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Items: 1 to 50 of 175

1.

Structural Studies of Multidrug Resistance Protein 1 Using "Almost" Cysless Template.

Trofimova DN, Deeley RG.

Drug Metab Dispos. 2018 Jun;46(6):794-804. doi: 10.1124/dmd.117.078709. Epub 2018 Mar 23.

PMID:
29572332
2.
3.

Structure of a human multidrug transporter in an inward-facing conformation.

Rosenberg MF, Oleschuk CJ, Wu P, Mao Q, Deeley RG, Cole SP, Ford RC.

J Struct Biol. 2010 Jun;170(3):540-7. doi: 10.1016/j.jsb.2010.01.011. Epub 2010 Jan 28.

4.

Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1).

Maeno K, Nakajima A, Conseil G, Rothnie A, Deeley RG, Cole SP.

Drug Metab Dispos. 2009 Jul;37(7):1411-20. doi: 10.1124/dmd.109.026633. Epub 2009 Apr 27.

5.

Residues responsible for the asymmetric function of the nucleotide binding domains of multidrug resistance protein 1.

Qin L, Zheng J, Grant CE, Jia Z, Cole SP, Deeley RG.

Biochemistry. 2008 Dec 30;47(52):13952-65. doi: 10.1021/bi801532g.

PMID:
19063607
6.

Multiple roles of charged amino acids in cytoplasmic loop 7 for expression and function of the multidrug and organic anion transporter MRP1 (ABCC1).

Conseil G, Rothnie AJ, Deeley RG, Cole SP.

Mol Pharmacol. 2009 Feb;75(2):397-406. doi: 10.1124/mol.108.052860. Epub 2008 Nov 17.

7.

Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3).

Grant CE, Gao M, DeGorter MK, Cole SP, Deeley RG.

Drug Metab Dispos. 2008 Dec;36(12):2571-81. doi: 10.1124/dmd.108.022491. Epub 2008 Sep 5.

8.

Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport.

Rothnie A, Conseil G, Lau AY, Deeley RG, Cole SP.

Mol Pharmacol. 2008 Dec;74(6):1630-40. doi: 10.1124/mol.108.049080. Epub 2008 Sep 2.

9.

Identification of regions required for apical membrane localization of human multidrug resistance protein 2.

Bandler PE, Westlake CJ, Grant CE, Cole SP, Deeley RG.

Mol Pharmacol. 2008 Jul;74(1):9-19. doi: 10.1124/mol.108.045674. Epub 2008 Apr 1.

10.

Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter.

Létourneau IJ, Nakajima A, Deeley RG, Cole SP.

Biochem Pharmacol. 2008 Apr 15;75(8):1659-69. doi: 10.1016/j.bcp.2008.01.009. Epub 2008 Feb 5.

PMID:
18336795
11.
12.

Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1).

DeGorter MK, Conseil G, Deeley RG, Campbell RL, Cole SP.

Biochem Biophys Res Commun. 2008 Jan 4;365(1):29-34. Epub 2007 Oct 31.

PMID:
17980150
13.

Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function.

Létourneau IJ, Slot AJ, Deeley RG, Cole SP.

Drug Metab Dispos. 2007 Aug;35(8):1372-9. Epub 2007 May 9.

14.

Transport of glutathione and glutathione conjugates by MRP1.

Cole SP, Deeley RG.

Trends Pharmacol Sci. 2006 Aug;27(8):438-46. Epub 2006 Jul 3. Review.

PMID:
16820223
15.
16.

ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells.

Tam SP, Mok L, Chimini G, Vasa M, Deeley RG.

Am J Physiol Cell Physiol. 2006 Sep;291(3):C490-502. Epub 2006 Apr 12.

17.

Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1).

Rothnie A, Callaghan R, Deeley RG, Cole SP.

J Biol Chem. 2006 May 19;281(20):13906-14. Epub 2006 Mar 24.

18.
19.

Substrate recognition and transport by multidrug resistance protein 1 (ABCC1).

Deeley RG, Cole SP.

FEBS Lett. 2006 Feb 13;580(4):1103-11. Epub 2005 Dec 21. Review.

21.
22.
23.

Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters.

Conseil G, Deeley RG, Cole SP.

Pharmacogenet Genomics. 2005 Aug;15(8):523-33. Review.

PMID:
16006996
24.

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense.

Leslie EM, Deeley RG, Cole SP.

Toxicol Appl Pharmacol. 2005 May 1;204(3):216-37. Review.

PMID:
15845415
25.
26.
27.

Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1).

Payen L, Gao M, Westlake C, Theis A, Cole SP, Deeley RG.

Mol Pharmacol. 2005 Jun;67(6):1944-53. Epub 2005 Mar 8.

28.

Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas.

Conseil G, Deeley RG, Cole SP.

Biochem Pharmacol. 2005 Feb 1;69(3):451-61. Epub 2004 Dec 16.

PMID:
15652236
29.

Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.

Westlake CJ, Payen L, Gao M, Cole SP, Deeley RG.

J Biol Chem. 2004 Dec 17;279(51):53571-83. Epub 2004 Sep 30.

30.
33.
34.

The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation.

Haimeur A, Conseil G, Deeley RG, Cole SP.

Curr Drug Metab. 2004 Feb;5(1):21-53. Review.

PMID:
14965249
36.

Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3.

Westlake CJ, Qian YM, Gao M, Vasa M, Cole SP, Deeley RG.

Biochemistry. 2003 Dec 9;42(48):14099-113.

PMID:
14640677
37.

Cloning and Characterization of the Murine and Rat mrp1 Promoter Regions.

Muredda M, Nunoya K, Burtch-Wright RA, Kurz EU, Cole SP, Deeley RG.

Mol Pharmacol. 2003 Nov;64(5):1259-69.

38.

Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1).

Campbell JD, Koike K, Moreau C, Sansom MS, Deeley RG, Cole SP.

J Biol Chem. 2004 Jan 2;279(1):463-8. Epub 2003 Oct 15.

41.
42.

Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1).

Payen LF, Gao M, Westlake CJ, Cole SP, Deeley RG.

J Biol Chem. 2003 Oct 3;278(40):38537-47. Epub 2003 Jul 27.

43.

Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1).

Nunoya K, Grant CE, Zhang D, Cole SP, Deeley RG.

Drug Metab Dispos. 2003 Aug;31(8):1016-26.

44.
45.

Structural requirements for functional interaction of glutathione tripeptide analogs with the human multidrug resistance protein 1 (MRP1).

Leslie EM, Bowers RJ, Deeley RG, Cole SP.

J Pharmacol Exp Ther. 2003 Feb;304(2):643-53. Erratum in: J Pharmacol Exp Ther. 2003 May;305(2):798.

46.
47.

Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1.

Koike K, Oleschuk CJ, Haimeur A, Olsen SL, Deeley RG, Cole SP.

J Biol Chem. 2002 Dec 20;277(51):49495-503. Epub 2002 Oct 17.

48.

Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3.

Oleschuk CJ, Deeley RG, Cole SP.

Am J Physiol Gastrointest Liver Physiol. 2003 Feb;284(2):G280-9. Epub 2002 Oct 9.

49.
50.

Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione.

Qian YM, Grant CE, Westlake CJ, Zhang DW, Lander PA, Shepard RL, Dantzig AH, Cole SP, Deeley RG.

J Biol Chem. 2002 Sep 20;277(38):35225-31. Epub 2002 Jul 22.

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