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Items: 1 to 50 of 143


Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack.

Oates JR, McKell MC, Moreno-Fernandez ME, Damen MSMA, Deepe GS Jr, Qualls JE, Divanovic S.

Front Immunol. 2019 Dec 12;10:2893. doi: 10.3389/fimmu.2019.02893. eCollection 2019. Review.


Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages.

Chowdhury D, Alrefai H, Landero Figueroa JA, Candor K, Porollo A, Fecher R, Divanovic S, Deepe GS Jr, Subramanian Vignesh K.

Cell Rep. 2019 Jun 25;27(13):3873-3886.e7. doi: 10.1016/j.celrep.2019.05.093.


The intersection of host and fungus through the zinc lens.

Wilson D, Deepe GS Jr.

Curr Opin Microbiol. 2019 Dec;52:35-40. doi: 10.1016/j.mib.2019.04.008. Epub 2019 May 24. Review.


The HIF-1α/LC3-II Axis Impacts Fungal Immunity in Human Macrophages.

Friedrich D, Zapf D, Lohse B, Fecher RA, Deepe GS Jr, Rupp J.

Infect Immun. 2019 Jun 20;87(7). pii: e00125-19. doi: 10.1128/IAI.00125-19. Print 2019 Jul.


Aeroallergens Exacerbate Histoplasma capsulatum Infection.

Bueter CL, Deepe GS Jr.

J Immunol. 2018 Dec 1;201(11):3352-3361. doi: 10.4049/jimmunol.1800644. Epub 2018 Oct 22.


Outbreaks of histoplasmosis: The spores set sail.

Deepe GS Jr.

PLoS Pathog. 2018 Sep 13;14(9):e1007213. doi: 10.1371/journal.ppat.1007213. eCollection 2018 Sep. Review. No abstract available.


Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis.

Kyrmizi I, Ferreira H, Carvalho A, Figueroa JAL, Zarmpas P, Cunha C, Akoumianaki T, Stylianou K, Deepe GS Jr, Samonis G, Lacerda JF, Campos A Jr, Kontoyiannis DP, Mihalopoulos N, Kwon-Chung KJ, El-Benna J, Valsecchi I, Beauvais A, Brakhage AA, Neves NM, Latge JP, Chamilos G.

Nat Microbiol. 2018 Jul;3(7):791-803. doi: 10.1038/s41564-018-0167-x. Epub 2018 May 30.


Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice.

Deepe GS Jr, Buesing WR, Ostroff GR, Abraham A, Specht CA, Huang H, Levitz SM.

Vaccine. 2018 May 31;36(23):3359-3367. doi: 10.1016/j.vaccine.2018.04.047. Epub 2018 May 2.


Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis That Amplifies Regulatory T Cells in a Pulmonary Fungal Infection.

Tweedle JL, Deepe GS Jr.

Infect Immun. 2018 May 22;86(6). pii: e00109-18. doi: 10.1128/IAI.00109-18. Print 2018 Jun.


Metallothioneins: Emerging Modulators in Immunity and Infection.

Subramanian Vignesh K, Deepe GS Jr.

Int J Mol Sci. 2017 Oct 23;18(10). pii: E2197. doi: 10.3390/ijms18102197. Review.


Investigation of an optimal cell lysis method for the study of the zinc metalloproteome of Histoplasma capsulatum.

Donnell AM, Lewis S, Abraham S, Subramanian K, Figueroa JL, Deepe GS Jr, Vonderheide AP.

Anal Bioanal Chem. 2017 Oct;409(26):6163-6172. doi: 10.1007/s00216-017-0556-7. Epub 2017 Aug 12.


Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1.

Horwath MC, Bell-Horwath TR, Lescano V, Krishnan K, Merino EJ, Deepe GS Jr.

Chembiochem. 2017 Oct 18;18(20):2069-2078. doi: 10.1002/cbic.201700105. Epub 2017 Sep 1.


Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells.

Nanjappa SG, McDermott AJ, Fites JS, Galles K, Wüthrich M, Deepe GS Jr, Klein BS.

PLoS Pathog. 2017 May 22;13(5):e1006356. doi: 10.1371/journal.ppat.1006356. eCollection 2017 May.


Elevated Circulating Concentrations of Interferon-Gamma in Latent Tuberculosis Infection.

Huaman MA, Deepe GS Jr, Fichtenbaum CJ.

Pathog Immun. 2016 Fall-Winter;1(2):291-303.


Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity.

Friedrich D, Fecher RA, Rupp J, Deepe GS Jr.

Microbes Infect. 2017 Mar;19(3):204-209. doi: 10.1016/j.micinf.2016.10.008. Epub 2016 Oct 31. Review.


IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages.

Subramanian Vignesh K, Landero Figueroa JA, Porollo A, Divanovic S, Caruso JA, Deepe GS Jr.

Cell Rep. 2016 Sep 20;16(12):3232-3246. doi: 10.1016/j.celrep.2016.08.057.


Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance.

George MM, Subramanian Vignesh K, Landero Figueroa JA, Caruso JA, Deepe GS Jr.

J Immunol. 2016 Sep 1;197(5):1864-76. doi: 10.4049/jimmunol.1600410. Epub 2016 Jul 27.


HcZrt2, a zinc responsive gene, is indispensable for the survival of Histoplasma capsulatum in vivo.

Dade J, DuBois JC, Pasula R, Donnell AM, Caruso JA, Smulian AG, Deepe GS Jr.

Med Mycol. 2016 Nov 1;54(8):865-75. doi: 10.1093/mmy/myw045. Epub 2016 Jun 22.


Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis.

Xiong Y, Lingrel JB, Wüthrich M, Klein BS, Vasudevan NT, Jain MK, George M, Deepe GS Jr.

mBio. 2016 Jun 14;7(3). pii: e00436-16. doi: 10.1128/mBio.00436-16.


Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum.

Fecher RA, Horwath MC, Friedrich D, Rupp J, Deepe GS Jr.

J Immunol. 2016 Jul 15;197(2):565-79. doi: 10.4049/jimmunol.1600342. Epub 2016 Jun 6.


Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora.

Hsieh H, Vignesh KS, Deepe GS Jr, Choubey D, Shertzer HG, Genter MB.

Toxicol In Vitro. 2016 Sep;35:24-30. doi: 10.1016/j.tiv.2016.05.003. Epub 2016 May 12.


Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2-/- mice.

Verma AH, Bueter CL, Rothenberg ME, Deepe GS.

Mucosal Immunol. 2017 Jan;10(1):194-204. doi: 10.1038/mi.2016.26. Epub 2016 Apr 6.


Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity.

Sterkel AK, Lorenzini JL, Fites JS, Subramanian Vignesh K, Sullivan TD, Wuthrich M, Brandhorst T, Hernandez-Santos N, Deepe GS Jr, Klein BS.

Cell Host Microbe. 2016 Mar 9;19(3):361-74. doi: 10.1016/j.chom.2016.02.001. Epub 2016 Feb 25.


Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses.

Subramanian Vignesh K, Deepe GS Jr.

Arch Biochem Biophys. 2016 Dec 1;611:66-78. doi: 10.1016/ Epub 2016 Feb 24. Review.


Histoplasma capsulatum, lung infection and immunity.

Horwath MC, Fecher RA, Deepe GS Jr.

Future Microbiol. 2015;10(6):967-75. doi: 10.2217/fmb.15.25. Review.


Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes.

Wüthrich M, Brandhorst TT, Sullivan TD, Filutowicz H, Sterkel A, Stewart D, Li M, Lerksuthirat T, LeBert V, Shen ZT, Ostroff G, Deepe GS Jr, Hung CY, Cole G, Walter JA, Jenkins MK, Klein B.

Cell Host Microbe. 2015 Apr 8;17(4):452-65. doi: 10.1016/j.chom.2015.02.009. Epub 2015 Mar 19.


Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33.

Verma A, Kroetz DN, Tweedle JL, Deepe GS Jr.

Mucosal Immunol. 2015 Mar;8(2):380-9. doi: 10.1038/mi.2014.75. Epub 2014 Aug 13.


Zinc sequestration: arming phagocyte defense against fungal attack.

Subramanian Vignesh K, Landero Figueroa JA, Porollo A, Caruso JA, Deepe GS Jr.

PLoS Pathog. 2013;9(12):e1003815. doi: 10.1371/journal.ppat.1003815. Epub 2013 Dec 26. Review. No abstract available.


Novel strategies to enhance vaccine immunity against coccidioidomycosis.

Cole GT, Hung CY, Sanderson SD, Hurtgen BJ, Wüthrich M, Klein BS, Deepe GS, Ostroff GR, Levitz SM.

PLoS Pathog. 2013;9(12):e1003768. doi: 10.1371/journal.ppat.1003768. Epub 2013 Dec 19. No abstract available.


Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells.

Figueroa JA, Vignesh KS, Deepe GS Jr, Caruso J.

Metallomics. 2014 Feb;6(2):301-15. doi: 10.1039/c3mt00283g.


Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival.

Subramanian Vignesh K, Landero Figueroa JA, Porollo A, Caruso JA, Deepe GS Jr.

Immunity. 2013 Oct 17;39(4):697-710. doi: 10.1016/j.immuni.2013.09.006.


NADPH oxidase regulates efficacy of vaccination in aspergillosis.

Deepe GS Jr.

J Clin Invest. 2012 May;122(5):1608-11. doi: 10.1172/JCI63417. Epub 2012 Apr 23.


CCR5 deficiency mitigates the deleterious effects of tumor necrosis factor α antagonism in murine histoplasmosis.

Kroetz DN, Deepe GS Jr.

J Infect Dis. 2012 Mar 15;205(6):955-63. doi: 10.1093/infdis/jir869. Epub 2012 Jan 23.


Adaptive immunity to fungi.

Wüthrich M, Deepe GS Jr, Klein B.

Annu Rev Immunol. 2012;30:115-48. doi: 10.1146/annurev-immunol-020711-074958. Epub 2012 Jan 3. Review.


Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection.

Deepe GS Jr, Buesing WR.

J Immunol. 2012 Jan 1;188(1):334-44. doi: 10.4049/jimmunol.1102175. Epub 2011 Nov 18.


The role of cytokines and chemokines in Histoplasma capsulatum infection.

Kroetz DN, Deepe GS.

Cytokine. 2012 Apr;58(1):112-7. doi: 10.1016/j.cyto.2011.07.430. Epub 2011 Aug 26. Review.


An aberrant thymus in CCR5-/- mice is coupled with an enhanced adaptive immune response in fungal infection.

Kroetz DN, Deepe GS Jr.

J Immunol. 2011 May 15;186(10):5949-55. doi: 10.4049/jimmunol.1003876. Epub 2011 Apr 8.


Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses.

Winters MS, Chan Q, Caruso JA, Deepe GS Jr.

J Infect Dis. 2010 Oct 1;202(7):1136-45. doi: 10.1086/656191.


CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection.

Kroetz DN, Deepe GS Jr.

J Immunol. 2010 May 1;184(9):5224-31. doi: 10.4049/jimmunol.1000032. Epub 2010 Mar 24.


Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection.

Szymczak WA, Deepe GS Jr.

Infect Immun. 2010 May;78(5):2125-37. doi: 10.1128/IAI.00065-10. Epub 2010 Mar 1.


The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity.

Szymczak WA, Deepe GS Jr.

J Immunol. 2009 Aug 1;183(3):1964-74. doi: 10.4049/jimmunol.0901316. Epub 2009 Jul 8.


Interleukins 17 and 23 influence the host response to Histoplasma capsulatum.

Deepe GS Jr, Gibbons RS.

J Infect Dis. 2009 Jul 1;200(1):142-51. doi: 10.1086/599333.


Histoplasma capsulatum proteome response to decreased iron availability.

Winters MS, Spellman DS, Chan Q, Gomez FJ, Hernandez M, Catron B, Smulian AG, Neubert TA, Deepe GS Jr.

Proteome Sci. 2008 Dec 24;6:36. doi: 10.1186/1477-5956-6-36.


Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells.

Medeiros AI, Sá-Nunes A, Turato WM, Secatto A, Frantz FG, Sorgi CA, Serezani CH, Deepe GS Jr, Faccioli LH.

J Immunol. 2008 Dec 15;181(12):8544-51.


The catalases of Paracoccidioides brasiliensis are differentially regulated: protein activity and transcript analysis.

Chagas RF, Bailão AM, Pereira M, Winters MS, Smullian AG, Deepe GS Jr, de Almeida Soares CM.

Fungal Genet Biol. 2008 Nov;45(11):1470-8. doi: 10.1016/j.fgb.2008.08.007. Epub 2008 Aug 30.


Vaccination with heat shock protein 60 induces a protective immune response against experimental Paracoccidioides brasiliensis pulmonary infection.

de Bastos Ascenço Soares R, Gomez FJ, de Almeida Soares CM, Deepe GS Jr.

Infect Immun. 2008 Sep;76(9):4214-21. doi: 10.1128/IAI.00753-07. Epub 2008 Jul 14.


Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs.

Deepe GS Jr, Gibbons RS, Smulian AG.

J Leukoc Biol. 2008 Sep;84(3):669-78. doi: 10.1189/jlb.0308154. Epub 2008 Jun 24.


Infection with Histoplasma capsulatum: Host-fungus interface.

Allendoerfer R, Deepe GS Jr.

Rev Iberoam Micol. 1998 Dec;15(4):256-60.


Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum.

Smulian AG, Gibbons RS, Demland JA, Spaulding DT, Deepe GS Jr.

Eukaryot Cell. 2007 Nov;6(11):2066-71. Epub 2007 Sep 14.

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