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Items: 24

1.

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole.

Lin M, Ly J, Takahashi R, Chen J, Deese A, Robinson SJ, Kolesnikov A, Wong S, Wang X, Chang JH.

Xenobiotica. 2018 Oct;48(10):1021-1027. doi: 10.1080/00498254.2017.1373312. Epub 2017 Sep 29.

PMID:
28845725
2.

Solid-State Characterization of Novel Propylene Glycol Ester Solvates Isolated from Lipid Formulations.

Chakravarty P, Kothari S, Deese A, Lubach JW.

Mol Pharm. 2015 Jul 6;12(7):2551-7. doi: 10.1021/mp5007695. Epub 2015 Jun 3.

PMID:
26013841
3.

Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans.

Smith BJ, Pithavala Y, Bu HZ, Kang P, Hee B, Deese AJ, Pool WF, Klamerus KJ, Wu EY, Dalvie DK.

Drug Metab Dispos. 2014 May;42(5):918-31. doi: 10.1124/dmd.113.056531. Epub 2014 Mar 7.

PMID:
24608633
4.

Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats.

Takahashi R, Ma S, Deese A, Yue Q, Kim-Kang H, Yi Y, Siu M, Hunt KW, Kallan NC, Hop CE, Liu X, Khojasteh SC.

Drug Metab Dispos. 2014 May;42(5):890-8. doi: 10.1124/dmd.114.057141. Epub 2014 Mar 4.

PMID:
24595682
5.

Chemoselective sp2-sp3 cross-couplings: iron-catalyzed alkyl transfer to dihaloaromatics.

Malhotra S, Seng PS, Koenig SG, Deese AJ, Ford KA.

Org Lett. 2013 Jul 19;15(14):3698-701. doi: 10.1021/ol401508u. Epub 2013 Jul 5.

PMID:
23829418
6.

Degradation of a pharmaceutical in HPLC grade methanol containing trace level formaldehyde.

Zhong Q, Stowers S, Segraves NL, Ngim KK, Zhang K, Bostick T, Deese A, Chetwyn NP.

Pharm Dev Technol. 2013 Jul-Aug;18(4):877-82. doi: 10.3109/10837450.2012.696265. Epub 2012 Jun 12.

PMID:
22686350
7.

An isolable acyclic hemiacetal of ansamitocin P-3.

Segraves NL, Yazzie D, Deese AJ.

Magn Reson Chem. 2012 Mar;50(3):256-9. doi: 10.1002/mrc.2876. Epub 2012 Feb 28.

PMID:
22374862
8.

Strategies for the analysis of highly reactive pinacolboronate esters.

Zhong Q, Ngim KK, Sun M, Li J, Deese A, Chetwyn NP.

J Chromatogr A. 2012 Mar 16;1229:216-22. doi: 10.1016/j.chroma.2012.01.050. Epub 2012 Jan 25.

PMID:
22321949
9.

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.

Zhang C, Kenny JR, Le H, Deese A, Ford KA, Lightning LK, Fan PW, Driscoll JP, Halladay JS, Hop CE, Khojasteh SC.

Chem Res Toxicol. 2011 Oct 17;24(10):1668-77. doi: 10.1021/tx2002228. Epub 2011 Sep 25.

PMID:
21905702
10.

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.

Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H.

Drug Metab Dispos. 2011 Oct;39(10):1840-9. doi: 10.1124/dmd.111.040840. Epub 2011 Jul 8.

PMID:
21742900
11.

Absorption, distribution, metabolism, and excretion of [¹⁴C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening.

Yue Q, Chen YH, Mulder T, Deese A, Takahashi R, Rudewicz PJ, Reynolds M, Solon E, Hop CE, Wong H, Khojasteh SC.

Drug Metab Dispos. 2011 Jun;39(6):952-65. doi: 10.1124/dmd.110.037374. Epub 2011 Mar 1.

PMID:
21363998
12.

Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.

Driscoll JP, Aliagas I, Harris JJ, Halladay JS, Khatib-Shahidi S, Deese A, Segraves N, Khojasteh-Bakht SC.

Chem Res Toxicol. 2010 May 17;23(5):861-3. doi: 10.1021/tx1000688.

PMID:
20369854
13.

Bioactivation of flutamide metabolites by human liver microsomes.

Kang P, Dalvie D, Smith E, Zhou S, Deese A, Nieman JA.

Drug Metab Dispos. 2008 Jul;36(7):1425-37. doi: 10.1124/dmd.108.020370. Epub 2008 Apr 14.

PMID:
18411402
14.

Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes.

Kang P, Dalvie D, Smith E, Zhou S, Deese A.

Drug Metab Dispos. 2007 Jul;35(7):1081-8. Epub 2007 Apr 2.

PMID:
17403914
15.

In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole.

Dalvie D, Smith E, Deese A, Bowlin S.

Drug Metab Dispos. 2006 Apr;34(4):709-17. Epub 2006 Jan 24.

PMID:
16434547
16.

Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine.

Bu HZ, Kang P, Deese AJ, Zhao P, Pool WF.

Drug Metab Dispos. 2005 Dec;33(12):1920-4. Epub 2005 Oct 4.

PMID:
16204461
17.

NMR of biofluids and pattern recognition: assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse.

Potts BC, Deese AJ, Stevens GJ, Reily MD, Robertson DG, Theiss J.

J Pharm Biomed Anal. 2001 Oct;26(3):463-76.

PMID:
11489392
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22.

Interaction of rhodopsin with two unsaturated phosphatidylcholines: a deuterium nuclear magnetic resonance study.

Deese AJ, Dratz EA, Dahlquist FW, Paddy MR.

Biochemistry. 1981 Oct 27;20(22):6420-7. No abstract available.

PMID:
7306517
23.

Retinal rod outer segment lipids form bilayers in the presence and absence of rhodopsin: a 31P NMR study.

Deese AJ, Dratz EA, Brown MF.

FEBS Lett. 1981 Feb 9;124(1):93-9. No abstract available.

24.

Optimum photography of fluorescent isoenzyme patterns.

Hathaway JA, Deese A.

Clin Chem. 1978 Jun;24(6):1081. No abstract available.

PMID:
207460

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