8-9):714-716. doi: 10.1051/medsci/20173308009. Epub 2017 Sep 18. French. No abstract available.


Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA.

Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10.


Comment on "Critical wind speed at which trees break".

Albrecht A, Badel E, Bonnesoeur V, Brunet Y, Constant T, Défossez P, de Langre E, Dupont S, Fournier M, Gardiner B, Mitchell SJ, Moore JR, Moulia B, Nicoll BC, Niklas KJ, Schelhaas MJ, Spatz HC, Telewski FW.

Phys Rev E. 2016 Dec;94(6-2):067001. doi: 10.1103/PhysRevE.94.067001. Epub 2016 Dec 13.


Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.

Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA.

Cancer Res. 2017 Jan 1;77(1):62-73. doi: 10.1158/0008-5472.CAN-16-1181. Epub 2016 Nov 4.


MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.

Santolini M, Sakakibara I, Gauthier M, Ribas-Aulinas F, Takahashi H, Sawasaki T, Mouly V, Concordet JP, Defossez PA, Hakim V, Maire P.

Nucleic Acids Res. 2016 Oct 14;44(18):8621-8640. Epub 2016 Jun 14.


Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program.

Ferrand M, Kirsh O, Griveau A, Vindrieux D, Martin N, Defossez PA, Bernard D.

Aging (Albany NY). 2015 Nov;7(11):986-1003.


Tree stability under wind: simulating uprooting with root breakage using a finite element method.

Yang M, Défossez P, Danjon F, Fourcaud T.

Ann Bot. 2014 Sep;114(4):695-709.


The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability.

Miotto B, Chibi M, Xie P, Koundrioukoff S, Moolman-Smook H, Pugh D, Debatisse M, He F, Zhang L, Defossez PA.

Cell Rep. 2014 Apr 24;7(2):575-587. doi: 10.1016/j.celrep.2014.03.030. Epub 2014 Apr 13.


MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain.

Baymaz HI, Fournier A, Laget S, Ji Z, Jansen PW, Smits AH, Ferry L, Mensinga A, Poser I, Sharrocks A, Defossez PA, Vermeulen M.

Proteomics. 2014 Oct;14(19):2179-89. doi: 10.1002/pmic.201400013. Epub 2014 Apr 24.


MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress.

Laget S, Miotto B, Chin HG, Estève PO, Roberts RJ, Pradhan S, Defossez PA.

Epigenetics. 2014 Apr;9(4):546-56. doi: 10.4161/epi.27695. Epub 2014 Jan 16.


Ceci n'est pas une DNMT: recently discovered functions of DNMT2 and their relation to methyltransferase activity (Comment on DOI 10.1002/bies.201300088).

Defossez PA.

Bioessays. 2013 Dec;35(12):1024. doi: 10.1002/bies.201300151. No abstract available.


[Epigenetic regulation in neuronal differentiation and brain function].

Kasprzyk L, Defossez PA, Miotto B.

Biol Aujourdhui. 2013;207(1):1-17. doi: 10.1051/jbio/2013001. Epub 2013 May 23. Review. French.


On how mammalian transcription factors recognize methylated DNA.

Buck-Koehntop BA, Defossez PA.

Epigenetics. 2013 Feb;8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16. Review.


The role of methyl-binding proteins in chromatin organization and epigenome maintenance.

Fournier A, Sasai N, Nakao M, Defossez PA.

Brief Funct Genomics. 2012 May;11(3):251-64. doi: 10.1093/bfgp/elr040. Epub 2011 Dec 19. Review.


Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer.

Kim K, Chadalapaka G, Lee SO, Yamada D, Sastre-Garau X, Defossez PA, Park YY, Lee JS, Safe S.

Oncogene. 2012 Feb 23;31(8):1034-44. doi: 10.1038/onc.2011.296. Epub 2011 Jul 18.


Biological functions of methyl-CpG-binding proteins.

Defossez PA, Stancheva I.

Prog Mol Biol Transl Sci. 2011;101:377-98. doi: 10.1016/B978-0-12-387685-0.00012-3. Review.


Mammalian methyl-binding proteins: what might they do?

Joulie M, Miotto B, Defossez PA.

Bioessays. 2010 Dec;32(12):1025-32. doi: 10.1002/bies.201000057. Epub 2010 Sep 30.


The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA.

Laget S, Joulie M, Le Masson F, Sasai N, Christians E, Pradhan S, Roberts RJ, Defossez PA.

PLoS One. 2010 Aug 6;5(8):e11982. doi: 10.1371/journal.pone.0011982.


Sequence-specific recognition of methylated DNA by human zinc-finger proteins.

Sasai N, Nakao M, Defossez PA.

Nucleic Acids Res. 2010 Aug;38(15):5015-22. doi: 10.1093/nar/gkq280. Epub 2010 Apr 19.


The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.

Yamada D, Pérez-Torrado R, Filion G, Caly M, Jammart B, Devignot V, Sasai N, Ravassard P, Mallet J, Sastre-Garau X, Schmitz ML, Defossez PA.

Oncogene. 2009 Jul 9;28(27):2535-44. doi: 10.1038/onc.2009.109. Epub 2009 May 18.


Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes.

Sasai N, Defossez PA.

Int J Dev Biol. 2009;53(2-3):323-34. doi: 10.1387/ijdb.082652ns. Review.


Saccharomyces cerevisiae linker histone Hho1p functionally interacts with core histone H4 and negatively regulates the establishment of transcriptionally silent chromatin.

Yu Q, Kuzmiak H, Zou Y, Olsen L, Defossez PA, Bi X.

J Biol Chem. 2009 Jan 9;284(2):740-50. doi: 10.1074/jbc.M806274200. Epub 2008 Nov 18.


[Master and servant: epigenetic deregulations as a cause and a consequence of cancer].

Laget S, Defossez PA.

Med Sci (Paris). 2008 Aug-Sep;24(8-9):725-30. doi: 10.1051/medsci/20082489725. Review. French.


The cell biology of DNA methylation in mammals.

Prokhortchouk E, Defossez PA.

Biochim Biophys Acta. 2008 Nov;1783(11):2167-73. doi: 10.1016/j.bbamcr.2008.07.015. Epub 2008 Jul 28. Review.


Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.

Weber A, Marquardt J, Elzi D, Forster N, Starke S, Glaum A, Yamada D, Defossez PA, Delrow J, Eisenman RN, Christiansen H, Eilers M.

EMBO J. 2008 Jun 4;27(11):1563-74. doi: 10.1038/emboj.2008.85. Epub 2008 May 1.


Assessment of sera for chromatin-immunoprecipitation.

Nguyen J, Yamada D, Schultz DC, Defossez PA.

Biotechniques. 2008 Jan;44(1):66, 68.


Born to bind: the BTB protein-protein interaction domain.

Perez-Torrado R, Yamada D, Defossez PA.

Bioessays. 2006 Dec;28(12):1194-202. Review.


Using reverse electrophoretic mobility shift assay to measure and compare protein-DNA binding affinities.

Filion GJ, Fouvry L, Defossez PA.

Anal Biochem. 2006 Oct 1;357(1):156-8. Epub 2006 Aug 4. No abstract available.


[Epigenetics and cancer].

Filion GJ, Defossez PA.

Bull Cancer. 2006 Apr;93(4):343-7. French.


Histone H1 of Saccharomyces cerevisiae inhibits transcriptional silencing.

Veron M, Zou Y, Yu Q, Bi X, Selmi A, Gilson E, Defossez PA.

Genetics. 2006 Jun;173(2):579-87. Epub 2006 Apr 2.


A family of human zinc finger proteins that bind methylated DNA and repress transcription.

Filion GJ, Zhenilo S, Salozhin S, Yamada D, Prokhortchouk E, Defossez PA.

Mol Cell Biol. 2006 Jan;26(1):169-81.


The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso.

Defossez PA, Kelly KF, Filion GJ, Pérez-Torrado R, Magdinier F, Menoni H, Nordgaard CL, Daniel JM, Gilson E.

J Biol Chem. 2005 Dec 30;280(52):43017-23. Epub 2005 Oct 17.


[Proteins binding to methylated DNA: interpreters of the epigenetic code].

Filion G, Defossez PA.

Med Sci (Paris). 2004 Jan;20(1):7-8. French. No abstract available.


A methyltransferase targeting assay reveals silencer-telomere interactions in budding yeast.

Lebrun E, Fourel G, Defossez PA, Gilson E.

Mol Cell Biol. 2003 Mar;23(5):1498-508.


The vertebrate protein CTCF functions as an insulator in Saccharomyces cerevisiae.

Defossez PA, Gilson E.

Nucleic Acids Res. 2002 Dec 1;30(23):5136-41.


General regulatory factors (GRFs) as genome partitioners.

Fourel G, Miyake T, Defossez PA, Li R, Gilson E.

J Biol Chem. 2002 Nov 1;277(44):41736-43. Epub 2002 Aug 27.


Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.

Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L.

Nature. 2002 Jul 18;418(6895):344-8.


Sound silencing: the Sir2 protein and cellular senescence.

Defossez PA, Lin SJ, McNabb DS.

Bioessays. 2001 Apr;23(4):327-32. Review.


Elimination of replication block protein Fob1 extends the life span of yeast mother cells.

Defossez PA, Prusty R, Kaeberlein M, Lin SJ, Ferrigno P, Silver PA, Keil RL, Guarente L.

Mol Cell. 1999 Apr;3(4):447-55.


Vicious circles: a mechanism for yeast aging.

Defossez PA, Park PU, Guarente L.

Curr Opin Microbiol. 1998 Dec;1(6):707-11. Review.


The ETS family member ERM contains an alpha-helical acidic activation domain that contacts TAFII60.

Defossez PA, Baert JL, Monnot M, de Launoit Y.

Nucleic Acids Res. 1997 Nov 15;25(22):4455-63.

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