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Items: 50

1.

Juvenile Diabetes Research Foundation: mission, strategy, and priorities.

Insel RA, Deecher DC, Brewer J.

Diabetes. 2012 Jan;61(1):30-5. doi: 10.2337/db11-1398. Review. No abstract available.

2.

Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).

O'Neill DJ, Adedoyin A, Bray JA, Deecher DC, Fensome A, Goldberg JA, Harrison J, Leventhal L, Mann C, Mark L, Nogle L, Sullivan NR, Spangler TB, Terefenko EA, Trybulski EJ, Uveges AJ, Vu A, Whiteside GT, Zhang P.

J Med Chem. 2011 Oct 13;54(19):6824-31. doi: 10.1021/jm200733r. Epub 2011 Sep 14.

PMID:
21916421
3.

WAY-318068: a novel, potent and selective noradrenaline re-uptake inhibitor with activity in rodent models of pain and depression.

Whiteside GT, Dwyer JM, Harrison JE, Beyer CE, Cummons T, Manzino L, Mark L, Johnston GH, Strassle BW, Adedoyin A, Lu P, Piesla MJ, Pulicicchio CM, Erve JC, Platt BJ, Hughes ZA, Rogers KE, Deecher DC, Trybulski EJ, Kennedy JD, Zhang P, Leventhal L.

Br J Pharmacol. 2010 Jul;160(5):1105-18. doi: 10.1111/j.1476-5381.2010.00690.x.

4.

Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter.

Gavrin LK, Mahaney PE, Jenkins D, Nogle LM, Mugford CA, Huselton C, Leiter J, Johnston GH, Bray JA, Burroughs KD, Cosmi SA, Alfinito P, Ho DM, Deecher DC, Trybulski EJ.

ACS Med Chem Lett. 2010 Mar 25;1(3):91-5. doi: 10.1021/ml100009p. eCollection 2010 Jun 10.

5.

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).

O'Neill DJ, Adedoyin A, Alfinito PD, Bray JA, Cosmi S, Deecher DC, Fensome A, Harrison J, Leventhal L, Mann C, McComas CC, Sullivan NR, Spangler TB, Uveges AJ, Trybulski EJ, Whiteside GT, Zhang P.

J Med Chem. 2010 Jun 10;53(11):4511-21. doi: 10.1021/jm100053t.

PMID:
20462211
6.

Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.

Sabatucci JP, Mahaney PE, Leiter J, Johnston G, Burroughs K, Cosmi S, Zhang Y, Ho D, Deecher DC, Trybulski E.

Bioorg Med Chem Lett. 2010 May 1;20(9):2809-12. doi: 10.1016/j.bmcl.2010.03.059. Epub 2010 Mar 15.

PMID:
20378347
7.

Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.

Fensome A, Goldberg J, McComas CC, Trybulski EJ, Woodworth RP, Deecher DC, Whiteside GT, Zhang P.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1555-8. doi: 10.1016/j.bmcl.2010.01.056. Epub 2010 Jan 20.

PMID:
20153188
8.

1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.

Vu AT, Cohn ST, Zhang P, Kim CY, Mahaney PE, Bray JA, Johnston GH, Koury EJ, Cosmi SA, Deecher DC, Smith VA, Harrison JE, Leventhal L, Whiteside GT, Kennedy JD, Trybulski EJ.

J Med Chem. 2010 Mar 11;53(5):2051-62. doi: 10.1021/jm901559e.

PMID:
20131864
9.

Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.

Heffernan GD, Coghlan RD, Manas ES, McDevitt RE, Li Y, Mahaney PE, Robichaud AJ, Huselton C, Alfinito P, Bray JA, Cosmi SA, Johnston GH, Kenney T, Koury E, Winneker RC, Deecher DC, Trybulski EJ.

Bioorg Med Chem. 2009 Nov 15;17(22):7802-15. doi: 10.1016/j.bmc.2009.09.023. Epub 2009 Sep 18.

PMID:
19836247
10.

Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.

Mahaney PE, Kim CY, Coghlan RD, Cohn ST, Heffernan GD, Huselton CA, Terefenko EA, Vu AT, Zhang P, Burroughs KD, Cosmi SA, Bray JA, Johnston GH, Deecher DC, Trybulski EJ.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5807-10. doi: 10.1016/j.bmcl.2009.07.050. Epub 2009 Aug 25.

PMID:
19713106
11.

Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.

Kim CY, Mahaney PE, McConnell O, Zhang Y, Manas E, Ho DM, Deecher DC, Trybulski EJ.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5029-32. doi: 10.1016/j.bmcl.2009.07.053. Epub 2009 Jul 23.

PMID:
19632110
12.

Estradiol increases catecholamine levels in the hypothalamus of ovariectomized rats during the dark-phase.

Alfinito PD, Chen X, Mastroeni R, Pawlyk AC, Deecher DC.

Eur J Pharmacol. 2009 Aug 15;616(1-3):334-9. doi: 10.1016/j.ejphar.2009.06.045. Epub 2009 Jul 2.

PMID:
19576879
13.

3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.

Vu AT, Cohn ST, Terefenko EA, Moore WJ, Zhang P, Mahaney PE, Trybulski EJ, Goljer I, Dooley R, Bray JA, Johnston GH, Leiter J, Deecher DC.

Bioorg Med Chem Lett. 2009 May 1;19(9):2464-7. doi: 10.1016/j.bmcl.2009.03.054. Epub 2009 Mar 18.

PMID:
19329313
14.

Simultaneous telemetric monitoring of tail-skin and core body temperature in a rat model of thermoregulatory dysfunction.

Cosmi S, Pawlyk AC, Alfinito PD, Roman J, Zhou T, Deecher DC.

J Neurosci Methods. 2009 Apr 15;178(2):270-5. doi: 10.1016/j.jneumeth.2008.12.013. Epub 2008 Dec 24.

PMID:
19135085
15.

Characterization of ligands for thyroid receptor subtypes and their interactions with co-regulators.

Koury EJ, Pawlyk AC, Berrodin TJ, Smolenski CL, Nagpal S, Deecher DC.

Steroids. 2009 Feb;74(2):270-6. doi: 10.1016/j.steroids.2008.11.014. Epub 2008 Nov 27.

PMID:
19073200
16.

Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.

McComas CC, Vu AT, Mahaney PE, Cohn ST, Fensome A, Marella MA, Nogle L, Trybulski EJ, Ye F, Zhang P, Alfinito P, Bray J, Johnston G, Koury E, Deecher DC.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):4929-31. doi: 10.1016/j.bmcl.2008.08.060. Epub 2008 Aug 22.

PMID:
18771916
17.

Effect of 17alpha-ethinyl estradiol on active phase rapid eye movement sleep microarchitecture.

Pawlyk AC, Alfinito PD, Deecher DC.

Eur J Pharmacol. 2008 Sep 4;591(1-3):315-8. doi: 10.1016/j.ejphar.2008.06.084. Epub 2008 Jun 27.

PMID:
18619956
18.

ICI 182,780 penetrates brain and hypothalamic tissue and has functional effects in the brain after systemic dosing.

Alfinito PD, Chen X, Atherton J, Cosmi S, Deecher DC.

Endocrinology. 2008 Oct;149(10):5219-26. doi: 10.1210/en.2008-0532. Epub 2008 Jul 3.

PMID:
18599545
19.

Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.

Mahaney PE, Gavrin LK, Trybulski EJ, Stack GP, Vu TA, Cohn ST, Ye F, Belardi JK, Santilli AA, Sabatucci JP, Leiter J, Johnston GH, Bray JA, Burroughs KD, Cosmi SA, Leventhal L, Koury EJ, Zhang Y, Mugford CA, Ho DM, Rosenzweig-Lipson SJ, Platt B, Smith VA, Deecher DC.

J Med Chem. 2008 Jul 10;51(13):4038-49. doi: 10.1021/jm8002262. Epub 2008 Jun 17.

PMID:
18557608
20.
21.

Subchronic 17alpha-ethinyl estradiol differentially affects subtypes of sleep and wakefulness in ovariectomized rats.

Pawlyk AC, Alfinito PD, Johnston GH, Deecher DC.

Horm Behav. 2008 Jan;53(1):217-24. Epub 2007 Oct 5.

PMID:
17976600
22.

Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.

Mason JN, Deecher DC, Richmond RL, Stack G, Mahaney PE, Trybulski E, Winneker RC, Blakely RD.

J Pharmacol Exp Ther. 2007 Nov;323(2):720-9. Epub 2007 Aug 2.

PMID:
17673606
23.

The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models.

Maswood N, Cosmi S, Alfinito PD, Leventhal L, Deecher DC.

Neuroendocrinology. 2006;84(5):330-8. Epub 2006 Dec 28.

PMID:
17192701
24.

Alleviation of thermoregulatory dysfunction with the new serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized rodent models.

Deecher DC, Alfinito PD, Leventhal L, Cosmi S, Johnston GH, Merchenthaler I, Winneker R.

Endocrinology. 2007 Mar;148(3):1376-83. Epub 2006 Nov 22.

PMID:
17122073
25.

Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation.

Pawlyk AC, Cosmi S, Alfinito PD, Maswood N, Deecher DC.

Brain Res. 2006 Dec 6;1123(1):135-44. Epub 2006 Oct 24.

PMID:
17067560
26.
27.

Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.

Deecher DC, Beyer CE, Johnston G, Bray J, Shah S, Abou-Gharbia M, Andree TH.

J Pharmacol Exp Ther. 2006 Aug;318(2):657-65. Epub 2006 May 4.

PMID:
16675639
28.

Physiology of thermoregulatory dysfunction and current approaches to the treatment of vasomotor symptoms.

Deecher DC.

Expert Opin Investig Drugs. 2005 Apr;14(4):435-48. Review.

PMID:
15882119
29.

Endogenously expressed estrogen receptors mediate neuroprotection in hippocampal cells (HT22).

Deecher DC, Daoud P, Bhat RA, O'Connor LT.

J Cell Biochem. 2005 May 15;95(2):302-12.

PMID:
15778979
30.
31.

Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.

Sipe K, Leventhal L, Burroughs K, Cosmi S, Johnston GH, Deecher DC.

Brain Res. 2004 Dec 3;1028(2):191-202.

PMID:
15527744
32.

A glutathione-S-transferase-FSHalpha subunit hybrid associates with FSHbeta, retains biological activity, and facilitates purification.

Stevis PE, Arey BJ, Deecher DC.

Biochem Biophys Res Commun. 2004 Jul 2;319(3):1026-31.

PMID:
15184084
33.

Characterization of a membrane-associated estrogen receptor in a rat hypothalamic cell line (D12).

Deecher DC, Swiggard P, Frail DE, O'Connor LT.

Endocrine. 2003 Dec;22(3):211-23.

PMID:
14709794
34.

Identification and characterization of a selective, nonpeptide follicle-stimulating hormone receptor antagonist.

Arey BJ, Deecher DC, Shen ES, Stevis PE, Meade EH Jr, Wrobel J, Frail DE, López FJ.

Endocrinology. 2002 Oct;143(10):3822-9.

PMID:
12239093
35.
36.

Galanin: neurobiologic mechanisms and therapeutic potential for Alzheimer's disease.

Counts SE, Perez SE, Kahl U, Bartfai T, Bowser RP, Deecher DC, Mash DC, Crawley JN, Mufson EJ.

CNS Drug Rev. 2001 Winter;7(4):445-70. Review.

37.

Synthesis of (bis)sulfonic acid, (bis)benzamides as follicle-stimulating hormone (FSH) antagonists.

Wrobel J, Green D, Jetter J, Kao W, Rogers J, Pérez MC, Hardenburg J, Deecher DC, López FJ, Arey BJ, Shen ES.

Bioorg Med Chem. 2002 Mar;10(3):639-56.

PMID:
11814852
38.

Galanin receptor plasticity within the nucleus basalis in early and late Alzheimer's disease: an in vitro autoradiographic analysis.

Mufson EJ, Deecher DC, Basile M, Izenwasse S, Mash DC.

Neuropharmacology. 2000 Jun 8;39(8):1404-12.

PMID:
10818256
39.

Differential effects of estradiol and estradiol-BSA conjugates.

Stevis PE, Deecher DC, Suhadolnik L, Mallis LM, Frail DE.

Endocrinology. 1999 Nov;140(11):5455-8.

PMID:
10537181
40.

Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line.

Fitzpatrick SL, Berrodin TJ, Jenkins SF, Sindoni DM, Deecher DC, Frail DE.

Endocrinology. 1999 Sep;140(9):3928-37.

PMID:
10465261
41.
42.

Expression of estrogen receptor-beta protein in rodent ovary.

Fitzpatrick SL, Funkhouser JM, Sindoni DM, Stevis PE, Deecher DC, Bapat AR, Merchenthaler I, Frail DE.

Endocrinology. 1999 Jun;140(6):2581-91.

PMID:
10342845
43.

Galanin expression within the basal forebrain in Alzheimer's disease. Comments on therapeutic potential.

Mufson EJ, Kahl U, Bowser R, Mash DC, Kordower JH, Deecher DC.

Ann N Y Acad Sci. 1998 Dec 21;863:291-304. Review.

PMID:
9928179
44.

Characterization and localization of galanin receptors in human entorhinal cortex.

Deecher DC, Mash DC, Staley JK, Mufson EJ.

Regul Pept. 1998 Feb 27;73(3):149-59.

PMID:
9556077
45.
46.

Induction of promiscuous G protein coupling of the follicle-stimulating hormone (FSH) receptor: a novel mechanism for transducing pleiotropic actions of FSH isoforms.

Arey BJ, Stevis PE, Deecher DC, Shen ES, Frail DE, Negro-Vilar A, Lopez FJ.

Mol Endocrinol. 1997 May;11(5):517-26.

PMID:
9139796
47.
48.
49.

Detection of 5-hydroxytryptamine2 receptors by radioligand binding, northern blot analysis, and Ca2+ responses in rat primary astrocyte cultures.

Deecher DC, Wilcox BD, Dave V, Rossman PA, Kimelberg HK.

J Neurosci Res. 1993 Jun 15;35(3):246-56.

PMID:
8394435
50.

Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies.

Deecher DC, Teitler M, Soderlund DM, Bornmann WG, Kuehne ME, Glick SD.

Brain Res. 1992 Feb 7;571(2):242-7.

PMID:
1377086

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