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Items: 41

1.

Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia.

Trossbach SV, Hecher L, Schafflick D, Deenen R, Popa O, Lautwein T, Tschirner S, Köhrer K, Fehsel K, Papazova I, Malchow B, Hasan A, Winterer G, Schmitt A, Meyer Zu Hörste G, Falkai P, Korth C.

Transl Psychiatry. 2019 May 31;9(1):156. doi: 10.1038/s41398-019-0486-6.

2.

CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine.

Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, Aufenvenne K, von Ameln F, Zurek M, Spannbrucker T, Eckermann O, Jakob S, Gorressen S, Abrams M, Grandoch M, Fischer JW, Köhrer K, Deenen R, Unfried K, Altschmied J, Haendeler J.

PLoS Biol. 2018 Jun 21;16(6):e2004408. doi: 10.1371/journal.pbio.2004408. eCollection 2018 Jun.

3.

Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro.

Suwala AK, Koch K, Rios DH, Aretz P, Uhlmann C, Ogorek I, Felsberg J, Reifenberger G, Köhrer K, Deenen R, Steiger HJ, Kahlert UD, Maciaczyk J.

Oncotarget. 2018 Apr 27;9(32):22703-22716. doi: 10.18632/oncotarget.25210. eCollection 2018 Apr 27.

4.

A transcriptome comparison of time-matched developing human, mouse and rat neural progenitor cells reveals human uniqueness.

Masjosthusmann S, Becker D, Petzuch B, Klose J, Siebert C, Deenen R, Barenys M, Baumann J, Dach K, Tigges J, Hübenthal U, Köhrer K, Fritsche E.

Toxicol Appl Pharmacol. 2018 Sep 1;354:40-55. doi: 10.1016/j.taap.2018.05.009. Epub 2018 May 9.

PMID:
29753005
5.

Long-Term, Low-Frequency Cluster of a German-Imipenemase-1-Producing Enterobacter hormaechei ssp. steigerwaltii ST89 in a Tertiary Care Hospital in Germany.

Wendel AF, Meyer S, Deenen R, Köhrer K, Kolbe-Busch S, Pfeffer K, Willmann M, Kaasch AJ, MacKenzie CR.

Microb Drug Resist. 2018 Nov;24(9):1305-1315. doi: 10.1089/mdr.2017.0433. Epub 2018 May 11.

PMID:
29750595
6.

Reprogramming of pro-inflammatory human macrophages to an anti-inflammatory phenotype by bile acids.

Wammers M, Schupp AK, Bode JG, Ehlting C, Wolf S, Deenen R, Köhrer K, Häussinger D, Graf D.

Sci Rep. 2018 Jan 10;8(1):255. doi: 10.1038/s41598-017-18305-x.

7.

Validation of a novel Mho microarray for a comprehensive characterisation of the Mycoplasma hominis action in HeLa cell infection.

Henrich B, Kretzmer F, Deenen R, Köhrer K.

PLoS One. 2017 Jul 28;12(7):e0181383. doi: 10.1371/journal.pone.0181383. eCollection 2017.

8.

Dominant TNFα and impaired IL-2 cytokine profiles of CD4+ T cells from children with type-1 diabetes.

Seyfarth J, Förtsch K, Ahlert H, Laws HJ, Karges B, Deenen R, Köhrer K, Mayatepek E, Meissner T, Jacobsen M.

Immunol Cell Biol. 2017 Aug;95(7):630-639. doi: 10.1038/icb.2017.24. Epub 2017 Apr 5.

PMID:
28377612
9.

Inorganic nitrite modulates miRNA signatures in acute myocardial in vivo ischemia/reperfusion.

Hendgen-Cotta UB, Messiha D, Esfeld S, Deenen R, Rassaf T, Totzeck M.

Free Radic Res. 2017 Jan;51(1):91-102. doi: 10.1080/10715762.2017.1282158.

PMID:
28090786
10.

Molecular- and microarray-based analysis of diversity among resting and osteogenically induced porcine mesenchymal stromal cells of several tissue origin.

Bayraktar S, Jungbluth P, Deenen R, Grassmann J, Schneppendahl J, Eschbach D, Scholz A, Windolf J, Suschek CV, Grotheer V.

J Tissue Eng Regen Med. 2018 Jan;12(1):114-128. doi: 10.1002/term.2375. Epub 2017 May 19.

11.

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR Jr, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R.

PLoS Pathog. 2016 Dec 9;12(12):e1006043. doi: 10.1371/journal.ppat.1006043. eCollection 2016 Dec.

12.

Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease.

Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Köhrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K.

Sci Transl Med. 2016 Oct 26;8(362):362ra146.

PMID:
27797962
13.

Aryl Hydrocarbon Receptor in Keratinocytes Is Essential for Murine Skin Barrier Integrity.

Haas K, Weighardt H, Deenen R, Köhrer K, Clausen B, Zahner S, Boukamp P, Bloch W, Krutmann J, Esser C.

J Invest Dermatol. 2016 Nov;136(11):2260-2269. doi: 10.1016/j.jid.2016.06.627. Epub 2016 Jul 16.

14.

Lenalidomide consolidation treatment in patients with multiple myeloma suppresses myelopoieses but spares erythropoiesis.

Wilk CM, Heinzler N, Boquoi A, Cadeddu RP, Strapatsas T, Dienst A, Majidi F, Deenen R, Bruns I, Schroeder T, Köhrer K, Haas R, Kobbe G, Fenk R.

Int J Cancer. 2016 Nov 15;139(10):2343-52. doi: 10.1002/ijc.30257. Epub 2016 Aug 13.

15.

MicroRNA-1-associated effects of neuron-specific brain-derived neurotrophic factor gene deletion in dorsal root ganglia.

Neumann E, Brandenburger T, Santana-Varela S, Deenen R, Köhrer K, Bauer I, Hermanns H, Wood JN, Zhao J, Werdehausen R.

Mol Cell Neurosci. 2016 Sep;75:36-43. doi: 10.1016/j.mcn.2016.06.003. Epub 2016 Jun 21.

PMID:
27346077
16.

Cutting Edge: IFN-β Expression in the Spleen Is Restricted to a Subpopulation of Plasmacytoid Dendritic Cells Exhibiting a Specific Immune Modulatory Transcriptome Signature.

Bauer J, Dress RJ, Schulze A, Dresing P, Ali S, Deenen R, Alferink J, Scheu S.

J Immunol. 2016 Jun 1;196(11):4447-51. doi: 10.4049/jimmunol.1500383. Epub 2016 May 2.

17.

Impact of dietary nitrate on age-related diastolic dysfunction.

Rammos C, Hendgen-Cotta UB, Totzeck M, Pohl J, Lüdike P, Flögel U, Deenen R, Köhrer K, French BA, Gödecke A, Kelm M, Rassaf T.

Eur J Heart Fail. 2016 Jun;18(6):599-610. doi: 10.1002/ejhf.535. Epub 2016 Apr 26.

18.

Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms.

Pinkerneil M, Hoffmann MJ, Deenen R, Köhrer K, Arent T, Schulz WA, Niegisch G.

Mol Cancer Ther. 2016 Feb;15(2):299-312. doi: 10.1158/1535-7163.MCT-15-0618. Epub 2016 Jan 15.

19.

Cooperative role of lymphotoxin β receptor and tumor necrosis factor receptor p55 in murine liver regeneration.

Sorg UR, Behnke K, Degrandi D, Reich M, Keitel V, Herebian D, Deenen R, Beyer M, Schultze JL, Köhrer K, Gabbert HE, Mayatepek E, Häussinger D, Pfeffer K.

J Hepatol. 2016 May;64(5):1108-1117. doi: 10.1016/j.jhep.2015.12.006. Epub 2015 Dec 19.

PMID:
26708145
20.

Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.

Kiene LS, Homann S, Suvorava T, Rabausch B, Müller J, Kojda G, Kretschmer I, Twarock S, Dai G, Deenen R, Hartwig S, Lehr S, Köhrer K, Savani RC, Grandoch M, Fischer JW.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):e9-16. doi: 10.1161/ATVBAHA.115.306607. Epub 2015 Nov 19.

21.

Interferon-β Modulates the Innate Immune Response against Glioblastoma Initiating Cells.

Wolpert F, Happold C, Reifenberger G, Florea AM, Deenen R, Roth P, Neidert MC, Lamszus K, Westphal M, Weller M, Eisele G.

PLoS One. 2015 Oct 6;10(10):e0139603. doi: 10.1371/journal.pone.0139603. eCollection 2015.

22.

Human endogenous retrovirus HERV-K(HML-2) activity in prostate cancer is dominated by a few loci.

Goering W, Schmitt K, Dostert M, Schaal H, Deenen R, Mayer J, Schulz WA.

Prostate. 2015 Dec;75(16):1958-71. doi: 10.1002/pros.23095. Epub 2015 Sep 18.

PMID:
26384005
23.

The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells.

Heubach J, Monsior J, Deenen R, Niegisch G, Szarvas T, Niedworok C, Schulz WA, Hoffmann MJ.

Mol Cancer. 2015 May 21;14:108. doi: 10.1186/s12943-015-0371-8.

24.

Dietary nitrate is a modifier of vascular gene expression in old male mice.

Rammos C, Totzeck M, Deenen R, Köhrer K, Kelm M, Rassaf T, Hendgen-Cotta UB.

Oxid Med Cell Longev. 2015;2015:658264. doi: 10.1155/2015/658264. Epub 2015 Mar 8.

25.

Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice.

Grandoch M, Feldmann K, Göthert JR, Dick LS, Homann S, Klatt C, Bayer JK, Waldheim JN, Rabausch B, Nagy N, Oberhuber A, Deenen R, Köhrer K, Lehr S, Homey B, Pfeffer K, Fischer JW.

Circ Res. 2015 Apr 10;116(8):e57-68. doi: 10.1161/CIRCRESAHA.116.305723. Epub 2015 Mar 4.

PMID:
25740843
26.

Target genes of recurrent chromosomal amplification and deletion in urothelial carcinoma.

Weilandt M, Koch A, Rieder H, Deenen R, Schwender H, Niegisch G, Schulz WA.

Cancer Genomics Proteomics. 2014 May-Jun;11(3):141-53.

PMID:
24969694
27.

Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient mice.

Freudenberger T, Deenen R, Kretschmer I, Zimmermann A, Seiler LF, Mayer P, Heim HK, Köhrer K, Fischer JW.

Br J Pharmacol. 2014 Nov;171(22):5032-48. doi: 10.1111/bph.12814. Epub 2014 Sep 5.

28.

Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS, Lang PA.

Immunity. 2014 Jun 19;40(6):949-60. doi: 10.1016/j.immuni.2014.05.004. Epub 2014 Jun 5.

29.

β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.

Blankenburg R, Hackert K, Wurster S, Deenen R, Seidman JG, Seidman CE, Lohse MJ, Schmitt JP.

Circ Res. 2014 Jul 7;115(2):227-37. doi: 10.1161/CIRCRESAHA.115.303178. Epub 2014 May 14.

30.

Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation.

Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Köhrer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F.

Exp Gerontol. 2014 Aug;56:59-68. doi: 10.1016/j.exger.2014.03.017. Epub 2014 Mar 31.

PMID:
24699405
31.

Interferon-β induces loss of spherogenicity and overcomes therapy resistance of glioblastoma stem cells.

Happold C, Roth P, Silginer M, Florea AM, Lamszus K, Frei K, Deenen R, Reifenberger G, Weller M.

Mol Cancer Ther. 2014 Apr;13(4):948-61. doi: 10.1158/1535-7163.MCT-13-0772. Epub 2014 Feb 13.

32.

Age-related vascular gene expression profiling in mice.

Rammos C, Hendgen-Cotta UB, Deenen R, Pohl J, Stock P, Hinzmann C, Kelm M, Rassaf T.

Mech Ageing Dev. 2014 Jan;135:15-23. doi: 10.1016/j.mad.2014.01.001. Epub 2014 Jan 18.

PMID:
24447783
33.

Comparing the gene expression profile of stromal cells from human cord blood and bone marrow: lack of the typical "bone" signature in cord blood cells.

Bosch J, Houben AP, Hennicke T, Deenen R, Köhrer K, Liedtke S, Kögler G.

Stem Cells Int. 2013;2013:631984. doi: 10.1155/2013/631984. Epub 2013 Sep 16.

34.

Two isoforms of Sister-Of-Mammalian Grainyhead have opposing functions in endothelial cells and in vivo.

Haendeler J, Mlynek A, Büchner N, Lukosz M, Graf M, Guettler C, Jakob S, Farrokh S, Kunze K, Goy C, Guardiola-Serrano F, Schaal H, Cortese-Krott M, Deenen R, Köhrer K, Winkler C, Altschmied J.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1639-46. doi: 10.1161/ATVBAHA.113.301428. Epub 2013 May 16.

PMID:
23685552
35.

Neonatal mesenchymal-like cells adapt to surrounding cells.

Liedtke S, Freytag EM, Bosch J, Houben AP, Radke TF, Deenen R, Köhrer K, Kögler G.

Stem Cell Res. 2013 Jul;11(1):634-46. doi: 10.1016/j.scr.2013.04.001. Epub 2013 Apr 10.

36.

Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines.

Luca AC, Mersch S, Deenen R, Schmidt S, Messner I, Schäfer KL, Baldus SE, Huckenbeck W, Piekorz RP, Knoefel WT, Krieg A, Stoecklein NH.

PLoS One. 2013;8(3):e59689. doi: 10.1371/journal.pone.0059689. Epub 2013 Mar 26.

37.

Host cell responses to persistent mycoplasmas--different stages in infection of HeLa cells with Mycoplasma hominis.

Hopfe M, Deenen R, Degrandi D, Köhrer K, Henrich B.

PLoS One. 2013;8(1):e54219. doi: 10.1371/journal.pone.0054219. Epub 2013 Jan 11.

38.

An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA.

Widera M, Erkelenz S, Hillebrand F, Krikoni A, Widera D, Kaisers W, Deenen R, Gombert M, Dellen R, Pfeiffer T, Kaltschmidt B, Münk C, Bosch V, Köhrer K, Schaal H.

J Virol. 2013 Mar;87(5):2707-20. doi: 10.1128/JVI.02755-12. Epub 2012 Dec 19.

39.

Immunoregulatory natural killer cells suppress autoimmunity by down-regulating antigen-specific CD8+ T cells in mice.

Ehlers M, Papewalis C, Stenzel W, Jacobs B, Meyer KL, Deenen R, Willenberg HS, Schinner S, Thiel A, Scherbaum WA, Ullrich E, Zitvogel L, Schott M.

Endocrinology. 2012 Sep;153(9):4367-79. doi: 10.1210/en.2012-1247. Epub 2012 Jun 25.

PMID:
22733969
40.

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases.

Linka RM, Risse SL, Bienemann K, Werner M, Linka Y, Krux F, Synaeve C, Deenen R, Ginzel S, Dvorsky R, Gombert M, Halenius A, Hartig R, Helminen M, Fischer A, Stepensky P, Vettenranta K, Köhrer K, Ahmadian MR, Laws HJ, Fleckenstein B, Jumaa H, Latour S, Schraven B, Borkhardt A.

Leukemia. 2012 May;26(5):963-71. doi: 10.1038/leu.2011.371. Epub 2012 Jan 6.

PMID:
22289921
41.

Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status.

Hüttmann A, Klein-Hitpass L, Thomale J, Deenen R, Carpinteiro A, Nückel H, Ebeling P, Führer A, Edelmann J, Sellmann L, Dührsen U, Dürig J.

Leukemia. 2006 Oct;20(10):1774-82. Epub 2006 Aug 17.

PMID:
16932341

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